Signal Transduction and Targeted Therapy

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LncRNA MIAT impairs cardiac contractile function by acting on mitochondrial translocator protein TSPO in a mouse model of myocardial infarction
Signal Transduction and Targeted Therapy - Tập 6 Số 1
Xue Bai, Chao Yang, Lei Jiao, Hongtao Diao, Ziyu Meng, Lei Wang, Hao Cui, Lihua Sun, Yong Zhang, Baofeng Yang
A retrospective cohort study of methylprednisolone therapy in severe patients with COVID-19 pneumonia
Signal Transduction and Targeted Therapy - Tập 5 Số 1
Wang Yin, Weiwei Jiang, Qi He, Cheng Wang, Baoju Wang, Pan Zhou, Nianguo Dong, Qiaoxia Tong
Demystifying the manipulation of host immunity, metabolism, and extraintestinal tumors by the gut microbiome
Signal Transduction and Targeted Therapy - Tập 4 Số 1
Ziying Zhang, Haosheng Tang, Peng Chen, Hui Xie, Yongguang Tao
AbstractThe trillions of microorganisms in the gut microbiome have attracted much attention recently owing to their sophisticated and widespread impacts on numerous aspects of host pathophysiology. Remarkable progress in large-scale sequencing and mass spectrometry has increased our understanding of the influence of the microbiome and/or its metabolites on the onse...... hiện toàn bộ
Adaptive immune responses to SARS-CoV-2 infection in severe versus mild individuals
Signal Transduction and Targeted Therapy - Tập 5 Số 1
Fan Zhang, Rui Gan, Ziqi Zhen, Xiaoli Hu, Xiang Li, Fengxia Zhou, Ying Liu, Chuangeng Chen, Shuangyu Xie, Bailing Zhang, WU Xiao-ke, Zhiwei Huang
AbstractThe global Coronavirus disease 2019 (COVID-19) pandemic caused by SARS-CoV-2 has affected more than eight million people. There is an urgent need to investigate how the adaptive immunity is established in COVID-19 patients. In this study, we profiled adaptive immune cells of PBMCs from recovered COVID-19 patients with varying disease severity using single-c...... hiện toàn bộ
Ứng dụng công nghệ chỉnh sửa gen trong điều trị nhắm mục tiêu các bệnh lý ở người: cơ chế, tiến bộ và triển vọng Dịch bởi AI
Signal Transduction and Targeted Therapy - Tập 5 Số 1
Hongyi Li, Yang Yang, Weiqi Hong, Mengyuan Huang, Min Wu, Xia Zhao
Tóm tắtDựa trên các nuclase được thiết kế hoặc nuclase vi khuẩn, sự phát triển của công nghệ chỉnh sửa gen đã mở ra khả năng nhắm mục tiêu và sửa đổi trực tiếp các trình tự gen trong hầu hết các tế bào nhân chuẩn. Chỉnh sửa gen đã mở rộng khả năng của chúng ta trong việc giải thích sự đóng góp của di truyền học đối với bệnh tật bằng cách thúc đẩy việc tạo ra các mô...... hiện toàn bộ
Targeting MUC1-C suppresses BCL2A1 in triple-negative breast cancer
Signal Transduction and Targeted Therapy - Tập 3 Số 1
Masayuki Hiraki, Takahiro Maeda, Neha Mehrotra, Caining Jin, Maroof Alam, Audrey Bouillez, Tsuyoshi Hata, Ashujit Tagde, Amy E. Keating, Surender Kharbanda, Harpal Singh, Donald Küfe
AbstractB-cell lymphoma 2-related protein A1 (BCL2A1) is a member of the BCL-2 family of anti-apoptotic proteins that confers resistance to treatment with anti-cancer drugs; however, there are presently no agents that target BCL2A1. The MUC1-C oncoprotein is aberrantly expressed in triple-negative breast cancer (TNBC) cells, induces the epithelial–mesenchymal trans...... hiện toàn bộ
Inflammation and atherosclerosis: signaling pathways and therapeutic intervention
Signal Transduction and Targeted Therapy - Tập 7 Số 1
Peng Kong, Ziyang Cui, Xiao-Fu Huang, Dandan Zhang, Rui-Juan Guo, Mei Han
AbstractAtherosclerosis is a chronic inflammatory vascular disease driven by traditional and nontraditional risk factors. Genome-wide association combined with clonal lineage tracing and clinical trials have demonstrated that innate and adaptive immune responses can promote or quell atherosclerosis. Several signaling pathways, that are associated with the inflammat...... hiện toàn bộ
Targeting IL-2: an unexpected effect in treating immunological diseases
Signal Transduction and Targeted Therapy - Tập 3 Số 1
Congxiu Ye, David Brand, Song Guo Zheng
AbstractRegulatory T cells (Treg) play a crucial role in maintaining immune homeostasis since Treg dysfunction in both animals and humans is associated with multi-organ autoimmune and inflammatory disease. While IL-2 is generally considered to promote T-cell proliferation and enhance effector T-cell function, recent studies have demonstrated that treatments that ut...... hiện toàn bộ
Storm of soluble immune checkpoints associated with disease severity of COVID-19
Signal Transduction and Targeted Therapy - Tập 5 Số 1
Yaxian Kong, Yu Wang, Xueying Wu, Junyan Han, Guoli Li, Mingxi Hua, Kai Han, Henghui Zhang, Ang Li, Hui Zeng
Lymphopenia predicts disease severity of COVID-19: a descriptive and predictive study
Signal Transduction and Targeted Therapy - Tập 5 Số 1
Li Tan, Li Wang, Duanyang Zhang, Jinya Ding, Qianchuan Huang, Yi‐Quan Tang, Qiongshu Wang, Hongming Miao
Tổng số: 29   
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