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Vascular Notch proteins and Notch signaling in the peri-implantation mouse uterus
Publiverse Online S.R.L - Tập 7 - Trang 1-17 - 2015
Carrie J. Shawber, Lu Lin, Maria Gnarra, Mark V. Sauer, Virginia E. Papaioannou, Jan K. Kitajewski, Nataki C. Douglas
Angiogenesis is essential for uterine decidualization, the progesterone-mediated transformation of the uterus allowing embryo implantation and initiation of pregnancy. In the current study, we define the vasculature, expression of Notch proteins and Notch ligands, and Notch activity in both endothelial cells and vascular-associated mural cells of blood vessels in the pre-implantation endometrium a... hiện toàn bộ
Gene expression analysis reveals marked differences in the transcriptome of infantile hemangioma endothelial cells compared to normal dermal microvascular endothelial cells
Publiverse Online S.R.L - Tập 5 - Trang 1-13 - 2013
Jessica M Stiles, Rebecca K Rowntree, Clarissa Amaya, Dolores Diaz, Victor Kokta, Dianne C Mitchell, Brad A Bryan
Infantile hemangiomas are benign vascular tumors primarily found on the skin in 10% of the pediatric population. The etiology of this disease is largely unknown and while large scale genomic studies have examined the transcriptomes of infantile hemangioma tumors as a whole, no study to date has compared the global gene expression profiles of pure infantile hemangioma endothelial cells (HEMECs) to ... hiện toàn bộ
Regulation of endothelial permeability and transendothelial migration of cancer cells by tropomyosin-1 phosphorylation
Publiverse Online S.R.L - Tập 4 - Trang 1-13 - 2012
Bryan Simoneau, François Houle, Jacques Huot
Loss of endothelial cell integrity and selective permeability barrier is an early event in the sequence of oxidant-mediated injury and may result in atherosclerosis, hypertension and facilitation of transendothelial migration of cancer cells during metastasis. We already reported that endothelial cell integrity is tightly regulated by the balanced co-activation of p38 and ERK pathways. In particul... hiện toàn bộ
A novel endothelial-derived anti-inflammatory activity significantly inhibits spontaneous choroidal neovascularisation in a mouse model
Publiverse Online S.R.L - Tập 8 - Trang 1-12 - 2016
Laura Paneghetti, Yin-Shan Eric Ng
Endothelial cells (EC) grown on collagen particles inhibit intimal hyperplasia in animal models when applied perivascularly, and this effect appears to be, at least in part, the result of EC-derived soluble factors that suppress local vascular inflammation. To elucidate the molecular basis of the therapeutic effects of EC grown on collagen particles, the anti-inflammatory activity of conditioned m... hiện toàn bộ
Therapeutic manipulation of angiogenesis with miR-27b
Publiverse Online S.R.L - Tập 7 Số 1 - 2015
Dorina Veliceasa, Dauren Biyashev, Gangjian Qin, Sol Misener, Alexander R Mackie, Raj Kishore, Olga V. Volpert
Effects of a novel cyclic RGD peptidomimetic on cell proliferation, migration and angiogenic activity in human endothelial cells
Publiverse Online S.R.L - Tập 6 - Trang 1-9 - 2014
Roberto Fanelli, Laura Schembri, Umberto Piarulli, Monica Pinoli, Emanuela Rasini, Mayra Paolillo, Marisa Carlotta Galiazzo, Marco Cosentino, Franca Marino
Cyclic RGD peptidomimetics containing a bifunctional diketopiperazine scaffold are a novel class of high-affinity ligands for the integrins αVβ3 and αVβ5. Since integrins are a promising target for the modulation of normal and pathological angiogenesis, the present study aimed at characterizing the ability of the RGD peptidomimetic cyclo[DKP-RGD] 1 proliferation, migration and network formation in... hiện toàn bộ
Myeloid cells in tumor inflammation
Publiverse Online S.R.L - Tập 4 - Trang 1-7 - 2012
Michael C Schmid, Judith A Varner
Bone marrow derived myeloid cells progressively accumulate in tumors, where they establish an inflammatory microenvironment that is favorable for tumor growth and spread. These cells are comprised primarily of monocytic and granulocytic myeloid derived suppressor cells (MDSCs) or tumor-associated macrophages (TAMs), which are generally associated with a poor clinical outcome. MDSCs and TAMs promot... hiện toàn bộ
Nanotechnology-mediated targeting of tumor angiogenesis
Publiverse Online S.R.L - Tập 3 - Trang 1-13 - 2011
Deboshri Banerjee, Rania Harfouche, Shiladitya Sengupta
Angiogenesis is disregulated in many diseased states, most notably in cancer. An emerging strategy for the development of therapies targeting tumor-associated angiogenesis is to harness the potential of nanotechnology to improve the pharmacology of chemotherapeutics, including anti-angiogenic agents. Nanoparticles confer several advantages over that of free drugs, including their capability to car... hiện toàn bộ
Mechanical stretch: physiological and pathological implications for human vascular endothelial cells
Publiverse Online S.R.L - Tập 7 Số 1 - 2015
Nurul Farhana Jufri, Abidali Mohamedali, Alberto Avolio, Mark S. Baker
Pleiotrophin expression and role in physiological angiogenesis in vivo: potential involvement of nucleolin
Publiverse Online S.R.L - Tập 4 Số 1 - Trang 4 - 2012
Μαρίνα Κουτσιούμπα, Γεωργία Δρόσου, Constantinos M. Mikelis, Katerina Theochari, Dionussios Vourtsis, Panagiotis Katsoris, Efstathia Giannopoulou, José Courty, Christos Petrou, Vassiliki Magafa, Paul Cordopatis, Εvangelia Papadimitriou
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