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Adoptive transfer of osteoclast-expanded natural killer cells for immunotherapy targeting cancer stem-like cells in humanized mice
Springer Science and Business Media LLC - Tập 65 - Trang 835-845 - 2016
Based on data obtained from oral, pancreatic and lung cancers, glioblastoma, and melanoma, we have established that natural killer (NK) cells target cancer stem-like cells (CSCs). CSCs displaying low MHC class I, CD54, and PD-L1 are killed by cytotoxic NK cells and are differentiated by split anergized NK cells through both membrane bound and secreted forms of TNF-α and IFN-γ. NK cells select and ...... hiện toàn bộ
Cytokine production in patients with papillary thyroid cancer and associated autoimmune Hashimoto thyroiditis
Springer Science and Business Media LLC - Tập 64 - Trang 1011-1019 - 2015
Hashimoto thyroiditis (HT) is the most frequent thyroid autoimmune disease, while papillary thyroid cancer (PTC) is one of the most common endocrine malignancies. A few patients with HT also develop PTC. The aim of this study was to analyze cytokine profiles in patients with PTC accompanied with autoimmune HT in comparison with those in patients with PTC alone or HT alone and healthy subjects. Cyt...... hiện toàn bộ
Antimetastatic effect of immunomodulators from Nocardia opaca in mice and rats activation of peritoneal macrophages by these fractions
Springer Science and Business Media LLC - Tập 25 Số 2 - 1987
Enhancement of cytotoxic and proliferative responses of lymphocytes from melanoma patients by incubation with monoclonal antibodies against ganglioside GD3
Springer Science and Business Media LLC - Tập 24 - Trang 144-150 - 1987
Previous studies have shown that monoclonal antibodies (M.Ab) to the ganglioside GD3 may induce partial remissions in tumour growth in patients with melanoma. In vitro studies demonstrated that M.Abs to GD3 may also enhance lymphocyte responses to phytohemagglutinin and interleukin 2 (IL2). The present study extended these findings by showing that the IL2-dependent proliferative and cytotoxic resp...... hiện toàn bộ
Myeloid-derived suppressor cells as intruders and targets: clinical implications in cancer therapy
Springer Science and Business Media LLC - Tập 65 - Trang 857-867 - 2016
Chronic inflammation, typical of various diseases including cancer, is a “silent bomb within the body,” leading to complications that are only evident in most cases upon their appearance, when disease is already deteriorated. Chronic inflammation is associated with accumulation of myeloid-derived suppressor cells (MDSCs), which lead to immunosuppression. MDSCs have numerous harmful effects as the...... hiện toàn bộ
A phase I vaccination study with dendritic cells loaded with NY-ESO-1 and α-galactosylceramide: induction of polyfunctional T cells in high-risk melanoma patients
Springer Science and Business Media LLC - Tập 67 - Trang 285-298 - 2017
Vaccines that elicit targeted tumor antigen-specific T-cell responses have the potential to be used as adjuvant therapy in patients with high risk of relapse. However, the responses induced by vaccines in cancer patients have generally been disappointing. To improve vaccine function, we investigated the possibility of exploiting the immunostimulatory capacity of type 1 Natural killer T (NKT) cells...... hiện toàn bộ
Targeting of cancer cells with monoclonal antibodies specific for C3b(i)
Springer Science and Business Media LLC - Tập 49 - Trang 551-562 - 2000
Purpose: The goal of this research is to determine the feasibility of an immunotherapeutic approach based on the use of monoclonal antibodies (mAb) to target complement activation fragments on opsonized cancer cells. Methods: We investigated whether treatment of LNCaP and C4-2 human prostate cancer cell lines with normal human serum would allow for deposition of sufficient amounts of the compleme...... hiện toàn bộ
Effects of interleukin-12 on in vitro culture with interleukin-2 of regional lymph node lymphocytes from lung cancer patients
Springer Science and Business Media LLC - Tập 43 - Trang 87-93 - 1996
In the present study, we carried out a functional analysis of regional lymph node lymphocytes (RLNL) from patients with lung cancer after in vitro activation by interleukin-2 (IL-2) and interleukin-12 (IL-12). IL-12 (100 U/ml) enhanced both the proliferation and cytotoxic activity of RLNL in a culture with low doses of IL-2 (5 – 10 JRU/ml). After comparing an RLNL culture with a low dose of IL-2 ...... hiện toàn bộ
An immunotoxin for the treatment of T-acute lymphoblastic leukemic meningitis: studies in rhesus monkeys
Springer Science and Business Media LLC - Tập 28 - Trang 59-66 - 1989
Monoclonal antibody WT1 (anti-CD7), conjugated to ricin A chain, was administered intrathecally to rhesus monkeys to test its suitability for use in the therapy of leukemic meningitis. The WT1-SMPT-dgRTA conjugate was cytotoxic to CEM (T-lymphoblastic leukemia) cells in vitro with an ID50 of 53 pM. Immunoperoxidase testing showed no binding of WT1 to normal human tissues other than lymph nodes. Th...... hiện toàn bộ
Latex bread technique for detection of the plaque-forming cell response to teratocarcinoma tumor antigens
Springer Science and Business Media LLC - Tập 15 - Trang 27-31 - 1983
A latex bead technique modified for measuring the plaque-forming cell (PFC) response to teratocarcinoma tumor antigens in syngeneic animals is described. With this method one can detect both the primary (IgM) and the secondary (IgG) immune response to tumor antigens. Optimal detection of the PFC response depends on the proper ratio of sheep red blood cells to latex beads and the dose of tumor cell...... hiện toàn bộ
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