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Clinician and patient views on janus kinase inhibitors in the treatment of inflammatory arthritis: a mixed methods study
Springer Science and Business Media LLC - Tập 8 - Trang 1-15 - 2024
Savia de Souza, Ruth Williams, Elena Nikiphorou
Janus kinase inhibitors (JAKi) are new targeted synthetic disease-modifying antirheumatic drugs (DMARDs) licenced in the UK to treat rheumatoid and psoriatic arthritides. Unlike currently often prescribed biological DMARDs, they target a different part of the inflammatory pathway and are taken orally. The aim of this study was to explore what UK-based rheumatology clinicians and inflammatory arthr... hiện toàn bộ
Evaluation of mindfulness based stress reduction in symptomatic knee or hip osteoarthritis patients: a pilot randomized controlled trial
Springer Science and Business Media LLC - Tập 6 - Trang 1-9 - 2022
Clémentine Marais, Yujie Song, Rosanna Ferreira, Safa Aounti, Claire Duflos, Grégory Baptista, Yves-Marie Pers
To evaluate the efficacy for symptomatic knee and hip osteoarthritis (OA) patients of a mindfulness-based stress reduction (MBSR) program versus usual care. Randomized, physician-blind, clinical trial in a monocentric prospective pilot study. Adult participants with symptomatic knee or hip OA were randomized into either intervention or control groups. The intervention group completed the MBSR prog... hiện toàn bộ
In vitro and in vivo characterization of the JAK1 selectivity of upadacitinib (ABT-494)
Springer Science and Business Media LLC - Tập 2 - Trang 1-11 - 2018
Julie M. Parmentier, Jeff Voss, Candace Graff, Annette Schwartz, Maria Argiriadi, Michael Friedman, Heidi S. Camp, Robert J. Padley, Jonathan S. George, Deborah Hyland, Matthew Rosebraugh, Neil Wishart, Lisa Olson, Andrew J. Long
Anti-cytokine therapies such as adalimumab, tocilizumab, and the small molecule JAK inhibitor tofacitinib have proven that cytokines and their subsequent downstream signaling processes are important in the pathogenesis of rheumatoid arthritis. Tofacitinib, a pan-JAK inhibitor, is the first approved JAK inhibitor for the treatment of RA and has been shown to be effective in managing disease. Howeve... hiện toàn bộ
Perceptions of first-degree relatives of patients with rheumatoid arthritis about lifestyle modifications and pharmacological interventions to reduce the risk of rheumatoid arthritis development: a qualitative interview study
Springer Science and Business Media LLC - Tập 2 - Trang 1-11 - 2018
Gwenda Simons, Rebecca J Stack, Michaela Stoffer-Marx, Matthias Englbrecht, Erika Mosor, Christopher D Buckley, Kanta Kumar, Mats Hansson, Axel Hueber, Tanja Stamm, Marie Falahee, Karim Raza
There is increasing interest in the identification of people at risk of rheumatoid arthritis (RA) to monitor the emergence of early symptoms (and thus allow early therapy), offer lifestyle advice to reduce the impact of environmental risk factors and potentially offer preventive pharmacological treatment for those at high risk. Close biological relatives of people with RA are at an increased risk ... hiện toàn bộ
Antibody response to 13-valent pneumococcal conjugate vaccine is not impaired in patients with rheumatoid arthritis or primary Sjögren’s syndrome without disease modifying treatment
Springer Science and Business Media LLC - Tập 2 - Trang 1-7 - 2018
Per Nived, Tore Saxne, Pierre Geborek, Thomas Mandl, Lillemor Skattum, Meliha C. Kapetanovic
Pneumococcal vaccination is recommended to patients with rheumatoid arthritis (RA) and primary Sjögren’s syndrome (pSS). However, little is known whether the diseases influence pneumococcal vaccine response. This study aimed to investigate antibody response and functionality of antibodies following immunization with 13-valent pneumococcal conjugate vaccine (PCV13) in RA patients or pSS patients wi... hiện toàn bộ
