Respiratory Research

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Circulating neutrophils levels are a predictor of pneumonia risk in chronic obstructive pulmonary disease
Respiratory Research - Tập 20 - Trang 1-10 - 2019
Steven J. Pascoe, Alberto Papi, Dawn Midwinter, Sally Lettis, Neil Barnes
Patients with chronic obstructive pulmonary disease (COPD) have excess risk of developing pneumonia; however, no definitive biomarkers of risk have been established. We hypothesized that blood neutrophils would help predict pneumonia risk in COPD. A meta-analysis of randomized, double-blind clinical trials of COPD patients meeting the following criteria were selected from the GlaxoSmithKline trial...... hiện toàn bộ
Substance P reconfigures the neural respiratory network in ventrolateral medulla in the neonatal rat brainstem in vitro
Respiratory Research - Tập 2 - Trang 1-2 - 2001
YN Shvarev, H Lagercrantz, Y Yamamoto
Differential effects of simvastatin on IL-13-induced cytokine gene expression in primary mouse tracheal epithelial cells
Respiratory Research - Tập 13 - Trang 1-9 - 2012
Amir A Zeki, Phil Thai, Nicholas J Kenyon, Reen Wu
Asthma causes significant morbidity worldwide in adults and children alike, and incurs large healthcare costs. The statin drugs, which treat hyperlipidemia and cardiovascular diseases, have pleiotropic effects beyond lowering cholesterol, including immunomodulatory, anti-inflammatory, and anti-fibrotic properties which may benefit lung health. Using an allergic mouse model of asthma, we previously...... hiện toàn bộ
Level and course of FEV1 in relation to polymorphisms in NFE2L2 and KEAP1 in the general population
Respiratory Research - Tập 10 - Trang 1-12 - 2009
Mateusz Siedlinski, Dirkje S Postma, Jolanda MA Boer, Gerrit van der Steege, Jan P Schouten, Henriette A Smit, H Marike Boezen
The metabolism of xenobiotics plays an essential role in smoking related lung function loss and development of Chronic Obstructive Pulmonary Disease. Nuclear Factor Erythroid 2-Like 2 (NFE2L2 or NRF2) and its cytosolic repressor Kelch-like ECH-associated protein-1 (KEAP1) regulate transcription of enzymes involved in cellular detoxification processes and Nfe2l2-deficient mice develop tobacco-induc...... hiện toàn bộ
Lung fibroblasts from patients with emphysema show markers of senescence in vitro
Respiratory Research - Tập 7 Số 1 - 2006
Müller Kc, Lutz Welker, K Paasch, B Feindt, Erpenbeck Vj, Jens M. Hohlfeld, Norbert Krug, Masaki Nakashima, D Branscheid, H Magnussen, Jörres Ra, Olaf Holz
Abstract Background The loss of alveolar walls is a hallmark of emphysema. As fibroblasts play an important role in the maintenance of alveolar structure, a change in fibroblast phenotype could be involved in the pathogenesis of this disease. In a previous study we found a reduced in...... hiện toàn bộ
Analysis of body mass index, weight loss and progression of idiopathic pulmonary fibrosis
Respiratory Research - Tập 21 - Trang 1-11 - 2020
Stéphane Jouneau, Bruno Crestani, Ronan Thibault, Mathieu Lederlin, Laurent Vernhet, Claudia Valenzuela, Marlies Wijsenbeek, Michael Kreuter, Wibke Stansen, Manuel Quaresma, Vincent Cottin
Nintedanib is an approved therapy for idiopathic pulmonary fibrosis (IPF). Some patients treated with nintedanib experience weight loss. Exploratory data suggest that low body mass index or weight loss are associated with worse outcomes in patients with IPF. We investigated whether BMI at baseline or weight loss over 52 weeks was associated with FVC decline, or influenced the effect of nintedanib,...... hiện toàn bộ
Erratum to: Risk factors for mortality in patients admitted to intensive care units with pneumonia
Respiratory Research - Tập 17 - Trang 1-1 - 2016
Guowei Li, Deborah J. Cook, Lehana Thabane, Jan O. Friedrich, Tim M. Crozier, John Muscedere, John Granton, Sangeeta Mehta, Steven C. Reynolds, Renato D. Lopes, Francois Lauzier, Andreas P. Freitag, Mitchell A. H. Levine
