Dermatan sulfate domains defined by the novel antibody GD3A12, in normal tissues and ovarian adenocarcinomasSpringer Science and Business Media LLC - Tập 132 - Trang 117-127 - 2009
Gerdy B. ten Dam, Shuhei Yamada, Fumi Kobayashi, Anurag Purushothaman, Els M.A. van de Westerlo, Johan Bulten, Anders Malmström, Kazuyuki Sugahara, Leon F. Massuger, Toin H. van Kuppevelt
Dermatan sulfate (DS) expression in normal tissue and ovarian cancer was investigated using the novel, phage display-derived antibody GD3A12 that was selected against embryonic glycosaminoglycans (GAGs). Antibody GD3A12 was especially reactive with DS rich in IdoA-GalNAc4S disaccharide units. IdoA residues are important for antibody recognition as DS polymers with low numbers of IdoA residues were...... hiện toàn bộ
Chromogranin A (CGA) in the gastro-entero-pancreatic (GEP) endocrine systemSpringer Science and Business Media LLC - Tập 85 - Trang 441-452 - 1986
D. Grube, D. Aunis, F. Bader, Y. Cetin, A. Jörns, S. Yoshie
Chromogranin A (CGA), a protein at first detected in the adrenal medulla, has recently been found also in other organs, e.g. the endocrine pancreas. However, immunohistochemical findings concerning the cellular source of pancreatic CGA were controversial. Therefore, the endocrine pancreas of 10 mammalian species (man, tupaia, mole, cat, dog, pig, guinea pig, rabbit, rat) was investigated immunohis...... hiện toàn bộ
A quantitative approach to trace the corticotrophs in culture after adrenalectomySpringer Science and Business Media LLC - Tập 73 - Trang 131-136 - 1981
G. Rappay, G. B. Makara
Anterior pituitaries of adrenalectomized and sham operated adult rats were dispersed by trypsin and cultured for 4 and 8 days. Adrenalectomy caused a moderate increase in number of corticotrophs in both zero-time cell suspensions and cultures. There was a pronounced elevation of immunoreactive ACTH content in both cells and media and an enhanced secretory response to stimulation of cultures with s...... hiện toàn bộ
Clustered carbohydrates as a target for natural killer cells: a model systemSpringer Science and Business Media LLC - Tập 127 - Trang 313-326 - 2007
Elena I. Kovalenko, Elena Abakushina, William Telford, Veena Kapoor, Elena Korchagina, Sergei Khaidukov, Irina Molotkovskaya, Alexander Sapozhnikov, Pavel Vlaskin, Nicolai Bovin
Membrane-associated oligosaccharides are known to take part in interactions between natural killer (NK) cells and their targets and modulate NK cell activity. A model system was therefore developed using synthetic glycoconjugates as tools to modify the carbohydrate pattern on NK target cell surfaces. NK cells were then assessed for function in response to synthetic glycoconjugates, using both cyto...... hiện toàn bộ
Local cerebral glucose utilization in the autoimmune New Zealand Black (NZB) mouseSpringer Science and Business Media LLC - Tập 92 - Trang 343-348 - 1989
A. Wree, T. Beck, G. W. Bielenberg, A. Schleicher, K. Zilles
By means of the [14C]-2-deoxyglucose method the local cerebral glucose utilization (LCGU) was measured in 41 brain regions in autoimmune New Zealand Black (NZB) mice and in Carworth Farm Winkelmann (CFW) mice, which served as the control strain. At the age of 6 months, the mean LCGU of all measured areas and brain stem nuclei was 67.7 μmol glucose/(100 g x min) in the nonautoimmune CFW mice. These...... hiện toàn bộ
Autoimmunity, cancer and COVID-19 abnormally activate wound healing pathways: critical role of inflammationSpringer Science and Business Media LLC - Tập 158 - Trang 415-434 - 2022
Peter Gál, Jan Brábek, Michal Holub, Milan Jakubek, Aleksi Šedo, Lukáš Lacina, Karolína Strnadová, Petr Dubový, Helena Hornychová, Aleš Ryška, Karel Smetana
Recent evidence indicates that targeting IL-6 provides broad therapeutic approaches to several diseases. In patients with cancer, autoimmune diseases, severe respiratory infections [e.g. coronavirus disease 2019 (COVID-19)] and wound healing, IL-6 plays a critical role in modulating the systemic and local microenvironment. Elevated serum levels of IL-6 interfere with the systemic immune response a...... hiện toàn bộ
Morphologic and cytochemical identification of microperoxisomes in human and non-human primate placental trophoblastSpringer Science and Business Media LLC - Tập 74 - Trang 115-121 - 1982
B. F. King
Human and non-human primate placental villi (near term) were incubated in an alkaline 3,3′ diamino benzidine (DAB) medium to identify the distribution of microperoxisomes in these tissues. Catalase-positive microperoxisomes were present in small numbers in cytotrophoblast, but were virtually absent from syncytiotrophoblast. Microperoxisomes were roughly circular in shape and about 0.2–0.3 μm in di...... hiện toàn bộ