Springer Science and Business Media LLC

Công bố khoa học tiêu biểu

* Dữ liệu chỉ mang tính chất tham khảo

Sắp xếp:  
Eg5 orchestrates porcine oocyte maturational progression by maintaining meiotic organelle arrangement
Springer Science and Business Media LLC - Tập 13 - Trang 1-12 - 2018
Yan Xie, Minghui Cheng, Shan Lu, Qilong Yuan, Dongyu Yang, Ying Chen, Chen Pan, Yurong Qiu, Bo Xiong
Kinesin superfamily proteins are microtubule-based molecular motors essential for the intracellular transport of various cargos, including organelles, proteins, and RNAs. However, their exact roles during mammalian oocyte meiosis have not been fully clarified. Herein, we investigated the critical events during porcine oocyte meiotic maturation with the treatment of Eg5-specific inhibitor monastrol... hiện toàn bộ
New insights into posttranslational modifications of Hippo pathway in carcinogenesis and therapeutics
Springer Science and Business Media LLC - Tập 11 - Trang 1-10 - 2016
Mingjing He, Zhuan Zhou, Anil A. Shah, Yang Hong, Qianming Chen, Yong Wan
PTMs (posttranslational modifications) such as ubiquitylation, sumoylation, acetylation and protein methylation are pivotal modifiers that determine the activation, deactivation or subcellular localization of signaling proteins, facilitating the initiation, amplification and transduction of signaling. Accumulating evidence suggest that several key signaling molecules in Hippo signaling pathway are... hiện toàn bộ
A human cancer-predisposing polymorphism in Cdc25A is embryonic lethal in the mouse and promotes ASK-1 mediated apoptosis
Springer Science and Business Media LLC - Tập 6 - Trang 1-9 - 2011
El Mustapha Bahassi, Moying Yin, Susan B Robbins, Ya-Qin Li, Deborah G Conrady, Zhenyu Yuan, Rhett A Kovall, Andrew B Herr, Peter J Stambrook
Failure to regulate the levels of Cdc25A phosphatase during the cell cycle or during a checkpoint response causes bypass of DNA damage and replication checkpoints resulting in genomic instability and cancer. During G1 and S and in cellular response to DNA damage, Cdc25A is targeted for degradation through the Skp1-cullin-β-TrCP (SCFβ-TrCP) complex. This complex binds to the Cdc25A DSG motif which ... hiện toàn bộ
Truy tìm dấu vết của XPD: vấn đề chu kỳ tế bào - làm rõ mối quan hệ kiểu gen - kiểu hình của các đột biến XPD Dịch bởi AI
Springer Science and Business Media LLC - Tập 5 - Trang 1-19 - 2010
Elisabetta Cameroni, Karin Stettler, Beat Suter
Các đột biến trong gen người mã hóa cho XPD dẫn đến tình trạng lão hóa từng phần - sự xuất hiện sớm của một số kiểu hình thường liên quan đến tuổi tác - mà có thể đi kèm hoặc không với sự gia tăng tần suất ung thư. XPD là cần thiết cho ít nhất ba chức năng tế bào quan trọng khác nhau: ngoài việc tham gia vào quá trình sửa chữa DNA bằng cách cắt bỏ nucleotide (NER), vốn loại bỏ các tổn thương DNA k... hiện toàn bộ
#XPD #chu kỳ tế bào #lão hóa #ung thư #sửa chữa DNA #di truyền học
MiR-146b-5p/SEMA3G regulates epithelial-mesenchymal transition in clear cell renal cell carcinoma
Springer Science and Business Media LLC - Tập 18 - Trang 1-13 - 2023
Mengxi Tang, Tao Xiong
The primary purpose was to unveil how the miR-146b-5p/SEMA3G axis works in clear cell renal cell carcinoma (ccRCC). ccRCC dataset was acquired from TCGA database, and target miRNA to be studied was further analyzed using survival analysis. We performed miRNA target gene prediction through the database, and those predicted miRNAs were intersected with differential mRNAs. After calculating the corre... hiện toàn bộ
Need telomere maintenance? Call 911
Springer Science and Business Media LLC - Tập 2 - Trang 1-6 - 2007
Sofia Francia, Robert S Weiss, Fabrizio d'Adda di Fagagna
"Natura non facit saltum" (nature makes no leap) the Latins used to say, meaning that nature does not like discontinuities. Cells make no exception and indeed any discontinuity in the DNA double helix is promptly detected, triggering an alteration of cell proliferation and an attempt to repair. Yet, linear chromosomes bear DNA ends that are compatible with normal cell proliferation and they escape... hiện toàn bộ
Cdk2 and Cdk4 cooperatively control the expression of Cdc2
Springer Science and Business Media LLC - Tập 1 - Trang 1-6 - 2006
Cyril Berthet, Philipp Kaldis
Progression through the mammalian cell cycle is associated with the activity of four cyclin dependent kinases (Cdc2/Cdk1, Cdk2, Cdk4, and Cdk6). Knockout mouse models have provided insight into the interplay of these Cdks. Most of these models do not exhibit major cell cycle defects revealing redundancies, and suggesting that a single Cdk might be sufficient to drive the cell cycle, similar as in ... hiện toàn bộ
A positive feedback loop between EZH2 and NOX4 regulates nucleus pulposus cell senescence in age-related intervertebral disc degeneration
Springer Science and Business Media LLC - Tập 15 - Trang 1-15 - 2020
Chang Liu, Libangxi Liu, Minghui Yang, Bin Li, Jiarong Yi, Xuezheng Ai, Yang Zhang, Bo Huang, Changqing Li, Chencheng Feng, Yue Zhou
The senescence of nucleus pulposus (NP) cells plays a vital role in the pathogenesis of intervertebral disc (IVD) degeneration (IDD). NADPH oxidase 4 (NOX4)-associated oxidative stress has been shown to induce premature NP cell senescence. Enhancer of zeste homolog 2 (EZH2) is a crucial gene regulating cell senescence. The aim of this study was to investigate the roles of EZH2 in NOX4-induced NP c... hiện toàn bộ
Asymmetric cell division of mammary stem cells
Springer Science and Business Media LLC - Tập 16 - Trang 1-15 - 2021
Shaan N. Chhabra, Brian W. Booth
Somatic stem cells are distinguished by their capacity to regenerate themselves and also to produce daughter cells that will differentiate. Self-renewal is achieved through the process of asymmetric cell division which helps to sustain tissue morphogenesis as well as maintain homeostasis. Asymmetric cell division results in the development of two daughter cells with different fates after a single ... hiện toàn bộ
JAB1/CSN5: a new player in cell cycle control and cancer
Springer Science and Business Media LLC - Tập 5 - Trang 1-14 - 2010
Terry J Shackleford, Francois X Claret
c-Jun activation domain-binding protein-1 (Jab1) acts as a modulator of intracellular signaling and affects cellular proliferation and apoptosis, through its existence as a monomer or as the fifth component of the constitutive photomorphogenic-9 signalosome (CSN5). Jab1/ CSN5 is involved in transcription factor specificity, deneddylation of NEDD8, and nuclear-to-cytoplasmic shuttling of key molecu... hiện toàn bộ
Tổng số: 199   
  • 1
  • 2
  • 3
  • 4
  • 5
  • 6
  • 10