Nuclear Stiffening Inhibits Migration of Invasive Melanoma Cells

citation_journal_title=J. Biomed. Opt.; citation_title=Investigation of nuclear nano-morphology marker as a biomarker for cancer risk assessment using a mouse model; citation_author=RK Bista, S Uttam, DJ Hartman, W Qiu, J Yu; citation_volume=17; citation_publication_date=2012; citation_pages=066014; citation_doi=10.1117/1.JBO.17.6.066014; citation_id=CR1 citation_journal_title=Integr. Biol. (Camb); citation_title=Hutchinson-Gilford progeria syndrome alters nuclear shape and reduces cell motility in three dimensional model substrates; citation_author=EA Booth-Gauthier, V Du, M Ghibaudo, AD Rape, KN Dahl, B Ladoux; citation_volume=5; citation_publication_date=2013; citation_pages=569-577; citation_doi=10.1039/c3ib20231c; citation_id=CR2 citation_journal_title=Trends Genet.; citation_title=Nuclear lamin functions and disease; citation_author=V Butin-Israeli, SA Adam, AE Goldman, RD Goldman; citation_volume=28; citation_publication_date=2012; citation_pages=464-471; citation_doi=10.1016/j.tig.2012.06.001; citation_id=CR3 citation_journal_title=Oncol. Res.; citation_title=Expression of c-Met proto-oncogene in metastatic macrophage x melanoma fusion hybrids: implication of its possible role in MSH-induced motility; citation_author=AK Chakraborty, N Kolesnikova, JDF Sousa, EM Espreafico, KC Peronni, J Pawelek; citation_volume=14; citation_publication_date=2003; citation_pages=163-174; citation_id=CR4 citation_journal_title=Mod. Pathol.; citation_title=Prognosticators of melanoma, the melanoma report, and the sentinel lymph node; citation_author=AN Crowson, CM Magro, MC Mihm; citation_volume=19; citation_issue=Suppl 2; citation_publication_date=2006; citation_pages=S71-S87; citation_doi=10.1038/modpathol.3800517; citation_id=CR5 citation_journal_title=Proc. Natl. Acad. Sci. USA; citation_title=Distinct structural and mechanical properties of the nuclear lamina in Hutchinson–Gilford progeria syndrome; citation_author=KN Dahl, P Scaffidi, MF Islam, AG Yodh, KL Wilson, T Misteli; citation_volume=103; citation_publication_date=2006; citation_pages=10271-10276; citation_doi=10.1073/pnas.0601058103; citation_id=CR6 citation_journal_title=Adv. Exp. Med. Biol.; citation_title=Nuclear mechanics in cancer; citation_author=C Denais, J Lammerding; citation_volume=773; citation_publication_date=2014; citation_pages=435-470; citation_doi=10.1007/978-1-4899-8032-8_20; citation_id=CR7 citation_journal_title=J. Biomech. Eng.; citation_title=Passive deformation analysis of human leukocytes; citation_author=C Dong, R Skalak, KL Sung, GW Schmid-Schonbein, S Chien; citation_volume=110; citation_publication_date=1988; citation_pages=27-36; citation_doi=10.1115/1.3108402; citation_id=CR8 citation_journal_title=Front Biosci.; citation_title=Micromechanics of tumor cell adhesion and migration under dynamic flow conditions; citation_author=C Dong, M Slattery, S Liang; citation_volume=10; citation_publication_date=2005; citation_pages=379-384; citation_doi=10.2741/1535; citation_id=CR9 citation_journal_title=J. Clin. Invest.; citation_title=Prelamin A and lamin A appear to be dispensable in the nuclear lamina; citation_author=LG Fong, JK Ng, J Lammerding, TA Vickers, M Meta; citation_volume=116; citation_publication_date=2006; citation_pages=743-752; citation_doi=10.1172/JCI27125; citation_id=CR10 citation_journal_title=Curr. Opin. Cell Biol.; citation_title=Nuclear mechanics during cell migration; citation_author=P Friedl, K Wolf, J Lammerding; citation_volume=23; citation_publication_date=2011; citation_pages=55-64; citation_doi=10.1016/j.ceb.2010.10.015; citation_id=CR11 