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Proteome profiling of human placenta reveals developmental stage-dependent alterations in protein signature
Springer Science and Business Media LLC - Tập 18 - Trang 1-13 - 2021
Sara Khorami Sarvestani, Sorour Shojaeian, Negar Vanaki, Behrouz Ghresi-Fard, Mehdi Amini, Kambiz Gilany, Hale Soltanghoraee, Soheila Arefi, Mahmood Jeddi-Tehrani, Amir-Hassan Zarnani
Placenta is a complex organ that plays a significant role in the maintenance of pregnancy health. It is a dynamic organ that undergoes dramatic changes in growth and development at different stages of gestation. In the first-trimester, the conceptus develops in a low oxygen environment that favors organogenesis in the embryo and cell proliferation and angiogenesis in the placenta; later in pregnan...... hiện toàn bộ
Development and evaluation of an immuno-MALDI (iMALDI) assay for angiotensin I and the diagnosis of secondary hypertension
Springer Science and Business Media LLC - Tập 10 - Trang 1-9 - 2013
Alexander G Camenzind, Jessica Grace van der Gugten, Robert Popp, Daniel T Holmes, Christoph H Borchers
Plasma renin activity (PRA) is an essential analytical tool for screening and diagnosis of secondary forms of hypertension. Typically, PRA is measured by competitive radioimmunoassay, but there are significant drawbacks to this technique including non-specificity, long analysis times, narrow calibration range, and the requirement for radionucleotides. In this paper, we report a method for plasma r...... hiện toàn bộ
Proteomic profiling of lung adenocarcinoma indicates heightened DNA repair, antioxidant mechanisms and identifies LASP1 as a potential negative predictor of survival
Springer Science and Business Media LLC - Tập 13 Số 1 - 2016
Johannes F. Fahrmann, Dmitry Grapov, Brett S. Phinney, Carol Stroble, Brian C. DeFelice, William N. Rom, David R. Gandara, Yanhong Zhang, Oliver Fiehn, Harvey I. Pass, Suzanne Miyamoto
Proteomic approaches for characterizing renal cell carcinoma
Springer Science and Business Media LLC - Tập 17 - Trang 1-18 - 2020
David J. Clark, Hui Zhang
Renal cell carcinoma is among the top 15 most commonly diagnosed cancers worldwide, comprising multiple sub-histologies with distinct genomic, proteomic, and clinicopathological features. Proteomic methodologies enable the detection and quantitation of protein profiles associated with the disease state and have been explored to delineate the dysregulated cellular processes associated with renal ce...... hiện toàn bộ
Correction to: Comprehensive proteome and phosphoproteome profiling shows negligible influence of RNAlater on protein abundance and phosphorylation
Springer Science and Business Media LLC - Tập 16 - Trang 1-1 - 2019
Jingi Bae, Su-Jin Kim, Seung-Eun Lee, Wooil Kwon, Hongbeom Kim, Youngmin Han, Jin-Young Jang, Min-Sik Kim, Sang-Won Lee
In the version of this article that was originally published [1], some information in the “Acknowledgements” section was omitted.
Glial cell proteome using targeted quantitative methods for potential multi-diagnostic biomarkers
Springer Science and Business Media LLC - Tập 20 - Trang 1-17 - 2023
Narae Kang, Hyun Jeong Oh, Ji Hye Hong, Hyo Eun Moon, Yona Kim, Hyeon-Jeong Lee, Hophil Min, Hyeonji Park, Sang Hun Lee, Sun Ha Peak, Jonghwa Jin
Glioblastoma is one of the most malignant primary brain cancer. Despite surgical resection with modern technology followed by chemo-radiation therapy with temozolomide, resistance to the treatment and recurrence is common due to its aggressive and infiltrating nature of the tumor with high proliferation index. The median survival time of the patients with glioblastomas is less than 15 months. Till...... hiện toàn bộ
CD44 glycoprotein in cancer: a molecular conundrum hampering clinical applications
Springer Science and Business Media LLC - Tập 15 - Trang 1-5 - 2018
Rita Azevedo, Cristiana Gaiteiro, Andreia Peixoto, Marta Relvas-Santos, Luís Lima, Lúcio Lara Santos, José Alexandre Ferreira
CD44 is a heavily glycosylated membrane receptor playing a key role in cell adhesion, signal transduction and cytoskeleton remodelling. It is also one of the most studied glycoproteins in cancer, frequently explored for stem cell identification, and associated with chemoresistance and metastasis. However, CD44 is a general designation for a large family of splicing variants exhibiting different de...... hiện toàn bộ
iTRAQ-based quantitative proteomic analysis of thoracic aortas from adult rats born to preeclamptic dams
Springer Science and Business Media LLC - Tập 18 Số 1 - 2021
Bin Yu, Hong-Dan Zhu, Xiaoliang Shi, Pan‐Pan Chen, Xiang-Mei Sun, Gui-Yu Xia, Min Fang, Yong-Xing Zhong, Xiaoli Tang, Tao Zhang, Hai‐Tao Pan
Abstract Background Preeclampsia and gestational hypertension can cause vascular function impairment in offspring. In our previous work, we described the protein expression profiles of umbilical artery tissues from patients with preeclampsia. ...... hiện toàn bộ
Cardiovascular proteomics in the era of big data: experimental and computational advances
Springer Science and Business Media LLC - Tập 13 - Trang 1-14 - 2016
Maggie P. Y. Lam, Edward Lau, Dominic C. M. Ng, Ding Wang, Peipei Ping
Proteomics plays an increasingly important role in our quest to understand cardiovascular biology. Fueled by analytical and computational advances in the past decade, proteomics applications can now go beyond merely inventorying protein species, and address sophisticated questions on cardiac physiology. The advent of massive mass spectrometry datasets has in turn led to increasing intersection bet...... hiện toàn bộ
New targets for an old drug
Springer Science and Business Media LLC - - 2004
Jacek J. Slon-Usakiewicz, Andrew Pasternak, Neil Reid, Leticia Toledo‐Sherman
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