Storm of soluble immune checkpoints associated with disease severity of COVID-19

Signal Transduction and Targeted Therapy - Tập 5 Số 1
Yaxian Kong1, Yu Wang2, Xueying Wu3, Junyan Han1, Guoli Li1, Mingxi Hua1, Kai Han1, Henghui Zhang1, Ang Li4, Hui Zeng1
1Institute of Infectious Diseases, Beijing Key Laboratory of Emerging Infectious Diseases, Beijing Ditan Hospital, Capital Medical University, Beijing 100015, China
2Department of Respiratory Medicine, Beijing Ditan Hospital, Capital Medical University, Beijing, 100015, China
3Immupeutics Medicine Institute, Beijing, 100191, China
4Department of Intensive Care Medicine, Beijing Ditan Hospital, Capital Medical University, Beijing, 100015, China

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Tài liệu tham khảo

Chen, G. et al. Clinical and immunological features of severe and moderate coronavirus disease 2019. J. Clin. Investig. 130, 2620–2629 (2020).

Zheng, H. Y. et al. Elevated exhaustion levels and reduced functional diversity of T cells in peripheral blood may predict severe progression in COVID-19 patients. Cell. Mol. Immunol. 17, 541–543 (2020).

Gu, D., Ao, X., Yang, Y., Chen, Z. & Xu, X. Soluble immune checkpoints in cancer: production, function and biological significance. J. Immunother. Cancer 6, 132 (2018).

Schultheiß, C. et al. Next generation sequencing of T and B cell receptor repertoires from COVID-19 patients showed signatures associated with severity of disease. Immunity 53, 442.e4–455.e4 (2020).

Robilotti, E. V. et al. Determinants of COVID-19 disease severity in patients with cancer. Nat. Med. 26, 1218–1223 (2020).

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Signal Transduction and Targeted Therapy

Tập 5 Số 1

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