Springer Science and Business Media LLC

Công bố khoa học tiêu biểu

* Dữ liệu chỉ mang tính chất tham khảo

Sắp xếp:  
Nhắm mục tiêu vào kinase liên quan đến ataxia telangiectasia-mutated và Rad3 (ATR) trong ung thư vú thiếu PTEN để điều trị cá nhân hóa Dịch bởi AI
Springer Science and Business Media LLC - Tập 169 - Trang 277-286 - 2018
Nouf Al-Subhi, Reem Ali, Tarek Abdel-Fatah, Paul M. Moseley, Stephen Y. T. Chan, Andrew R. Green, Ian O. Ellis, Emad A. Rakha, Srinivasan Madhusudan
Phosphatase và tenin homolog (PTEN), một chất điều hòa tiêu cực của tín hiệu PI3K, có vai trò trong việc sửa chữa DNA. ATR là một cảm biến chính của tổn thương DNA và căng thẳng sao chép. Chúng tôi đã đánh giá liệu tín hiệu ATR có ý nghĩa lâm sàng và có thể được nhắm mục tiêu bởi tính độc hại tổng hợp trong ung thư vú ba âm tính (TNBC) thiếu PTEN hay không. Mức độ protein của PTEN, ATR và pCHK1Ser...... hiện toàn bộ
#PTEN #ATR #ung thư vú ba âm tính #độc hại tổng hợp #sửa chữa DNA
The impact of ductal carcinoma in situ on health services utilization
Springer Science and Business Media LLC - Tập 182 - Trang 159-168 - 2020
Lawrence Paszat, Rinku Sutradhar, Eileen Rakovitch
To determine the intermediate-term impact of diagnosis and treatment of ductal carcinoma in situ of the breast (DCIS) on health services utilization, we compared utilization by cases of DCIS to unaffected controls. We identified a population-based cohort of Ontario females diagnosed with DCIS between 2010 and 2015. We matched 5 controls without any history of cancer to each case, on the date of di...... hiện toàn bộ
Loco-regional treatment in metastatic breast cancer patients: Is there a survival benefit?
Springer Science and Business Media LLC - Tập 119 - Trang 537-545 - 2009
Bevan H. Ly, Nam P. Nguyen, Vincent Vinh-Hung, Elisabetta Rapiti, Georges Vlastos
A number of studies have recently demonstrated a survival benefit in stage IV breast cancer patients following surgical resection of the primary tumor. Here, we investigate the relationship between loco-regional treatment and survival in patients with metastatic breast cancer and evaluate the impact of different loco-regional treatments. We conducted a systematic review of the literature using Pub...... hiện toàn bộ
Utilization of Professional Supportive Care Services by Women with Breast Cancer
Springer Science and Business Media LLC - Tập 64 - Trang 253-258 - 2000
Ross E. Gray, Vivek Goel, Margaret I. Fitch, Edmee Franssen, Pamela Chart, Marlene Greenberg, Debra Bakker, Manon Labrecque, Eric Hollowaty, Raylene Godel, Anne Wray Hampson
This paper reports on the results of a survey of utilization of professional supportive care services by women with breast cancer, and on patterns of differential service utilization by sub-groups of patients. Study participants were women with invasive breast cancer diagnosed 23–36 months prior to contact about the study, and randomly selected from the Ontario Cancer Registry. From among 1,119 el...... hiện toàn bộ
Unenhanced magnetic resonance screening using fused diffusion-weighted imaging and maximum-intensity projection in patients with a personal history of breast cancer: role of fused DWI for postoperative screening
Springer Science and Business Media LLC - Tập 165 - Trang 119-128 - 2017
Ji Won Kang, Hee Jung Shin, Ki Chang Shin, Eun Young Chae, Woo Jung Choi, Joo Hee Cha, Hak Hee Kim
To assess the diagnostic performance of unenhanced abbreviated protocol (AP) comprising fused diffusion-weighted imaging (DWI) using T1-weighted imaging (T1WI) with DWI maximum-intensity projections (DWI MIPs) for screening patients with a personal history of breast cancer (PHBC). This institutional review board-approved retrospective observational study included 343 patients with PHBC who underwe...... hiện toàn bộ
