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Porous Membranes Promote Endothelial Differentiation of Adipose-Derived Stem Cells and Perivascular Interactions
Springer Science and Business Media LLC - - 2014
Andrea R. Mazzocchi, Alan J. Man, Jon-Paul S. DesOrmeaux, Thomas R. Gaborski
Efforts to create physiologically relevant microenvironments for cell differentiation have led to the creation of three-dimensional (3D) support matrices with varying physical and chemical properties. In an effort to simplify the complexity of these matrices, while maintaining their unique permeable nature, we investigated the culture and differentiation of adipose-derived stem cells (ADSCs) on po...... hiện toàn bộ
Perspectives on Non-Animal Alternatives for Assessing Sensitization Potential in Allergic Contact Dermatitis
Springer Science and Business Media LLC - Tập 5 - Trang 52-72 - 2011
Nripen S. Sharma, Rohit Jindal, Bhaskar Mitra, Serom Lee, Lulu Li, Tim J. Maguire, Rene Schloss, Martin L. Yarmush
Skin sensitization remains a major environmental and occupational health hazard. Animal models have been used as the gold standard method of choice for estimating chemical sensitization potential. However, a growing international drive and consensus for minimizing animal usage have prompted the development of in vitro methods to assess chemical sensitivity. In this paper, we examine existing appro...... hiện toàn bộ
Conformational Transition of Glycoprotein Ibα Mutants in Flow Molecular Dynamics Simulation
Springer Science and Business Media LLC - Tập 4 - Trang 495-504 - 2011
Qingsheng Huang, Jizhong Lou, Jianhua Wu, Cheng Zhu
Glycoprotein Ibα (GPIbα) interacts with von Willebrand factor (VWF) inducing the tethering of platelets to injured vessel walls and subsequent hemostasis process. We have previously shown that the conformation of the β-switch region of GPIbαN can be regulated by flow. Flow induces a loop-to-β-hairpin conformational change in this region, which is a suggested mechanism for the flow-enhanced binding...... hiện toàn bộ
Measuring Receptor–Ligand Binding Kinetics on Cell Surfaces: From Adhesion Frequency to Thermal Fluctuation Methods
Springer Science and Business Media LLC - Tập 1 - Trang 276-288 - 2008
Wei Chen, Veronika I. Zarnitsyna, Krishna K. Sarangapani, Jun Huang, Cheng Zhu
Interactions between surface-anchored receptors and ligands mediate cell–cell and cell–environment communications in many biological processes. Molecular interactions across two apposing cell membrane are governed by two-dimensional (2D) kinetics, which are physically distinct from and biologically more relevant than three-dimensional (3D) kinetics with at least one interacting molecular species i...... hiện toàn bộ
Kernel Based Non-Iterative Automatic Fast Capacitance Compensation in Patch-Clamp Experiments
Springer Science and Business Media LLC - - 2012
Jun Luo, Panpan Hou, Jiuping Ding, Ang Qu
Dose–Response Relationship and Threshold Drug Dosage Identification for a Novel Hybrid Mechanical-Thrombolytic System with an Ultra-Low Dose Patch
Springer Science and Business Media LLC - - 2021
Zhen Qin, Chi Hang Chon, John Ching Kwong Kwok, Peter Yat Ming Woo, David Chuen Chun Lam
Elucidating Mechanotransduction Processes During Magnetomechanical Neuromodulation Mediated by Magnetic Nanodiscs
Springer Science and Business Media LLC - Tập 16 - Trang 283-298 - 2023
Amanda Gomez, Nicolas Muzzio, Ania Dudek, Athena Santi, Carolina Redondo, Raquel Zurbano, Rafael Morales, Gabriela Romero
Noninvasive cell-type-specific manipulation of neural signaling is critical in basic neuroscience research and in developing therapies for neurological disorders. Magnetic nanotechnologies have emerged as non-invasive neuromodulation approaches with high spatiotemporal control. We recently developed a wireless force-induced neurostimulation platform utilizing micro-sized magnetic discs (MDs) and l...... hiện toàn bộ
Mechanical Stability Determines Stress Fiber and Focal Adhesion Orientation
Springer Science and Business Media LLC - Tập 2 - Trang 475-485 - 2009
Dimitrije Stamenović, Konstantinos A. Lazopoulos, Athanassios Pirentis, Béla Suki
It is well documented in a variety of adherent cell types that in response to anisotropic signals from the microenvironment cells alter their cytoskeletal organization. Previous theoretical studies of these phenomena were focused primarily on the elasticity of cytoskeletal actin stress fibers (SFs) and of the substrate while the contribution of focal adhesions (FAs) through which the cytoskeleton ...... hiện toàn bộ
Generating Chondromimetic Mesenchymal Stem Cell Spheroids by Regulating Media Composition and Surface Coating
Springer Science and Business Media LLC - Tập 11 - Trang 99-115 - 2017
BanuPriya Sridharan, Amy D. Laflin, Michael S. Detamore
Spheroids of mesenchymal stem cells (MSCs) in cartilage tissue engineering have been shown to enhance regenerative potential owing to their 3D structure. In this study, we explored the possibility of priming spheroids under different media to replace the use of inductive surface coatings for chondrogenic differentiation. Rat bone marrow-derived MSCs were organized into cell spheroids by the hangin...... hiện toàn bộ
Microfibrous Scaffolds Enhance Endothelial Differentiation and Organization of Induced Pluripotent Stem Cells
Springer Science and Business Media LLC - Tập 10 - Trang 417-432 - 2017
Joseph J. Kim, Luqia Hou, Guang Yang, Nicholas P. Mezak, Maureen Wanjare, Lydia M. Joubert, Ngan F. Huang
Human induced pluripotent stem cells (iPSCs) are a promising source of endothelial cells (iPSC-ECs) for engineering three-dimensional (3D) vascularized cardiac tissues. To mimic cardiac microvasculature, in which capillaries are oriented in parallel, we hypothesized that endothelial differentiation of iPSCs within topographically aligned 3D scaffolds would be a facile one-step approach to generate...... hiện toàn bộ
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