Pulmonary Circulation
SCIE-ISI SCOPUS (2011-2025)
2045-8932
2045-8940
Mỹ
Cơ quản chủ quản: WILEY , John Wiley and Sons Inc.
Lĩnh vực:
Pulmonary and Respiratory Medicine
Phân tích ảnh hưởng
Các bài báo tiêu biểu
Epigenetic Modifications: Basic Mechanisms and Role in Cardiovascular Disease (2013 Grover Conference Series)
Tập 4 Số 2 - Trang 169-174 - 2014
Epigenetics refers to heritable traits that are not a consequence of DNA
sequence. Three classes of epigenetic regulation exist: DNA methylation, histone
modification, and noncoding RNA action. In the cardiovascular system, epigenetic
regulation affects development, differentiation, and disease propensity or
expression. Defining the determinants of epigenetic regulation offers
opportunities for no...
In the eye of the storm: the right ventricle in COVID‐19
Tập 10 Số 3 - Trang 1-7 - 2020
The corona virus disease of 2019 pandemic caused by the SARS‐CoV‐2 virus
continues to inflict significant morbidity and mortality around the globe. A
variety of cardiovascular presentations of SARS‐CoV‐2 infection have been
described so far. However, the impact of SARS‐CoV‐2 on the right ventricle is
largely unknown. Due to its pathophysiologic relevance, the right ventricle
finds itself in the ey...
Levosimendan in pulmonary hypertension and right heart failure
Tập 8 Số 3 - Trang 1-7 - 2018
Pulmonary hypertension is a multifactorial disease with a high morbidity and
mortality. Right ventricular function is the most important predictor of
morbidity and mortality in patients suffering from pulmonary hypertension, but
currently there are no approved treatments directly supporting the failing right
ventricle. Levosimendan is a calcium sensitizing agent with inotropic, pulmonary
vasodilat...
Hypoxic Pulmonary Hypertension in Mice with Constitutively Active Platelet‐Derived Growth Factor Receptor‐β
Tập 1 Số 2 - Trang 259-268 - 2011
Platelet‐derived growth factor (PDGF) has been implicated in the pathobiology of
vascular remodeling. The multikinase inhibitor imatinib that targets PDGF
receptor (PDGFR), c‐kit and Abl kinases, shows therapeutic efficacy against
experimental pulmonary hypertension (PH); however, the role of PDGFR‐β in
experimental PH has not been examined by genetic approach. We investigated the
chronic hypoxia‐...
Sphingosine‐1‐Phosphate is Involved in the Occlusive Arteriopathy of Pulmonary Arterial Hypertension
Tập 6 Số 3 - Trang 369-380 - 2016
Despite several advances in the pathobiology of pulmonary arterial hypertension
(PAH), its pathogenesis is not completely understood. Current therapy improves
symptoms but has disappointing effects on survival. Sphingosine‐1‐phosphate
(S1P) is a lysophospholipid synthesized by sphingosine kinase 1 (SphK1) and
SphK2. Considering the regulatory roles of S1P in several tissues leading to
vasoconstric...
Platelets in Pulmonary Vascular Physiology and Pathology
Tập 2 Số 3 - Trang 291-308 - 2012
Almost a trillion platelets pass through the pulmonary circulation every minute,
yet little is known about how they support pulmonary physiology or contribute to
the pathogenesis of lung diseases. When considering this conundrum, three
questions jump out: Does platelet production in the lungs occur? Why does severe
thrombocytopenia—which undercuts the principal physiological role of platelets
to e...
Improving risk prediction for pulmonary embolism in COVID‐19 patients using echocardiography
Tập 12 Số 1 - 2022
AbstractSARS‐CoV‐2 infection is associated with increased risk for pulmonary
embolism (PE), a fatal complication that can cause right ventricular (RV)
dysfunction. Serum D‐dimer levels are a sensitive test to suggest PE, however
lacks specificity in COVID‐19 patients. The goal of this study was to identify a
model that better predicts PE diagnosis in hospitalized COVID‐19 patients using
clinical, ...