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Identification and verification of plasma protein biomarkers that accurately identify an ectopic pregnancyAbstract
Background
Differentiating between a normal intrauterine pregnancy (IUP) and abnormal conditions including early pregnancy loss (EPL) or ectopic pregnancy (EP) is a major clinical challenge in early pregnancy. Currently, serial β-human chorionic gonadotropin (β-hCG) and progesterone are the... ... hiện toàn bộ
Springer Science and Business Media LLC - Tập 20 Số 1 - 2023
Kinase inhibitor pulldown assay (KiP) for clinical proteomics
Springer Science and Business Media LLC - Tập 21 - Trang 1-17 - 2024
Protein kinases are frequently dysregulated and/or mutated in cancer and represent essential targets for therapy. Accurate quantification is essential. For breast cancer treatment, the identification and quantification of the protein kinase ERBB2 is critical for therapeutic decisions. While immunohistochemistry (IHC) is the current clinical diagnostic approach, it is only semiquantitative. Mass sp...... hiện toàn bộ
Glycoproteomics revealed novel N-glycosylation biomarkers for early diagnosis of lung adenocarcinoma cancers
Springer Science and Business Media LLC - Tập 19 - Trang 1-13 - 2022
Circulating biomarkers play important roles in diagnosis of malignant tumors. N-glycosylation is an important post-translation patter and obviously affect biological behaviors of malignant tumor cells. However, the role of N-glycosylation sites in early diagnosis of tumors still remains further investigation. In this study, plasma from 20 lung adenocarcinoma (LUAD), which were all classified as st...... hiện toàn bộ
Comparative proteomic network signatures in seminal plasma of infertile men as a function of reactive oxygen species
Springer Science and Business Media LLC - Tập 12 - Trang 1-20 - 2015
Reactive oxygen species (ROS) plays a major role in the pathology of male infertility. It is an independent biomarker of sperm function. Seminal plasma is a natural reservoir of antioxidants responsible for the nourishment, protection, capacitation, and motility of sperm within the female reproductive tract resulting in successful fertilization and implantation of the embryo. A comparative proteom...... hiện toàn bộ
Correction to: Quantitative phosphoproteomic analysis reveals reciprocal activation of receptor tyrosine kinases between cancer epithelial cells and stromal fibroblasts
Springer Science and Business Media LLC - Tập 15 - Trang 1-4 - 2018
Unfortunately, after publication of this article [1], errors were noticed in Figs. 3 and 4.
Proteomic characterization of serine hydrolase activity and composition in normal urine
Springer Science and Business Media LLC - Tập 10 Số 1 - Trang 1-11 - 2013
Serine hydrolases constitute a large enzyme family involved in a diversity of proteolytic and metabolic processes which are essential for many aspects of normal physiology. The roles of serine hydrolases in renal function are largely unknown and monitoring their activity may provide important insights into renal physiology. The goal of this study was to profile urinary serine hydrolases with activ...... hiện toàn bộ
Urinary proteomics in chronic kidney disease: diagnosis and risk of progression beyond albuminuria
Springer Science and Business Media LLC - Tập 12 - Trang 1-9 - 2015
The contrast between a high prevalence of chronic kidney disease (CKD) and the low incidence of end-stage renal disease highlights the need for new biomarkers of progression beyond albuminuria testing. Urinary proteomics is a promising method, but more studies focusing on progression rate and patients with hypertensive nephropathy are needed. We analyzed urine samples with capillary electrophoresi...... hiện toàn bộ
Second generation multiple reaction monitoring assays for enhanced detection of ultra-low abundance Mycobacterium tuberculosis peptides in human serum
Springer Science and Business Media LLC - Tập 14 - Trang 1-10 - 2017
Mycobacterium tuberculosis (Mtb) is the causative agent of Tuberculosis (TB), the number one cause of death due to an infectious disease. TB diagnosis is performed by microscopy, culture or PCR amplification of bacterial DNA, all of which require patient sputum or the biopsy of infected tissue. Detection of mycobacterial products in serum, as biomarkers of diagnosis or ...... hiện toàn bộ
Proteomic and phosphoproteomic measurements enhance ability to predict ex vivo drug response in AML
Springer Science and Business Media LLC - Tập 19 - Trang 1-15 - 2022
Acute Myeloid Leukemia (AML) affects 20,000 patients in the US annually with a five-year survival rate of approximately 25%. One reason for the low survival rate is the high prevalence of clonal evolution that gives rise to heterogeneous sub-populations of leukemic cells with diverse mutation spectra, which eventually leads to disease relapse. This genetic heterogeneity drives the activation of co...... hiện toàn bộ
Proteomic characterization of high-density lipoprotein particles in patients with non-alcoholic fatty liver disease
Springer Science and Business Media LLC - Tập 15 - Trang 1-9 - 2018
Metabolic diseases such as obesity and diabetes are associated with changes in high-density lipoprotein (HDL) particles, including changes in particle size and protein composition, often resulting in abnormal function. Recent studies suggested that patients with non-alcoholic fatty liver disease (NAFLD), including individuals with non-alcoholic steatohepatitis (NASH), have smaller HDL particles wh...... hiện toàn bộ
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