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LncRNA LINC02535 Induces Colorectal Adenocarcinoma Progression via Modulating miR-30d-5p/CHD1
Springer Science and Business Media LLC - Tập 65 - Trang 1346-1358 - 2022
Jiguang Li, Jianhua Xu, Sen Zheng, Si Cheng
Growing evidence has suggested that lncRNAs play a significant role in the development of colorectal adenocarcinoma. LncRNA LINC02535 was a potential novel lncRNA marker of neoplastic processes of the colon. Nevertheless, the function and mechanisms of LINC02535 in colorectal adenocarcinoma remain unclear. Proteins levels were measured by western blotting. EdU, CCK-8, Transwell, and wound healing ...... hiện toàn bộ
miR-181-5p/KLHL5 Promoted Proliferation and Migration of Gastric Cancer Through Activating METTL3-Mediated m6A Process
Springer Science and Business Media LLC -
Rong Li, Yixing Li, Zhiyu Wang, Ruiyang Suo, Ruining Ma, Zhiyuan Jia
Heterologous Overexpression and Biochemical Characterization of a Nitroreductase from Gluconobacter oxydans 621H
Springer Science and Business Media LLC - Tập 58 - Trang 428-440 - 2016
Yuanyuan Yang, Jinping Lin, Dongzhi Wei
A NADPH-dependent and FMN-containing nitroreductase (Gox0834) from Gluconobacter oxydans was cloned and heterogeneously expressed in Escherichia coli. The purified enzyme existed as a dimer with an apparent molecular mass of about 31.4 kDa. The enzyme displayed broad substrate specificity and reduced a variety of mononitrated, polynitrated, and polycyclic nitroaromatic compounds to the correspondi...... hiện toàn bộ
Assembly and Purification of Polyomavirus-Like Particles from Plants
Springer Science and Business Media LLC - Tập 57 - Trang 904-913 - 2015
Emeline V. B. Catrice, Frank Sainsbury
Polyomaviruses are small DNA viruses that have a history of use in biotechnology. The capsids of a number of species have been developed into experimental prophylactic and therapeutic virus-like particle (VLP) vaccines. In order to explore plants as a host for the expression and purification of polyomavirus-like particles, we have transiently expressed the major capsid protein, VP1, in Nicotiana b...... hiện toàn bộ
Mouldy Sioud (ed): siRNA and miRNA Gene Silencing: from Bench to Bedside
Springer Science and Business Media LLC - Tập 54 - Trang 723-723 - 2012
Francesco Nicassio
Template-Based Modelling of the Structure of Fungal Effector Proteins
Springer Science and Business Media LLC - - Trang 1-30 - 2023
Lina Rozano, Darcy A. B. Jones, James K. Hane, Ricardo L. Mancera
The discovery of new fungal effector proteins is necessary to enable the screening of cultivars for disease resistance. Sequence-based bioinformatics methods have been used for this purpose, but only a limited number of functional effector proteins have been successfully predicted and subsequently validated experimentally. A significant obstacle is that many fungal effector proteins discovered so ...... hiện toàn bộ
A yeast genetic assay for caspase cleavage of the amyloid-β precursor protein
Springer Science and Business Media LLC - Tập 15 - Trang 29-37 - 2000
Paul L. Gunyuzlu, W. Hunter White, Gary L. Davis, Gregory F. Hollis, Jeremy H. Toyn
A functional assay for proteolytic processing of the amyloid precursor protein (APP) was set up in yeast. This consisted of a membrane-bound chimeric protein containing the β-secretase cleaved C-terminal fragment of APP fused to the Gal4 transcription factor. Using this chimera in a GAL-reporter yeast strain, an expression library of human cDNAs was screened for clones that could activate the GAL-...... hiện toàn bộ
Cataloging the relationships between proteins
Springer Science and Business Media LLC - Tập 34 - Trang 69-93 - 2006
Carol Rohl, Yancey Price, Tiffany B. Fischer, Milissa Paczkowski, Michael F. Zettel, Jerry Tsai
By organizing and making widely accessible the increasing amounts of data from high-throughput analyses, protein interaction databases have become an integral resource for the biological community in relating sequence data with higher-order function. To provide a sense of the use and applicability of these databases, we describe each of the major comprehensive interaction databases as well as some...... hiện toàn bộ
Novel functional assay for proteases and modulators
Springer Science and Business Media LLC - Tập 18 - Trang 1-10 - 2001
Yonghong Li, Yu-Wang Liu, Barbara Cordell
Proteases play a critical role in many cellular functions and have been an attractive therapeutic target due to their involvement in a number of disease processes. One prominent example is the secretases responsible for the generation of amyloid β peptide, which is believed to be central for the development of Alzheimer’s disease. It is therefore desirable to identify and characterize these protea...... hiện toàn bộ
Recombinant HAP Phytase of the Thermophilic Mold Sporotrichum thermophile: Expression of the Codon-Optimized Phytase Gene in Pichia pastoris and Applications
Springer Science and Business Media LLC - Tập 58 Số 2 - Trang 137-147 - 2016
Bibhuti Ranjan, T. Satyanarayana
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