Pharmaceutical Research
1573-904X
Cơ quản chủ quản: N/A
Phân tích ảnh hưởng
Các bài báo tiêu biểu
The Effect of Excipients on the Molecular Mobility of Lyophilized Formulations, as Measured by Glass Transition Temperature and NMR Relaxation-Based Critical Mobility Temperature
Tập 16 Số 1 - Trang 135-140 - 1999
Purpose. The dependence of the molecular mobility of lyophilized formulations on pharmaceutical polymer excipients was studied. Molecular mobility as determined by NMR relaxation-based critical temperature of molecular mobility (Tmc) and glass transition temperature (Tg) is discussed in relation to the plasticizing effect of water in formulations. Methods. The Tmc and Tg of lyophilized γ-globulin ......
Use of Modified Ethylcellulose Lattices for Microporous Coating of Osmotic Tablets
Tập 8 Số 5 - Trang 600-604 - 1991
Commercially available lattices are often used to coat nonpareils or beads. Drug release occurs via diffusion through the polymer coating. Adequate release rates may be achieved with small particles because the surface area is large. However, tablets coated with unmodified lattices have exceedingly slow release rates. Therefore, a pore-forming agent, urea, was added to a commercially available eth......
Intestinal Drug Absorption and Metabolism in Cell Cultures: Caco-2 and Beyond
Tập 14 Số 12 - Trang 1655-1658 - 1997
Assay for Hydralazine as Its Stable p-Nitrobenzaldehyde Hydrazone
Tập 5 Số 6 - Trang 383-386 - 1988
A new method of analysis for the antihypertensive drug, hydralazine, is introduced. The assay involves the addition of p-nitrobenzaldehyde to blood samples containing hydralazine, to form a stable Schiff's base, hydralazine p-nitrobenzaldehyde hydrazone. The derivative is extracted from the blood into hexane and the samples are dried under a nitrogen stream. The extracts are then dissolved in mobi......
The Stability of Insulin in Crystalline and Amorphous Solids: Observation of Greater Stability for the Amorphous Form
Tập 14 Số 10 - Trang 1379-1387 - 1997
Purpose. Generalizations based upon behavior of small molecules have established that a crystalline solid is generally much more stable toward chemical degradation than is the amorphous solid. This study examines the validity of this generalization for proteins using biosynthetic human insulin as the model protein. Methods. Amorphous insulin was prepared by freeze drying the supernate from a suspe......
In Vivo and in Vitro Assessment of Baseline Blood-Brain Barrier Parameters in the Presence of Novel Nanoparticles
Tập 20 Số 5 - Trang 705-713 - 2003
Purpose. Nanoparticles have advantage as CNS drug delivery vehicles given they disguise drug permeation limiting characteristics. Conflicting toxicological data, however, is published with regard to blood-brain barrier integrity and gross mortality. Methods. To address this issue two novel nanoparticle types: “emulsifying wax/Brij 78”and Brij 72/Tween 80 nanoparticles were evaluated in vivo for ef......
Antisense c-myc Oligodeoxyribonucleotide Cellular Uptake
Tập 9 Số 8 - Trang 1010-1017 - 1992
Antisense oligonucleotides have therapeutic potential as inhibitors of gene expression. However, the mechanism by which an intact oligonucleotide reaches the intracellular site of action is unknown. In this study, we use an Oligodeoxyribonucleotide 21-mer complementary to the translation initiation codon of the c-myc proto-oncogene to study the mechanism of oligonucleotide uptake and internalizati......
Cationic Polymer Based Gene Delivery Systems
Tập 17 Số 2 - Trang 113-126 - 2000
Gene transfer to humans requires carriers for the plasmid DNA which canefficiently and safely carrythe gene into the nucleus of the desired cells. A series of chemically differentcationic polymers arecurrently being investigated for these purposes. Although many cationic polymersindeed condense DNAspontaneously, which is a requirement for gene transfer in most types of cells,the physicochemical an......
Immunostimulating Polysaccharides from Panax notoginseng
Tập 13 Số 8 - Trang 1196-1200 - 1996
Purpose. The main purpose of this study is to prepare and characterize polysaccharides from Panax notoginseng, investigate their effects on immune system in vitro in order to find new immunostimulants for the prevention and supporting treatment of infection and immunodeficiency related diseases. Methods. Polysaccharides were extracted with aqueous solution, separated with column chromatography. Th......