circRNA_0001006 predicts prognosis and regulates cellular processes of triple-negative breast cancer via miR-424-5p

Springer Science and Business Media LLC - Tập 18 - Trang 1-9 - 2023
Jiaqi Liu1, Linna Kong1, Wenqing Bian2, Xiaona Lin1, Feifei Wei3, Jun Chu1
1Department of Breast and Thyroid Surgery, Zibo Central Hospital, Zibo, China
2Maternal and Child Health Hospital of Zibo, Zibo, China
3Weifang Maternal and Child Health Hospital, Weifang, China

Tóm tắt

circular RNAs (circRNAs) have been considered novel biomarker candidates for human cancers, such as triple-negative breast cancer (TNBC). circ_0001006 was identified as a differentially expressed circRNA in metastatic breast cancer, but its significance and function in TNBC were unclear. The significance of circ_0001006 in TNBC was assessed and exploring its potential molecular mechanism to provide a therapeutic target for TNBC. circ_0001006 showed significant upregulation in TNBC and close association with patients’ histological grade, Ki67 level, and TNM stage. Upregulated circ_0001006 could predict a worse prognosis and high risk of TNBC patients. In TNBC cells, silencing circ_0001006 suppressed cell proliferation, migration, and invasion. In mechanism, circ_0001006 could negatively regulate miR-424-5p, which mediated the inhibition of cellular processes by circ_0001006 knockdown. Upregulated circ_0001006 in TNBC served as a poor prognosis predictor and tumor promoter via negatively regulating miR-424-5p.

Tài liệu tham khảo

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