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Regulation of germline stem cell proliferation downstream of nutrient sensing
Springer Science and Business Media LLC - - 2006
Stem cells have recently attracted significant attention largely due to their potential therapeutic properties, but also because of their role in tumorigenesis and their resemblance, in many aspects, to cancerous cells. Understanding how stem cells are regulated, namely with respect to the control of their proliferation and differentiation within a functional organism, is thus primordial to safely...... hiện toàn bộ
Anti cancer effects of curcumin: cycle of life and death
Springer Science and Business Media LLC - Tập 3 - Trang 1-14 - 2008
Increasing knowledge on the cell cycle deregulations in cancers has promoted the introduction of phytochemicals, which can either modulate signaling pathways leading to cell cycle regulation or directly alter cell cycle regulatory molecules, in cancer therapy. Most human malignancies are driven by chromosomal translocations or other genetic alterations that directly affect the function of critical...... hiện toàn bộ
Fez1/Lzts1 a new mitotic regulator implicated in cancer development
Springer Science and Business Media LLC - Tập 2 - Trang 1-5 - 2007
Considerable evidence has accumulated suggesting that cancer has genetic origin, based on the development of genomic alterations, such as deletions, mutations, and/or methylations in critical genes for homeostasis of cellular functions, including cell survival, DNA replication and cell cycle control. Mechanism controlling the precise timing and sequence of cell cycle events as well as checkpoints ...... hiện toàn bộ
Replication of somatic micronuclei in bovine enucleated oocytes
Springer Science and Business Media LLC - Tập 7 - Trang 1-10 - 2012
Microcell-mediated chromosome transfer (MMCT) was developed to introduce a low number of chromosomes into a host cell. We have designed a novel technique combining part of MMCT with somatic cell nuclear transfer, which consists of injecting a somatic micronucleus into an enucleated oocyte, and inducing its cellular machinery to replicate such micronucleus. It would allow the isolation and manipula...... hiện toàn bộ
APC/C-Cdh1-dependent anaphase and telophase progression during mitotic slippage
Springer Science and Business Media LLC - Tập 7 - Trang 1-15 - 2012
The spindle assembly checkpoint (SAC) inhibits anaphase progression in the presence of insufficient kinetochore-microtubule attachments, but cells can eventually override mitotic arrest by a process known as mitotic slippage or adaptation. This is a problem for cancer chemotherapy using microtubule poisons. Here we describe mitotic slippage in yeast bub2Δ mutant cells that are defective in the rep...... hiện toàn bộ
SUMO: regulating the regulator
Springer Science and Business Media LLC - Tập 1 - Trang 1-8 - 2006
Post-translational modifiers of the SUMO (S mall U biquitin-related M odifier) family have emerged as key regulators of protein function and fate. While the past few years have seen an enormous increase in knowledge on SUMO enzymes, substrates, and consequences of modification, regulation of SUMO conjugation is far from being understood. This brief review will provide an overview on recent advance...... hiện toàn bộ
MIF coordinates the cell cycle with DNA damage checkpoints. Lessons from knockout mouse models
Springer Science and Business Media LLC - Tập 2 - Trang 1-7 - 2007
Macrophage migration inhibitory factor (MIF) is a ubiquitously expressed pro-inflammatory mediator that has also been implicated in the process of oncogenic transformation and tumor progression. We used a genetic approach to show that deletion of the MIF gene in mice has several major consequences for the proliferative and transforming properties of cells. MIF-deficient cells exhibit increased res...... hiện toàn bộ
Kinetics of DNA methylation inheritance by the Dnmt1-including complexes during the cell cycle
Springer Science and Business Media LLC - Tập 7 - Trang 1-11 - 2012
The clonal transmission of lineage-specific DNA methylation patterns in a mammalian genome during the cellular division is a crucial biological process controlled by the DNA methyltransferase Dnmt1, mainly. To investigate possible dynamic mechanisms of DNA methylation inheritance during the cell cycle, we used a Proximity Ligation In Situ Assay (P-LISA) to analyze the kinetic of formation and DNA ...... hiện toàn bộ
Cytotoxicity, anti-angiogenic, apoptotic effects and transcript profiling of a naturally occurring naphthyl butenone, guieranone A
Springer Science and Business Media LLC - - 2012
Malignant diseases are responsible of approximately 13% of all deaths each year in the world. Natural products represent a valuable source for the development of novel anticancer drugs. The present study was aimed at evaluating the cytotoxicity of a naphtyl butanone isolated from the leaves of Guiera senegalensis, guieranone A (GA). The results indicated that GA was active on 91.67% of the 12 test...... hiện toàn bộ
Phân Chia Tế Bào, một diễn đàn trực tuyến mở mới cho cộng đồng chu kỳ tế bào Dịch bởi AI
Springer Science and Business Media LLC - Tập 1 - Trang 1-2 - 2006
Phân Chia Tế Bào là một tạp chí trực tuyến mở, truy cập tự do, được đồng nghiệp đánh giá, xuất bản các bài báo tiên tiến, bình luận và tổng quan về tất cả các khía cạnh hấp dẫn của kiểm soát chu kỳ tế bào ở eukaryote. Một mục tiêu chính của tạp chí mới này là xuất bản các nghiên cứu kịp thời và có ý nghĩa về các sai lệch trong mạng lưới chu kỳ tế bào xảy ra trong ung thư và các bệnh khác.
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