citation_journal_title=Cell Biochem. Biophys.; citation_title=Intracellular mechanics and activity of breast cancer cells correlate with metastatic potential; citation_author=N Gal, D Weihs; citation_volume=63; citation_publication_date=2012; citation_pages=199-209; citation_doi=10.1007/s12013-012-9356-z; citation_id=CR12 citation_journal_title=Proc. Natl. Acad. Sci. USA; citation_title=Accumulation of mutant lamin A causes progressive changes in nuclear architecture in Hutchinson-Gilford progeria syndrome; citation_author=RD Goldman, DK Shumaker, MR Erdos, M Eriksson, AE Goldman; citation_volume=101; citation_publication_date=2004; citation_pages=8963-8968; citation_doi=10.1073/pnas.0402943101; citation_id=CR13 citation_journal_title=Int. J. Radiat. Oncol. Biol. Phys.; citation_title=Older age predicts decreased metastasis and prostate cancer-specific death for men treated with radiation therapy: meta-analysis of radiation therapy oncology group trials; citation_author=DA Hamstra, K Bae, MV Pilepich, GE Hanks, DJ Grignon; citation_volume=81; citation_publication_date=2011; citation_pages=1293-1301; citation_doi=10.1016/j.ijrobp.2010.07.2004; citation_id=CR14 citation_journal_title=J. Cell Biol.; citation_title=Nuclear lamin stiffness is a barrier to 3D migration, but softness can limit survival; citation_author=T Harada, J Swift, J Irianto, JW Shin, KR Spinler; citation_volume=204; citation_publication_date=2014; citation_pages=669-682; citation_doi=10.1083/jcb.201308029; citation_id=CR15 citation_journal_title=Oncogene; citation_title=Melanoma cell migration to type IV collagen requires activation of NF-kappaB; citation_author=L Hodgson, AJ Henderson, C Dong; citation_volume=22; citation_publication_date=2003; citation_pages=98-108; citation_doi=10.1038/sj.onc.1206059; citation_id=CR16 citation_journal_title=Annu. Rev. Biomed. Eng.; citation_title=Cell mechanics: dissecting the physical responses of cells to force; citation_author=BD Hoffman, JC Crocker; citation_volume=11; citation_publication_date=2009; citation_pages=259-288; citation_doi=10.1146/annurev.bioeng.10.061807.160511; citation_id=CR17 citation_journal_title=Biomed. Microdev.; citation_title=Deformability study of breast cancer cells using microfluidics; citation_author=HW Hou, QS Li, GY Lee, AP Kumar, CN Ong, CT Lim; citation_volume=11; citation_publication_date=2009; citation_pages=557-564; citation_doi=10.1007/s10544-008-9262-8; citation_id=CR18 citation_journal_title=Cancer Res.; citation_title=Transiently entrapped circulating tumor cells interact with neutrophils to facilitate lung metastasis development; citation_author=SJ Huh, S Liang, A Sharma, C Dong, GP Robertson; citation_volume=70; citation_publication_date=2010; citation_pages=6071-6082; citation_doi=10.1158/0008-5472.CAN-09-4442; citation_id=CR19 citation_journal_title=J. Cell Sci.; citation_title=Lamins in disease: why do ubiquitously expressed nuclear envelope proteins give rise to tissue-specific disease phenotypes?; citation_author=CJ Hutchison, M Alvarez-Reyes, OA Vaughan; citation_volume=114; citation_publication_date=2001; citation_pages=9-19; citation_id=CR20 citation_journal_title=Biophys. J.; citation_title=Calcium causes a conformational change in lamin A tail domain that promotes farnesyl-mediated membrane association; citation_author=A Kalinowski, Z Qin, K Coffey, R Kodali, MJ Buehler; citation_volume=104; citation_publication_date=2013; citation_pages=2246-2253; citation_doi=10.1016/j.bpj.2013.04.016; citation_id=CR21 citation_journal_title=Exp. Cell Res.; citation_title=Disruption of IGF-1R signaling increases TRAIL-induced