Research in Experimental Medicine
1433-8580
0300-9130
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Possible interaction of platelets and adrenaline in the early phase of myocardial infarction
Tập 187 - Trang 385-393 - 1987
It is known that in most cases of transmural acute myocardial infarction a platelet clot originates within a coronary artery. In acute myocardial infarction patients increased levels of the plasma catecholamines adrenaline and noradrenaline as well as the platelet release proteins platelet factor 4 andβ-thromboglobulin have been reported. In this study, significantly higher values were found of platelet factor 4 (P < 0.0001) andβ-thromboglobulin (P < 0.002) in 17 acute myocardial infarction patients as compared to 17 control patients (on intensive care due to non-cardiac disorders), while the plasma levels of adrenaline and noradrenaline were not different. Positive correlations were obtained between the two catecholamines and the platelet products in the control group and between adrenaline and both platelet factor 4 (r = 0.715,P < 0.01) andβ-thromboglobulin (r = 0.547,P < 0.05) in the acute myocardial infarction patients. The data suggest that a stimulation of the platelets by adrenaline may facilitate in vitro activation during sampling in patients with high catecholamine load. On the other hand, a “preactivation” of the platelets by an increase of adrenaline might be of significance for thrombus formation in acute myocardial infarction.
Effects of clofibric acid and bezafibrate administration on activities of alkaline phosphatase and other enzymes in livers of rats
Tập 179 - Trang 153-161 - 1981
Administration of clofibric acid and bezafibrate to rats lowers plasma lipids, increases the liver weight, and causes a slight decrease in the activity of alkaline phosphatase in plasma. However, both these drugs increase the activity of alkaline phosphatase in liver over threefold. The activity of other enzymes did not change by the same magnitude. The increase in the alkaline phosphatase activity in liver tissue appears to be due to increase in the activity of this enzyme in parenchymal cells. Clofibric acid and bezafibrate increase the activity of bilirubin-glucuronyl transferase activity over twofold in liver microsomes. It is thus evident that both these drugs cause similar changes in various enzyme activities in liver even though bezafibrate has been reported to have a much shorter biologic halflife than clofibric acid.
Über die colorimetrische Bestimmung der flüchtigen Carbonylverbindungen im Harn
Tập 113 - Trang 336-340 - 1944
Es wird eine Methode zur Bestimmung flüchtiger Carbonylverbindungen im Harn entwickelt, die es gestattet, hydrazon- und osazonbildende Substanzen getrennt zu bestimmen. Sie beruht auf dem Prinzip einer, nach Ausschaltung des überschüssigen zur Reaktion verwandten 2.4 Dinitrophenylhydrazins, colorimetrischen Auswertung der durch eine Reaktion von Kalilauge mit den Kondensationsprodukten entstehenden verschiedenen Farbabstufungen, die von der Menge letzterer abhängig sind.
Über Thromboseprophylaxe durch Verminderung der intravasalen Gerinnungsfähigkeit des Blutes
Tập 112 - Trang 309-319 - 1943
Es ist möglich, durch Gerinnungsinhibitoren Thromboseprophylaxe zu betreiben. Die Dosierung bereitet große Schwierigkeiten. Wegen der damit verbundenen Blutungsgefahr, muß Überdosierung vermieden werden. Heparin ist als Thromboseprophylaktikum dem Neodymacetat unterlegen, weil seine Wirkungsdauer hinter der des Neodymacetats weit zurückbleibt. Tierversuche haben ergeben, daß 4 mg Neodymacetat pro Kilogramm den „Gerinnungstod“ des Kaninchens, den man durch intravenöse Injektion von frischem Muskelsaft hervorrufen kann, verhüten. Die vorliegende Literatur — auch klinische Untersuchungen — beweist, daß tägliche Injektionen von 250 mg Neodymacetat (also eine Menge, die den Frühgifttod verhindert) völlig unschädlich sind. Es wird empfohlen klinisch zu erproben, ob 250 mg Neodymacetat2 täglich intravenös injiziert, Thrombosen verhüten können.
Experimentelle Untersuchungen über den Einfluß der Nebenschilddrüsen auf den Blutdruck
Tập 124 - Trang 407-417 - 1954