Springer Science and Business Media LLC

Công bố khoa học tiêu biểu

* Dữ liệu chỉ mang tính chất tham khảo

Sắp xếp:  
SUMOylation modulates eIF5A activities in both yeast and pancreatic ductal adenocarcinoma cells
Springer Science and Business Media LLC - Tập 29 - Trang 1-29 - 2024
Rocío Seoane, Tomás Lama-Díaz, Antonia María Romero, Ahmed El Motiam, Arantxa Martínez-Férriz, Santiago Vidal, Yanis H. Bouzaher, María Blanquer, Rocío M. Tolosa, Juan Castillo Mewa, Manuel S. Rodríguez, Adolfo García-Sastre, Dimitris Xirodimas, James D. Sutherland, Rosa Barrio, Paula Alepuz, Miguel G. Blanco, Rosa Farràs, Carmen Rivas
The eukaryotic translation initiation protein eIF5A is a highly conserved and essential factor that plays a critical role in different physiological and pathological processes including stress response and cancer. Different proteomic studies suggest that eIF5A may be a small ubiquitin-like modifier (SUMO) substrate, but whether eIF5A is indeed SUMOylated and how relevant is this modification for e...... hiện toàn bộ
The human telomerase catalytic subunit and viral telomerase RNA reconstitute a functional telomerase complex in a cell-free system, but not in human cells
Springer Science and Business Media LLC - Tập 17 - Trang 598-615 - 2012
Laetitia Trapp-Fragnet, Delphine T. Marie-Egyptienne, Johans Fakhoury, Denis Rasschaert, Chantal Autexier
The minimal vertebrate telomerase enzyme is composed of a protein component (telomerase reverse transcriptase, TERT) and an RNA component (telomerase RNA, TR). Expression of these two subunits is sufficient to reconstitute telomerase activity in vitro, while the formation of a holoenzyme comprising telomerase-associated proteins is necessary for proper telomere length maintenance. Previous reports...... hiện toàn bộ
The transition from HIF-1 to HIF-2 during prolonged hypoxia results from reactivation of PHDs and HIF1A mRNA instability
Springer Science and Business Media LLC - Tập 27 - Trang 1-19 - 2022
Maciej Jaśkiewicz, Adrianna Moszyńska, Jarosław Króliczewski, Aleksandra Cabaj, Sylwia Bartoszewska, Agata Charzyńska, Magda Gebert, Michał Dąbrowski, James F. Collawn, Rafal Bartoszewski
The hypoxia-inducible factors (HIF) are transcription factors that activate the adaptive hypoxic response when oxygen levels are low. The HIF transcriptional program increases oxygen delivery by inducing angiogenesis and by promoting metabolic reprograming that favors glycolysis. The two major HIFs, HIF-1 and HIF-2, mediate this response during prolonged hypoxia in an overlapping and sequential fa...... hiện toàn bộ
An Fc-muted bispecific antibody targeting PD-L1 and 4-1BB induces antitumor immune activity in colorectal cancer without systemic toxicity
Springer Science and Business Media LLC - Tập 28 Số 1
Luyang Cheng, Meifang Zhu, Yan Gao, Wenting Liu, Yin Wang, Jin Zhou, Zhen Zhu, Liwen Niu, Xiaoli Zeng, Dayan Zhang, Feng‐Ling Qing, Feng-Rong Wang, Qun Zhao, Yan Zhang, Guodong Shen
Abstract Background Resistance to immune checkpoint inhibitor (ICI) therapy narrows the efficacy of cancer immunotherapy. Although 4-1BB is a promising drug target as a costimulatory molecule of immune cells, no 4-1BB agonist has been given clinical approval because of severe liver toxicity or limit...... hiện toàn bộ
Response gene to complement 32 regulates the G2/M phase checkpoint during renal tubular epithelial cell repair
Springer Science and Business Media LLC - Tập 21 - Trang 1-9 - 2016
Yun-lin Shen, Hua-jie Liu, Lei Sun, Xiao-ling Niu, Xin-yu Kuang, Ping Wang, Sheng Hao, Wen-yan Huang
