Respiratory Research
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Sắp xếp:
Neopterin in patients with COPD, asthma, and ACO: association with endothelial and lung functions
Respiratory Research - Tập 25 Số 1
Abstract Background and objective Endothelial dysfunction has been widely
recognized in chronic airway diseases, including chronic obstructive pulmonary
disease (COPD) and asthma; however, it remains unclear in asthma-COPD overlap
(ACO). Neopterin (NP), a metabolite of guanosine triphosphate, is a novel
biomarker for identifying the increased risk of adverse cardiovascular events.
This study aims ...
Impaired cell–cell communication and axon guidance because of pulmonary hypoperfusion during postnatal alveolar development
Respiratory Research - Tập 24 - Trang 1-17 - 2023
Pulmonary hypoperfusion is common in children with congenital heart diseases
(CHDs) or pulmonary hypertension (PH) and causes adult pulmonary dysplasia.
Systematic reviews have shown that some children with CHDs or PH have mitigated
clinical outcomes with COVID-19. Understanding the effects of pulmonary
hypoperfusion on postnatal alveolar development may aid in the development of
methods to improv...
Sputum ACE2, TMPRSS2 and FURIN gene expression in severe neutrophilic asthma
Respiratory Research - Tập 22 - Trang 1-10 - 2021
Patients with severe asthma may have a greater risk of dying from COVID-19
disease. Angiotensin converting enzyme-2 (ACE2) and the enzyme proteases,
transmembrane protease serine 2 (TMPRSS2) and FURIN, are needed for viral
attachment and invasion into host cells. We examined microarray mRNA expression
of ACE2, TMPRSS2 and FURIN in sputum, bronchial brushing and bronchial biopsies
of the European U...
Nitric oxide induces MUC5AC mucin in respiratory epithelial cells through PKC and ERK dependent pathways
Respiratory Research - Tập 8 - Trang 1-12 - 2007
Nitric oxide (NO) is generally increased during inflammatory airway diseases.
This increased NO stimulates the secretion of mucin from the goblet cell and
submucosal glands but the mechanism is still unknown precisely. In this study,
we investigated potential signaling pathways involving protein kinase C (PKC)
and mitogen-activated protein kinase (MAPK) in the NO-induced MUC5AC mucin gene
and prot...
Retraction Note: Protective role of p120-catenin in maintaining the integrity of adherens and tight junctions in ventilator-induced lung injury
Respiratory Research - Tập 25 - Trang 1-1 - 2024
Uric acid, lung function, physical capacity and exacerbation frequency in patients with COPD: a multi-dimensional approach
Respiratory Research - Tập 19 - Trang 1-10 - 2018
Recent investigations showed single associations between uric acid levels,
functional parameters, exacerbations and mortality in COPD patients. The aim of
this study was to describe the role of uric acid within the network of multiple
relationships between function, exacerbation and comorbidities. We used baseline
data from the German COPD cohort COSYCONET which were evaluated by standard
multiple...
Enhanced endogenous bone morphogenetic protein signaling protects against bleomycin induced pulmonary fibrosis
Respiratory Research - Tập 16 - Trang 1-10 - 2015
Effective treatments for fibrotic diseases such as idiopathic pulmonary fibrosis
are largely lacking. Transforming growth factor beta (TGFβ) plays a central role
in the pathophysiology of fibrosis. We hypothesized that bone morphogenetic
proteins (BMP), another family within the TGFβ superfamily of growth factors,
modulate fibrogenesis driven by TGFβ. We therefore studied the role of
endogenous BM...
Analysis of body mass index, weight loss and progression of idiopathic pulmonary fibrosis
Respiratory Research - Tập 21 - Trang 1-11 - 2020
Nintedanib is an approved therapy for idiopathic pulmonary fibrosis (IPF). Some
patients treated with nintedanib experience weight loss. Exploratory data
suggest that low body mass index or weight loss are associated with worse
outcomes in patients with IPF. We investigated whether BMI at baseline or weight
loss over 52 weeks was associated with FVC decline, or influenced the effect of
nintedanib,...
Influenza A virus enhances ciliary activity and mucociliary clearance via TLR3 in airway epithelium
Respiratory Research - Tập 21 - Trang 1-13 - 2020
Viral respiratory tract infections, such as influenza A virus (IAV), are common
and life-threatening illnesses worldwide. The mechanisms by which viruses are
removed from the respiratory tract are indispensable for airway host defense.
Mucociliary clearance is an airway defense mechanism that removes pathogens from
the respiratory tract. The coordination and modulation of the ciliary beating of
ai...
Erratum to: Risk factors for mortality in patients admitted to intensive care units with pneumonia
Respiratory Research - Tập 17 - Trang 1-1 - 2016
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