apoptosis: a new potential therapy for the treatment of melanoma; citation_author=TB Karasic, TK Hei, VN Ivanov; citation_volume=316; citation_publication_date=2010; citation_pages=1994-2007; citation_doi=10.1016/j.yexcr.2010.04.014; citation_id=CR22 citation_journal_title=Oncogene; citation_title=CD82/KAI expression prevents IL-8-mediated endothelial gap formation in late-stage melanomas; citation_author=P Khanna, CY Chung, RI Neves, GP Robertson, C Dong; citation_volume=33; citation_publication_date=2014; citation_pages=2898-2908; citation_doi=10.1038/onc.2013.249; citation_id=CR23 citation_journal_title=Nucleus; citation_title=Identification of differential protein interactors of lamin A and progerin; citation_author=N Kubben, JW Voncken, J Demmers, C Calis, G Almen; citation_volume=1; citation_publication_date=2010; citation_pages=513-525; citation_doi=10.4161/nucl.1.6.13512; citation_id=CR24 citation_journal_title=Cancer Metastasis Rev.; citation_title=Mechanics, malignancy, and metastasis: the force journey of a tumor cell; citation_author=S Kumar, VM Weaver; citation_volume=28; citation_publication_date=2009; citation_pages=113-127; citation_doi=10.1007/s10555-008-9173-4; citation_id=CR25 citation_journal_title=J. Biomech. Eng.; citation_title=Design of a side-view particle imaging velocimetry flow system for cell-substrate adhesion studies; citation_author=J Leyton-Mange, S Yang, MH Hoskins, RF Kunz, JD Zahn, C Dong; citation_volume=128; citation_publication_date=2006; citation_pages=271-278; citation_doi=10.1115/1.2165689; citation_id=CR26 citation_journal_title=Cancer Res.; citation_title=Targeting mutant (V600E) B-Raf in melanoma interrupts immunoediting of leukocyte functions and melanoma extravasation; citation_author=S Liang, A Sharma, HH Peng, G Robertson, C Dong; citation_volume=67; citation_publication_date=2007; citation_pages=5814-5820; citation_doi=10.1158/0008-5472.CAN-06-4233; citation_id=CR27 citation_journal_title=Ann. Biomed. Eng.; citation_title=Hydrodynamic shear rate regulates melanoma-leukocyte aggregation, melanoma adhesion to the endothelium, and subsequent extravasation; citation_author=S Liang, MJ Slattery, D Wagner, SI Simon, C Dong; citation_volume=36; citation_publication_date=2008; citation_pages=661-671; citation_doi=10.1007/s10439-008-9445-8; citation_id=CR28 citation_journal_title=Sci. Am.; citation_title=Cancer cell invasion and metastasis; citation_author=LA Liotta; citation_volume=266; citation_issue=54–9; citation_publication_date=1992; citation_pages=62-63; citation_id=CR29 citation_journal_title=Biophys. J.; citation_title=Mesenchymal stem cell mechanics from the attached to the suspended state; citation_author=JM Maloney, D Nikova, F Lautenschlager, E Clarke, R Langer; citation_volume=99; citation_publication_date=2010; citation_pages=2479-2487; citation_doi=10.1016/j.bpj.2010.08.052; citation_id=CR30 citation_journal_title=Trends Cell Biol.; citation_title=Epithelial organization, cell polarity and tumorigenesis; citation_author=LM McCaffrey, IG Macara; citation_volume=21; citation_publication_date=2011; citation_pages=727-735; citation_doi=10.1016/j.tcb.2011.06.005; citation_id=CR31 citation_journal_title=Proc. Natl. Acad. Sci. USA; citation_title=Independent regulation of tumor cell migration by matrix stiffness and confinement; citation_author=A Pathak, S Kumar; citation_volume=109; citation_publication_date=2012; citation_pages=10334-10339; citation_doi=10.1073/pnas.1118073109; citation_id=CR32 citation_journal_title=Exp. Cell Res.; citation_title=Regulation of interleukin-8 expression in melanoma-stimulated neutrophil inflammatory