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Exploring the potential of EphA2 receptor signaling pathway: a comprehensive review in cancer treatment
Springer Science and Business Media LLC - - 2024
The protein encoded by the ephrin type-A receptor 2 (EphA2) gene is a member of the ephrin receptor subfamily of the receptor tyrosine kinase family (RTKs). Eph receptors play a significant role in various biological processes, particularly cancer progression, development, and pathogenesis. They have been observed to regulate cancer cell growth, migration, invasion, tumor development, invasiveness...... hiện toàn bộ
A structurally novel salt-regulated promoter of duplicated carbonic anhydrase gene 1 from Dunaliella salina
Springer Science and Business Media LLC - Tập 37 - Trang 1143-1154 - 2009
It has been demonstrated that the duplicated carbonic anhydrase is induced by salt in the Dunaliella salina (D. salina) and duplicated carbonic anhydrase 1 (DCA1) is a member of carbonic anhydrase family. The purpose of this study was to identify whether both the DCA1 gene and its promoter from D. salina are salt-inducible. In this study, the results of real time RT–PCR showed that the transcripts...... hiện toàn bộ
Family-1 UDP glycosyltransferases in pear (Pyrus bretschneideri): Molecular identification, phylogenomic characterization and expression profiling during stone cell formation
Springer Science and Business Media LLC - Tập 46 Số 2 - Trang 2153-2175 - 2019
Determination of genotoxic damages of picloram and dicamba with comet assay in Allium cepa rooted in tissue culture and distilled water
Springer Science and Business Media LLC - Tập 49 Số 12 - Trang 11273-11280 - 2022
miR-19a and miR-421 target PCA3 long non-coding RNA and restore PRUNE2 tumor suppressor activity in prostate cancer
Springer Science and Business Media LLC - Tập 49 - Trang 6803-6815 - 2021
Prostate cancer antigen 3 (PCA3) is the most promising diagnostic biomarker for the differential diagnosis of prostate cancer identified to date. As a dominant-negative oncogene, PCA3 negatively regulates the expression of tumor suppressor PRUNE2 (a human homolog of the Drosophila prune gene) gene. Although interaction between PCA3-PRUNE2 was clearly reported, the precise mechanism how PCA3 is upr...... hiện toàn bộ
Factors influencing circulating microRNAs as biomarkers for liver diseases
Springer Science and Business Media LLC - Tập 49 - Trang 4999-5016 - 2022
MicroRNAs (microRNAs) have been implicated to play crucial roles in various liver diseases. Hepatic microRNAs are released in to the circulation in a systematic fashion, and are, therefore, being extensively explored for their role as prognostic or diagnostic markers or therapeutic targets for numerous hepatic diseases. Advantages such as disease- or tissue-specific expression, and ease of detecti...... hiện toàn bộ
Molecular characterization and phylogenetic analysis of a yak (Bos grunniens) κ-casein cDNA from lactating mammary gland
Springer Science and Business Media LLC - Tập 38 - Trang 2711-2718 - 2010
κ-Casein is one of the major proteins in the milk of mammals. It plays an important role in determining the size and specific function of milk micelles. We have previously identified and characterized a genetic variant of yak κ-casein by evaluating genomic DNA. Here, we isolate and characterize a yak κ-casein cDNA harboring the full-length open reading frame (ORF) from lactating mammary gland. Tot...... hiện toàn bộ
Long-term exposure to lead nitrate and zinc sulfate Nile tilapia impact the Aeromonas hydrophila treatment
Springer Science and Business Media LLC - Tập 51 - Trang 1-12 - 2024
Pollution with heavy metals (HMs) is time- and concentration-dependent. Lead and zinc pollute the aquatic environment, causing severe health issues in aquatic animals. Nile tilapia, the predominant cultured fish in Egypt, were experimentally exposed to 10% of LC50 of lead nitrate (PbNO3) and zinc sulfate (ZnSO4). Samples were collected in three different periods, 4, 6, and 8 weeks, in addition to ...... hiện toàn bộ
An association of epidermal growth factor receptor mutation subtypes with prognostic prediction and site-specific recurrence in advanced stage lung cancer patients
Springer Science and Business Media LLC - Tập 50 - Trang 5105-5115 - 2023
Concerning the different clinical behavior of epidermal growth factor receptor (EGFR) subtypes in advanced-stage lung cancer patients, the current study aimed to evaluate the clinical, pathological, and prognostic significance of EGFR mutation subtypes, and treatment response in patients with advanced-stage lung cancer. A retrospective study enrolled a total of 346 patients with advanced-stage lun...... hiện toàn bộ
The APOE4 allele is associated with a decreased risk of retinopathy in type 2 diabetics
Springer Science and Business Media LLC - Tập 48 - Trang 5873-5879 - 2021
Common polymorphisms within the apolipoprotein E (APOE) gene are suggested to be associated with the development of type 2 diabetes mellitus (T2DM), but the potential association with T2DM complications (nephropathy, neuropathy and retinopathy) remains unclear. We perform the case–control study to analyse the association between the APOE polymorphism and risk of T2DM and to analysed the potential ...... hiện toàn bộ
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