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Nanopatterned Human iPSC-Based Model of a Dystrophin-Null Cardiomyopathic Phenotype
Springer Science and Business Media LLC - Tập 8 Số 3 - Trang 320-332 - 2015
Human induced pluripotent stem cell derived cardiomyocytes (hiPSC-CMs) offer
unprecedented opportunities to study inherited heart conditions in vitro, but
are phenotypically immature, limiting their ability to effectively model
adult-onset diseases. Cardiomyopathy is becoming the leading cause of death in
patients with Duchenne muscular dystrophy (DMD), but the pathogenesis of this
disease phenoty...
Fusing Tissue Engineering and Systems Biology Toward Fulfilling Their Promise
Springer Science and Business Media LLC - Tập 1 - Trang 33-41 - 2008
Tissue engineering has progressed to enable development of engineered 3D in
vitro tissue models that can recapitulate in vivo cellular physiologies through
the control of an expansive variety of microenvironmental design features,
including mechanical, extracellular matrix, and soluble stimulatory cues.
Microenviromental cues stimulate cells through a system of interconnected
molecular regulatory ...
Porous Membranes Promote Endothelial Differentiation of Adipose-Derived Stem Cells and Perivascular Interactions
Springer Science and Business Media LLC - - 2014
Efforts to create physiologically relevant microenvironments for cell
differentiation have led to the creation of three-dimensional (3D) support
matrices with varying physical and chemical properties. In an effort to simplify
the complexity of these matrices, while maintaining their unique permeable
nature, we investigated the culture and differentiation of adipose-derived stem
cells (ADSCs) on po...
Alterations in Pulse Pressure Affect Artery Function
Springer Science and Business Media LLC - - 2012
Pulse pressure changes in response to cardiovascular diseases and interventions,
but its effect on vascular wall structure and function is poorly understood. We
examined the effect of increased or decreased pulse pressure on artery function,
cellular function, and extracellular matrix remodeling. Porcine carotid arteries
were cultured under non-pulsatile (100 mmHg), pulsatile (70–130 mmHg), or
hyp...
Measurement Science in the Circulatory System
Springer Science and Business Media LLC - Tập 7 - Trang 1-14 - 2013
The dynamics of the cellular and molecular constituents of the circulatory
system are regulated by the biophysical properties of the heart, vasculature and
blood cells and proteins. In this review, we discuss measurement techniques that
have been developed to characterize the physical and mechanical parameters of
the circulatory system across length scales ranging from the tissue scale (cm)
to the...
Fibronectin Mechanobiology Regulates Tumorigenesis
Springer Science and Business Media LLC - Tập 9 - Trang 1-11 - 2015
Fibronectin (Fn) is an essential extracellular matrix (ECM) glycoprotein
involved in both physiological and pathological processes. The
structure–function relationship of Fn has been and is still being studied, as
changes in its molecular structure are integral in regulating (or dysregulating)
its biological activities via its cell, matrix component, and growth factor
binding sites. Fn comprises t...
Dynamic Systems Model for Lymphocyte Interactions with Macrophages at Biomaterial Surfaces
Springer Science and Business Media LLC - - 2009
Modeling of Cell Aggregation Dynamics Governed by Receptor–Ligand Binding Under Shear Flow
Springer Science and Business Media LLC - Tập 4 - Trang 427-441 - 2011
Shear-induced cell aggregation and disaggregation, governed by specific
receptor–ligand binding, play important roles in many biological and biophysical
processes. While a lot of studies have focused on elucidating the shear rate and
shear stress dependence of cell aggregation, the majority of existing models
based on population balance equation (PBE) has rarely dealt with cell
aggregation dynamic...
Role of Intercellular Junctions in Redistribution of Focal Adhesions and Orientation of Vascular Endothelial Cells Exposed to Cyclic Stretching
Springer Science and Business Media LLC - Tập 4 - Trang 368-378 - 2011
The redistribution of focal adhesions (FAs) containing integrin β1 and paxillin
plays an important role in the cyclic stretching-induced morphological changes
of endothelial cells (ECs). In addition to focal adhesion kinase (FAK), known to
be a primary regulator for FA redistribution, intercellular junctions (IJs) have
recently been reported to be involved in signaling upstream of FAs. Here, we
ad...
Nuclear Stiffening Inhibits Migration of Invasive Melanoma Cells
Springer Science and Business Media LLC - Tập 7 Số 4 - Trang 544-551 - 2014
During metastasis, melanoma cells must be sufficiently deformable to squeeze
through extracellular barriers with small pore sizes. We visualize and quantify
deformability of single cells using micropipette aspiration and examine the
migration potential of a population of melanoma cells using a flow migration
apparatus. We artificially stiffen the nucleus with recombinant overexpression
of Δ50 lami...
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