Quarterly Reviews of Biophysics

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Exploiting the light–metal interaction for biomolecular sensing and imaging
Quarterly Reviews of Biophysics - Tập 45 Số 2 - Trang 209-255 - 2012
Christiane Höppener, Lukáš Novotný
AbstractThe ability of metal surfaces and nanostructures to localize and enhance optical fields is the primary reason for their application in biosensing and imaging. Local field enhancement boosts the signal-to-noise ratio in measurements and provides the possibility of imaging with resolutions significantly better than the diffraction limit. In fluorescence imaging, local field enhancement leads... hiện toàn bộ
Ion transport across thin lipid membranes: a critical discussion of mechanisms in selected systems
Quarterly Reviews of Biophysics - Tập 5 Số 2 - Trang 187-282 - 1972
D.A. Haydon, Stephen B. Hladky
There are now well-established examples of carriers and pores which facilitate the transfer of ions across thin lipid membranes. In the absence of such agents, lipid bilayer membranes are extremely impermeable to the common inorganic ions. Thus, the conductance of a pure lecithin + decane or glyceryl mono-oleate + decane membrane in M/10 NaCl is less than10−9Ω−1cm−2. However, on the addition of sm... hiện toàn bộ
Molecular aspects of photoreceptor function
Quarterly Reviews of Biophysics - Tập 8 Số 2 - Trang 129-184 - 1975
Thomas G. Ebrey, Barry Honig
The description of the molecular processes which underlie visual excitation is the fundamental problem in understanding vision at the level of a single photoreceptor. Thus far only a general outline of photoreceptor function has emerged with little known about actual biochemical and biophysical mechanisms.
Structure calculation of biological macromolecules from NMR data
Quarterly Reviews of Biophysics - Tập 31 Số 2 - Trang 145-237 - 1998
Peter Güntert
The relationship between amino acid sequence, three-dimensional structure and biological function of proteins is one of the most intensely pursued areas of molecular biology and biochemistry. In this context, the three-dimensional structure has a pivotal role, its knowledge being essential to understand the physical, chemical and biological properties of a protein (Branden & Tooze, 1991; Creighton... hiện toàn bộ
Physical principles of membrane organization
Quarterly Reviews of Biophysics - Tập 13 Số 2 - Trang 121-200 - 1980
Jacob N. Israelachvili, S. Marčelja, Roger G. Horn
Membranes are the most common cellular structures in both plants and animals. They are now recognized as being involved in almost all aspects of cellular activity ranging from motility and food entrapment in simple unicellular organisms, to energy transduction, immunorecognition, nerve conduction and biosynthesis in plants and higher organisms. This functional diversity is reflected in the wide va... hiện toàn bộ
Linkage graphs: a study in the thermodynamics of macromolecules
Quarterly Reviews of Biophysics - Tập 17 Số 4 - Trang 453-488 - 1984
Jeffries Wyman
In earlier papers (Wyman, 1975a, b, 1981) I have called attention to the existence of a group of linkage potentials derivable from one another by a corresponding group of Legendre transformations. These potentials are applicable to any system in a state of equilibrium but are especially useful in the study of the behaviour, or, as we may say, the functional chemistry, of a macromolecule in the pre... hiện toàn bộ
Haemocyanins
Quarterly Reviews of Biophysics - Tập 15 Số 1 - Trang 1-129 - 1982
Kensal E. van Holde, Karen I. Miller
About ten years ago, one of the authors participated in a review of haemocyanin structure and function (van Holde & van Bruggen, 1971). At that time, it was possible to describe the field in terms of a limited amount of exciting new structural information, and a long list of unanswered questions. While the stoichiometry of oxygen binding was understood, virtually nothing was known about the active... hiện toàn bộ
The NADH:ubiquinone oxidoreductase (complex I) of respiratory chains
Quarterly Reviews of Biophysics - Tập 25 Số 3 - Trang 253-324 - 1992
John E. Walker
The inner membranes of mitochondria contain three multi-subunit enzyme complexes that act successively to transfer electrons from NADH to oxygen, which is reduced to water (Fig. I). The first enzyme in the electron transfer chain, NADH:ubiquinone oxidoreductase (or complex I), is the subject of this review. It removes electrons from NADH and passes them via a series of enzyme-bound redox centres (... hiện toàn bộ
Các bệnh amyloid có phải được gây ra bởi các protein kết tập bắt chước độc tố tạo lỗ trên vi khuẩn hay không? Dịch bởi AI
Quarterly Reviews of Biophysics - Tập 39 Số 2 - Trang 167-201 - 2006
Hilal A. Lashuel, Peter T. Lansbury
1. Giới thiệu 22. Ý nghĩa của các đặc tính cấu trúc chung của các sợi amyloid liên quan đến bệnh? 32.1 Cơ chế hình thành sợi amyloid in vitro 62.1.1 Quá trình hình thành sợi in vitro bao gồm sự tập hợp tạm thời của các chất kết tập có độ ổn định trung gian, hoặc protofibrils 63. Các đặc tính độc hại của protofibrils 73.1 Các protofibrils, chứ không phải sợi fibrils, có khả năng là chất gây bệnh 73... hiện toàn bộ
#Amyloid diseases #protein fibrillization #protofibrils #neurodegenerative diseases #amyloid pore #protein aggregation #pathogenesis #membrane permeabilization #proteasome inhibition
Homing endonuclease structure and function
Quarterly Reviews of Biophysics - Tập 38 Số 01 - Trang 49
Barry Stoddard
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