Respiratory Research
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Sputum ACE2, TMPRSS2 and FURIN gene expression in severe neutrophilic asthma
Respiratory Research - Tập 22 - Trang 1-10 - 2021
Patients with severe asthma may have a greater risk of dying from COVID-19 disease. Angiotensin converting enzyme-2 (ACE2) and the enzyme proteases, transmembrane protease serine 2 (TMPRSS2) and FURIN, are needed for viral attachment and invasion into host cells. We examined microarray mRNA expression of ACE2, TMPRSS2 and FURIN in sputum, bronchial brushing and bronchial biopsies of the European U......
Nitric oxide induces MUC5AC mucin in respiratory epithelial cells through PKC and ERK dependent pathways
Respiratory Research - Tập 8 - Trang 1-12 - 2007
Nitric oxide (NO) is generally increased during inflammatory airway diseases. This increased NO stimulates the secretion of mucin from the goblet cell and submucosal glands but the mechanism is still unknown precisely. In this study, we investigated potential signaling pathways involving protein kinase C (PKC) and mitogen-activated protein kinase (MAPK) in the NO-induced MUC5AC mucin gene and prot......
Retraction Note: Protective role of p120-catenin in maintaining the integrity of adherens and tight junctions in ventilator-induced lung injury
Respiratory Research - Tập 25 - Trang 1-1 - 2024
Cigarette smoking, cadmium exposure, and zinc intake on obstructive lung disorder
Respiratory Research - Tập 11 Số 1 - Trang 1-8 - 2010
This study examined whether zinc intake was associated with lower risk of smoking-induced obstructive lung disorder through interplay with cadmium, one of major toxicants in cigarette smoke. Data were obtained from a sample of 6,726 subjects aged 40+ from the Third National Health and Nutrition Examination Survey. The forced expiratory volume in 1 second (FEV1) and forced vital capacity (FVC) were......
Association of tobacco product use with chronic obstructive pulmonary disease (COPD) prevalence and incidence in Waves 1 through 5 (2013–2019) of the Population Assessment of Tobacco and Health (PATH) Study
Respiratory Research - Tập 23 - Trang 1-13 - 2022
We examined the association of non-cigarette tobacco use on chronic obstructive pulmonary disease (COPD) risk in the Population Assessment of Tobacco and Health (PATH) Study. There were 13,752 participants ≥ 40 years with Wave 1 (W1) data for prevalence analyses, including 6945 adults without COPD for incidence analyses; W1–5 (2013–2019) data were analyzed. W1 tobacco use was modeled as 12 mutuall......
Characterization of proximal pulmonary arterial cells from chronic thromboembolic pulmonary hypertension patientsAbstract
Background
Chronic thromboembolic pulmonary hypertension (CTEPH) is associated with proximal pulmonary artery obstruction and vascular remodeling. We hypothesized that pulmonary arterial smooth muscle (PASMC) and endothelial cells (PAEC) may actively contribute to remodeling of the proxi... ...
Respiratory Research - Tập 13 Số 1 - 2012
Giai đoạn đầu của việc giải quyết viêm niêm mạc do bạch cầu ưa acid trong bệnh viêm mũi dị ứng Dịch bởi AI
Respiratory Research - Tập 11 - Trang 1-9 - 2010
Người ta thường giả định rằng quá trình apoptosis của bạch cầu ưa acid là một thành phần trung tâm trong việc giải quyết bệnh đường hô hấp dị ứng. Tuy nhiên, điều này chưa được chứng minh trên đường hô hấp dị ứng ở người trong điều kiện in vivo. Dựa trên các quan sát in vivo ở động vật, chúng tôi đã giả thuyết rằng quá trình giải quyết viêm niêm mạc do bạch cầu ưa acid ở người do steroid gây ra li......
#viêm mũi dị ứng #bạch cầu ưa acid #CCL5 #CCL11 #budesonide
Potential therapeutic implications of new insights into respiratory syncytial virus disease
Respiratory Research - Tập 3 - Trang 1-6 - 2002
Viral bronchiolitis is the most common cause of hospitalization in infants under 6 months of age, and 70% of all cases of bronchiolitis are caused by respiratory syncytial virus (RSV). Early RSV infection is associated with respiratory problems such as asthma and wheezing later in life. RSV infection is usually spread by contaminated secretions and infects the upper then lower respiratory tracts. ......
Investigating the role of MRGPRC11 and capsaicin-sensitive afferent nerves in the anti-influenza effects exerted by SLIGRL-amide in murine airways
Respiratory Research - Tập 17 - Trang 1-14 - 2016
The hexapeptide SLIGRL-amide activates protease-activated receptor-2 (PAR-2) and mas-related G protein-coupled receptor C11 (MRGPRC11), both of which are known to be expressed on populations of sensory nerves. SLIGRL-amide has recently been reported to inhibit influenza A (IAV) infection in mice independently of PAR-2 activation, however the explicit roles of MRGPRC11 and sensory nerves in this pr......
Pro-inflammatory endothelial cell dysfunction is associated with intersectin-1s down-regulation
Respiratory Research - Tập 12 - Trang 1-14 - 2011
The response of lung microvascular endothelial cells (ECs) to lipopolysaccharide (LPS) is central to the pathogenesis of lung injury. It is dual in nature, with one facet that is pro-inflammatory and another that is cyto-protective. In previous work, overexpression of the anti-apoptotic Bcl-XL rescued ECs from apoptosis triggered by siRNA knockdown of intersectin-1s (ITSN-1s), a pro-survival prote......
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