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iTRAQ-based quantitative proteomic analysis of thoracic aortas from adult rats born to preeclamptic dams
Springer Science and Business Media LLC - Tập 18 Số 1 - 2021
Bin Yu, Hong-Dan Zhu, Xiaoliang Shi, Pan‐Pan Chen, Xiang-Mei Sun, Gui-Yu Xia, Min Fang, Yong-Xing Zhong, Xiaoli Tang, Tao Zhang, Hai‐Tao Pan
Abstract Background Preeclampsia and gestational hypertension can cause vascular function impairment in offspring. In our previous work, we described the protein expression profiles of umbilical artery tissues from patients with preeclampsia. ...... hiện toàn bộ
New targets for an old drug
Springer Science and Business Media LLC - - 2004
Jacek J. Slon-Usakiewicz, Andrew Pasternak, Neil Reid, Leticia Toledo‐Sherman
Activity-based protein profiling guided identification of urine proteinase 3 activity in subclinical rejection after renal transplantation
Springer Science and Business Media LLC - Tập 17 Số 1 - 2020
Mario Navarrete, Brice Korkmaz, Carla Guarino, Adam Lesner, Ying Lao, Julie Ho, Peter Nickerson, John A. Wilkins
Abstract Background The pathophysiology of subclinical versus clinical rejection remains incompletely understood given their equivalent histological severity but discordant graft function. The goal was to evaluate serine hydrolase enzyme activities to explore if there were any underlying differences...... hiện toàn bộ
Identification of novel biomarker and therapeutic target candidates for acute intracerebral hemorrhage by quantitative plasma proteomics
Springer Science and Business Media LLC - Tập 14 - Trang 1-12 - 2017
Guo-chun Li, Lina Zhang, Ming Yu, Haiyu Jia, Ting Tian, Junqin Wang, Fuqiang Wang, Ling Zhou
The systematic mechanisms of acute intracerebral hemorrhage are still unknown and unverified, although many recent researches have indicated the secondary insults. This study was aimed to disclose the pathological mechanism and identify novel biomarker and therapeutic target candidates by plasma proteome. Patients with AICH (n = 8) who demographically matched healthy controls (n = 4) were prospect...... hiện toàn bộ
Mass spectrometry-based analyses showing the effects of secretor and blood group status on salivary N-glycosylation
Springer Science and Business Media LLC - Tập 12 - Trang 1-16 - 2015
Matthew E. Albertolle, Maria E. Hassis, Connie Jen Ng, Severino Cuison, Katherine Williams, Akraporn Prakobphol, Andrew B. Dykstra, Steven C. Hall, Richard K. Niles, H. Ewa Witkowska, Susan J. Fisher
The carbohydrate portions of salivary glycoproteins play important roles, including mediating bacterial and leukocyte adhesion. Salivary glycosylation is complex. Many of its glycoproteins present ABO and Lewis blood group determinants. An individual’s genetic complement and secretor status govern the expression of blood group antigens. We queried the extent to which salivary glycosylation varies ...... hiện toàn bộ
Predictive proteomic signatures for response of pancreatic cancer patients receiving chemotherapy
Springer Science and Business Media LLC - Tập 16 - Trang 1-12 - 2019
Hong Peng, Ru Chen, Teresa A. Brentnall, Jimmy K. Eng, Vincent J. Picozzi, Sheng Pan
Pancreatic ductal adenocarcinoma (PDAC) is a lethal cancer that is characterized by its poor prognosis, rapid progression and development of drug resistance. Chemotherapy is a vital treatment option for most of PDAC patients. Stratification of PDAC patients, who would have a higher likelihood of responding to chemotherapy, could facilitate treatment selection and patient management. A quantitative...... hiện toàn bộ
A robust mass spectrometry method for rapid profiling of erythrocyte ghost membrane proteomes
Springer Science and Business Media LLC - Tập 15 Số 1 - Trang 1-8 - 2018
Fye, Haddy K. S., Mrosso, Paul, Bruce, Lesley, Thézénas, Marie-Laëtitia, Davis, Simon, Fischer, Roman, Rwegasira, Gration L., Makani, Julie, Kessler, Benedikt M.
Red blood cell (RBC) physiology is directly linked to many human disorders associated with low tissue oxygen levels or anemia including chronic obstructive pulmonary disease, congenital heart disease, sleep apnea and sickle cell anemia. Parasites such as Plasmodium spp. and phylum Apicomplexa directly target RBCs, and surface molecules within the RBC membrane are critical for pathogen interactions...... hiện toàn bộ
Urinary Peptidomic Analysis Identifies Potential Biomarkers for Acute Rejection of Renal Transplantation
Springer Science and Business Media LLC - - 2009
Tara K. Sigdel, Xuefeng B. Ling, Ken Lau, Li Li, James Schilling, Minnie M. Sarwal
Abstract Introduction Human urine is a complex matrix of proteins, endogenous peptides, lipids, and metabolites. The level of any or all of these components can reflect the pathophysiological status of an individual especially of the kidney at the time of urine collection. The naturally occurring...... hiện toàn bộ
Phân đoạn C-terminus của Thụ thể Adiponectin-1 (CTF) trong huyết tương: Dấu hiệu tiềm năng cho Tiểu đường Dịch bởi AI
Springer Science and Business Media LLC - Tập 5 - Trang 156-162 - 2009
Michael J. Pugia, Deanna D. H. Franke, Sean L. Barnes, Amy Zercher, David Brock, Mary Foltz, Roland Valdes, Saeed A. Jortani
Các phân đoạn polypeptide từ các thụ thể bề mặt tế bào khi xuất hiện trong huyết tương có thể là chỉ báo về sự điều chỉnh thụ thể trong các tình trạng bệnh lý. Đã có nghiên cứu cho thấy những đối tượng mắc bệnh tiểu đường có nồng độ huyết tương của adiponectin, một hormone được tiết ra từ mô mỡ, thấp hơn đáng kể so với những người không mắc tiểu đường. Hormone này tương tác với các thụ thể bề mặt ...... hiện toàn bộ
#Thụ thể Adiponectin #Tiểu đường #Khối phổ miễn dịch #Polypeptide #Biomarker #Fragment C-terminus
A multiplex immunoassay of serum biomarkers for the detection of uveal melanoma
Springer Science and Business Media LLC - Tập 16 - Trang 1-13 - 2019
Jin Song, Shannath L. Merbs, Lori J. Sokoll, Daniel W. Chan, Zhen Zhang
Approximately 50% of uveal melanoma (UM) patients develop metastases preferentially in the liver leading to death within 15 months. Currently, there is no effective treatment for metastatic UM, in part because the tumor burden is typically high when liver metastases are detected through abnormal liver function tests (LFTs) or imaging studies. The use of LFTs results followed by diagnostic tests ha...... hiện toàn bộ
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