Platelets in Pulmonary Vascular Physiology and Pathology

Pulmonary Circulation - Tập 2 Số 3 - Trang 291-308 - 2012
Michael H. Kroll1, Vahid Afshar Kharghan1,2
1M.D. Anderson Cancer Center, Houston, Texas, USA
2Pulmonary Medicine

Tóm tắt

Almost a trillion platelets pass through the pulmonary circulation every minute, yet little is known about how they support pulmonary physiology or contribute to the pathogenesis of lung diseases. When considering this conundrum, three questions jump out: Does platelet production in the lungs occur? Why does severe thrombocytopenia—which undercuts the principal physiological role of platelets to effect hemostasis—not lead to pulmonary hemorrhage? Why does atherothrombosis—which platelets initiate, maintain, and trigger is other critically important arterial beds—not develop in the pulmonary artery? The purpose of this review is to explore these and derivative questions by providing data within a conceptual framework that begins to organize a subject that is largely unassembled.

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Tài liệu tham khảo

10.1182/blood-2011-02-338244

10.1007/978-0-387-87429-6_24

10.1182/blood-2007-05-088500

10.1097/MOH.0b013e3282bad151

10.1126/science.1146304

10.1056/NEJMct1014202

10.1182/blood.V26.6.720.720

10.1111/j.1600-0609.1993.tb00637.x

10.1046/j.1365-2257.2002.00375.x

10.1016/S0002-9440(10)64518-X

10.1182/blood-2011-08-373811

10.1016/j.mvr.2004.06.001

Smyth SS, 2010, Williams Hematology, 1735

10.1111/j.1538-7836.2009.03586.x

Kroll MH, 2002, Thrombosis and Hemorrhage, 187

10.1111/j.1538-7836.2010.03893.x

Croce KJ, 2008, Platelets in Hematologic and Cardiovascular Disorders, 106

10.1172/JCI29499

10.1111/j.1600-0463.2010.02651.x

10.1096/fj.10-159921

10.1189/jlb.0907615

10.1056/NEJMra0800887

10.1016/S1470-2045(02)00789-1

10.1084/jem.158.2.603

10.1016/S0021-9258(19)81346-7

10.1080/09537100701777311

10.1084/jem.20041497

10.1055/s-2006-939770

10.1002/1096-8652(200009)65:1<50::AID-AJH9>3.0.CO;2-5

10.5483/BMBRep.2005.38.2.128

10.1038/nrmicro1425

10.1111/j.1538-7836.2011.04264.x

10.1182/blood-2011-03-343061

10.1182/blood-2011-06-362764

10.1016/j.immuni.2011.05.006

10.1378/chest.11-2293

10.1152/physrev.1973.53.2.419

10.1007/s004290050197

Andrews RK, 2008, Platelet adhesion: A game of catch and release, J Clin Invest, 118, 3009

10.1126/science.1075452

10.1586/14779072.3.5.941

Yago T, 2008, Platelet glycoprotein Ibalpha forms catch bonds with human WT vWF but not with type 2B von Willebrand disease vWF, J Clin Invest, 118, 3195

10.1056/NEJMra020528

10.1161/01.ATV.0000071347.69358.D9

10.1111/j.1538-7836.2005.01360.x

10.1016/S0378-1119(01)00861-7

10.1056/NEJMra0804411

10.1111/j.1749-6632.2010.05580.x

Shou Y, 2004, Preliminary look at why some vessels get atherosclerosis and others don't, Conf Proc IEEE Eng Med Biol Soc, 7, 5073

10.1055/s-2005-922036

10.1038/sj.bmt.1703731

10.1038/sj.bmt.1705695

10.1097/00005792-198411000-00002

10.1016/j.ccm.2004.04.007

10.1016/j.semarthrit.2005.05.006

10.1016/S0954-6111(98)90188-3

10.1097/00005792-200211000-00002

Ener RA, 2006, Alveolar hemorrhage associated with platelet glycoprotein IIb/IIIa receptor inhibitors, J Invasive Cardiol, 18, 254

Huisman MV, 2008, Platelets in Hematologic and Cardiovascular Disorders, 471

10.1016/0049-3848(83)90399-7

10.1378/chest.85.3.329

10.1056/NEJMoa1114238

10.1056/NEJMe1201911

10.1016/0002-9343(78)90818-5

10.1097/01.tp.0000226066.82066.fa

10.1182/blood-2008-02-078170

10.1084/jem.20080130

10.1001/jama.2008.598

10.1002/ajh.20653

10.1056/NEJMra0804411

10.1055/s-0038-1650055

10.1016/S0022-3476(83)80258-3

10.1055/s-0038-1661088

10.4065/73.11.1085

Vaillant P, 1996, The role of cytokines in human lung fibrosis, Monaldi Arch Chest Dis, 51, 145

10.1016/j.blre.2005.12.003

10.1038/ng.884

10.1111/j.1365-2141.1990.tb06350.x

10.1159/000091609

10.1016/j.yjmcc.2007.09.006

10.1080/10245330600938281

10.1038/sj.leu.2404943

10.1182/blood-2005-08-3319

10.1016/0002-9343(90)90111-P

10.1016/S0022-2143(99)90094-X

10.1056/NEJMra035363

10.7326/0003-4819-130-6-199903160-00014

10.1159/000069290

10.1164/ajrccm.162.4.2003124

10.3109/10428199409049721

10.1183/09031936.96.09020356

10.2174/187152506775268794

10.1378/chest.114.3_Supplement.200S

10.1159/000314271

10.1161/01.CIR.102.22.2720

10.1016/S0002-8703(00)90038-3

10.1161/01.CIR.0000139859.68513.FC

10.7326/0003-4819-143-6-200509200-00017

10.3324/haematol.12426

Haznedaroglu IC, 2002, Thrombopoietin inside the pulmonary vessels in patients with and without pulmonary hypertension, Platelets, 13, 395

10.7326/0003-4819-95-5-636

10.1182/blood-2009-10-247296

10.1073/pnas.0700625104

10.1111/j.1538-7836.2009.03559.x

10.1016/S0049-3848(12)70013-0

10.1016/j.ccr.2011.09.009

10.1016/j.ccr.2006.10.002

10.1016/S0140-6736(10)62110-1

10.1056/NEJMra0910203

10.1161/CIR.0b013e318214914f

10.1038/nm.2515

10.1016/j.berh.2012.01.006

10.1177/0961203308096344

10.1097/00005792-199805000-00005

10.1016/j.jaut.2009.02.008

10.1016/j.autrev.2011.04.031

10.1378/chest.109.5.1388

10.1097/01.pas.0000209834.69972.e5

10.1172/JCI30664

10.1046/j.1537-2995.2003.00385.x

10.1378/chest.126.1.249

10.1067/mai.2003.1514

10.1002/path.1565

10.1182/blood-2004-06-2098

10.1056/NEJM199503303321303

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Pulmonary Circulation

Tập 2 Số 3

291-308

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