Pharmaceutical Research
1573-904X
Cơ quản chủ quản: N/A
Phân tích ảnh hưởng
Các bài báo tiêu biểu
Ritonavir: An Extraordinary Example of Conformational Polymorphism
Tập 18 Số 6 - Trang 859-866 - 2001
Purpose. In the summer of 1998, Norvir semi-solid capsules supplies were
threatened as a result of a new much less soluble crystal form of ritonavir.
This report provides characterization of the two polymorphs and the structures
and hydrogen bonding network for each form. Methods. Ritonavir polymorphism was
investigated using solid state spectroscopy and microscopy techniques including
solid state...
Hydrophilic Matrices for Controlled Drug Delivery: An Improved Mathematical Model to Predict the Resulting Drug Release Kinetics (the “sequential Layer” Model)
Tập 17 Số 10 - Trang 1290-1298 - 2000
Purpose. The aims of this study were (i) to elucidate the transport mechanisms
involved in drug release from hydrophilic matrices; and (ii) to develop an
improved mathematical model allowing quantitative predictions of the resulting
release kinetics. Methods. Our previously presented model has been substantially
modified, by adding: (i) inhomogeneous swelling; (ii) poorly water-soluble
drugs; and ...
What is the True Solubility Advantage for Amorphous Pharmaceuticals?
Tập 17 Số 4 - Trang 397-404 - 2000
Purpose. To evaluate the magnitude of the solubility advantage foramorphous
pharmaceutical materials when compared to their crystallinecounterparts.Methods.
The thermal properties of several drugs in their amorphousand crystalline states
were determined using differential scanningcalorimetry. From these properties
the solubility advantage for theamorphous form was predicted as a function of
temper...
Poly(d,l-Lactide-Co-Glycolide) Encapsulated Poly(Vinyl Alcohol) Hydrogel as a Drug Delivery System
Tập 19 Số 11 - Trang 1713-1719 - 2002
Purpose. The efficiency of encapsulation of water-soluble drugs in biodegradable
polymer is often low and occasionally these microcapsules are associated with
high burst effect. The primary objective of this study is to develop a novel
microencapsulation technique with high efficiency of encapsulation and low burst
effect. Method. Pentamidine was used as a model drug in this study.
Pentamidine/pol...
Induction of Apoptosis in WEHI 231 Cells by Cationic Liposomes
Tập 17 Số 5 - Trang 515-520 - 2000
Purpose. Liposomes are of considerable interest as drug carriers
andimmunoadjuvants. However, few investigators have studied thechanges exerted
by liposomes in the cells with which they interact.The purpose of this study was
to investigate whether liposomes induceapoptosis in B cells. Methods. The mouse
immature B cell line WEHI 231 cells and mousesplenic B cells were treated with
liposomes, and t...
Proteolysis of Human Calcitonin in Excised Bovine Nasal Mucosa: Elucidation of the Metabolic Pathway by Liquid Secondary lonization Mass Spectrometry (LSIMS) and Matrix Assisted Laser Desorption lonization Mass Spectrometry (MALDI)
Tập 13 Số 11 - Trang 1679-1685 - 1996
Purpose. Two calcitonins, i.e. human calcitonin (hCT) and, for comparison,
salmon calcitonin (sCT), were chosen as peptide models to investigate nasal
mucosal metabolism. Methods. The susceptibility of hCT and sCT to nasal mucosal
enzymes was assessed by in-and-out reflection kinetics experiments in an in
vitro model based on the use of freshly excised bovine nasal mucosa, with the
mucosal surface...
A Solid-State NMR Study of Protein Hydration and Stability
Tập 15 Số 12 - Trang 1816-1821 - 1998
Purpose. The mobility of protein in powders at different hydration levels was
studied in relation to aggregation and activity. Methods. Magic angle spinning
13C, 15N, 1H, 2H, and 17O NMR techniques were used to determine changes in the
mobility of surface residues in proteins as a function of hydration and related
to changes in activity. NMR relaxation measurements of high frequency (ω0, T1)
and l...
Comparison of the Anticancer Effect of Free and HPMA Copolymer-Bound Adriamycin in Human Ovarian Carcinoma Cells
Tập 16 Số 7 - Trang 986-996 - 1999
Purpose. To study peculiarities and the mechanism of the anticancer effect of
free and HPMA copolymer-bound ADR in sensitive and resistant human ovarian
carcinoma cells. Methods. Sensitive A2780 and ADR resistant A2780/AD cells were
exposed to different doses of drugs during 12, 24, 36, 48, 60, and 72 hours.
Cell viability, drug accumulation, apoptosis, cellular metabolism, lipid
peroxidation, DNA...
Effect of Some Penetration Enhancers on Epithelial Membrane Lipid Domains: Evidence from Fluorescence Spectroscopy Studies
Tập 11 Số 2 - Trang 288-294 - 1994
The effect of the penetration enhancers Azone, oleic acid, 1-dodecanol, dodecyl
N,N-dimethylaminoacetate (DDAA), and dodecyl N,N-dimethylaminoisopropionate
(DDAIP) on epithelial membrane lipids was examined using human buccal cell
membranes as a model for epithelial lipid bilayer. Buccal epithelial cells (BEC)
were labeled with l,6-diphenyl-l,3,5-hexatriene (DPH),
l-(4-(trimethylammonio)phenyl)-6-...
5′-Amino Acid Esters of Antiviral Nucleosides, Acyclovir, and AZT Are Absorbed by the Intestinal PEPT1 Peptide Transporter
Tập 15 Số 8 - Trang 1154-1159 - 1998
Purpose. General use of nucleoside analogues in the treatment of viral
infections and cancer is often limited by poor oral absorption. Valacyclovir, a
water soluble amino acid ester prodrug of acyclovir has been reported to
increase the oral bioavailability of acyclovir but its absorption mechanism is
unknown. This study characterized the intestinal absorption mechanism of
5′-amino acid ester prod...