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Monoclonal immunoglobulins— Development of a concept
Springer Science and Business Media LLC - Tập 1 Số 4 - Trang 225-226 - 1984
Development of new anti-cancer drugs
Springer Science and Business Media LLC - Tập 3 - Trang 63-69 - 1986
In the first award lecture of the European Society of Medical Oncology (ESMO) the topic of new drug development and the role of the European Organization for Research and Treatment of Cancer (EORTC) was highlighted. New aspects in each of the drug development steps are discussed: acquisition, screening, formulation, toxicology and phase I studies. In the search for new compounds to treat human sol...... hiện toàn bộ
Methodologies for quantifying the results of intravesical chemotherapy of superficial tumors of the bladder
Springer Science and Business Media LLC - Tập 2 - Trang 249-254 - 1985
Various evaluation methods exist to report results of installation therapy on superficial urinary bladder cancer. The following three, based on material previously gathered from 30 patients treated with adriamycin instillations, are analysed in this study: (1) The graphic expression method which covers the most necessary details, but demands space and does not permit adequate statistical analysis....... hiện toàn bộ
Phase I clinical and pharmacokinetic study of orally administeredN 4-palmitoyl-1-β-d-arabinofuranosylcytosine
Springer Science and Business Media LLC - Tập 4 - Trang 67-73 - 1987
A phase I study ofN
4-palmitoyl-1-β-d-arabinofuranosylcytosine (PLAC) was conducted in 88 patients; 36 with solid tumors and 52 with hematological malignancies, using 2 different schedules. Schedule 1 employed a single oral administration and Schedule 2, 5-day consecutive daily oral administration. In Schedule 1, the daily dose was initiated with 1 mg kg−1 which was escalated up to...... hiện toàn bộ
Serum thymidine kinase in diagnosis and follow-up of the small cell carcinoma of the lung
Springer Science and Business Media LLC - Tập 8 - Trang 29-34 - 1991
Serum thymicline-kinase (sTK) was assayed in 48 males affected by small cell carcinoma of the lung (SCCL) at the time of diagnosis. On the same drawing carcinoembryonic antigen (CEA) and β2microglobulin (β2μG) were assayed in 19 of these subjects. For staging, the criterion of limited (LD) and extensive (ED) disease was used. Mean sTK and CEA values were above normal range in both the LD and ED gr...... hiện toàn bộ
Obituary-Peter Reizenstein MD
Springer Science and Business Media LLC - Tập 10 - Trang 189-189 - 1993
Chemotherapy and immunotherapy of colorectal cancer
Springer Science and Business Media LLC - Tập 8 - Trang 207-220 - 1991
More than 50% of the patients with large bowel cancer develop disseminated disease and invariably succumb. Adjuvant chemotherapy with 5-FU and levamisole have been shown to be more efficient than 5-FU alone or in combination with cytostatics. The combination of 5-FU, leukovorin and methotrexate induces prolonged survival with a good quality of life in metastatic colorectal cancer (CRC). During the...... hiện toàn bộ
Cyclosporin a (Csp) — An immunosuppressive drug specific for T-helper cells?
Springer Science and Business Media LLC - Tập 2 - Trang 63-63 - 1985
Nabilone and metoclopramide in the treatment of nausea and vomiting due to cisplatinum: A double blind study
Springer Science and Business Media LLC - Tập 3 - Trang 39-42 - 1986
Thirty-two patients were entered into a double blind trial of antiemetic support in patients being treated with cisplatin. Patients were allocated to receive either oral nabilone (1 mg 8 hourly) or intravenous metoclopramide (1 mg kg−1 3 hourly) in random order over 4 courses. There was no difference between the two treatments in the overall incidence or severity of vomiting, although a subgroup o...... hiện toàn bộ
Aneuploidy as a prognostic factor in breast cancer
Springer Science and Business Media LLC - Tập 6 Số 2 - Trang 117-120 - 1989
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