A phase III randomized trial of cyclophosphamide, mitoxantrone, and 5-fluorouracil (CNF) versus cyclophosphamide, adriamycin, and 5-fluorouracil (CAF) in patients with metastatic breast cancer
Springer Science and Business Media LLC - Tập 34 - Trang 15-24 - 1995
M. C. Alonso, J. M. Tabernero, B. Ojeda, M. Llanos, C. Solà, M. A. Climent, M. A. Seguí, J. J. López
One hundred patients with metastatic breast cancer were randomly selected to receive combined chemotherapy treatment with adriamycin (50 mg/m2) or mitoxantrone (12 mg/m2) associated with 5-fluorouracil (600 mg/m2) and cyclophosphamide (600 mg/m2) administered intravenously every 21 days with a maximum of ten cycles. All patients included in this study were under 75 years of age and had ECOG perfor...... hiện toàn bộ
The methodology of quantitation of microvessel density and prognostic value of neovascularization associated with long‐term survival in Japanese patients with breast cancer
Springer Science and Business Media LLC - Tập 53 - Trang 19-31 - 1999
Takao Kato, Tsunehito Kimura, Nobue Ishii, Akiho Fujii, Kazuko Yamamoto, Shingo Kameoka, Toshio Nishikawa, Takeshi Kasajima
The present study updates results on methodology of quantitation of tumor neovascularization and those on the prognostic value of microvessel density (MVD) in breast cancer tissue previously published in the World J. Surg. 21: 49–56, 1997. The follow‐up period of observation of the series was extended to 20 years, and new biological indicators (i.e., proliferating cell nuclear antigen (PCNA), c‐er...... hiện toàn bộ
Physical activity and breast cancer incidence in middle-aged women: a prospective cohort study
Springer Science and Business Media LLC - Tập 97 - Trang 209-214 - 2005
Amy J. Mertens, Carol Sweeney, Eyal Shahar, Wayne D. Rosamond, and Aaron R. Folsom
Many reports suggest that physically active women have a somewhat lower breast cancer incidence than physically inactive women. We hypothesized that indices of physical activity are associated inversely with breast cancer incidence after adjustment for confounders. The sample comprised 7994 women, aged 45–64, who participated in the Atherosclerosis Risk in Communities (ARIC) Study. Baseline physic...... hiện toàn bộ
Does nipple preservation in mastectomy improve satisfaction with cosmetic results, psychological adjustment, body image and sexuality?
Springer Science and Business Media LLC - Tập 118 - Trang 623-633 - 2008
F. Didier, D. Radice, S. Gandini, R. Bedolis, N. Rotmensz, A. Maldifassi, B. Santillo, A. Luini, V. Galimberti, E. Scaffidi, F. Lupo, S. Martella, J. Y. Petit
We investigated the influence of nipple areolar complex (NAC) sparing in mastectomy, on patient satisfaction with cosmetic results, body-image, sexuality and psychological well-being. We developed a specific questionnaire and compared two groups of women who underwent radical mastectomy with immediate breast reconstruction (IBR). Between 2004 and 2006, 310 women with NAC preservation and 143 patie...... hiện toàn bộ
Pre-diagnostic sex hormone levels and survival among breast cancer patients
Springer Science and Business Media LLC - Tập 174 - Trang 749-758 - 2019
Kevin H. Kensler, A. Heather Eliassen, Bernard A. Rosner, Susan E. Hankinson, Myles Brown, Rulla M. Tamimi
Higher levels of circulating sex steroid hormones are associated with increased breast cancer risk, though their association with prognosis remains unclear. We evaluated the association between circulating sex hormone levels and breast cancer survival in two large cohorts. We evaluated this association among 2073 breast cancer cases from the Nurses’ Health Study (NHS) and Nurses’ Health Study II (...... hiện toàn bộ
Tổng số: 7,655   
  • 1
  • 2
  • 3
  • 4
  • 5
  • 6
  • 10