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Nanopatterned Human iPSC-Based Model of a Dystrophin-Null Cardiomyopathic Phenotype
Springer Science and Business Media LLC - Tập 8 Số 3 - Trang 320-332 - 2015
Macadangdang, Jesse, Guan, Xuan, Smith, Alec S. T., Lucero, Rachel, Czerniecki, Stefan, Childers, Martin K., Mack, David L., Kim, Deok-Ho
Human induced pluripotent stem cell derived cardiomyocytes (hiPSC-CMs) offer unprecedented opportunities to study inherited heart conditions in vitro, but are phenotypically immature, limiting their ability to effectively model adult-onset diseases. Cardiomyopathy is becoming the leading cause of death in patients with Duchenne muscular dystrophy (DMD), but the pathogenesis of this disease phenoty...... hiện toàn bộ
Fusing Tissue Engineering and Systems Biology Toward Fulfilling Their Promise
Springer Science and Business Media LLC - Tập 1 - Trang 33-41 - 2008
Benjamin D. Cosgrove, Linda G. Griffith, Douglas A. Lauffenburger
Tissue engineering has progressed to enable development of engineered 3D in vitro tissue models that can recapitulate in vivo cellular physiologies through the control of an expansive variety of microenvironmental design features, including mechanical, extracellular matrix, and soluble stimulatory cues. Microenviromental cues stimulate cells through a system of interconnected molecular regulatory ...... hiện toàn bộ
Porous Membranes Promote Endothelial Differentiation of Adipose-Derived Stem Cells and Perivascular Interactions
Springer Science and Business Media LLC - - 2014
Andrea R. Mazzocchi, Alan J. Man, Jon-Paul S. DesOrmeaux, Thomas R. Gaborski
Efforts to create physiologically relevant microenvironments for cell differentiation have led to the creation of three-dimensional (3D) support matrices with varying physical and chemical properties. In an effort to simplify the complexity of these matrices, while maintaining their unique permeable nature, we investigated the culture and differentiation of adipose-derived stem cells (ADSCs) on po...... hiện toàn bộ
Alterations in Pulse Pressure Affect Artery Function
Springer Science and Business Media LLC - - 2012
Danika M. Hayman, Yangming Xiao, Qingping Yao, Zonglai Jiang, Merry L. Lindsey, Hai-Chao Han
Pulse pressure changes in response to cardiovascular diseases and interventions, but its effect on vascular wall structure and function is poorly understood. We examined the effect of increased or decreased pulse pressure on artery function, cellular function, and extracellular matrix remodeling. Porcine carotid arteries were cultured under non-pulsatile (100 mmHg), pulsatile (70–130 mmHg), or hyp...... hiện toàn bộ
Measurement Science in the Circulatory System
Springer Science and Business Media LLC - Tập 7 - Trang 1-14 - 2013
Casey M. Jones, Sandra M. Baker-Groberg, Flor A. Cianchetti, Jeremy J. Glynn, Laura D. Healy, Wai Yan Lam, Jonathan W. Nelson, Diana C. Parrish, Kevin G. Phillips, Devon E. Scott-Drechsel, Ian J. Tagge, Jaime E. Zelaya, Monica T. Hinds, Owen J. T. McCarty
The dynamics of the cellular and molecular constituents of the circulatory system are regulated by the biophysical properties of the heart, vasculature and blood cells and proteins. In this review, we discuss measurement techniques that have been developed to characterize the physical and mechanical parameters of the circulatory system across length scales ranging from the tissue scale (cm) to the...... hiện toàn bộ
Fibronectin Mechanobiology Regulates Tumorigenesis
Springer Science and Business Media LLC - Tập 9 - Trang 1-11 - 2015
Karin Wang, Bo Ri Seo, Claudia Fischbach, Delphine Gourdon
Fibronectin (Fn) is an essential extracellular matrix (ECM) glycoprotein involved in both physiological and pathological processes. The structure–function relationship of Fn has been and is still being studied, as changes in its molecular structure are integral in regulating (or dysregulating) its biological activities via its cell, matrix component, and growth factor binding sites. Fn comprises t...... hiện toàn bộ
Dynamic Systems Model for Lymphocyte Interactions with Macrophages at Biomaterial Surfaces
Springer Science and Business Media LLC - - 2009
David T. Chang, Gerald M. Saidel, James M. Anderson
Modeling of Cell Aggregation Dynamics Governed by Receptor–Ligand Binding Under Shear Flow
Springer Science and Business Media LLC - Tập 4 - Trang 427-441 - 2011
Changliang Fu, Chunfang Tong, Cheng Dong, Mian Long
Shear-induced cell aggregation and disaggregation, governed by specific receptor–ligand binding, play important roles in many biological and biophysical processes. While a lot of studies have focused on elucidating the shear rate and shear stress dependence of cell aggregation, the majority of existing models based on population balance equation (PBE) has rarely dealt with cell aggregation dynamic...... hiện toàn bộ
Role of Intercellular Junctions in Redistribution of Focal Adhesions and Orientation of Vascular Endothelial Cells Exposed to Cyclic Stretching
Springer Science and Business Media LLC - Tập 4 - Trang 368-378 - 2011
Wenjing Huang, Naoya Sakamoto, Kazuhiko Hanamura, Ryotaro Miyazawa, Masaaki Sato
The redistribution of focal adhesions (FAs) containing integrin β1 and paxillin plays an important role in the cyclic stretching-induced morphological changes of endothelial cells (ECs). In addition to focal adhesion kinase (FAK), known to be a primary regulator for FA redistribution, intercellular junctions (IJs) have recently been reported to be involved in signaling upstream of FAs. Here, we ad...... hiện toàn bộ
Nuclear Stiffening Inhibits Migration of Invasive Melanoma Cells
Springer Science and Business Media LLC - Tập 7 Số 4 - Trang 544-551 - 2014
Ribeiro, Alexandre J. S., Khanna, Payal, Sukumar, Aishwarya, Dong, Cheng, Dahl, Kris Noel
During metastasis, melanoma cells must be sufficiently deformable to squeeze through extracellular barriers with small pore sizes. We visualize and quantify deformability of single cells using micropipette aspiration and examine the migration potential of a population of melanoma cells using a flow migration apparatus. We artificially stiffen the nucleus with recombinant overexpression of Δ50 lami...... hiện toàn bộ
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