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SUMOylation modulates eIF5A activities in both yeast and pancreatic ductal adenocarcinoma cells
Springer Science and Business Media LLC - Tập 29 - Trang 1-29 - 2024
Rocío Seoane, Tomás Lama-Díaz, Antonia María Romero, Ahmed El Motiam, Arantxa Martínez-Férriz, Santiago Vidal, Yanis H. Bouzaher, María Blanquer, Rocío M. Tolosa, Juan Castillo Mewa, Manuel S. Rodríguez, Adolfo García-Sastre, Dimitris Xirodimas, James D. Sutherland, Rosa Barrio, Paula Alepuz, Miguel G. Blanco, Rosa Farràs, Carmen Rivas
The eukaryotic translation initiation protein eIF5A is a highly conserved and essential factor that plays a critical role in different physiological and pathological processes including stress response and cancer. Different proteomic studies suggest that eIF5A may be a small ubiquitin-like modifier (SUMO) substrate, but whether eIF5A is indeed SUMOylated and how relevant is this modification for e...... hiện toàn bộ
Gemini ester quat surfactants and their biological activity
Springer Science and Business Media LLC - Tập 18 - Trang 89-101 - 2012
Jacek Łuczyński, Renata Frąckowiak, Aleksandra Włoch, Halina Kleszczyńska, Stanisław Witek
Cationic gemini surfactants are an important class of surface-active compounds that exhibit much higher surface activity than their monomeric counterparts. This type of compound architecture lends itself to the compound being easily adsorbed at interfaces and interacting with the cellular membranes of microorganisms. Conventional cationic surfactants have high chemical stability but poor chemical ...... hiện toàn bộ
Therapeutic utility of mesenchymal stromal cell (MSC)-based approaches in chronic neurodegeneration: a glimpse into underlying mechanisms, current status, and prospects
Springer Science and Business Media LLC - Tập 27 - Trang 1-36 - 2022
Mohaddeseh Rahbaran, Angelina Olegovna Zekiy, Mahta Bahramali, Mohammadsaleh Jahangir, Mahsa Mardasi, Delaram Sakhaei, Lakshmi Thangavelu, Navid Shomali, Majid Zamani, Ali Mohammadi, Negin Rahnama
Recently, mesenchymal stromal cell (MSC)-based therapy has become an appreciated therapeutic approach in the context of neurodegenerative disease therapy. Accordingly, a myriad of studies in animal models and also some clinical trials have evinced the safety, feasibility, and efficacy of MSC transplantation in neurodegenerative conditions, most importantly in Alzheimer’s disease (AD), Parkinson’s ...... hiện toàn bộ
The human telomerase catalytic subunit and viral telomerase RNA reconstitute a functional telomerase complex in a cell-free system, but not in human cells
Springer Science and Business Media LLC - Tập 17 - Trang 598-615 - 2012
Laetitia Trapp-Fragnet, Delphine T. Marie-Egyptienne, Johans Fakhoury, Denis Rasschaert, Chantal Autexier
The minimal vertebrate telomerase enzyme is composed of a protein component (telomerase reverse transcriptase, TERT) and an RNA component (telomerase RNA, TR). Expression of these two subunits is sufficient to reconstitute telomerase activity in vitro, while the formation of a holoenzyme comprising telomerase-associated proteins is necessary for proper telomere length maintenance. Previous reports...... hiện toàn bộ
LncRNA DRAIC inhibits proliferation and metastasis of gastric cancer cells through interfering with NFRKB deubiquitination mediated by UCHL5
Springer Science and Business Media LLC - Tập 25 - Trang 1-17 - 2020
Zheng Zhang, Xiaoxuan Hu, Jia Kuang, Jinmao Liao, Qi Yuan
Long non-coding RNA (lncRNA) as a widespread and pivotal epigenetic molecule participates in the occurrence and progression of malignant tumors. DRAIC, a kind of lncRNA whose coding gene location is on 15q23 chromatin, has been found to be weakly expressed in a variety of malignant tumors and acts as a suppressor, but its characteristics and role in gastric cancer (GC) remain to be elucidated. Six...... hiện toàn bộ
