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Treatment with TNF-α and IFN-γ alters the activation of SER/THR protein kinases and the metabolic response to IGF-I in mouse c2c12 myogenic cells
Springer Science and Business Media LLC - Tập 15 - Trang 13-31 - 2009
Katarzyna Grzelkowska-Kowalczyk, Wioletta Wieteska-Skrzeczyńska
The aim of this study was to compare the effects of TNF-α, IL-1β and IFN-γ on the activation of protein kinase B (PKB), p70S6k, mitogen-activated protein kinase (MAPK) and p90 rsk , and on IGF-I-stimulated glucose uptake and protein synthesis in mouse C2C12 myotubes. 100 nmol/l IGF-I stimulated glucose uptake in C2C12 myotubes by 198.1% and 10 ng/ml TNF-α abolishe...... hiện toàn bộ
The identification of human aldo-keto reductase AKR7A2 as a novel cytoglobin-binding partner
Springer Science and Business Media LLC - - 2016
Xin Li, Sheng Zou, Zhen Li, Gaotai Cai, Bohong Chen, Ping Wang, Dong Wang
LAGE3 promoted cell proliferation, migration, and invasion and inhibited cell apoptosis of hepatocellular carcinoma by facilitating the JNK and ERK signaling pathway
Springer Science and Business Media LLC - Tập 26 Số 1 - 2021
Ying Xing, Yang Liu, Qi Zhong, Zhengrong Liu, Xin Wang, Hongyi Zhang
Abstract Background Hepatocellular carcinoma (HCC) is now the second leading cause of cancer death worldwide and lacks effectual therapy due to its high rate of tumor recurrence and metastasis. The aim of this study was to investigate the effects of L antigen family member 3 (LAGE3, a member of the ...... hiện toàn bộ
DU-145 prostate carcinoma cells that selectively transmigrate narrow obstacles express elevated levels of Cx43
Springer Science and Business Media LLC - Tập 16 - Trang 625-637 - 2011
Katarzyna Szpak, Ewa Wybieralska, Ewa Niedziałkowska, Monika Rak, Iga Bechyne, Marta Michalik, Zbigniew Madeja, Jarosław Czyż
The formation of aqueous intercellular channels mediating gap junctional intercellular coupling (GJIC) is a canonical function of connexins (Cx). In contrast, mechanisms of GJIC-independent involvement of connexins in cancer formation and metastasis remain a matter of debate. Because of the role of Cx43 in the determination of carcinoma cell invasive potential, we addressed the problem of the poss...... hiện toàn bộ
17β-Estradiol promotes cell proliferation in rat osteoarthritis model chondrocytes via PI3K/Akt pathway
Springer Science and Business Media LLC - Tập 16 - Trang 564-575 - 2011
Jia Gu Huang, Chun Xia, Xin Peng Zheng, Ting Ting Yi, Xiao Yong Wang, Gang Song, Bing Zhang
Osteoarthritis (OA) is the most common cause of musculoskeletal pain and disability. The importance of chondrocytes in the pathogenesis of OA is unequivocal. 17β-estradiol (E2) has a potential protective effect against OA. However, the mechanism of E2 in OA chondrocytes remains unclear. In this study, we investigated the regulative effect of E2 on cell growth and the relationship between E2 and th...... hiện toàn bộ
Deletion of CD36 exhibits limited impact on normal hematopoiesis and the leukemia microenvironment
Springer Science and Business Media LLC - Tập 28 - Trang 1-21 - 2023
Yiting Meng, Mateusz Pospiech, Atham Ali, Ritu Chandwani, Mary Vergel, Sandra Onyemaechi, George Yaghmour, Rong Lu, Houda Alachkar
CD36 has been identified as a potential therapeutic target both in leukemic cells and in the tumor immune microenvironment. In acute myeloid leukemia (AML), we found that APOC2 acts with CD36 to promote leukemia growth by activating the LYN-ERK signaling. CD36 also plays a role in lipid metabolism of cancer associated T-cells leading to impaired cytotoxic CD8+ T-cell and enhanced Treg cell functio...... hiện toàn bộ
Therapeutic overexpression of miR-92a-2-5p ameliorated cardiomyocyte oxidative stress injury in the development of diabetic cardiomyopathy
Springer Science and Business Media LLC - Tập 27 - Trang 1-17 - 2022
Manli Yu, Yangyong Sun, Xinghua Shan, Fan Yang, Guojun Chu, Qian Chen, Lin Han, Zhifu Guo, Guokun Wang
Diabetic cardiomyopathy (DCM) results from pathological changes in cardiac structure and function caused by diabetes. Excessive oxidative stress is an important feature of DCM pathogenesis. MicroRNAs (miRNAs) are key regulators of oxidative stress in the cardiovascular system. In the present study, we screened for the expression of oxidative stress-responsive miRNAs in the development of DCM. Furt...... hiện toàn bộ
Protective effect of intermedin on myocardial cell in a rat model of severe acute pancreatitis
Springer Science and Business Media LLC - Tập 16 - Trang 462-476 - 2011
Xiaodong Du, Yu Cao, Ping Xue, Ziqi Lin, Zhi Zeng, Qing Xia
Severe acute pancreatitis (SAP) is a common disease with a poor prognosis. Heart failure is one cause of SAP patient death. Intermedin (IMD) is a potent endogenous cardio-protective substance. Administration of exogenous IMD showed beneficial effects in cardiovascular diseases. The aim of this study was to investigate the myocardial damage in SAP and to determine the therapeutic potential of IMD f...... hiện toàn bộ
Retraction Note to: Downregulation of miR-483-5p decreases hypoxia-induced injury in human cardiomyocytes by targeting MAPK3
Springer Science and Business Media LLC - Tập 26 Số 1 - 2021
Yan Hao, Haitao Yuan, Haiqing Yu
This article has been retracted. Please see the Retraction Notice for more detail: https://doi.org/10.1186/s11658-021-00252-1
Estrogen stimulates SREBP2 expression in hepatic cell lines via an estrogen response element in the SREBP2 promoter
Springer Science and Business Media LLC - - 2019
Yahan Meng, Lu Zong
AbstractObjectiveHypoestrogenism in women is strongly associated with menopause and it can lead to lipid disorder, which predisposes people to premature cardiovascular disease. However, the mechanism of lipid disorder remains unclear. Sterol regulatory element-binding protein 2 (SREBP2) is the key transcription factor regulating c...... hiện toàn bộ
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