Physiological Research

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Age-Dependent Salt Hypertension in Dahl Rats: Fifty Years of Research
Physiological Research - - Trang S35-S87 - 2012
Josef Zicha, Z Dobešová, M. Vokurková, H Rauchová, Silvie Hojná, Michaela Kadlecová, Michal Behuliak, Ivana Vaněčková, Jaroslav Kuneš
Fifty years ago, Lewis K. Dahl has presented a new model of salt hypertension – salt-sensitive and salt-resistant Dahl rats. Twenty years later, John P. Rapp has published the first and so far the only comprehensive review on this rat model covering numerous aspects of pathophysiology and genetics of salt hypertension. When we summarized 25 years of our own research on Dahl/Rapp rats, we have real... hiện toàn bộ
Red wine polyphenols prevent cyclosporine-induced nephrotoxicity at the level of the intrinsic apoptotic pathway
Physiological Research - - Trang 511-519 - 2009
Rita Rezzani, Sandra Tengattini, Francesca Bonomini, Francesca Filippini, Oľga Pecháňová, Rossella Bianchi, Ramaroson Andriantsitohaina
Flavonoids, polyphenol derivatives of plant origin, possess a broad range of pharmacological properties. A number of studies have found both pro/anti-apoptotic effects for many of these compounds. For these reasons we investigated whether ProvinolsTM, flavonoids obtained from red wine, have antiapoptotic properties. The investigations have been carried out in rats treated with Cyclosporine A (CsA)... hiện toàn bộ
Adhesion, Growth and Differentiation of Osteoblasts on Surface-Modified Materials Developed for Bone Implants
Physiological Research - - Trang 403-417 - 2011
Marta Vandrovcová, Lucie Bačáková
This review briefly outlines the history and possibilities of bone reconstruction using various types of artificial materials, which allow interaction with cells only on the surface of the implant or enable ingrowth of cells inside the material. Information is also provided on the most important properties of bone cells taking part in bone tissue development, and on diseases and regeneration. The ... hiện toàn bộ
Effect of High Glucose Concentrations on Expression of ELAM 1, VCAM-1 and ICAM-1 in HUVEC with and without Cytokine Activation.
Physiological Research - - Trang 77-82 - 2004
Tsevegjav Altannavch, K Roubalová, P Kučera, Michal Anděl
Diabetes mellitus is associated with an increased prevalence of endothelial dysfunction and development of atherosclerotic vascular diseases. We demonstrate here that hyperglycemia results in the expression of adhesion molecules on endothelial cells in vitro. Incubation of human umbilical vein endothelial cells (HUVEC) in a culture medium with 11.0 mM, 16.5 mM and 22.0 mM glucose concentrations in... hiện toàn bộ
The Steroid Spectrum During and After Quitting Smoking
Physiological Research - - Trang S211-S218 - 2015
Hana Jandíková, Michaela Dušková, Kateřina Šimůnková, B. Rácz, Martin Hill, Eva Králíková, K Vondra, L Stárka
Addiction to tobacco results in an imbalance of endocrine homeostasis in both sexes. This can also have impacts on fertility problems. The male reproductive system is less susceptible than that of females, with a worsening spermiogram in smokers, the most cited effect in the literature. However, the literature is inconsistent as to the effects of smoking on steroid hormone levels in men, and there... hiện toàn bộ
Defective Ca2+ Handling Proteins Regulation During Heart Failure
Physiological Research - - Trang 27-37 - 2011
S.-T. HU, Gang Liu, Y.-F. SHEN, Yongliang Wang, Yansong Tang, Y.-J. YANG
Abnormal release of Ca2+ from sarcoplasmic reticulum (SR) via the cardiac ryanodine receptor (RyR2) may contribute to contractile dysfunction in heart failure (HF). We previously demonstrated that RyR2 macromolecular complexes from HF rat were significantly more depleted of FK506 binding protein (FKBP12.6). Here we assessed expression of key Ca2+ handling proteins and measured SR Ca2+ content in c... hiện toàn bộ
Lipoprotein (a) and its position among other risk factors of atherosclerosis
Physiological Research - - Trang 777-784 - 2008
Lukáš Zlatohlávek, K Zídková, Michal Vráblík, Tara L. Haas, Martina Vaclová, Helena Svobodová, R Češka
Lipoprotein(a) [Lp(a)] comprises of an LDL particle and apolipoprotein(a) [apo(a)] and its elevated levels are considered a risk factor for atherosclerosis. The aim of our study was to find out whether elevated Lp(a) levels are associated with increased risk of atherosclerosis in patients with multiple other risk factors. We further tested the association of three polymorphisms of the apo(a) gene ... hiện toàn bộ
Spectral analysis of heart rate variability in sleep.
Physiological Research - - Trang 369-376 - 2005
Petr Bušek, J Vaňková, J Opavský, Johanna Salinger, Soňa Nevšímalová
Spectral analysis of heart rate variability (HRV) during overnight polygraphic recording was performed in 11 healthy subjects. The total spectrum power, power of the VLF, LF and HF spectral bands and the mean R-R were evaluated. Compared to Stage 2 and Stage 4 non-REM sleep, the total spectrum power was significantly higher in REM sleep and its value gradually increased in the course of each REM c... hiện toàn bộ
Induction of MicroRNA-24 by HIF-1 Protects Against Ischemic Injury in Rat Cardiomyocytes
Physiological Research - - Trang 555-565 - 2012
Dong Li, Jing Tian, Xin Guo, Longtai Huang, Yungen Xu, Chih‐Chieh Wang, Jia Wang, Anmin Ren, Wei Yuan, Longxin Lin
MicroRNAs are emerging as important regulators of cardiac function. This study investigated the role of microRNA-24 (miR-24) in ischemic cardiomyocytes, based on the observation that miR-24 expression was significantly enhanced in the ischemic myocardium of rats. Using primary cultured rat cardiomyocytes, cell injury was induced by ischemic conditions, and the cells were evaluated for changes in l... hiện toàn bộ
New Insights Into the Physiology of Bone Regulation: the Role of Neurohormones
Physiological Research - - Trang 421-427 - 2014
I Žofková, Petr Matucha
Bone metabolism is regulated by interaction between two skeletal cells – osteoclasts and osteoblasts. Function of these cells is controlled by a number of humoral factors, including neurohormones, which ensure equilibrium between bone resorption and bone formation. Influence of neurohormones on bone metabolism is often bimodal and depends on the tissue, in which the hormone is expressed. While hyp... hiện toàn bộ
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