Study of the mechanism of Corynebacterium parvum antitumour activity: Protective effect in mice submitted to sublethal doses of irradiation

Springer Science and Business Media LLC - Tập 7 - Trang 85-91 - 1979
Cypka Mazurek1, Claude Stiffel1, Huguette Chalvet1, Guido Biozzi1
1Department of Immunogenetics (U 125 INSERM and E.R. 70 CNRS), Institut Curie, Section de Biologie, Paris Cedes 05, France

Tóm tắt

The antitumour activity of C. parvum against two different tumours, a lymphosarcoma grafted in XVII mice and a mammary carcinoma grafted in C3H mice, was a radiosensitive phenomenon. A dose of X-rays as low as 100 rads was sufficient to abrogate the C. parvum-induced protection. The duration of this inhibition increased with augmentation of the X-ray dose. The stimulation of macrophage-phagocytic activity induced by C. parvum was not inhibited by a dose of 500 rads. A chronological parallelism has been demonstrated in the recovery of the C. parvum antitumour effect and the restoration of antibody responsiveness after the suppression of these two activities by 500 rads of X-rays in the case of the C3H mice grafted with mammary carcinoma cells. No such concomitant recovery has been observed in XVII mice. In these mice, the recovery of C. parvum antitumour activity took place before the restoration of antibody responsiveness.

Tài liệu tham khảo

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Springer Science and Business Media LLC

Tập 7

85-91

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