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Pharmaceutical Research

  1573-904X

 

 

 

Cơ quản chủ quản:  N/A

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Các bài báo tiêu biểu

In Vivo and in Vitro Assessment of Baseline Blood-Brain Barrier Parameters in the Presence of Novel Nanoparticles
Tập 20 Số 5 - Trang 705-713 - 2003
Lockman, Paul R., Koziara, Joanna, Roder, Karen E., Paulson, Jennifer, Abbruscato, Thomas J., Mumper, Russell J., Allen, David D.
Purpose. Nanoparticles have advantage as CNS drug delivery vehicles given they disguise drug permeation limiting characteristics. Conflicting toxicological data, however, is published with regard to blood-brain barrier integrity and gross mortality. Methods. To address this issue two novel nanoparticle types: “emulsifying wax/Brij 78”and Brij 72/Tween 80 nanoparticles were evaluated in vivo for ef... hiện toàn bộ
Comparison of the Anticancer Effect of Free and HPMA Copolymer-Bound Adriamycin in Human Ovarian Carcinoma Cells
Tập 16 Số 7 - Trang 986-996 - 1999
Minko, Tamara, Kopečková, Pavla, Kopeček, Jindřich
Purpose. To study peculiarities and the mechanism of the anticancer effect of free and HPMA copolymer-bound ADR in sensitive and resistant human ovarian carcinoma cells. Methods. Sensitive A2780 and ADR resistant A2780/AD cells were exposed to different doses of drugs during 12, 24, 36, 48, 60, and 72 hours. Cell viability, drug accumulation, apoptosis, cellular metabolism, lipid peroxidation, DNA... hiện toàn bộ
Evidence for Overlapping Substrate Specificity Between Large Neutral Amino Acid (LNAA) and Dipeptide (hPEPTl) Transporters for PD 158473, an NMDA Antagonist
Tập 16 Số 3 - Trang 391-395 - 1999
Surendran, Narayanan, Covitz, Kuang-Ming Y., Han, Hyo-kyung, Sadee, Wolfgang, Oh, Doo-Man, Amidon, Gordon L., Williamson, Rufus M., Bigge, Christopher F., Stewart, Barbra H.
Purpose. The objective of this research was to investigate the substrate specificity of large neutral amino acid carrier (LNAA) and di/tripeptide (hPEPTl) transporters with respect to PD 158473, an NMDA antagonist. Methods. Cellular uptake studies were carried out using two types of Chinese Hamster Ovary (CHO). CHO-K1 cells represent the wild type with inherent large neutral amino acid (LNAA) acti... hiện toàn bộ
A Solid-State NMR Study of Protein Hydration and Stability
Tập 15 Số 12 - Trang 1816-1821 - 1998
Separovic, F., Lam, Y. H., Ke, X., Chan, H.-K.
Purpose. The mobility of protein in powders at different hydration levels was studied in relation to aggregation and activity. Methods. Magic angle spinning 13C, 15N, 1H, 2H, and 17O NMR techniques were used to determine changes in the mobility of surface residues in proteins as a function of hydration and related to changes in activity. NMR relaxation measurements of high frequency (ω0, T1) and l... hiện toàn bộ
Development of a Remote Electrode System for Monitoring the Water Content of Materials Inside a Glass Vial
Tập 19 Số 3 - Trang 337-344 - 2002
Suherman, Phe Man, Taylor, Peter M., Smith, Geoff
Purpose: This article explores the use of a remote electrode dielectric measurement system to monitor the water content of hydrated ovalbumin inside a glass vial. Methods: The intrinsic dielectric properties of hydrated ovalbumin were characterized first using conventional parallel plate electrodes. The second stage was to simulate a remote electrode measurement by placing nonconductive, nondisper... hiện toàn bộ
Techniques for Assessing the Effects of Pharmaceutical Excipients on the Aggregation of Porcine Growth Hormone
Tập 10 Số 7 - Trang 954-962 - 1993
Charman, Susan A., Mason, Kaye L., Charman, William N.
Three denaturing techniques have been evaluated for their ability to induce irreversible aggregation and precipitation of recombinant porcine growth hormone (pGH). The denaturing stimuli included thermal denaturation, interfacial denaturation through the introduction of a high air/water interface by vortex agitation, and a guanidine (Gdn) HC1 technique which involved rapid dilution of a partially ... hiện toàn bộ
Mucoadhesive Polymers in Peroral Peptide Drug Delivery. II. Carbomer and Polycarbophil Are Potent Inhibitors of the Intestinal Proteolytic Enzyme Trypsin
Tập 12 Số 9 - Trang 1293-1298 - 1995
Lueßen, Henrik L., Verhoef, J. Coos, Borchard, Gerrit, Lehr, Claus-M., de Boer, A. (Bert) G., Junginger, Hans E.
Purpose. The evaluation of the inhibitory action of two mucoadhesive poly(acrylates), polycarbophil and carbomer, registered by the Food and Drug Administration (FDA), on the intestinal proteolytic enzyme trypsin. Methods. The effect of the polymers on trypsin activity by measuring the degradation of a trypsin specific substrate. Binding of Ca2+ ions and proteins (125I-BSA) to the poly(acrylates).... hiện toàn bộ
Hot Melt Extrusion of Acrylic Films
Tập 13 Số 5 - Trang 804-808 - 1996
Aitken-Nichol, Carolyn, Zhang, Feng, McGinity, James W.
Hydrophilic Matrices for Controlled Drug Delivery: An Improved Mathematical Model to Predict the Resulting Drug Release Kinetics (the “sequential Layer” Model)
Tập 17 Số 10 - Trang 1290-1298 - 2000
Siepmann, J., Peppas, N. A.
Purpose. The aims of this study were (i) to elucidate the transport mechanisms involved in drug release from hydrophilic matrices; and (ii) to develop an improved mathematical model allowing quantitative predictions of the resulting release kinetics. Methods. Our previously presented model has been substantially modified, by adding: (i) inhomogeneous swelling; (ii) poorly water-soluble drugs; and ... hiện toàn bộ
Uptake of FITC-Chitosan Nanoparticles by A549 Cells
Tập 19 Số 10 - Trang 1488-1494 - 2002
Huang, Min, Ma, Zengshuan, Khor, Eugene, Lim, Lee-Yong
Purpose. The objective of this study was to evaluate the extent and mechanism of uptake of fluorescent chitosan nanoparticles by the A549 cells, a human cell line derived from the respiratory epithelium. Methods. Covalent conjugation with fluorescein-5-isothiocyanate yielded stably labeled chitosan molecules, which were successfully formulated into nanoparticles by ionotropic gelation. Uptake of f... hiện toàn bộ