Quarterly Reviews of Biophysics

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What vibrations tell about proteins
Quarterly Reviews of Biophysics - Tập 35 Số 4 - Trang 369-430 - 2002
Andreas Barth, Christian Zscherp
1. Introduction 3702. Infrared (IR) spectroscopy – general principles 3722.1 Vibrations 3722.2 Information that can be derived from the vibrational spectrum 3722.3 Absorption of IR light 3753. Protein IR absorption 3763.1...... hiện toàn bộ
Reverse-correlation methods in auditory research
Quarterly Reviews of Biophysics - Tập 16 Số 3 - Trang 341-414 - 1983
J. J. Eggermont, P. I. M. Johannesma, Ad Aertsen
Single unit recordings have provided us with a basis for understanding the auditory system, especially about how it behaves under stimulation with simple sounds such as clicks and tones. The experimental as well as the theoretical approach to single unit studies has been dichotomous. One approach, the more familiar, gives a representation of nervous system activity in the form of peri-stim...... hiện toàn bộ
A sequence-specific DNA binding small molecule triggers the release of immunogenic signals and phagocytosis in a model of B-cell lymphoma
Quarterly Reviews of Biophysics - Tập 48 Số 4 - Trang 453-464 - 2015
JeenJoo S. Kang, Peter B. Dervan
AbstractMeans to cause an immunogenic cell death could lead to significant insight into how cancer escapes immune control. In this study, we screened a library of five pyrrole–imidazole polyamides coding for different DNA sequences in a model of B-cell lymphoma for the upregulation of surface calreticulin, a pro-phagocytosis signal implicated in immunogenic cell de...... hiện toàn bộ
Trifluoroethanol and colleagues: cosolvents come of age. Recent studies with peptides and proteins
Quarterly Reviews of Biophysics - Tập 31 Số 3 - Trang 297-355 - 1998
Matthias Buck
Alcohol based cosolvents, such as trifluoroethanol (TFE) have been used for many decades to denature proteins and to stabilize structures in peptides. Nuclear magnetic resonance spectroscopy and site directed mutagenesis have recently made it possible to characterize the effects of TFE and of other alcohols on polypeptide structure and dynamics at high resolution. This review examines...... hiện toàn bộ
Destabilization and stabilization of proteins
Quarterly Reviews of Biophysics - Tập 38 Số 4 - Trang 351-361 - 2005
John A. Schellman
Introduction 351Part I. A succession of concepts 3521. Cooperativity 3522. Cosolvent interaction 3523. Linearity 3544. Solvent exchange 3545....... hiện toàn bộ
Charge regulation in biomolecular solution
Quarterly Reviews of Biophysics - Tập 46 Số 3 - Trang 265-281 - 2013
Mikael Lund, Bo Jönsson
AbstractProteins and other biomolecules contain acidic and basic titratable groups that give rise to intricate charge distributions and control electrostatic interactions. ‘Charge regulation’ concerns how the proton equilibria of these sites are perturbed when approached by alien molecular matter such as other proteins, surfaces and membranes, DNA, polyelectrolytes...... hiện toàn bộ
Molecular electrostatic potential of the nucleic acids
Quarterly Reviews of Biophysics - Tập 14 Số 3 - Trang 289-380 - 1981
Alberte Pullman, Bernard Pullman
It is generally acknowledged that geometrical and conformational properties of biopolymers have an important effect on their biochemical behaviour. It is less easily recognized that these properties depend also on their macromolecular electronic characteristics.The aim of this review is to demonstrate the significance of such macromolecular electronic effects. Particularly...... hiện toàn bộ
Các bệnh amyloid có phải được gây ra bởi các protein kết tập bắt chước độc tố tạo lỗ trên vi khuẩn hay không? Dịch bởi AI
Quarterly Reviews of Biophysics - Tập 39 Số 2 - Trang 167-201 - 2006
Hilal A. Lashuel, Peter T. Lansbury
1. Giới thiệu 22. Ý nghĩa của các đặc tính cấu trúc chung của các sợi amyloid liên quan đến bệnh? 32.1 Cơ chế hình thành sợi amyloid in vitro 62.1.1 Quá trình hình thành sợi in vitro bao gồm sự tập hợp tạm thời của các chất kết tập có độ ổn ...... hiện toàn bộ
#Amyloid diseases #protein fibrillization #protofibrils #neurodegenerative diseases #amyloid pore #protein aggregation #pathogenesis #membrane permeabilization #proteasome inhibition
Lanthanides as probes for calcium in biological systems
Quarterly Reviews of Biophysics - Tập 12 Số 2 - Trang 181-209 - 1979
Bruce Martin, F. S. Richardson
Calcium ion plays an essential role in many biological processes. The environment about Ca2+may be probed by substitution of tripositive lanthanide ions, Ln3+. Ca2+proteins fall into two broad classes: those that are inhibited by Ln3+substitution and those that are not. It is suggested that although Ca... hiện toàn bộ
Tracking RNA with light: selection, structure, and design of fluorescence turn-on RNA aptamers
Quarterly Reviews of Biophysics - Tập 52 - 2019
Robert J. Trachman, A.R. Ferré-D′Amaré
AbstractFluorescence turn-on aptamers,in vitroevolved RNA molecules that bind conditional fluorophores and activate their fluorescence, have emerged as RNA counterparts of the fluorescent proteins. Turn-on aptamers have been selected to bind diverse fluorophores, and they achieve varying degrees of specificity and affinity. These RNA–fluo...... hiện toàn bộ
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