Cardiovascular disease risk in early rheumatoid arthritis: the impact of cartilage oligomeric matrix protein (COMP) and disease activity
Springer Science and Business Media LLC - Tập 7 - Trang 1-9 - 2023
Emil Rydell, Lennart TH Jacobsson, Tore Saxne, Carl Turesson
To investigate whether baseline serum cartilage oligomeric matrix protein (COMP), patient characteristics, traditional cardiovascular disease (CVD) risk factors and disease activity over time predict CVD, in early rheumatoid arthritis (RA). This study included patients with early RA (< 12 months disease duration) (n = 233) recruited 1995–2005. Potential predictors of CVD and coronary artery diseas... hiện toàn bộ
Serum protein biomarkers for juvenile dermatomyositis: a pilot study
Springer Science and Business Media LLC - Tập 4 - Trang 1-15 - 2020
Shefa M. Tawalbeh, Wilfredo Marin, Gabrielle A. Morgan, Utkarsh J. Dang, Yetrib Hathout, Lauren M. Pachman
Blood accessible biomarkers to assess disease activity and their response to therapies in Juvenile Dermatomyositis (JDM) are urgently needed. This pilot study aims to identify serum protein biomarkers associated with clinical disease activity in untreated JDM and their response to medical therapy. SomaScan® technology screened JDM patients for 1305 proteins at three points: 1) before start of trea... hiện toàn bộ
Raynaud’s phenomenon and positive antinuclear antibodies as first manifestation of POEMS syndrome (polyneuropathy, organomegaly, endocrinopathy, monoclonal gammopathy, and skin changes): a case report
Springer Science and Business Media LLC - Tập 6 - Trang 1-5 - 2022
Fabio Torres-Saavedra, Lina León-Sierra
POEMS syndrome is a rare paraneoplastic syndrome caused by plasma cell disorder almost always lambda restricted. Secondary Raynaud’s phenomenon is an overlooked skin manifestation of the disease even though it is present in twenty percent of patients. On POEMS syndrome have not been described positive antinuclear antibodies (ANA) and this could lead to a misdiagnosis of autoimmune disease, mainly ... hiện toàn bộ
Interpretation of DAS28 and its components in the assessment of inflammatory and non-inflammatory aspects of rheumatoid arthritis
Springer Science and Business Media LLC - Tập 2 - Trang 1-12 - 2018
Daniel F. McWilliams, Patrick D. W. Kiely, Adam Young, Nalinie Joharatnam, Deborah Wilson, David A. Walsh
DAS28 is interpreted as the inflammatory disease activity of RA. Non-inflammatory pain mechanisms can confound assessment. We aimed to examine the use of DAS28 components or DAS28-derived measures that have been published as indices of non-inflammatory pain mechanisms, to inform interpretation of disease activity. Data were used from multiple observational epidemiology studies of people with RA. S... hiện toàn bộ
The development of rapidly progressive glomerulonephritis associated with both antineutrophil cytoplasmic antibody-associated vasculitis and anti-glomerular basement membrane nephritis in the course of nontuberculous mycobacterium infection: a case report
Springer Science and Business Media LLC - Tập 4 - Trang 1-6 - 2020
Mikiya Kato, Risa Wakiya, Tomohiro Kameda, Kousuke Inoue, Tadashi Sofue, Yusuke Ushio, Koichi Sugihara, Shusaku Nakashima, Hiromi Shimada, Mai Mahmoud Fahmy Mansour, Norimitsu Kadowaki, Hiroaki Dobashi
Antineutrophil cytoplasmic antibodies (ANCA) and Anti-glomerular basement membrane (GBM) antibodies often induce rapidly progressive glomerulonephritis (RPGN). Some reports have demonstrated RPGN with the sequential appearance of ANCA then anti-GBM antibodies, suggesting that ANCA may induce the development of anti-GBM antibodies. Whereas, many reports have shown that the development of ANCA is as... hiện toàn bộ
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