Long-acting antimuscarinic therapy in patients with chronic obstructive pulmonary disease receiving beta-blockers
Respiratory Research - Tập 22 - Trang 1-10 - 2021
Kenneth R. Chapman, Robert A. Wise, Benjamin M. Scirica, Deepak L. Bhatt, Sami Z. Daoud, Dan Lythgoe, Esther Garcia Gil
Beta-blocker therapies for cardiovascular comorbidities are often withheld in patients with chronic obstructive pulmonary disease (COPD) due to potential adverse effects on airway obstruction. We carried out a post hoc analysis to determine the efficacy and safety of aclidinium in patients with moderate-to-very severe COPD and increased cardiovascular risk receiving beta-blockers at baseline versu...... hiện toàn bộ
Impact of chronic obstructive pulmonary disease on short-term outcome in patients with ST-elevation myocardial infarction during COVID-19 pandemic: insights from the international multicenter ISACS-STEMI registry
Respiratory Research - Tập 23 - Trang 1-9 - 2022
Giuseppe De Luca, Matteo Nardin, Magdy Algowhary, Berat Uguz, Dinaldo C. Oliveira, Vladimir Ganyukov, Zan Zimbakov, Miha Cercek, Lisette Okkels Jensen, Poay Huan Loh, Lucian Calmac, Gerard Roura Ferrer, Alexandre Quadros, Marek Milewski, Fortunato Scotto di Uccio, Clemens von Birgelen, Francesco Versaci, Jurrien Ten Berg, Gianni Casella, Aaron Wong Sung Lung, Petr Kala, José Luis Díez Gil, Xavier Carrillo, Maurits Dirksen, Victor M. Becerra-Munoz, Michael Kang-yin Lee, Dafsah Arifa Juzar, Rodrigo de Moura Joaquim, Roberto Paladino, Davor Milicic, Periklis Davlouros, Nikola Bakraceski, Filippo Zilio, Luca Donazzan, Adriaan Kraaijeveld, Gennaro Galasso, Arpad Lux, Lucia Marinucci, Vincenzo Guiducci, Maurizio Menichelli, Alessandra Scoccia, Aylin Hatice Yamac, Kadir Ugur Mert, Xacobe Flores Rios, Tomas Kovarnik, Michal Kidawa, Josè Moreu, Vincent Flavien, Enrico Fabris, Iñigo Lozano Martínez-Luengas, Marco Boccalatte, Francisco Bosa Ojeda, Carlos Arellano-Serrano, Gianluca Caiazzo, Giuseppe Cirrincione, Hsien-Li Kao, Juan Sanchis Forés, Luigi Vignali, Helder Pereira, Stephane Manzo, Santiago Ordoñez, Alev Arat Özkan, Bruno Scheller, Heidi Lehtola, Rui Teles, Christos Mantis, Ylitalo Antti, João A. Brum Silveira, Rodrigo Zoni, Ivan Bessonov, Stefano Savonitto, George Kochiadakis, Dimitrios Alexopoulos, Carlos E. Uribe, John Kanakakis, Benjamin Faurie, Gabriele Gabrielli, Alejandro Gutierrez Barrios, Juan Pablo Bachini, Alex Rocha, Frankie Chor-Cheung Tam, Alfredo Rodriguez, Antonia Anna Lukito, Veauthyelau Saint-Joy, Gustavo Pessah, Andrea Tuccillo, Giuliana Cortese, Guido Parodi, Mohamed Abed Bouraghda, Elvin Kedhi, Pablo Lamelas, Harry Suryapranata, Monica Verdoia
Chronic obstructive pulmonary disease (COPD) is projected to become the third cause of mortality worldwide. COPD shares several pathophysiological mechanisms with cardiovascular disease, especially atherosclerosis. However, no definite answers are available on the prognostic role of COPD in the setting of ST elevation myocardial infarction (STEMI), especially during COVID-19 pandemic, among patien...... hiện toàn bộ
Passive immunoprophylaxis and therapy with humanized monoclonal antibody specific for influenza A H5 hemagglutinin in mice
Respiratory Research - Tập 7 - Trang 1-10 - 2006
Brendon J Hanson, Adrianus CM Boon, Angeline PC Lim, Ashley Webb, Eng Eong Ooi, Richard J Webby
Highly pathogenic avian H5N1 influenza virus is a major public health concern. Given the lack of effective vaccine and recent evidence of antiviral drug resistance in some isolates, alternative strategies for containment of a possible future pandemic are needed. Humanized monoclonal antibodies (mAbs) that neutralize H5N1 virus could be used as prophylaxis and treatment to aid in the containment of...... hiện toàn bộ
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