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The soluble form of CD160 acts as a tumor mediator of immune escape in melanoma
Springer Science and Business Media LLC - Tập 71 - Trang 2731-2742 - 2022
Marie-Léa Gauci, Jérôme Giustiniani, Clémence Lepelletier, Christian Garbar, Nicolas Thonnart, Nicolas Dumaz, Arnaud Foussat, Céleste Lebbé, Armand Bensussan, Anne Marie-Cardine
Melanoma is responsible for 90% of skin cancer-related deaths. Major therapeutic advances have led to a considerable improvement in the prognosis of patients, with the development of targeted therapies (BRAF or MEK inhibitors) and immunotherapy (anti-CTLA-4 or -PD-1 antibodies). However, the tumor constitutes an immunosuppressive microenvironment that prevents the therapeutic efficacy and/or promo...... hiện toàn bộ
Monocyte antibody-dependent cellular cytotoxicity in cancer patients
Springer Science and Business Media LLC - Tập 18 - Trang 54-58 - 1984
Neville J. De Young, P. Grantley Gill
Antibody-dependent cellular cytotoxicity (ADCC) mediated by peripheral blood monocytes was determined in 120 patients who had gastrointestinal tract (GIT), lung and breast cancer, melanoma, or Hodgkin's and non-Hodgkin's lymphoma. Results were expressed in terms of maximum cytotoxicity and cytotoxicity at E : T=1 : 10 and were compared with the results obtained in 63 normal subjects. There was a s...... hiện toàn bộ
Immunization of mice with melanoma cells transfected to secrete the superantigen, staphylococcal enterotoxin A
Springer Science and Business Media LLC - Tập 46 - Trang 7-13 - 1998
David P. Shrayer, Nicolas Kouttab, Vincent J. Hearing, Harold J. Wanebo
Immunization of mice with a melanoma vaccine coupled with staphylococcal enterotoxin A (SEA) inhibits the growth of primary melanoma tumors in mice. We have now successfully transfected B16 cells with the sea gene and have immunized C57BL/6 mice subcutaneously once per week for 4 weeks prior to tumor challenge with vaccines of irradiated B16 cells or, 4 weeks following tumor challenge of naïve mi...... hiện toàn bộ
Targeting the extrinsic apoptosis signaling pathway for cancer therapy
Springer Science and Business Media LLC - Tập 60 - Trang 1173-1180 - 2011
Thomas J. Sayers
The extrinsic apoptosis pathway is triggered by the binding of death ligands of the tumor necrosis factor (TNF) family to their appropriate death receptors (DRs) on the cell surface. One TNF family member, TNF-related apoptosis-inducing ligand (TRAIL or Apo2L), seems to preferentially cause apoptosis of transformed cells and can be systemically administered in the absence of severe toxicity. There...... hiện toàn bộ
Acknowledgement
Springer Science and Business Media LLC - Tập 56 - Trang 747-751 - 2007
Effects of 1-methyltryptophan stereoisomers on IDO2 enzyme activity and IDO2-mediated arrest of human T cell proliferation
Springer Science and Business Media LLC - - 2012
Feng Qian, Jianqun Liao, Jeannine Villella, Robert P. Edwards, Paweł Kaliński, Shashikant Lele, Protul Shrikant, Kunle Odunsi
Complement insufficiency limits efficacy in a xenograft model of hyperacute rejection for cancer therapy
Springer Science and Business Media LLC - Tập 56 - Trang 60-69 - 2006
James M. G. Larkin, Colin D. Porter
Hyperacute rejection (HAR) is a rapid immunological response to an organ xenotransplant caused by recognition of endothelial galactose(α1,3)galactose (αGal) epitopes and complement-mediated cell lysis by host anti-αGal antibody (‘natural antibody’). The αGal epitope is synthesised by a galactosyl transferase ((α1,3)GT) which humans lack. Because human cells transduced with (α1,3)GT are sensitised ...... hiện toàn bộ
Hairy cell sensitivity to the lysis in vitro
Springer Science and Business Media LLC - Tập 30 - Trang 254-256 - 1989
G. Semenzato, L. Trentin, R. Zambello, C. Agostini, T. Chisesi, G. Pizzolo
Experiments herein reported were designed to clarify the degree of sensitivity of hairy cells to lysis in vitro. The cytotoxic capacity of peripheral blood lymphocytes from hairy cell leukemia patients against autologous and/or allogenic hairy cells was tested both at resting conditions and after in vitro stimulation. While effectors activated by interferon α, lectins, or interleukin-2 were unable...... hiện toàn bộ
Increased expression of TGF-β1 reduces tumor growth of human U-87 Glioblastoma Cells in vivo
Springer Science and Business Media LLC - Tập 55 - Trang 918-927 - 2005
Jen-Jung Pan, Wei-Jen Chang, Tara A. Barone, Robert J. Plunkett, Peter T. Ostrow, Steven J. Greenberg
The role that transforming growth factor β1 (TGF-β1) plays in influencing growth of glioma cells is somewhat controversial. To further understand the potential growth-regulatory effects of TGF-β1,we constructed an animal astroglial tumor model by injecting either wild-type or virally transduced human U-87 glioblastoma cells into nude rat brains. Wild type U-87 cells produced very low amounts of TG...... hiện toàn bộ
A Novel bispecific T-cell engager (BiTE) targeting CD22 and CD3 has both in vitro and in vivo activity and synergizes with blinatumomab in an acute lymphoblastic leukemia (ALL) tumor model
Springer Science and Business Media LLC - Tập 72 - Trang 2939-2948 - 2023
Joshua F. Meckler, Daniel J. Levis, Daniel P. Vang, Joseph M. Tuscano
Immunotherapy has revolutionized cancer therapy. Two recently FDA-approved immunotherapies for B-cell malignancies target CD19, in the form of a Bispecific T-Cell Engager (BiTE) antibody construct or chimeric antigen receptor T (CAR-T) cells. Blinatumomab, an FDA-approved BiTE, binds to CD19 on B cells and to CD3 on T cells, mediating effector-target cell contact and T-cell activation that results...... hiện toàn bộ
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