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SUMOylation modulates eIF5A activities in both yeast and pancreatic ductal adenocarcinoma cells
Springer Science and Business Media LLC - Tập 29 - Trang 1-29 - 2024
The eukaryotic translation initiation protein eIF5A is a highly conserved and
essential factor that plays a critical role in different physiological and
pathological processes including stress response and cancer. Different proteomic
studies suggest that eIF5A may be a small ubiquitin-like modifier (SUMO)
substrate, but whether eIF5A is indeed SUMOylated and how relevant is this
modification for e...
Gemini ester quat surfactants and their biological activity
Springer Science and Business Media LLC - Tập 18 - Trang 89-101 - 2012
Cationic gemini surfactants are an important class of surface-active compounds
that exhibit much higher surface activity than their monomeric counterparts.
This type of compound architecture lends itself to the compound being easily
adsorbed at interfaces and interacting with the cellular membranes of
microorganisms. Conventional cationic surfactants have high chemical stability
but poor chemical ...
Therapeutic utility of mesenchymal stromal cell (MSC)-based approaches in chronic neurodegeneration: a glimpse into underlying mechanisms, current status, and prospects
Springer Science and Business Media LLC - Tập 27 - Trang 1-36 - 2022
Recently, mesenchymal stromal cell (MSC)-based therapy has become an appreciated
therapeutic approach in the context of neurodegenerative disease therapy.
Accordingly, a myriad of studies in animal models and also some clinical trials
have evinced the safety, feasibility, and efficacy of MSC transplantation in
neurodegenerative conditions, most importantly in Alzheimer’s disease (AD),
Parkinson’s ...
The human telomerase catalytic subunit and viral telomerase RNA reconstitute a functional telomerase complex in a cell-free system, but not in human cells
Springer Science and Business Media LLC - Tập 17 - Trang 598-615 - 2012
The minimal vertebrate telomerase enzyme is composed of a protein component
(telomerase reverse transcriptase, TERT) and an RNA component (telomerase RNA,
TR). Expression of these two subunits is sufficient to reconstitute telomerase
activity in vitro, while the formation of a holoenzyme comprising
telomerase-associated proteins is necessary for proper telomere length
maintenance. Previous reports...
LncRNA DRAIC inhibits proliferation and metastasis of gastric cancer cells through interfering with NFRKB deubiquitination mediated by UCHL5
Springer Science and Business Media LLC - Tập 25 - Trang 1-17 - 2020
Long non-coding RNA (lncRNA) as a widespread and pivotal epigenetic molecule
participates in the occurrence and progression of malignant tumors. DRAIC, a
kind of lncRNA whose coding gene location is on 15q23 chromatin, has been found
to be weakly expressed in a variety of malignant tumors and acts as a
suppressor, but its characteristics and role in gastric cancer (GC) remain to be
elucidated. Six...
Effect of the glycine-rich domain in GAREM2 on its unique subcellular localization upon EGF stimulation
Springer Science and Business Media LLC - Tập 26 - Trang 1-11 - 2021
In mammals, there are two subtypes of Grb2-associated regulator of Erk/MAPK
(GAREM), an adaptor protein that functions downstream of the cell growth factor
receptor. GAREM1 is ubiquitously expressed, whereas GAREM2 is mainly expressed
in the brain. However, the precise mechanism of the translocation of each GAREM
subtype in growth factor-stimulated cells is still unclear. In this study,
immunofluo...
The transition from HIF-1 to HIF-2 during prolonged hypoxia results from reactivation of PHDs and HIF1A mRNA instability
Springer Science and Business Media LLC - Tập 27 - Trang 1-19 - 2022
The hypoxia-inducible factors (HIF) are transcription factors that activate the
adaptive hypoxic response when oxygen levels are low. The HIF transcriptional
program increases oxygen delivery by inducing angiogenesis and by promoting
metabolic reprograming that favors glycolysis. The two major HIFs, HIF-1 and
HIF-2, mediate this response during prolonged hypoxia in an overlapping and
sequential fa...
An Fc-muted bispecific antibody targeting PD-L1 and 4-1BB induces antitumor immune activity in colorectal cancer without systemic toxicity
Springer Science and Business Media LLC - Tập 28 Số 1
Abstract Background Resistance to immune checkpoint inhibitor (ICI) therapy
narrows the efficacy of cancer immunotherapy. Although 4-1BB is a promising drug
target as a costimulatory molecule of immune cells, no 4-1BB agonist has been
given clinical approval because of severe liver toxicity or limited efficacy.
Therefore, a safe and efficient immunostimulatory molecule is urgently needed
for cance...
Response gene to complement 32 regulates the G2/M phase checkpoint during renal tubular epithelial cell repair
Springer Science and Business Media LLC - Tập 21 - Trang 1-9 - 2016
The aim of this study was to evaluate the influence of RGC-32 (response gene to
complement 32) on cell cycle progression in renal tubular epithelial cell
injury. NRK-52E cells with overexpressed or silenced RGC-32 were constructed via
transient transfection with RGC-32 expression plasmid and RGC-32 siRNA plasmid,
and the cell cycle distribution was determined. The expression levels of
fibrosis fac...
Honokiol giảm thiểu tổn thương thận cấp tính do nhiễm trùng trong mô hình chuột bằng cách nhắm vào con đường tín hiệu miR-218-5p/heme oxygenase-1 Dịch bởi AI
Springer Science and Business Media LLC - Tập 24 - Trang 1-15 - 2019
Honokiol là một sản phẩm tự nhiên có trọng lượng phân tử thấp và đã được báo cáo
có hoạt động chống viêm. Nghiên cứu của chúng tôi nhằm điều tra ảnh hưởng của
honokiol lên tổn thương thận cấp tính do nhiễm trùng (AKI) trong mô hình chuột.
Một phẫu thuật thắt và chọc ruột (CLP) đã được thực hiện để thiết lập mô hình
tổn thương thận cấp tính do nhiễm trùng ở chuột. Phân tích hình thái học thận đã
đư...
#Honokiol #tổn thương thận cấp tính #miR-218-5p #heme oxygenase-1 #nhiễm trùng #chuột.
Tổng số: 667
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