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The metabolome as a link in the genotype-phenotype map for peroxide resistance in the fruit fly, Drosophila melanogaster
Springer Science and Business Media LLC - Tập 21 Số 1 - 2020
Ben Harrison, Lu Wang, Erika Gajda, Elise V. Hoffman, Brian Y. Chung, Scott D. Pletcher, Daniel Raftery, Daniel Promislow
AbstractBackgroundGenetic association studies that seek to explain the inheritance of complex traits typically fail to explain a majority of the heritability of the trait under study. Thus, we are left with a gap in the map from genotype to phenotype. Several approaches have been used to fill this gap, including those that attempt...... hiện toàn bộ
An optimized protocol for microarray validation by quantitative PCR using amplified amino allyl labeled RNA
Springer Science and Business Media LLC - Tập 11 - Trang 1-13 - 2010
Céline Jeanty, Dan Longrois, Paul-Michel Mertes, Daniel R Wagner, Yvan Devaux
Validation of microarrays data by quantitative real-time PCR (qPCR) is often limited by the low amount of available RNA. This raised the possibility to perform validation experiments on the amplified amino allyl labeled RNA (AA-aRNA) leftover from microarrays. To test this possibility, we used an ongoing study of our laboratory aiming at identifying new biomarkers of graft rejection by the transcr...... hiện toàn bộ
Comparative genomic analysis of innate immunity reveals novel and conserved components in crustacean food crop species
Springer Science and Business Media LLC - Tập 18 Số 1 - 2017
Alvina Lai, A. Aziz Aboobaker
The planarian regeneration transcriptome reveals a shared but temporally shifted regulatory program between opposing head and tail scenarios
Springer Science and Business Media LLC - Tập 14 - Trang 1-17 - 2013
Damian Kao, Daniel Felix, Aziz Aboobaker
Planarians can regenerate entire animals from a small fragment of the body. The regenerating fragment is able to create new tissues and remodel existing tissues to form a complete animal. Thus different fragments with very different starting components eventually converge on the same solution. In this study, we performed an extensive RNA-seq time-course on regenerating head and tail fragments to o...... hiện toàn bộ
Epilepsy: knowledge, attitude and awareness in Jeddah Saudi Arabia
Springer Science and Business Media LLC - - 2014
Deena Fuad Haneef, Heyam Abdulsamad Abdulqayoum, Ahad Abdullah Sherbeni, Muhammad Faheem, Adeel G. Chaudhary, Mohammad H. Al-Qahtani, Muhammad Imran Naseer
Identification and application of piwi-interacting RNAs from seminal plasma exosomes in Cynoglossus semilaevis
Springer Science and Business Media LLC - Tập 21 Số 1 - 2020
Bo Zhang, Na Zhao, Jia Lu, Jinyuan Che, Xiaoxu He, Kefeng Liu, Baolong Bao
Abstract Background Piwi-interacting RNAs (piRNAs) have been linked to epigenetic and post-transcriptional gene silencing of retrotransposons in germ line cells, particularly in spermatogenesis. Exosomes are important mediators of vesicle transport, and the piRNAs in exosomes might play an important role in cell communication and ...... hiện toàn bộ
Tumor characterization and stratification by integrated molecular profiles reveals essential pan-cancer features
Springer Science and Business Media LLC - Tập 16 - Trang 1-12 - 2015
Zhaoqi Liu, Shihua Zhang
Identification of tumor heterogeneity and genomic similarities across different cancer types is essential to the design of effective stratified treatments and for the discovery of treatments that can be extended to different types of tumors. However, systematic investigations on comprehensive molecular profiles have not been fully explored to achieve this goal. Here, we performed a network-based i...... hiện toàn bộ
GAAP: Genome-organization-framework-Assisted Assembly Pipeline for prokaryotic genomes
Springer Science and Business Media LLC - Tập 18 - Trang 1-8 - 2017
Lina Yuan, Yang Yu, Yanmin Zhu, Yulai Li, Changqing Li, Rujiao Li, Qin Ma, Gilman Kit-Hang Siu, Jun Yu, Taijiao Jiang, Jingfa Xiao, Yu Kang
Next-generation sequencing (NGS) technologies have greatly promoted the genomic study of prokaryotes. However, highly fragmented assemblies due to short reads from NGS are still a limiting factor in gaining insights into the genome biology. Reference-assisted tools are promising in genome assembly, but tend to result in false assembly when the assigned reference has extensive rearrangements. Herei...... hiện toàn bộ
Analysis of BAC end sequences in oak, a keystone forest tree species, providing insight into the composition of its genome
Springer Science and Business Media LLC - Tập 12 - Trang 1-13 - 2011
Patricia Faivre Rampant, Isabelle Lesur, Clément Boussardon, Frédérique Bitton, Marie-Laure Martin-Magniette, Catherine Bodénès, Grégoire Le Provost, Hélène Bergès, Sylvia Fluch, Antoine Kremer, Christophe Plomion
One of the key goals of oak genomics research is to identify genes of adaptive significance. This information may help to improve the conservation of adaptive genetic variation and the management of forests to increase their health and productivity. Deep-coverage large-insert genomic libraries are a crucial tool for attaining this objective. We report herein the construction of a BAC library for Q...... hiện toàn bộ
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