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Dopamine transporters in the cerebellum of mutant mice
Springer Science and Business Media LLC - Tập 4 - Trang 105-111 - 2005
In the central nervous system, dopamine is known to play a critical role in motor and cognitive functions. Although the cerebellum plays a role in the control of movement and posture and in cognitive functions, it has not been considered to be a dopaminergic region and the dopamine present was thought to represent a precursor of noradrenaline. However, recent evidence suggests that in the cerebell......
Brain development, environment and sex: what can we learn from studying graviperception, gravitransduction and the gravireaction of the developing CNS to altered gravity?
Springer Science and Business Media LLC - Tập 7 - Trang 223-239 - 2008
As man embarks on space exploration and contemplates space habitation, there is a critical need for basic understanding of the impact of the environmental factors of space, and in particular gravity, on human survival, health, reproduction and development. This review summarizes our present knowledge on the effect of altered gravity on the developing CNS with respect to the response of the develop......
Are Purkinje Cell Pauses Drivers of Classically Conditioned Blink Responses?Abstract
Several lines of evidence show that classical or Pavlovian conditioning of blink responses depends on the cerebellum. Recordings from cerebellar Purkinje cells that control the eyelid and the conditioned blink show that during training with a conditioning protocol, a Purkinje cell develops a pause response to the conditional stimulus. This condit... ...
Springer Science and Business Media LLC - Tập 15 Số 4 - Trang 526-534 - 2016
Tremor-Dominant Cervical Dystonia: a Cerebellar Syndrome
Springer Science and Business Media LLC - Tập 20 - Trang 300-305 - 2020
The objective of this study is to examine the role of the cerebellum in the tremor-dominant subtype of cervical dystonia (CD). CD patients with head tremor at onset (Tr-CD) were age- and sex-matched to CD patients without head tremor at onset (nTr-CD). All patients were evaluated for cerebellar disability using the Scale for the Assessment and Rating of Ataxia (SARA), gait variability using ProtoK......
Greater Disruption to Control of Voluntary Saccades in Autistic Disorder than Asperger’s Disorder: Evidence for Greater Cerebellar Involvement in Autism?
Springer Science and Business Media LLC - Tập 10 - Trang 70-80 - 2010
It remains unclear whether autism and Asperger’s disorder (AD) exist on a symptom continuum or are separate disorders with discrete neurobiological underpinnings. In addition to impairments in communication and social cognition, motor deficits constitute a significant clinical feature in both disorders. It has been suggested that motor deficits and in particular the integrity of cerebellar modulat......
Linking Essential Tremor to the Cerebellum—Animal Model Evidence
Springer Science and Business Media LLC - Tập 15 - Trang 285-298 - 2015
In this review, we hope to stimulate interest in animal models as opportunities to understand tremor mechanisms within the cerebellar system. We begin by considering the harmaline model of essential tremor (ET), which has ET-like anatomy and pharmacology. Harmaline induces the inferior olive (IO) to burst fire rhythmically, recruiting rhythmic activity in Purkinje cells (PCs) and deep cerebellar n......
Metalinguistic Deficits in Patients with Cerebellar Dysfunction: Empirical Support for the Dysmetria of Thought Theory
Springer Science and Business Media LLC - Tập 14 - Trang 50-58 - 2014
The cerebellar cognitive affective syndrome (CCAS) includes disruption of linguistic processing such as verbal fluency, verbal working memory, grammar, and speech perception. We set out to examine linguistic capabilities in patients with cerebellar lesions to determine which domains are spared and which impaired and to evaluate the underlying cognitive structure of these deficits. Forty-four patie......
The Contributions of the Cerebellum in Sensorimotor Control: What Are the Prevailing Opinions Which Will Guide Forthcoming Studies?
Springer Science and Business Media LLC - Tập 12 - Trang 313-315 - 2013
Although considerable progress has been made in developing models of cerebellar function in sensorimotor control, the exact nature of the basic operations performed by the cerebellum remain elusive. Several major theories have emerged these last decades. According to the hypothesis of Marr and Albus, the climbing fiber input carries an error signal weakening the strength of a subset of parallel fi......
Correction to: Translation, Cross-Cultural Adaptation, and Validation to Brazilian Portuguese of the Cerebellar Cognitive Affective/Schmahmann Syndrome Scale
Springer Science and Business Media LLC -
Prevalence and Diagnostic Journey of Friedreich’s Ataxia in the State of São Paulo, Brazil
Springer Science and Business Media LLC - - 2024
Friedreich's Ataxia (FRDA) is the leading cause of ataxia worldwide, but data on epidemiology and diagnostic journey are scarce, particularly in Latin America. Herein we estimated the prevalence of FRDA in the most populous Brazilian state and characterized the diagnostic odyssey of the disease. We received anonymized data of patients with FRDA from advocacy groups and physicians. Prevalence was e......
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