Pulmonary Circulation

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Hypoxic Pulmonary Hypertension in Mice with Constitutively Active Platelet‐Derived Growth Factor Receptor‐β
Pulmonary Circulation - Tập 1 Số 2 - Trang 259-268 - 2011
Bhola K. Dahal, Rainer Heuchel, Soni Savai Pullamsetti, Jochen Wilhelm, Hossein A. Ghofrani, Norbert Weißmann, Werner Seeger, Friedrich Grimminger, Ralph T. Schermuly
Platelet‐derived growth factor (PDGF) has been implicated in the pathobiology of vascular remodeling. The multikinase inhibitor imatinib that targets PDGF receptor (PDGFR), c‐kit and Abl kinases, shows therapeutic efficacy against experimental pulmonary hypertension (PH); however, the role of PDGFR‐β in experimental PH has not been examined by genetic approach. We investigated the chronic ...... hiện toàn bộ
Epigenetic Modifications: Basic Mechanisms and Role in Cardiovascular Disease (2013 Grover Conference Series)
Pulmonary Circulation - Tập 4 Số 2 - Trang 169-174 - 2014
Joseph Loscalzo, Diane E. Handy
Epigenetics refers to heritable traits that are not a consequence of DNA sequence. Three classes of epigenetic regulation exist: DNA methylation, histone modification, and noncoding RNA action. In the cardiovascular system, epigenetic regulation affects development, differentiation, and disease propensity or expression. Defining the determinants of epigenetic regulation offers opportunitie...... hiện toàn bộ
Sphingosine‐1‐Phosphate is Involved in the Occlusive Arteriopathy of Pulmonary Arterial Hypertension
Pulmonary Circulation - Tập 6 Số 3 - Trang 369-380 - 2016
Salina Gairhe, Sachindra R. Joshi, Mrigendra M. Bastola, Jared M. McLendon, Masahiko Oka, Karen A. Fagan, Ivan F. McMurtry
Despite several advances in the pathobiology of pulmonary arterial hypertension (PAH), its pathogenesis is not completely understood. Current therapy improves symptoms but has disappointing effects on survival. Sphingosine‐1‐phosphate (S1P) is a lysophospholipid synthesized by sphingosine kinase 1 (SphK1) and SphK2. Considering the regulatory roles of S1P in several tissues leading to vaso...... hiện toàn bộ
Platelets in Pulmonary Vascular Physiology and Pathology
Pulmonary Circulation - Tập 2 Số 3 - Trang 291-308 - 2012
Michael H. Kroll, Vahid Afshar Kharghan
Almost a trillion platelets pass through the pulmonary circulation every minute, yet little is known about how they support pulmonary physiology or contribute to the pathogenesis of lung diseases. When considering this conundrum, three questions jump out: Does platelet production in the lungs occur? Why does severe thrombocytopenia—which undercuts the principal physiological role of platel...... hiện toàn bộ
Levosimendan in pulmonary hypertension and right heart failure
Pulmonary Circulation - Tập 8 Số 3 - Trang 1-7 - 2018
Mona Sahlholdt Hansen, Asger Andersen, Jens Erik Nielsen‐Kudsk
Pulmonary hypertension is a multifactorial disease with a high morbidity and mortality. Right ventricular function is the most important predictor of morbidity and mortality in patients suffering from pulmonary hypertension, but currently there are no approved treatments directly supporting the failing right ventricle. Levosimendan is a calcium sensitizing agent with inotropic, pulmonary v...... hiện toàn bộ
Improving risk prediction for pulmonary embolism in COVID‐19 patients using echocardiography
Pulmonary Circulation - Tập 12 Số 1 - 2022
Monika Satoskar, Thomas S. Metkus, Alborz Soleimani‐Fard, Julie K. Shade, Natalia A. Trayanova, Erin D. Michos, Monica Mukherjee, Madeline Schiminger, Wendy S. Post, Allison G. Hays
AbstractSARS‐CoV‐2 infection is associated with increased risk for pulmonary embolism (PE), a fatal complication that can cause right ventricular (RV) dysfunction. Serum D‐dimer levels are a sensitive test to suggest PE, however lacks specificity in COVID‐19 patients. The goal of this study was to identify a model that better predicts PE diagnosis in hospitalized C...... hiện toàn bộ
In the eye of the storm: the right ventricle in COVID‐19
Pulmonary Circulation - Tập 10 Số 3 - Trang 1-7 - 2020
John F. Park, Somanshu Banerjee, Soban Umar
The corona virus disease of 2019 pandemic caused by the SARS‐CoV‐2 virus continues to inflict significant morbidity and mortality around the globe. A variety of cardiovascular presentations of SARS‐CoV‐2 infection have been described so far. However, the impact of SARS‐CoV‐2 on the right ventricle is largely unknown. Due to its pathophysiologic relevance, the right ventricle finds itself i...... hiện toàn bộ
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