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Clinicopathologic significance of human leukocyte antigen class I expression in patients with stage II and III gastric cancer
Springer Science and Business Media LLC - Tập 68 - Trang 1779-1790 - 2019
Yujun Park, Jiwon Koh, Yoonjin Kwak, Sang-Hoon Ahn, Do Joong Park, Hyung-Ho Kim, Woo Ho Kim, Hye Seung Lee
Human leukocyte antigen class I (HLA I) molecules composed of alpha (heavy) chain, including HLA-A, -B, or -C encoded by HLA genes, and beta-2-microglobulin (β2M) are membrane proteins on all nucleated cells that display peptide antigens for recognition by CD8-positive cytotoxic T cells. Here, we examined the clinicopathologic signification of HLA I expression in patients with gastric cancer (GC)....... hiện toàn bộ
Relationship between CD8-dependent antigen recognition, T cell functional avidity, and tumor cell recognition
Springer Science and Business Media LLC - Tập 58 Số 5 - Trang 719-728 - 2009
Tamson V. Moore, Gretchen E. Lyons, Natasha Brasic, J Roszkowski, Simon Voelkl, Andréas Mackensen, W. Martin Kast, I. Caroline Le Poole, Michael I. Nishimura
TIM-3 blockade combined with bispecific antibody MT110 enhances the anti-tumor effect of γδ T cells
Springer Science and Business Media LLC - Tập 69 - Trang 2571-2587 - 2020
Qingming Guo, Peng Zhao, Zhen Zhang, Jinyu Zhang, Zheng Zhang, Yanan Hua, Bin Han, Ning Li, Xiaowen Zhao, Lin Hou
As ideal cells that can be used for adoptive cell therapy, γδ T cells are a group of homogeneous cells with high proliferative and tumor killing ability. However, γδ T cells are apt to apoptosis and show decreased cytotoxicity under persistent stimulation in vitro and cannot aggregate at tumor sites efficiently in vivo, both of which are two main obstacles to tumor adoptive immunotherapy. In this ...... hiện toàn bộ
Interleukin-2-stimulated natural killer cells are less susceptible to mycophenolate mofetil than non-activated NK cells: possible consequences for immunotherapy
Springer Science and Business Media LLC - Tập 63 - Trang 821-833 - 2014
Claudia Brehm, Sabine Huenecke, Ruth Esser, Stephan Kloess, Andrea Quaiser, Sibille Betz, Olga Zimmermann, Jan Soerensen, Jakob R. Passweg, Thomas Klingebiel, Dirk Schwabe, Peter Bader, Ulrike Koehl
In a clinical phase I/II trial, pediatric patients with high-risk malignancies were treated with ex vivo IL-2-stimulated donor natural killer (NK) cells after transplantation with haploidentical stem cells. To evaluate the potential negative effects of the immunosuppressive drug mycophenolate mofetil (MMF) used for immunotherapy, the functionality and signaling of ex vivo NK cells was investigated...... hiện toàn bộ
Influence of the culture conditions of brucella abortus on its antitumor properties
Springer Science and Business Media LLC - Tập 14 - Trang 207-208 - 1983
B. Collet, L. Dazord, J. Portoukalian, F. Sauvager, A. Ruffault, C. David
A heat-inactivated rough mutant of B. abortus increased resistance to a transplantable lymphoma when cultured on solid agar (ag) but not when cultured on a fluid medium (fl). The ag organisms were smaller, more toxic and induced more interferon 2 h after injection than fl. They also contained a phospholipid (cardiolipin) absent from fl preparations.
A case of pembrolizumab-induced type-1 diabetes mellitus and discussion of immune checkpoint inhibitor-induced type 1 diabetes
Springer Science and Business Media LLC - Tập 66 - Trang 25-32 - 2016
Young Kwang Chae, Lauren Chiec, Nisha Mohindra, Ryan Gentzler, Jyoti Patel, Francis Giles
Immune checkpoint inhibitors such as pembrolizumab, ipilimumab, and nivolumab, now FDA-approved for use in treating several types of cancer, have been associated with immune-related adverse effects. Specifically, the antibodies targeting the programmed-cell death-1 immune checkpoint, pembrolizumab and nivolumab, have been rarely reported to induce the development of type 1 diabetes mellitus. Here ...... hiện toàn bộ
Vaccination with anti-idiotype antibody ganglidiomab mediates a GD2-specific anti-neuroblastoma immune response
Springer Science and Business Media LLC - - 2013
Holger N. Lode, Manuela Schmidt, Daniel Seidel, Nicole Huebener, Diana Brackrock, Matthias Bleeke, Daniel Reker, Sven Van Brandt, Hans-Peter Mueller, Christiane A. Helm, Nikolai Siebert
The soluble form of CD160 acts as a tumor mediator of immune escape in melanoma
Springer Science and Business Media LLC - Tập 71 - Trang 2731-2742 - 2022
Marie-Léa Gauci, Jérôme Giustiniani, Clémence Lepelletier, Christian Garbar, Nicolas Thonnart, Nicolas Dumaz, Arnaud Foussat, Céleste Lebbé, Armand Bensussan, Anne Marie-Cardine
Melanoma is responsible for 90% of skin cancer-related deaths. Major therapeutic advances have led to a considerable improvement in the prognosis of patients, with the development of targeted therapies (BRAF or MEK inhibitors) and immunotherapy (anti-CTLA-4 or -PD-1 antibodies). However, the tumor constitutes an immunosuppressive microenvironment that prevents the therapeutic efficacy and/or promo...... hiện toàn bộ
Low-dose melphalan-induced shift in the production of a Th2-type cytokine to a Th1-type cytokine in mice bearing a large MOPC-315 tumor
Springer Science and Business Media LLC - Tập 39 Số 2 - Trang 117-126 - 1994
Leonid Gorelik, A Prokhorova, Margalit B. Mokyr
Study of the mechanism of Corynebacterium parvum antitumour activity: Protective effect in mice submitted to sublethal doses of irradiation
Springer Science and Business Media LLC - Tập 7 - Trang 85-91 - 1979
Cypka Mazurek, Claude Stiffel, Huguette Chalvet, Guido Biozzi
The antitumour activity of C. parvum against two different tumours, a lymphosarcoma grafted in XVII mice and a mammary carcinoma grafted in C3H mice, was a radiosensitive phenomenon. A dose of X-rays as low as 100 rads was sufficient to abrogate the C. parvum-induced protection. The duration of this inhibition increased with augmentation of the X-ray dose. The stimulation of macrophage-phagocytic ...... hiện toàn bộ
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