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Monocyte antibody-dependent cellular cytotoxicity in cancer patients
Springer Science and Business Media LLC - Tập 18 - Trang 54-58 - 1984
Neville J. De Young, P. Grantley Gill
Antibody-dependent cellular cytotoxicity (ADCC) mediated by peripheral blood monocytes was determined in 120 patients who had gastrointestinal tract (GIT), lung and breast cancer, melanoma, or Hodgkin's and non-Hodgkin's lymphoma. Results were expressed in terms of maximum cytotoxicity and cytotoxicity at E : T=1 : 10 and were compared with the results obtained in 63 normal subjects. There was a s...... hiện toàn bộ
Targeting the extrinsic apoptosis signaling pathway for cancer therapy
Springer Science and Business Media LLC - Tập 60 - Trang 1173-1180 - 2011
Thomas J. Sayers
The extrinsic apoptosis pathway is triggered by the binding of death ligands of the tumor necrosis factor (TNF) family to their appropriate death receptors (DRs) on the cell surface. One TNF family member, TNF-related apoptosis-inducing ligand (TRAIL or Apo2L), seems to preferentially cause apoptosis of transformed cells and can be systemically administered in the absence of severe toxicity. There...... hiện toàn bộ
Efficacy and safety of Wilms’ tumor 1 helper peptide OCV-501 in elderly patients with acute myeloid leukemia: a multicenter, randomized, double-blind, placebo-controlled phase 2 trial
Springer Science and Business Media LLC - Tập 71 - Trang 1419-1430 - 2021
Toru Kiguchi, Masaki Yamaguchi, Naoki Takezako, Shuichi Miyawaki, Koichi Masui, Yuichiro Ihara, Masao Hirota, Naoko Shimofurutani, Tomoki Naoe
Complete remission (CR) of acute myeloid leukemia (AML) in elderly patients has a short duration, and there is no suitable post-remission therapy. We explored the role of the Wilms’ tumor 1 helper peptide OCV-501 to prevent recurrence after remission. This placebo-controlled phase 2 study was designed to evaluate accurately the efficacy and immunogenicity of OCV-501 in elderly AML patients. Elder...... hiện toàn bộ
An immunotoxin for the treatment of T-acute lymphoblastic leukemic meningitis: studies in rhesus monkeys
Springer Science and Business Media LLC - Tập 28 - Trang 59-66 - 1989
Andrew A. Hertler, David M. Schlossman, Michael J. Borowitz, David G. Poplack, Arthur E. Frankel
Monoclonal antibody WT1 (anti-CD7), conjugated to ricin A chain, was administered intrathecally to rhesus monkeys to test its suitability for use in the therapy of leukemic meningitis. The WT1-SMPT-dgRTA conjugate was cytotoxic to CEM (T-lymphoblastic leukemia) cells in vitro with an ID50 of 53 pM. Immunoperoxidase testing showed no binding of WT1 to normal human tissues other than lymph nodes. Th...... hiện toàn bộ
Comparative analysis of IFN-γ B7.1 and antisense TGF-β gene transfer on the tumorigenicity of a poorly immunogenic metastatic mammary carcinoma
Springer Science and Business Media LLC - - 2001
Rita S. Wu, James J. Kobie, David G. Besselsen, Tim C. Fong, Vivian D. Mack, Julie A. McEarchern, Emmanuel T. Akporiaye
Cancer progression is attributed in part to immune evasion strategies that include lack of co-stimulation, down-regulation of cell surface MHC molecules, and secretion of immunosuppressive factors, such as transforming growth factor-β (TGF-β). Gene therapy has been employed to counter these mechanisms of immune evasion by transference of B7.1, IFN-γ or antisense TGF-β genes into tumor cells, resu...... hiện toàn bộ
Shikonin induces immunogenic cell death in tumor cells and enhances dendritic cell-based cancer vaccine
Springer Science and Business Media LLC - Tập 61 Số 11 - Trang 1989-2002 - 2012
Huiming Chen, Pi-Hsueh Wang, Swey-Shen Chen, Chih-Chun Wen, Yun‐Hsiang Chen, Wen‐Chin Yang, Ning‐Sun Yang
No evidence that HLA genotype influences the driver mutations that occur in cancer patients
Springer Science and Business Media LLC - Tập 71 Số 4 - Trang 819-827 - 2022
Noor Kherreh, Siobhán Cleary, Cathal Seoighe
AbstractThe major histocompatibility (MHC) molecules are capable of presenting neoantigens resulting from somatic mutations on cell surfaces, potentially directing immune responses against cancer. This led to the hypothesis that cancer driver mutations may occur in gaps in the capacity to present neoantigens that are dependent on MHC genotype. If this is correct, i...... hiện toàn bộ
Interactions between interferon γ and retinoic acid with transforming growth factor β in the induction of immune recognition molecules
Springer Science and Business Media LLC - Tập 37 - Trang 112-118 - 1993
Richard Darley, Alan Morris, James Passas, Wendy Bateman
The cell-surface expression of major histocompatibility (MHC) antigens and the adhesion molecule intercellular adhesion molecule 1 (ICAM-1) is essential for target cell recognition by T lymphocytes. The expression of both classes of molecule is induced by various cytokines, notably interferon γ (IFNγ). Since transforming growth factor β (TGFβ) has been recently reported to antagonise HLA-DR induct...... hiện toàn bộ
Detection of antibodies bound to tumor cell surface antigens with radioiodinated Staphylococcus aureus protein A (SPA)
Springer Science and Business Media LLC - Tập 5 - Trang 243-252 - 1979
S. K. Nayak, F. B. Knotts, C. R. Drogemuller, Y. H. Pilch
Staphylococcal protein A (SPA) is known to bind to the Fc portion of certain subclasses of IgG. On the basis of this property, radioiodinated SPA (125I-SPA) was used to detect antibodies reacting with surface antigens of tumor cells. Target cells derived from an osteosarcoma growing in C3H/fHeJ mice and antiserum to this tumor prepared in female Hartley guineapigs were used to establish optimum co...... hiện toàn bộ
Cellular characteristics of peripheral blood lymphocytes and tumour-infiltrating lymphocytes in patients with gynaecological tumours
Springer Science and Business Media LLC - Tập 44 Số 2 - Trang 88-96 - 1997
Thomas Schöndorf, Heike Engel, Carsten Lindemann, Hannelore Kolhagen, A A von Rücker, Peter Mallmann
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