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Avibacterium paragallinarum: an emerging birds pathogen in Qinling wildlife conservation center, China
AbstractThe bacterium Avibacterium paragallinarum, previously known as
Haemophilus paragallinarum, is responsible for causing infectious coryza (IC) in
chickens and other avian species. In this case report, an outbreak of
Avibacterium paragallinarum occurred in the Qinling area of China, resulting in
clinical symptoms of facial swelling in several bird species, including Golden
pheasant, Temminck'...
CRISPR-Cas9 mediated phage therapy as an alternative to antibiotics
Tập 3 Số 1
AbstractInappropriate use of antibiotics is globally creating public health
hazards associated with antibiotic resistance. Bacteria often acquire antibiotic
resistance by altering their genes through mutation or acquisition of
plasmid-encoding resistance genes. To treat drug-resistant strains of bacteria,
the recently developed CRISPR-Cas9 system might be an alternative molecular tool
to conventio...
Design of live-attenuated animal vaccines based on pseudorabies virus platform
Tập 2 Số 1 - 2022
AbstractPseudorabies virus (PRV) is a double-stranded DNA virus with a genome
approximating 150 kb in size. PRV contains many non-essential genes that can be
replaced with genes encoding heterogenous antigens without affecting viral
propagation. With the ability to induce cellular, humoral and mucosal immune
responses in the host, PRV is considered to be an ideal and potential live
vector for gene...
Chinese herbal extracts with antiviral activity: evaluation, mechanisms, and potential for preventing PRV, PEDV and PRRSV infections
Tập 3 Số 1
AbstractThe rapid expansion of large-scale pig farming has brought about a surge
in viral diseases with high morbidity rates and diverse manifestations. This
widespread occurrence of multiple viral diseases in pig farms has inflicted
severe economic losses on the global swine industry. Consequently, there is an
urgent need for eco-friendly and efficient antiviral drugs that can effectively
combat ...
Isolation of a feline-derived feline panleukopenia virus with an A300P substitution in the VP2 protein and confirmation of its pathogenicity in dogs
AbstractFeline panleukopenia virus (FPV) is a single-stranded DNA virus that can
infect cats and cause feline panleukopenia, which is a highly contagious and
fatal disease in felines. The sequence of FPV is highly variable, and mutations
in the amino acids of its capsid protein play crucial roles in altering viral
virulence, immunogenicity, host selection, and other abilities. In this study,
the e...
Identification of tick-borne pathogens using metagenomic analyses in H. longicornis feeding on humans in downtown Beijing
- 2021
AbstractOn August 14th, 2018, a Beijing resident living in Xicheng District
found a female H. longicornis tick attached to the skin at the front of his
upper shin. On examination, the patient was afebrile and appeared well. The
species of the tick was identified through morphological characteristics and
phylogenetic analysis based on cytochrome C oxidase subunit I. This H.
longicornis tick was scr...
Selenium nanoparticles reduce oxidative stress-induced cardiomyocyte apoptosis in ascites syndrome in broiler chickens via the ATF6-DR5 signaling pathway
Tập 3 Số 1
AbstractBroiler ascites syndrome (AS) is one of the main diseases threatening
the health of broilers. It is well documented that myocardial hypertrophy and
failure is one of the key mechanisms of broiler ascites syndrome. Therefore,
prevention of cardiac hypertrophy and failure would be one goal to reduce
broiler ascites syndrome incidence. Myocardial hypertrophy and failure are
closely related to...
Ancylostoma ceylanicum and other zoonotic canine hookworms: neglected public and animal health risks in the Asia–Pacific region
Tập 4 Số 1
AbstractZoonotic hookworm infections remain a significant public health problem,
causing nearly 500 million cases globally and approximately four million
disability-adjusted life years lost annually. More than one-fifth of these cases
are attributed to Ancylostoma ceylanicum, an emerging zoonotic health issue in
the Asia-Pacific region. This review presents key research gaps regarding the
epidemio...
Are dogs not susceptible to retroviral infections?
AbstractRetroviruses have been proven to cause infections and diseases in a
series of mammalian hosts but not in dogs. Then, this letter discussed the dog
susceptibility to retrovirus infection, encompassing arguments to understand why
dogs may have not been infected by retroviruses thus far. The potential
resistance of retrovirus in dogs enables this provocative short communication to
discuss thi...
Hot melt emulsification shear method for solid lipid-based suspension: from laboratory-scale to pilot-scale production
Tập 3 Số 1
AbstractThe clinical application of solid lipid particles (SLPs) is hampered due
to the need for advanced nano/micro-suspension production technology. This
research aims to establish a pilot-scale production line employing high-speed
shears as emulsification equipment. The primary purpose is to manufacture
nano/micro-suspensions using solid lipid particles (SLPs). The study also
exhaustively intro...