response; citation_author=HH Peng, S Liang, AJ Henderson, C Dong; citation_volume=313; citation_publication_date=2007; citation_pages=551-559; citation_doi=10.1016/j.yexcr.2006.10.030; citation_id=CR33 citation_journal_title=J. Biomech.; citation_title=Nuclear mechanotransduction: response of the lamina to extracellular stress with implications in aging; citation_author=JT Philip, KN Dahl; citation_volume=41; citation_publication_date=2008; citation_pages=3164-3170; citation_doi=10.1016/j.jbiomech.2008.08.024; citation_id=CR34 citation_journal_title=Cell Mol. Life Sci.; citation_title=Tumor cell migration in complex microenvironments; citation_author=WJ Polacheck, IK Zervantonakis, RD Kamm; citation_volume=70; citation_publication_date=2013; citation_pages=1335-1356; citation_doi=10.1007/s00018-012-1115-1; citation_id=CR35 citation_journal_title=J. Struct. Biol.; citation_title=Structure and stability of the lamin A tail domain and HGPS mutant; citation_author=Z Qin, A Kalinowski, KN Dahl, MJ Buehler; citation_volume=175; citation_publication_date=2011; citation_pages=425-433; citation_doi=10.1016/j.jsb.2011.05.015; citation_id=CR36 citation_journal_title=Biomaterials; citation_title=On the role of the actin cytoskeleton and nucleus in the biomechanical response of spread cells; citation_author=NH Reynolds, W Ronan, EP Dowling, P Owens, RM McMeeking, JP McGarry; citation_volume=35; citation_publication_date=2014; citation_pages=4015-4025; citation_doi=10.1016/j.biomaterials.2014.01.056; citation_id=CR37 citation_journal_title=Conf. Proc. IEEE Eng. Med. Biol. Soc.; citation_title=The nucleus as a central structure in defining the mechanical properties of stem cells; citation_author=AS Ribeiro, KN Dahl; citation_volume=2010; citation_publication_date=2010; citation_pages=831-834; citation_id=CR38 citation_journal_title=J. Biomech.; citation_title=Mechanical characterization of adult stem cells from bone marrow and perivascular niches; citation_author=AJ Ribeiro, S Tottey, RW Taylor, R Bise, T Kanade; citation_volume=45; citation_publication_date=2012; citation_pages=1280-1287; citation_doi=10.1016/j.jbiomech.2012.01.032; citation_id=CR39 citation_journal_title=PLoS Biol.; citation_title=The cell nucleus and aging: tantalizing clues and hopeful promises; citation_author=P Scaffidi, L Gordon, T Misteli; citation_volume=3; citation_publication_date=2005; citation_pages=e395; citation_doi=10.1371/journal.pbio.0030395; citation_id=CR40 citation_journal_title=Science; citation_title=Lamin A-dependent nuclear defects in human aging; citation_author=P Scaffidi, T Misteli; citation_volume=312; citation_publication_date=2006; citation_pages=1059-1063; citation_doi=10.1126/science.1127168; citation_id=CR41 citation_journal_title=Cancer Res.; citation_title=Targeting mitogen-activated protein kinase/extracellular signal-regulated kinase kinase in the mutant (V600E) B-Raf signaling cascade effectively inhibits melanoma lung metastases; citation_author=A Sharma, MA Tran, S Liang, AK Sharma, S Amin; citation_volume=66; citation_publication_date=2006; citation_pages=8200-8209; citation_doi=10.1158/0008-5472.CAN-06-0809; citation_id=CR42 citation_journal_title=Am. J. Physiol. Cell Physiol.; citation_title=Distinct role of hydrodynamic shear in leukocyte-facilitated tumor cell extravasation; citation_author=MJ Slattery, S Liang, C Dong; citation_volume=288; citation_publication_date=2005; citation_pages=C831-C839; citation_doi=10.1152/ajpcell.00439.2004; citation_id=CR43 citation_journal_title=Nat. Rev. Mol. Cell Biol.; citation_title=DNA damage checkpoints in stem cells, ageing and cancer; citation_author=T