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Proteome profiling of human placenta reveals developmental stage-dependent alterations in protein signature
Springer Science and Business Media LLC - Tập 18 - Trang 1-13 - 2021
Placenta is a complex organ that plays a significant role in the maintenance of
pregnancy health. It is a dynamic organ that undergoes dramatic changes in
growth and development at different stages of gestation. In the first-trimester,
the conceptus develops in a low oxygen environment that favors organogenesis in
the embryo and cell proliferation and angiogenesis in the placenta; later in
pregnan...
Development and evaluation of an immuno-MALDI (iMALDI) assay for angiotensin I and the diagnosis of secondary hypertension
Springer Science and Business Media LLC - Tập 10 - Trang 1-9 - 2013
Plasma renin activity (PRA) is an essential analytical tool for screening and
diagnosis of secondary forms of hypertension. Typically, PRA is measured by
competitive radioimmunoassay, but there are significant drawbacks to this
technique including non-specificity, long analysis times, narrow calibration
range, and the requirement for radionucleotides. In this paper, we report a
method for plasma r...
Proteomic profiling of lung adenocarcinoma indicates heightened DNA repair, antioxidant mechanisms and identifies LASP1 as a potential negative predictor of survival
Springer Science and Business Media LLC - Tập 13 Số 1 - 2016
Proteomic approaches for characterizing renal cell carcinoma
Springer Science and Business Media LLC - Tập 17 - Trang 1-18 - 2020
Renal cell carcinoma is among the top 15 most commonly diagnosed cancers
worldwide, comprising multiple sub-histologies with distinct genomic, proteomic,
and clinicopathological features. Proteomic methodologies enable the detection
and quantitation of protein profiles associated with the disease state and have
been explored to delineate the dysregulated cellular processes associated with
renal ce...
Correction to: Comprehensive proteome and phosphoproteome profiling shows negligible influence of RNAlater on protein abundance and phosphorylation
Springer Science and Business Media LLC - Tập 16 - Trang 1-1 - 2019
In the version of this article that was originally published [1], some
information in the “Acknowledgements” section was omitted.
Glial cell proteome using targeted quantitative methods for potential multi-diagnostic biomarkers
Springer Science and Business Media LLC - Tập 20 - Trang 1-17 - 2023
Glioblastoma is one of the most malignant primary brain cancer. Despite surgical
resection with modern technology followed by chemo-radiation therapy with
temozolomide, resistance to the treatment and recurrence is common due to its
aggressive and infiltrating nature of the tumor with high proliferation index.
The median survival time of the patients with glioblastomas is less than
15 months. Till...
CD44 glycoprotein in cancer: a molecular conundrum hampering clinical applications
Springer Science and Business Media LLC - Tập 15 - Trang 1-5 - 2018
CD44 is a heavily glycosylated membrane receptor playing a key role in cell
adhesion, signal transduction and cytoskeleton remodelling. It is also one of
the most studied glycoproteins in cancer, frequently explored for stem cell
identification, and associated with chemoresistance and metastasis. However,
CD44 is a general designation for a large family of splicing variants exhibiting
different de...
iTRAQ-based quantitative proteomic analysis of thoracic aortas from adult rats born to preeclamptic dams
Springer Science and Business Media LLC - Tập 18 Số 1 - 2021
Abstract Background Preeclampsia and gestational hypertension can cause vascular
function impairment in offspring. In our previous work, we described the protein
expression profiles of umbilical artery tissues from patients with preeclampsia.
Methods To gain insights into the mechanisms of vascular dysfunction in adult
rats born to preeclamptic dams, we analyzed thoracic aorta tissues by using
iTR...
Cardiovascular proteomics in the era of big data: experimental and computational advances
Springer Science and Business Media LLC - Tập 13 - Trang 1-14 - 2016
Proteomics plays an increasingly important role in our quest to understand
cardiovascular biology. Fueled by analytical and computational advances in the
past decade, proteomics applications can now go beyond merely inventorying
protein species, and address sophisticated questions on cardiac physiology. The
advent of massive mass spectrometry datasets has in turn led to increasing
intersection bet...
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