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Exosomal miRNA profiling from H5N1 avian influenza virus-infected chickens
Springer Science and Business Media LLC - Tập 52 - Trang 1-11 - 2021
Yeojin Hong, Anh Duc Truong, Jiae Lee, Thi Hao Vu, Sooyeon Lee, Ki-Duk Song, Hyun S. Lillehoj, Yeong Ho Hong
Exosomes are membrane vesicles containing proteins, lipids, DNA, mRNA, and micro RNA (miRNA). Exosomal miRNA from donor cells can regulate the gene expression of recipient cells. Here, Ri chickens were divided into resistant (Mx/A; BF2/B21) and susceptible (Mx/G; BF2/B13) trait by genotyping of Mx and BF2 genes. Then, Ri chickens were infected with H5N1, a highly pathogenic avian influenza virus (...... hiện toàn bộ
Deletion of the GI-2 integrase and the wbkA flanking transposase improves the stability of Brucella melitensis Rev 1 vaccine
Springer Science and Business Media LLC - Tập 44 - Trang 1-12 - 2013
Marcos Mancilla, María-Jesús Grilló, María-Jesús de Miguel, Ignacio López-Goñi, Beatriz San-Román, Ana Zabalza-Baranguá, Ignacio Moriyón
Brucella melitensis Rev 1 is the best vaccine available for the prophylaxis of small ruminant brucellosis and, indirectly, for reducing human brucellosis. However, Rev 1 shows anomalously high rates of spontaneous dissociation from smooth (S) to rough (R) bacteria, the latter being inefficacious as vaccines. This S-R instability results from the loss of the O-polysaccharide. To overcome this probl...... hiện toàn bộ
Host-specific differences in the response of cultured macrophages to Campylobacter jejuni capsule and O-methyl phosphoramidate mutants
Springer Science and Business Media LLC - - 2018
Sung-Won Kim, Andrea Vela, Sara Clohisey, Spiridoula Athanasiadou, Pete Kaiser, Mark P. Stevens, Lonneke Vervelde
MicroRNA expression profiling of goat peripheral blood mononuclear cells in response to peste des petits ruminants virus infection
Springer Science and Business Media LLC - Tập 49 - Trang 1-10 - 2018
Xuefeng Qi, Ting Wang, Qinghong Xue, Zhen Li, Bo Yang, Jingyu Wang
Peste des petits ruminants virus (PPRV) belongs to the genus Morbillivirus that causes an acute and highly contagious disease in goats and sheep. Virus infection can trigger the change in the cellular microRNA (miRNA) expression profile, which play important post-transcriptional regulatory roles in gene expression and can greatly influence viral replication and pathogenesis. Here, we employed deep...... hiện toàn bộ
A live attenuated Salmonella Enteritidis secreting detoxified heat labile toxin enhances mucosal immunity and confers protection against wild-type challenge in chickens
Springer Science and Business Media LLC - Tập 47 Số 1 - 2016
Jonathan Lalsiamthara, Nitin Machindra Kamble, John Hwa Lee
Exploring the alternative virulence determinants PB2 S155N and PA S49Y/D347G that promote mammalian adaptation of the H9N2 avian influenza virus in mice
Springer Science and Business Media LLC - Tập 54 - Trang 1-17 - 2023
Yanna Guo, Xuebing Bai, Zhiyuan Liu, Bing Liang, Yiqing Zheng, Samar Dankar, Jihui Ping
The occurrence of human infections caused by avian H9N2 influenza viruses has raised concerns regarding the potential for human epidemics and pandemics. The molecular basis of viral adaptation to a new host needs to be further studied. Here, the bases of nucleotides 627 and 701 of PB2 were changed according to the uncoverable purine-to-pyrimidine transversion to block the development of PB2 627K a...... hiện toàn bộ
The lipopolysaccharide outer core transferase genes pcgD and hptE contribute differently to the virulence of Pasteurella multocida in ducks
Springer Science and Business Media LLC - Tập 52 - Trang 1-13 - 2021
Xinxin Zhao, Hui Shen, Sheng Liang, Dekang Zhu, Mingshu Wang, Renyong Jia, Shun Chen, Mafeng Liu, Qiao Yang, Ying Wu, Shaqiu Zhang, Juan Huang, Xumin Ou, Sai Mao, Qun Gao, Ling Zhang, Yunya Liu, Yanling Yu, Leichang Pan, Anchun Cheng
Fowl cholera caused by Pasteurella multocida exerts a massive economic burden on the poultry industry. Lipopolysaccharide (LPS) is essential for the growth of P. multocida genotype L1 strains in chickens and specific truncations to the full length LPS structure can attenuate bacterial virulence. Here we further dissected the roles of the outer core transferase genes pcgD and hptE in bacterial resi...... hiện toàn bộ
In vivo passage of Salmonella Typhimurium results in minor mutations in the bacterial genome and increases in vitro invasiveness
Springer Science and Business Media LLC - Tập 50 - Trang 1-10 - 2019
Andrea R. McWhorter, Rick Tearle, Talia S. Moyle, Kapil K. Chousalkar
Eggs and raw or undercooked egg-containing food items are frequently identified as the bacterial source during epidemiolocal investigation of Salmonella outbreaks. Multi-locus variable number of tandem repeats analysis (MLVA) is a widely used Salmonella typing method enabling the study of diversity within populations of the same serotype. In vivo passage, however, has been linked with changes in M...... hiện toàn bộ
RNA-Seq analysis of European sea bass (Dicentrarchus labrax L.) infected with nodavirus reveals powerful modulation of the stress response
Springer Science and Business Media LLC - Tập 51 - Trang 1-22 - 2020
Raquel Lama, Patricia Pereiro, Valentina Valenzuela-Muñoz, Cristian Gallardo-Escárate, Lluis Tort, Antonio Figueras, Beatriz Novoa
Nodavirus, or nervous necrosis virus (NNV), is the causative agent of viral encephalopathy and retinopathy (VER), a severe disease affecting numerous fish species worldwide. European sea bass, a cultured species of great economic importance, is highly susceptible to the disease. To better understand the response of this organism to NNV, we conducted RNA-Seq analysis of the brain and head kidney fr...... hiện toàn bộ
Review on PRNP genetics and susceptibility to chronic wasting disease of Cervidae
Springer Science and Business Media LLC - Tập 52 - Trang 1-15 - 2021
Katayoun Moazami-Goudarzi, Olivier Andréoletti, Jean-Luc Vilotte, Vincent Béringue
To date, chronic wasting disease (CWD) is the most infectious form of prion disease affecting several captive, free ranging and wild cervid species. Responsible for marked population declines in North America, its geographical spread is now becoming a major concern in Europe. Polymorphisms in the prion protein gene (PRNP) are an important factor influencing the susceptibility to prions and their r...... hiện toàn bộ
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