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Neurochemichal aspects of the pharmacological effect of 2,3,4-trimethoxy-N’-(8-methyl-8-azabicyclo[3.2.1.] octan-3-ylidene) benzohydrazide hydrochloride (LK-933)
Pleiades Publishing Ltd - Tập 11 - Trang 242-245 - 2017
P. L. Naplekova, V. B. Narkevich, V. S. Kudrin, L. M. Kostochka, T. A. Voronina
The objective of this study was to investigate the effects of 2,3,4-trimethoxy-N'-(8-metyl-8-azabicyclo[3.2.1.] octan-3-ylidene) benzohydrazide hydrochloride (LK-933), a compound of the tropane group with anxiolytic and antimigraine activity, on the levels of monoamines and their metabolites in different brain structures of outbred mice using HPLC–ED. Administration of LK-933 caused an increase in...... hiện toàn bộ
Ferroptosis in the Pathogenesis of Alzheimer’s Disease: The New Evidence for Validation of FAB Model
Pleiades Publishing Ltd - - 2023
M. I. Aghajanov, H. S. Harutyunyan, Arpine Khamperyan, G. A. Karapetyan, Katarine Fereshetyan, Konstantin Yenkoyan
Abstract Alzheimer’s disease is an age-associated progressive disorder, characterized by neurodegeneration and following cognitive decline. Several pathological alterations are implicated in its pathogenesis, hence etiology is still poorly understood. Ferroptosis is an alternative form of cell death, driven by intracellula...... hiện toàn bộ
The acute and delayed effects of perinatal hypoxic brain damage in children and in model experiments with rodents
Pleiades Publishing Ltd - Tập 10 - Trang 258-272 - 2016
I. A. Sukhanova, E. A. Sebentsova, N. G. Levitskaya
Perinatal hypoxia is an important factor that has a negative influence on the development of the central nervous system. Children who experience perinatal hypoxia are characterized by disturbances of locomotor functions, decreased learning abilities, attention disorder, hyperactivity, increased anxiety, and other cognitive impairments. The consequences of perinatal hypoxia are actively studied in ...... hiện toàn bộ
Activation of Serotonin System in the Medial Prefrontal Cortex by Sound Signals of Danger
Pleiades Publishing Ltd - Tập 14 - Trang 408-414 - 2020
N. B. Saul’skaya, O. E. Marchuk, M. A. Puzanova, N. A. Trofimova
Abstract—Intracerebral microdialysis in Sprague-Dawley rats showed that a conditioned sound signal (CS+) previously reinforced by unavoidable electrocutaneous stimulation (fear conditioning test) is accompanied by an increased level of extracellular serotonin in the medial prefrontal cortex and provokes freezing behavior (fear index). A differential sound signal (CS–) not associated with pain stim...... hiện toàn bộ
Influence of Prenatal Stress on the Activity of Antioxidant Enzymes in the Subcellular Fractions of the Neurons and Neuroglia of the Rat Neocortex
Pleiades Publishing Ltd - Tập 14 - Trang 187-190 - 2020
A. V. V’yushina, A. V. Pritvorova, O. G. Semenova, N. E. Ordyan
Abstract—We studied the effect of prenatal stress on the activity of glutathione-bound enzymes in the subcellular fractions of neurons and neuroglia of rat neocortex. The results of the study showed that prenatal stress causes changes in the activity of these enzymes in both neurons and neocortical neuroglia. These changes differ in the subcellular fractions of the studied cell populations. In the...... hiện toàn bộ
The Effect of Subchronic Alcoholization on the Behavior and Monoaminergic Systems of the Brains of Mice with a Predisposition to Depression-Like Behavior
Pleiades Publishing Ltd - - 2023
Д. В. Базовкина, Е. М. Кондаурова, S. N. Adonina, Ekaterina Bazhenova, А. В. Куликов
The role of glutamate and GABA receptors in the anticonvulsive effects of levetiracetam and a 4-phenylpirrolidone derivative (GIZh-290) in rats
Pleiades Publishing Ltd - Tập 11 - Trang 332-339 - 2017
I. G. Kovalev, E. V. Vasil’eva, E. A. Kondrakhin, T. A. Voronina, G. I. Kovalev
The method of radioligand binding ex vivo has been used to evaluate the involvement of the ionotropic and metabotropic glutamate and GABA receptors in the mechanism of anticonvulsant action of levetiracetam and the original compound GIZh-290 (2-oxo-4-phenylpyrrolidin-1-yl) acetic acid) in the rat brain. We found that at the peak of lithium-pilocarpine seizures, the Bmax value (the density of speci...... hiện toàn bộ
Effects of guanidine derivatives on the activities of superoxide dismutase and catalase during postischemic reperfusion in the rat brain
Pleiades Publishing Ltd - Tập 4 - Trang 217-221 - 2010
A. V. Makeeva, T. N. Popova, O. V. Sukhoveeva, L. F. Panchenko
We studied the effects of guanidine derivatives on the activity of superoxide dismutase and catalase in the brain tissue and blood serum of rats after cerebral ischemia-reperfusion. We found that treatment with N-[imino(1-piperidinyl)methyl]guanidine or N-[imino(4-morpholinyl)methyl]guanidine resulted in normalization of the level of the primary products of lipid peroxidation, which was increased ...... hiện toàn bộ
The Effect of Noopept on Neurochemical Changes in the Retina during the Experimental Thrombosis of Its Vessels
Pleiades Publishing Ltd - Tập 13 - Trang 62-67 - 2019
A. V. Kolesnikov, A. V. Shchul’kin, O. I. Barenina, E. N. Yakusheva, V. S. Kudrin, R. U. Ostrovskaya, M. G. Uzbekov, M. M. Shishkin
We studied the effect of the neuroprotective dipeptide drug noopept on the level of biogenic amines in the retina during the thrombosis of its vessels in experiments with male chinchilla rabbits. Ischemic lesion of the retina was modeled by intravenous administration of rose bengal at a dose of 40 mg/kg body weight followed by 10-min transpupillary focal illumination of the temporal vascular arcad...... hiện toàn bộ
A Predicted Molecular Model for Development of Human Intelligence
Pleiades Publishing Ltd - - 2018
Hadi Najafi, Seyed Abolfazl Hosseini, Mahmood Tavallaie, Bahram Mohammad Soltani
Tổng số: 579   
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