Physiological Research
SCIE-ISI SCOPUS (1969,1991-2023)
0862-8408
1802-9973
Cộng hòa Séc
Cơ quản chủ quản: Czech Academy of Sciences , ACAD SCIENCES CZECH REPUBLIC, INST PHYSIOLOGY
Lĩnh vực:
Medicine (miscellaneous)Physiology
Các bài báo tiêu biểu
Mast-Cell Degranulation Induced by Physical Stimuli Involves the Activation of Transient-Receptor-Potential Channel TRPV2A characteristic of mast cells is the degranulation in response to various stimuli. Here we have investigated the effects of various physical stimuli in the human mast-cell line HMC-1. We have shown that HMC-1 express the transient receptor potential channels TRPV1, TRPV2 and TRPV4. In the whole-cell patch-clamp configuration, increasing mechanical stress applied to the mast cell by hydros... ...
- Trang 113-124 - 2012
Adhesion, Growth and Differentiation of Osteoblasts on Surface-Modified Materials Developed for Bone ImplantsThis review briefly outlines the history and possibilities of bone reconstruction using various types of artificial materials, which allow interaction with cells only on the surface of the implant or enable ingrowth of cells inside the material. Information is also provided on the most important properties of bone cells taking part in bone tissue development, and on diseases and regenerati... ...
- Trang 403-417 - 2011
Spectral analysis of heart rate variability in sleep.Spectral analysis of heart rate variability (HRV) during overnight polygraphic recording was performed in 11 healthy subjects. The total spectrum power, power of the VLF, LF and HF spectral bands and the mean R-R were evaluated. Compared to Stage 2 and Stage 4 non-REM sleep, the total spectrum power was significantly higher in REM sleep and its value gradually increased in the course of ea... ...
- Trang 369-376 - 2005
Genetic defects of cytochrome c oxidase assemblyCytochrome c oxidase (COX), the terminal enzyme of the mitochondrial respiratory chain, is one of the key functional and regulatory sites of the mammalian energy metabolism. Owing to the importance of the enzyme, pathogenetic mutations affecting COX frequently result in severe, often fatal metabolic disorders. No satisfactory therapy is currently available so that the treatment remains lar... ...
- Trang S213-S223 - 2004
Effect of High Glucose Concentrations on Expression of ELAM 1, VCAM-1 and ICAM-1 in HUVEC with and without Cytokine Activation.Diabetes mellitus is associated with an increased prevalence of endothelial dysfunction and development of atherosclerotic vascular diseases. We demonstrate here that hyperglycemia results in the expression of adhesion molecules on endothelial cells in vitro. Incubation of human umbilical vein endothelial cells (HUVEC) in a culture medium with 11.0 mM, 16.5 mM and 22.0 mM glucose concentra... ...
- Trang 77-82 - 2004
The influence of wine polyphenols on reactive oxygen and nitrogen species production by rat macrophages RAW 264.7The aim was to study the antioxidant properties of four wine
polyphenols (flavonoids catechin, epicatechin, and quercetin, and
hydroxystilbene resveratrol). All three flavonoids exerted
significant and dose-dependent scavenging effects against
peroxyl radical and nitric oxide in chemical systems. The
scavenging effect of resveratrol was significantly lower. All
polyphenols decreased produc... ...
- Trang 393-402 - 2008
Age-Dependent Salt Hypertension in Dahl Rats: Fifty Years of ResearchFifty years ago, Lewis K. Dahl has presented a new model of salt hypertension – salt-sensitive and salt-resistant Dahl rats. Twenty years later, John P. Rapp has published the first and so far the only comprehensive review on this rat model covering numerous aspects of pathophysiology and genetics of salt hypertension. When we summarized 25 years of our own research on Dahl/Rapp rats, we h... ...
- Trang S35-S87 - 2012
Biogenesis of eukaryotic cytochrome c oxidaseEukaryotic cytochrome c oxidase (CcO), the terminal component of the mitochondrial electron transport chain is a heterooligomeric complex that belongs to the superfamily of heme-copper containing terminal oxidases. The enzyme, composed of both mitochondrially and nuclear encoded subunits, is embedded in the inner mitochondrial membrane, where it catalyzes the transfer of electrons form red... ...
- Trang S27-S41 - 2006
Cardiovascular parameters in rat model of chronic renal failure induced by subtotal nephrectomyChronic renal failure (CRF) is associated with high incidence of
cardiovascular complications. To clarify pathogenesis of CRF
numerous animal models have been developed. The aim of our
work was to describe methodology of subtotal surgical renal
ablation in rat and to characterize some biochemical and
cardiovascular parameters of this animal model. Male rats
underwent 5/6 surgical nephrecto... ...
- Trang S81-S88 - 2010
Allosteric Modulation of Ligand Gated Ion Channels by IvermectinIvermectin acts as a positive allosteric regulator of several ligand-gated channels including the glutamate-gated chloride channel (GluCl), aminobutyric acid type-A receptor, glycine receptor, neuronal α7-nicotinic receptor and purinergic P2X4 receptor. In most of the ivermectin-sensitive channels, the effects of ivermectin include the potentiation of agonist-induced currents at low conc... ...
- Trang S215-S224 - 2014