The Steroid Spectrum During and After Quitting Smoking

Physiological Research - Trang S211-S218 - 2015
Hana Jandíková1, Michaela Dušková1, Kateřina Šimůnková1,2, B. Rácz1, Martin Hill1, Eva Králíková3,4, K Vondra1, L Stárka1
1Institute of Endocrinology, Prague, Czech Republic
2Third Department of Medicine, First Faculty of Medicine, Charles University and General University Hospital, Prague, Czech Republic
3Institute of Hygiene and Epidemiology, First Faculty of Medicine, Charles University and General University Hospital, Prague, Czech Republic
4The Center for Tobacco Dependence, Third Medical Department -Department of Endocrinology and Metabolism, First Faculty of Medicine, Charles University and General University Hospital, Prague, Czech Republic,

Tóm tắt

Addiction to tobacco results in an imbalance of endocrine homeostasis in both sexes. This can also have impacts on fertility problems. The male reproductive system is less susceptible than that of females, with a worsening spermiogram in smokers, the most cited effect in the literature. However, the literature is inconsistent as to the effects of smoking on steroid hormone levels in men, and there is very little data on the effects of quitting smoking in men. In this study we followed 76 men before quitting smoking, and then after 6, 12, and 24 weeks and 1 year of abstinence. We measured basic anthropomorphic data and steroid hormone levels along with steroid neuroactive metabolites using GC-MS. We demonstrate lower androgen levels in men who smoke, and these changes worsened after quitting smoking. There was a drop in SHBG already in the first week of non-smoking, and levels continued to remain low. Male smokers have lower androgen levels compared to non-smokers. The lower the initial level of androgen, the lower the likelihood of success in quitting smoking. Changes in steroid hormones proved to be a promising marker for the prediction of success in quitting smoking.

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Tài liệu tham khảo

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Physiological Research

S211-S218

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