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Fabrication of polymer microstructures for MEMS: sacrificial layer micromolding and patterned substrate micromolding
Springer Science and Business Media LLC - Tập 9 - Trang 815-821 - 2007
Nicholas Ferrell, James Woodard, Derek Hansford
Two soft lithography based fabrication techniques are employed for fabricating mechanically independent, freely suspended polymer microstructure from poly(n-propyl methacrylate) (PPMA), poly(methyl methacrylate) (PMMA), and polystyrene. Both methods involve a micromolding process followed by thermal bonding to the substrate. The first method, sacrificial layer micromolding, uses a water soluble sa...... hiện toàn bộ
Frequency-controlled wireless shape memory polymer microactuator for drug delivery application
Springer Science and Business Media LLC - Tập 19 - Trang 1-10 - 2017
M. A. Zainal, A. Ahmad, M. S. Mohamed Ali
This paper reports the wireless Shape-Memory-Polymer actuator operated by external radio frequency magnetic fields and its application in a drug delivery device. The actuator is driven by a frequency-sensitive wireless resonant heater which is bonded directly to the Shape-Memory-Polymer and is activated only when the field frequency is tuned to the resonant frequency of heater. The heater is fabri...... hiện toàn bộ
A primary current distribution model of a novel micro-electroporation channel configuration
Springer Science and Business Media LLC - Tập 12 - Trang 833-840 - 2010
Gregory D. Troszak, Boris Rubinsky
Traditional macro and micro-electroporation devices utilize facing electrodes, which generate electric fields inversely proportional to their separation distance. Although the separation distances in micro-electroporation devices are significantly smaller than those in macro-electroporation devices, they are limited by cell size. Because of this, significant potential differences are required to i...... hiện toàn bộ
Bubble removal with the use of a vacuum pressure generated by a converging-diverging nozzle
Springer Science and Business Media LLC - Tập 19 - Trang 1-7 - 2017
Theodore Christoforidis, Carlos Ng, David T. Eddington
Bubbles are an intrinsic problem in microfluidic devices and they can appear during the initial filling of the device or during operation. This report presents a generalizable technique to extract bubbles from microfluidic networks using an adjacent microfluidic negative pressure network over the entire microfluidic channel network design. We implement this technique by superimposing a network of ...... hiện toàn bộ
Electrical properties characterization of single yeast cells by dielectrophoretic motion and electro-rotation
Springer Science and Business Media LLC - Tập 23 - Trang 1-9 - 2021
Liang Huang, Qiang Fang
The electrical parameters of single cells are label-free and intrinsic properties that can reflect the physiological characteristics. In recent years, many measurement methods based on impedance spectroscopy and rotation spectrum analysis have been developed. However, most of these works need to measure the response at whole frequency range to obtain DEP spectra and estimate the electrical paramet...... hiện toàn bộ
Patterning alginate hydrogels using light-directed release of caged calcium in a microfluidic device
Springer Science and Business Media LLC - Tập 12 - Trang 145-151 - 2009
Bor-han Chueh, Ying Zheng, Yu-suke Torisawa, Amy Y. Hsiao, Chunxi Ge, Susan Hsiong, Nathaniel Huebsch, Renny Franceschi, David J. Mooney, Shuichi Takayama
This paper describes a simple reversible hydrogel patterning method for 3D cell culture. Alginate gel is formed in select regions of a microfluidic device through light-triggered release of caged calcium. In the pre-gelled alginate solution, calcium is chelated by DM-nitrophen (DM-n) to prevent cross-linking of alginate. After sufficient UV exposure the caged calcium is released from DM-n causing ...... hiện toàn bộ
Parallel Detection and Quantification Using Nine Immunoassays in a Protein Microarray for Drug from Serum Samples
Springer Science and Business Media LLC - - 2005
Hong Du, Weiping Yang, Wanli Xing, Yao Su, Jing Cheng
Ultra sensitive affinity chromatography on avidin-functionalized PMMA microchip for low abundant post-translational modified protein enrichment
Springer Science and Business Media LLC - Tập 14 - Trang 67-81 - 2011
Hui Xia, Kermit Murray, Steven Soper, June Feng
Post-translational modifications (PTM) of proteins play essential roles in cellular physiology and disease. The identification of protein substrates and detection of modification site helps understand PTM-mediated regulation in essential biological pathways and functions in various diseases. However, PTM proteins are typically present only at trace levels, making them difficult to identify in mass...... hiện toàn bộ
Immunocapture of prostate cancer cells by use of anti-PSMA antibodies in microdevices
Springer Science and Business Media LLC - Tập 14 - Trang 401-407 - 2011
Steven M. Santana, He Liu, Neil H. Bander, Jason P. Gleghorn, Brian J. Kirby
Patients suffering from cancer can shed tumor cells into the bloodstream, leading to one of the most important mechanisms of metastasis. As such, the capture of these cells is of great interest. Circulating tumor cells are typically extracted from circulation through positive selection with the epithelial cell-adhesion molecule (EpCAM), leading to currently unknown biases when cells are undergoing...... hiện toàn bộ
A microfabricated platform for establishing oxygen gradients in 3-D constructs
Springer Science and Business Media LLC - - 2013
Shawn C. Oppegard, David T. Eddington
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