Effect of the glycine-rich domain in GAREM2 on its unique subcellular localization upon EGF stimulation
Springer Science and Business Media LLC - Tập 26 - Trang 1-11 - 2021
Tasuku Nishino, Tsuyoshi Oshika, Moriatsu Kyan, Hiroaki Konishi
In mammals, there are two subtypes of Grb2-associated regulator of Erk/MAPK (GAREM), an adaptor protein that functions downstream of the cell growth factor receptor. GAREM1 is ubiquitously expressed, whereas GAREM2 is mainly expressed in the brain. However, the precise mechanism of the translocation of each GAREM subtype in growth factor-stimulated cells is still unclear. In this study, immunofluo...... hiện toàn bộ
The transition from HIF-1 to HIF-2 during prolonged hypoxia results from reactivation of PHDs and HIF1A mRNA instability
Springer Science and Business Media LLC - Tập 27 - Trang 1-19 - 2022
Maciej Jaśkiewicz, Adrianna Moszyńska, Jarosław Króliczewski, Aleksandra Cabaj, Sylwia Bartoszewska, Agata Charzyńska, Magda Gebert, Michał Dąbrowski, James F. Collawn, Rafal Bartoszewski
The hypoxia-inducible factors (HIF) are transcription factors that activate the adaptive hypoxic response when oxygen levels are low. The HIF transcriptional program increases oxygen delivery by inducing angiogenesis and by promoting metabolic reprograming that favors glycolysis. The two major HIFs, HIF-1 and HIF-2, mediate this response during prolonged hypoxia in an overlapping and sequential fa...... hiện toàn bộ
An Fc-muted bispecific antibody targeting PD-L1 and 4-1BB induces antitumor immune activity in colorectal cancer without systemic toxicity
Springer Science and Business Media LLC - Tập 28 Số 1
Luyang Cheng, Meifang Zhu, Yan Gao, Wenting Liu, Yin Wang, Jin Zhou, Zhen Zhu, Liwen Niu, Xiaoli Zeng, Dayan Zhang, Feng‐Ling Qing, Feng-Rong Wang, Qun Zhao, Yan Zhang, Guodong Shen
Abstract Background Resistance to immune checkpoint inhibitor (ICI) therapy narrows the efficacy of cancer immunotherapy. Although 4-1BB is a promising drug target as a costimulatory molecule of immune cells, no 4-1BB agonist has been given clinical approval because of severe liver toxicity or limit...... hiện toàn bộ
Response gene to complement 32 regulates the G2/M phase checkpoint during renal tubular epithelial cell repair
Springer Science and Business Media LLC - Tập 21 - Trang 1-9 - 2016
Yun-lin Shen, Hua-jie Liu, Lei Sun, Xiao-ling Niu, Xin-yu Kuang, Ping Wang, Sheng Hao, Wen-yan Huang
The aim of this study was to evaluate the influence of RGC-32 (response gene to complement 32) on cell cycle progression in renal tubular epithelial cell injury. NRK-52E cells with overexpressed or silenced RGC-32 were constructed via transient transfection with RGC-32 expression plasmid and RGC-32 siRNA plasmid, and the cell cycle distribution was determined. The expression levels of fibrosis fac...... hiện toàn bộ
Honokiol giảm thiểu tổn thương thận cấp tính do nhiễm trùng trong mô hình chuột bằng cách nhắm vào con đường tín hiệu miR-218-5p/heme oxygenase-1 Dịch bởi AI
Springer Science and Business Media LLC - Tập 24 - Trang 1-15 - 2019
Tao Zhang, Lei Xiang
Honokiol là một sản phẩm tự nhiên có trọng lượng phân tử thấp và đã được báo cáo có hoạt động chống viêm. Nghiên cứu của chúng tôi nhằm điều tra ảnh hưởng của honokiol lên tổn thương thận cấp tính do nhiễm trùng (AKI) trong mô hình chuột. Một phẫu thuật thắt và chọc ruột (CLP) đã được thực hiện để thiết lập mô hình tổn thương thận cấp tính do nhiễm trùng ở chuột. Phân tích hình thái học thận đã đư...... hiện toàn bộ
#Honokiol #tổn thương thận cấp tính #miR-218-5p #heme oxygenase-1 #nhiễm trùng #chuột.
Tổng số: 667   
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