The aim of this study was to evaluate the influence of RGC-32 (response gene to complement 32) on cell cycle progression in renal tubular epithelial cell injury. NRK-52E cells with overexpressed or silenced RGC-32 were constructed via transient transfection with RGC-32 expression plasmid and RGC-32 siRNA plasmid, and the cell cycle distribution was determined. The expression levels of fibrosis fac...... hiện toàn bộ
Senescence-associated reprogramming induced by interleukin-1 impairs response to EGFR neutralization
Springer Science and Business Media LLC - Tập 27 - Trang 1-17 - 2022
Donatella Romaniello, Valerio Gelfo, Federica Pagano, Enea Ferlizza, Michela Sgarzi, Martina Mazzeschi, Alessandra Morselli, Carmen Miano, Gabriele D’Uva, Mattia Lauriola
EGFR targeting is currently the main treatment strategy for metastatic colorectal cancer (mCRC). Results of different clinical trials show that patients with wild-type KRAS and BRAF benefit from anti-EGFR monoclonal antibodies (moAbs) cetuximab (CTX) or panitumumab. Unfortunately, despite initial response, patients soon became refractory. Tumor heterogeneity and multiple escaping routes have been ...... hiện toàn bộ
E2F1 promotes cell cycle progression by stabilizing spindle fiber in colorectal cancer cells
Springer Science and Business Media LLC - Tập 27 - Trang 1-21 - 2022
Zejun Fang, Min Lin, Shenghui Chen, Hong Liu, Minjing Zhu, Yanyan Hu, Shanshan Han, Yizhang Wang, Long Sun, Fengjiao Zhu, Chengfu Xu, Chaoju Gong
E2F1 is a transcription factor that regulates cell cycle progression. It is highly expressed in most cancer cells and activates transcription of cell cycle-related kinases. Stathmin1 and transforming acidic coiled-coil-containing protein 3 (TACC3) are factors that enhance the stability of spindle fiber. The E2F1-mediated transcription of transforming acidic coiled-coil-containing protein 3 (TACC3)...... hiện toàn bộ
Ubiquitous protein lactylation in health and diseases
Springer Science and Business Media LLC - Tập 29 Số 1 - Trang 1-18 - 2024
Wang, Junyong, Wang, Ziyi, Wang, Qixu, Li, Xiao, Guo, Yaping
For decades, lactate has been considered a byproduct of glycolysis. The lactate shuttle hypothesis shifted the lactate paradigm, demonstrating that lactate not only plays important roles in cellular metabolism but also cellular communications, which can transcend compartment barriers and can occur within and among different cells, tissues and organs. Recently, the discovery that lactate can induce...... hiện toàn bộ
Overexpression of miR-92a attenuates kidney ischemia–reperfusion injury and improves kidney preservation by inhibiting MEK4/JNK1-related autophagy
Springer Science and Business Media LLC - Tập 28 - Trang 1-14 - 2023
Ming Ma, Hui Li, Saifu Yin, Tao Lin, Turun Song
Kidney ischemia–reperfusion injury is inevitable in kidney transplantation, and is essential for primary graft dysfunction and delayed graft function. Our previous study has proved that miR-92a could ameliorate kidney ischemia–reperfusion injury, but the mechanism has not been studied. This study conducted further research on the role of miR-92a in kidney ischemia–reperfusion injury and organ pres...... hiện toàn bộ
MicroRNA-146a protects against myocardial ischaemia reperfusion injury by targeting Med1
Springer Science and Business Media LLC - Tập 24 Số 1 - 2019
Tiantian Zhang, Yinjiao Ma, Lin Gao, Chengyu Mao, Huasu Zeng, Xiaofei Wang, Yapin Sun, Jianmin Gu, Yue Wang, Kan Chen, Zhihua Han, Yuqi Fan, Jun Gu, Junfeng Zhang, Changqian Wang
Abstract Background Myocardial ischaemia reperfusion injury (MIRI) is a difficult problem in clinical practice, and it may involve various microRNAs. This study investigated the role that endogenous microRNA-146a plays in myocardial ischaemia reperfusion and explored the possible target genes. ... hiện toàn bộ
Tổng số: 667   
  • 1
  • 2
  • 3
  • 4
  • 5
  • 6
  • 10