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Models of cell signaling uncover molecular mechanisms of high-risk neuroblastoma and predict disease outcome
Springer Science and Business Media LLC - Tập 13 Số 1 - 2018
Những khoảng thời gian stasis dài được ngắt quãng bởi những đợt chọn lọc tích cực trong sự tiến hóa theo mùa của virus cúm A Dịch bởi AI Tóm tắt
Đặt vấn đề
Sự tiến hóa giữa các đợt đại dịch của protein hemagglutinin (HA) virus cúm A thường được coi là một hình mẫu cho sự thay đổi tiến hóa nhanh chóng dưới áp lực chọn lọc tích cực, trong đó các thay thế acid amin được cố định nhờ tác động của chúng lên tính kháng nguyên, giúp virus... ... hiện toàn bộ
Springer Science and Business Media LLC - Tập 1 Số 1 - 2006
An age-dependent branching process model for the analysis of CFSE-labeling experiments
Springer Science and Business Media LLC - Tập 5 - Trang 1-17 - 2010
Over the past decade, flow cytometric CFSE-labeling experiments have gained considerable popularity among experimentalists, especially immunologists and hematologists, for studying the processes of cell proliferation and cell death. Several mathematical models have been presented in the literature to describe cell kinetics during these experiments. We propose a multi-type age-dependent branching p...... hiện toàn bộ
Impairment of translation in neurons as a putative causative factor for autism
Springer Science and Business Media LLC - Tập 9 Số 1 - Trang 1-13 - 2014
A dramatic increase in the prevalence of autism and Autistic Spectrum Disorders (ASD) has been observed over the last two decades in USA, Europe and Asia. Given the accumulating data on the possible role of translation in the etiology of ASD, we analyzed potential effects of rare synonymous substitutions associated with ASD on mRNA stability, splicing enhancers and silencers, and codon usage. We h...... hiện toàn bộ
Pharmacological inhibition of mTORC1 reduces neural death and damage volume after MCAO by modulating microglial reactivity
Springer Science and Business Media LLC - - 2024
Ischemic stroke is a sudden and acute disease characterized by neuronal death, increment of reactive gliosis (reactive microglia and astrocytes), and a severe inflammatory process. Neuroinflammation is an early event after cerebral ischemia, with microglia playing a leading role. Reactive microglia involve functional and morphological changes that drive a wide variety of phenotypes. In this contex...... hiện toàn bộ
Antibiotic resistance and metabolic profiles as functional biomarkers that accurately predict the geographic origin of city metagenomics samples
Springer Science and Business Media LLC - Tập 14 Số 1 - 2019
Preservation of methylated CpG dinucleotides in human CpG islands
Springer Science and Business Media LLC - Tập 11 - Trang 1-15 - 2016
CpG dinucleotides are extensively underrepresented in mammalian genomes. It is widely accepted that genome-wide CpG depletion is predominantly caused by an elevated CpG > TpG mutation rate due to frequent cytosine methylation in the CpG context. Meanwhile the CpG content in genomic regions called CpG islands (CGIs) is noticeably higher. This observation is usually explained by lower CpG > TpG subs...... hiện toàn bộ
Small extracellular vesicles derived from Nrf2-overexpressing human amniotic mesenchymal stem cells protect against lipopolysaccharide-induced acute lung injury by inhibiting NLRP3
Springer Science and Business Media LLC - Tập 17 - Trang 1-13 - 2022
Acute lung injury (ALI) is a major cause of respiratory failure in critically ill patients that results in significant morbidity and mortality. Recent studies indicate that cell-based therapies may be beneficial in the treatment of ALI. We recently demonstrated that Nrf2-overexpressing human amniotic mesenchymal stem cells (hAMSCs) reduce lung injury, fibrosis and inflammation in lipopolysaccharid...... hiện toàn bộ
Long-term administration of Western diet induced metabolic syndrome in mice and causes cardiac microvascular dysfunction, cardiomyocyte mitochondrial damage, and cardiac remodeling involving caveolae and caveolin-1 expression
Springer Science and Business Media LLC - - 2023
Long-term consumption of an excessive fat and sucrose diet (Western diet, WD) has been considered a risk factor for metabolic syndrome (MS) and cardiovascular disease. Caveolae and caveolin-1 (CAV-1) proteins are involved in lipid transport and metabolism. However, studies investigating CAV-1 expression, cardiac remodeling, and dysfunction caused by MS, are limited. This study aimed to investigate...... hiện toàn bộ
Chordopoxvirus protein F12 implicated in enveloped virion morphogenesis is an inactivated DNA polymerase
Springer Science and Business Media LLC - Tập 9 - Trang 1-6 - 2014
Through the course of their evolution, viruses with large genomes have acquired numerous host genes, most of which perform function in virus reproduction in a manner that is related to their original activities in the cells, but some are exapted for new roles. Here we report the unexpected finding that protein F12, which is conserved among the chordopoxviruses and is implicated in the morphogenesi...... hiện toàn bộ
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