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The Effect of Atypical Antipsychotic Drugs on the Neurotrophic Factors Gene Expression in the MPTP Model of Parkinson’s Disease
Pleiades Publishing Ltd - - 2019
А. С. Цыбко, Tatiana V. Ilchibaeva, Nikita V. Khotskin, A. I. Kovetskaya, В. С. Науменко, Н. К. Попова
A Short Review of Biochemical Mechanisms in Iminodipropionitrile-Induced Movement Disorder
Pleiades Publishing Ltd - Tập 14 - Trang 9-12 - 2020
Sara T. Alrashood, Mohamed S. Elrobh, Salman Alamery, Hamza A. Odeibat, Haseeb A. Khan
Iminodipropionitrile (IDPN) is a synthetic nitrile that produces permanent behavioral syndrome characterized by repetitive head movements, circling and back walking in rodents. Other synthetic nitriles of industrial importance such as crotonitrile and allylnitrile are also able to produce similar motor deficits in experimental animals. Among these nitriles, IDPN has been recognized as a prototype ... hiện toàn bộ
Neurochemichal aspects of the pharmacological effect of 2,3,4-trimethoxy-N’-(8-methyl-8-azabicyclo[3.2.1.] octan-3-ylidene) benzohydrazide hydrochloride (LK-933)
Pleiades Publishing Ltd - Tập 11 - Trang 242-245 - 2017
P. L. Naplekova, V. B. Narkevich, V. S. Kudrin, L. M. Kostochka, T. A. Voronina
The objective of this study was to investigate the effects of 2,3,4-trimethoxy-N'-(8-metyl-8-azabicyclo[3.2.1.] octan-3-ylidene) benzohydrazide hydrochloride (LK-933), a compound of the tropane group with anxiolytic and antimigraine activity, on the levels of monoamines and their metabolites in different brain structures of outbred mice using HPLC–ED. Administration of LK-933 caused an increase in... hiện toàn bộ
Signal functions of NCAM
Pleiades Publishing Ltd - - 2007
V. P. Chekhonin, I. I. Shepeleva, О. И. Гурина
Quantification of the hypothalamic proline rich polypeptide-1 in rat blood serum
Pleiades Publishing Ltd - Tập 8 - Trang 38-43 - 2014
S. S. Abrahamyan, T. K. Davtyan, A. R. Khachatryan, N. V. Tumasyan, I. K. Sahakyan, H. A. Harutyunyan, S. G. Chailyan, A. A. Galoyan
Proline rich polypeptide-1 (PRP-1) consisting of 15 amino acid residues (AGAPEPAEPAQPGVY) is a regulatory hypothalamic peptide possessing neuroprotective, immunoregulatory, hematopoietic, and antimicrobial properties. In order to quantify PRP-1 in rat blood, an enzyme linked immunosorbent assay (ELISA) has been applied using polyclonal antibody raised against the synthetic PRP-1 named “Galarmin”. ... hiện toàn bộ
Cholesterol and lipid rafts in the plasma membrane of nerve terminal and membrane of synaptic vesicles
Pleiades Publishing Ltd - Tập 5 - Trang 13-19 - 2011
A. M. Petrov, K. E. Kudryashova, Yu. G. Odnoshivkina, A. L. Zefirov
In this study, using neuromusclar preparations of frog cutaneous pectoris muscle and mouse diaphragm we have shown that the membranes of nerve terminals (NT) contain nearly two times more cholesterol than the plasma membrane of muscle fibers. Using the fluorescent B subunit of cholera toxin (CT-B), we identified the areas in the NT membranes with high concentrations of GM1 ganglioside, the marker ... hiện toàn bộ
Ferroptosis in the Pathogenesis of Alzheimer’s Disease: The New Evidence for Validation of FAB Model
Pleiades Publishing Ltd - - 2023
M. I. Aghajanov, H. S. Harutyunyan, Arpine Khamperyan, G. A. Karapetyan, Katarine Fereshetyan, Konstantin Yenkoyan
Abstract Alzheimer’s disease is an age-associated progressive disorder, characterized by neurodegeneration and following cognitive decline. Several pathological alterations are implicated in its pathogenesis, hence etiology is still poorly understood. Ferroptosis is an alternative form of cell death, driven by intracellular accumulation of iron with subsequent reactive oxygen species formation, wh... hiện toàn bộ
Analysis of conditions that are important for the beginning of consolidation in a model of long-term synaptic potentiation
Pleiades Publishing Ltd - Tập 7 - Trang 184-191 - 2013
I. V. Kudryashova
Long-term potentiation (LTP) is one of the most studied forms of long-term plasticity. Irreversible final modifications are a specific feature of the late phase of LTP. However, the initial modifications may disappear spontaneously or under conditions of less intense tetanization or the influence of depotentiating factors. The protein-dependent consolidation process, which mainly occurs within the... hiện toàn bộ
The acute and delayed effects of perinatal hypoxic brain damage in children and in model experiments with rodents
Pleiades Publishing Ltd - Tập 10 - Trang 258-272 - 2016
I. A. Sukhanova, E. A. Sebentsova, N. G. Levitskaya
Perinatal hypoxia is an important factor that has a negative influence on the development of the central nervous system. Children who experience perinatal hypoxia are characterized by disturbances of locomotor functions, decreased learning abilities, attention disorder, hyperactivity, increased anxiety, and other cognitive impairments. The consequences of perinatal hypoxia are actively studied in ... hiện toàn bộ
Activation of Serotonin System in the Medial Prefrontal Cortex by Sound Signals of Danger
Pleiades Publishing Ltd - Tập 14 - Trang 408-414 - 2020
N. B. Saul’skaya, O. E. Marchuk, M. A. Puzanova, N. A. Trofimova
Abstract—Intracerebral microdialysis in Sprague-Dawley rats showed that a conditioned sound signal (CS+) previously reinforced by unavoidable electrocutaneous stimulation (fear conditioning test) is accompanied by an increased level of extracellular serotonin in the medial prefrontal cortex and provokes freezing behavior (fear index). A differential sound signal (CS–) not associated with pain stim... hiện toàn bộ
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