Sperka, J Wang, KL Rudolph; citation_volume=13; citation_publication_date=2012; citation_pages=579-590; citation_doi=10.1038/nrm3420; citation_id=CR44 citation_journal_title=Cancer Res.; citation_title=Mechanical stiffness grades metastatic potential in patient tumor cells and in cancer cell lines; citation_author=V Swaminathan, K Mythreye, ET O’Brien, A Berchuck, GC Blobe, R Superfine; citation_volume=71; citation_publication_date=2011; citation_pages=5075-5080; citation_doi=10.1158/0008-5472.CAN-11-0247; citation_id=CR45 citation_journal_title=J. Med. Genet.; citation_title=Akt activation and localisation correlate with tumour invasion and oncogene expression in thyroid cancer; citation_author=V Vasko, M Saji, E Hardy, M Kruhlak, A Larin; citation_volume=41; citation_publication_date=2004; citation_pages=161-170; citation_doi=10.1136/jmg.2003.015339; citation_id=CR46 citation_journal_title=Mol. Biol. Cell; citation_title=Involvement of integrin alpha(v)beta(3) and cell adhesion molecule L1 in transendothelial migration of melanoma cells; citation_author=EB Voura, RA Ramjeesingh, AM Montgomery, CH Siu; citation_volume=12; citation_publication_date=2001; citation_pages=2699-2710; citation_doi=10.1091/mbc.12.9.2699; citation_id=CR47 citation_journal_title=Math. Biosci. Eng.; citation_title=Monte carlo simulation of heterotypic cell aggregation in nonlinear shear flow; citation_author=J Wang, MJ Slattery, MH Hoskins, S Liang, C Dong, Q Du; citation_volume=3; citation_publication_date=2006; citation_pages=683-696; citation_doi=10.3934/mbe.2006.3.683; citation_id=CR48 citation_journal_title=J. Cancer Res. Clin. Oncol.; citation_title=Higher cell stiffness indicating lower metastatic potential in B16 melanoma cell variants and in (−)-epigallocatechin gallate-treated cells; citation_author=T Watanabe, H Kuramochi, A Takahashi, K Imai, N Katsuta; citation_volume=138; citation_publication_date=2012; citation_pages=859-866; citation_doi=10.1007/s00432-012-1159-5; citation_id=CR49 citation_journal_title=Nat. Rev. Cancer; citation_title=The physics of cancer: the role of physical interactions and mechanical forces in metastasis; citation_author=D Wirtz, K Konstantopoulos, PC Searson; citation_volume=11; citation_publication_date=2011; citation_pages=512-522; citation_doi=10.1038/nrc3080; citation_id=CR50 citation_journal_title=Cold Spring Harb. Perspect. Biol.; citation_title=Diseases of the nuclear envelope; citation_author=HJ Worman, C Ostlund, Y Wang; citation_volume=2; citation_publication_date=2010; citation_pages=a000760; citation_doi=10.1101/cshperspect.a000760; citation_id=CR51 citation_journal_title=J. Exp. Clin. Cancer Res.; citation_title=Reduced expression of lamin A/C correlates with poor histological differentiation and prognosis in primary gastric carcinoma; citation_author=Z Wu, L Wu, D Weng, D Xu, J Geng, F Zhao; citation_volume=28; citation_publication_date=2009; citation_pages=8; citation_doi=10.1186/1756-9966-28-8; citation_id=CR52 citation_journal_title=J. Immunol.; citation_title=Sequential binding of alphaVbeta3 and ICAM-1 determines fibrin-mediated melanoma capture and stable adhesion to CD11b/CD18 on neutrophils; citation_author=P Zhang, T Ozdemir, CY Chung, GP Robertson, C Dong; citation_volume=186; citation_publication_date=2011; citation_pages=242-254; citation_doi=10.4049/jimmunol.1000494; citation_id=CR53 citation_journal_title=Nat. Rev. Cancer; citation_title=Nuclear structure in cancer cells; citation_author=D Zink, AH Fischer, JA Nickerson; citation_volume=4; citation_publication_date=2004; citation_pages=677-687; citation_doi=10.1038/nrc1430; citation_id=CR54