Springer Science and Business Media LLC

Công bố khoa học tiêu biểu

* Dữ liệu chỉ mang tính chất tham khảo

Sắp xếp:  
Structure-Guided Molecular Engineering of a Vascular Endothelial Growth Factor Antagonist to Treat Retinal Diseases
Springer Science and Business Media LLC - Tập 13 Số 5 - Trang 405-418 - 2020
Rakeeb Kureshi, Angela Y. Zhu, Jikui Shen, Stephany Y. Tzeng, Leilani R. Astrab, Paul R. Sargunas, Jordan J. Green, Peter A. Campochiaro, Jamie B. Spangler
In vivo Multimotor Force–Velocity Curves by Tracking and Sizing Sub-Diffraction Limited Vesicles
Springer Science and Business Media LLC - Tập 2 - Trang 190-199 - 2009
Yuri Shtridelman, George M. Holzwarth, Clayton T. Bauer, Natalie R. Gassman, David A. DeWitt, Jed C. Macosko
Determining in vivo force–velocity relationships of motor proteins is a critical step toward clarifying how they accomplish intracellular transport. We show that in vivo force–velocity curves corresponding to an estimated 1, 2, and 3 motors-per-vesicle can be constructed by tracking and sizing transported vesicles. The force range for these curves would normally be constrained by diffraction limit...... hiện toàn bộ
Integrins Direct Cell Adhesion in a Substrate-Dependent Manner
Springer Science and Business Media LLC - Tập 8 - Trang 488-495 - 2015
Andreas P. Kourouklis, Harry Bermudez
The relationship between substrate properties and cell behavior is complex, including roles for both mechanics and biochemistry. Here we investigate the role of viscous dissipation on cell adhesion behaviors, using polymer films of tunable lateral mobility. We find that fibroblasts selectively use $$\alpha _v \beta _3$$ ...... hiện toàn bộ
Cyclic Hydraulic Pressure and Fluid Flow Differentially Modulate Cytoskeleton Re-Organization in MC3T3 Osteoblasts
Springer Science and Business Media LLC - Tập 2 - Trang 133-143 - 2008
Joseph D. Gardinier, Shyama Majumdar, Randall L. Duncan, Liyun Wang
Mechanical loads are essential toward maintaining bone mass and skeletal integrity. Such loads generate various stimuli at the cellular level, including cyclic hydraulic pressure (CHP) and fluid shear stress (FSS). To gain insight into the anabolic responses of osteoblasts to CHP and FSS, we subjected MC3T3-E1 preosteoblasts to either FSS (12 dynes/cm2) or CHP varying from 0 to 68 kPa at 0.5 Hz. A...... hiện toàn bộ
Towards a Biohybrid Lung Assist Device: N-Acetylcysteine Reduces Oxygen Toxicity and Changes Endothelial Cells’ Morphology
Springer Science and Business Media LLC - Tập 10 - Trang 153-161 - 2016
Tobias Plein, Anja Lena Thiebes, Nicole Finocchiaro, Felix Hesselmann, Thomas Schmitz-Rode, Stefan Jockenhoevel, Christian G. Cornelissen
The development of an endothelialized membrane oxygenator requires solution strategies combining the knowledge of oxygenators with endothelial cells’ biology. Since it is well known that exposing cells towards pure oxygen causes oxidative stress, this aspect has to be taken into account in the development of a biohybrid oxygenator system. N-Acetylcysteine (NAC) is known for its antioxidant propert...... hiện toàn bộ
Improved Estimation of Solute Diffusivity Through Numerical Analysis of FRAP Experiments
Springer Science and Business Media LLC - Tập 2 - Trang 104-117 - 2009
Onyinyechi N. Irrechukwu, Marc E. Levenston
Accurate determination of solute diffusivities from fluorescence recovery after photobleaching (FRAP) experiments is often hindered by limitations of existing analytical models. This study describes the development and validation of a finite-element-based direct diffusion simulation parameter estimation (DDSPE) method for determining solute diffusivities from FRAP data. The DDSPE method improves o...... hiện toàn bộ
Modeling DNA Unwinding by AddAB Helicase–Nuclease and Modulation by Chi Sequences: Comparison with AdnAB and RecBCD
Springer Science and Business Media LLC - Tập 12 - Trang 179-191 - 2018
Ping Xie
AddAB enzyme is a helicase–nuclease complex that initiates recombinational repair of double-stranded DNA breaks. It catalyzes processive DNA unwinding and concomitant resection of the unwound strands, which are modulated by the recognition of a recombination hotspot called Chi in the 3′-terminated strand. Despite extensive structural, biochemical and single molecule studies, the detailed molecular...... hiện toàn bộ
The 2022 Young Innovators of Cellular and Molecular Bioengineering
Springer Science and Business Media LLC - Tập 15 - Trang 353-354 - 2022
Michael R. King, Cheng Dong, Beth L. Pruitt
Structure-Based Design of Novel Peptidomimetics Targeting the SARS-CoV-2 Spike Protein
Springer Science and Business Media LLC - Tập 14 - Trang 177-185 - 2020
Manikandan Alagumuthu, Sajjan Rajpoot, Mirza S. Baig
SARS-CoV-2 is a SARS-like novel coronavirus strain first identified in December 2019 in Wuhan, China. The virus has since spread globally, resulting in the current ongoing coronavirus disease 19 (COVID-19) pandemic. SARS-CoV-2 spike protein is a critical factor in the COVID-19 pathogenesis via interactions with the host cell angiotensin-converting enzyme 2 (ACE2) PD domain. Worldwide, numerous eff...... hiện toàn bộ
Mechanisms of Reduced Astrocyte Surface Coverage in Cortical Neuron-Glia Co-cultures on Nanoporous Gold Surfaces
Springer Science and Business Media LLC - Tập 9 - Trang 433-442 - 2016
Christopher A. R. Chapman, Hao Chen, Marianna Stamou, Pamela J. Lein, Erkin Seker
Nanoporous gold (np-Au) is a promising multifunctional material for neural electrodes. We have previously shown that np-Au nanotopography reduces astrocyte surface coverage (linked to undesirable gliosis) while maintaining high neuronal coverage in a cortical primary neuron-glia co-culture model as long as 2 weeks in vitro. Here, we investigate the potential influence of secreted soluble factors f...... hiện toàn bộ
Tổng số: 522   
  • 1
  • 2
  • 3
  • 4
  • 5
  • 6
  • 10