Respiratory Research

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Neopterin in patients with COPD, asthma, and ACO: association with endothelial and lung functions
Respiratory Research - Tập 25 Số 1
Yangli Liu, Fengjia Chen, Zhifan Zeng, Chengcheng Lei, Dubo Chen, Xiaoyu Zhang
Abstract Background and objective Endothelial dysfunction has been widely recognized in chronic airway diseases, including chronic obstructive pulmonary disease (COPD) and asthma; however, it remains unclear in asthma-COPD overlap (ACO). Neopterin (NP), a metabolite of guanosine triphosphate, is a n...... hiện toàn bộ
Impaired cell–cell communication and axon guidance because of pulmonary hypoperfusion during postnatal alveolar development
Respiratory Research - Tập 24 - Trang 1-17 - 2023
Debao Li, Jing Wang, Yuan Fang, Yuqing Hu, Yingying Xiao, Qing Cui, Chuan Jiang, Sijuan Sun, Hao Chen, Lincai Ye, Qi Sun
Pulmonary hypoperfusion is common in children with congenital heart diseases (CHDs) or pulmonary hypertension (PH) and causes adult pulmonary dysplasia. Systematic reviews have shown that some children with CHDs or PH have mitigated clinical outcomes with COVID-19. Understanding the effects of pulmonary hypoperfusion on postnatal alveolar development may aid in the development of methods to improv...... hiện toàn bộ
Sputum ACE2, TMPRSS2 and FURIN gene expression in severe neutrophilic asthma
Respiratory Research - Tập 22 - Trang 1-10 - 2021
Nazanin Zounemat Kermani, Woo-Jung Song, Yusef Badi, Ali Versi, Yike Guo, Kai Sun, Pank Bhavsar, Peter Howarth, Sven-Erik Dahlen, Peter J. Sterk, Ratko Djukanovic, Ian M. Adcock, Kian Fan Chung
Patients with severe asthma may have a greater risk of dying from COVID-19 disease. Angiotensin converting enzyme-2 (ACE2) and the enzyme proteases, transmembrane protease serine 2 (TMPRSS2) and FURIN, are needed for viral attachment and invasion into host cells. We examined microarray mRNA expression of ACE2, TMPRSS2 and FURIN in sputum, bronchial brushing and bronchial biopsies of the European U...... hiện toàn bộ
Nitric oxide induces MUC5AC mucin in respiratory epithelial cells through PKC and ERK dependent pathways
Respiratory Research - Tập 8 - Trang 1-12 - 2007
Jeong Sup Song, Chun Mi Kang, Moon Bin Yoo, Seung Joon Kim, Hyung Kyu Yoon, Young Kyoon Kim, Kwan Hyung Kim, Hwa Sik Moon, Sung Hak Park
Nitric oxide (NO) is generally increased during inflammatory airway diseases. This increased NO stimulates the secretion of mucin from the goblet cell and submucosal glands but the mechanism is still unknown precisely. In this study, we investigated potential signaling pathways involving protein kinase C (PKC) and mitogen-activated protein kinase (MAPK) in the NO-induced MUC5AC mucin gene and prot...... hiện toàn bộ
Retraction Note: Protective role of p120-catenin in maintaining the integrity of adherens and tight junctions in ventilator-induced lung injury
Respiratory Research - Tập 25 - Trang 1-1 - 2024
Changping Gu, Mengjie Liu, Tao Zhao, Dong Wang, Yuelan Wang
Enhanced endogenous bone morphogenetic protein signaling protects against bleomycin induced pulmonary fibrosis
Respiratory Research - Tập 16 - Trang 1-10 - 2015
Ellen De Langhe, Frederic Cailotto, Vanessa De Vooght, Carolina Aznar-Lopez, Jeroen Alfons Vanoirbeek, Frank Prosper Luyten, Rik Jozef Urbain Lories
Effective treatments for fibrotic diseases such as idiopathic pulmonary fibrosis are largely lacking. Transforming growth factor beta (TGFβ) plays a central role in the pathophysiology of fibrosis. We hypothesized that bone morphogenetic proteins (BMP), another family within the TGFβ superfamily of growth factors, modulate fibrogenesis driven by TGFβ. We therefore studied the role of endogenous BM...... hiện toàn bộ
Analysis of body mass index, weight loss and progression of idiopathic pulmonary fibrosis
Respiratory Research - Tập 21 - Trang 1-11 - 2020
Stéphane Jouneau, Bruno Crestani, Ronan Thibault, Mathieu Lederlin, Laurent Vernhet, Claudia Valenzuela, Marlies Wijsenbeek, Michael Kreuter, Wibke Stansen, Manuel Quaresma, Vincent Cottin
Nintedanib is an approved therapy for idiopathic pulmonary fibrosis (IPF). Some patients treated with nintedanib experience weight loss. Exploratory data suggest that low body mass index or weight loss are associated with worse outcomes in patients with IPF. We investigated whether BMI at baseline or weight loss over 52 weeks was associated with FVC decline, or influenced the effect of nintedanib,...... hiện toàn bộ
Influenza A virus enhances ciliary activity and mucociliary clearance via TLR3 in airway epithelium
Respiratory Research - Tập 21 - Trang 1-13 - 2020
Yosuke Kamiya, Tomoyuki Fujisawa, Mineo Katsumata, Hideki Yasui, Yuzo Suzuki, Masato Karayama, Hironao Hozumi, Kazuki Furuhashi, Noriyuki Enomoto, Yutaro Nakamura, Naoki Inui, Mitsutoshi Setou, Masahiko Ito, Tetsuro Suzuki, Koji Ikegami, Takafumi Suda
Viral respiratory tract infections, such as influenza A virus (IAV), are common and life-threatening illnesses worldwide. The mechanisms by which viruses are removed from the respiratory tract are indispensable for airway host defense. Mucociliary clearance is an airway defense mechanism that removes pathogens from the respiratory tract. The coordination and modulation of the ciliary beating of ai...... hiện toàn bộ
Erratum to: Risk factors for mortality in patients admitted to intensive care units with pneumonia
Respiratory Research - Tập 17 - Trang 1-1 - 2016
Guowei Li, Deborah J. Cook, Lehana Thabane, Jan O. Friedrich, Tim M. Crozier, John Muscedere, John Granton, Sangeeta Mehta, Steven C. Reynolds, Renato D. Lopes, Francois Lauzier, Andreas P. Freitag, Mitchell A. H. Levine
High resolution CT and histological findings in idiopathic pleuroparenchymal fibroelastosis: Features and differential diagnosis
Respiratory Research - Tập 12 - Trang 1-5 - 2011
Sara Piciucchi, Sara Tomassetti, Gianluca Casoni, Nicola Sverzellati, Angelo Carloni, Alessandra Dubini, Giampaolo Gavelli, Alberto Cavazza, Marco Chilosi, Venerino Poletti
Idiopathic pleuroparenchymal fibroelastosis (IPPFE) is a recently described clinical-pathologic entity characterized by pleural and subpleural parenchymal fibrosis, mainly in the upper lobes. As this disease is extremely rare (only 7 cases have been described in the literature to date) poorly defined cases of IPPFE can go unrecognized. The clinical course of disease is progressive and prognosis is...... hiện toàn bộ
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