Pharmaceutical Research

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Freeze-Drying of Poly((2-dimethylamino)ethyl Methacrylate)-Based Gene Delivery Systems
Pharmaceutical Research - Tập 14 Số 12 - Trang 1838-1841 - 1997
Cherng, Jong-Yuh, van de Wetering, Petra, Talsma, Herre, Crommelin, Daan J. A., Hennink, Wim E.
In Vitro Evaluation of Polymerized Liposomes as an Oral Drug Delivery System
Pharmaceutical Research - Tập 12 Số 4 - Trang 576-582 - 1995
Okada, Jun'ichi, Cohen, Smadar, Langer, Robert
The physical characteristics of polymerized liposomes for potential use as an oral drug delivery system were examined in vitro. The trap efficiency in monomeric liposomes composed of 1,2-di (2,4-octadecadienoyl) phosphatidylcholine was increased from 3% for original multilamellar vesicles to 35% for freeze-thaw treated liposomes. Polymerized liposomes with azobis (isobutyronitrile) and azobis (2-a... hiện toàn bộ
Photo-Oxidation Mechanisms in Liquid Pharmaceutical Formulations: The Overlooked Role of Singlet Oxygen Presented as a Case Study
Pharmaceutical Research - - 2022
Brunell, Margaret, Tignor, Steven, Pierson, Elizabeth, Walsh, Paul L.
Oxidation is one of the most common degradation pathways for active pharmaceutical ingredients (APIs) in pharmaceutical formulations, mostly involving 1-electron processes via peroxy radicals and 2-electron processes by peroxides. In liquid pharmaceutical formulations, several factors can impact oxidative instabilities including pH, excipient impurities, headspace oxygen, and the potential for pho... hiện toàn bộ
Kinetics of Drug Decomposition by Heat Conduction Calorimetry
Pharmaceutical Research - Tập 6 Số 1 - Trang 20-27 - 1989
Hansen, Lee D., Lewis, Edwin A., Eatough, Delbert J., Bergstrom, Robert G., DeGraft-Johnson, Damans
The application of heat conduction calorimetry to the determination of decomposition mechanisms and rates for drugs is shown to be a rapid and generally useful method. The application of the method to determine the nature of the decomposition reaction, sources of systematic errors in the method, the equations relating the calorimetric signal to the kinetics of the reaction, and some examples of re... hiện toàn bộ
Water-Soluble and Low Molecular Weight Chitosan-Based Plasmid DNA Delivery
Pharmaceutical Research - Tập 18 Số 4 - Trang 427-431 - 2001
Lee, Minhyung, Nah, Jae-Woon, Kwon, Youngmin, Koh, Jae Joon, Ko, Kyung Soo, Kim, Sung Wan
Purpose. Chitosan, a natural cationic polysaccharide, is a candidate non-viral vector for gene delivery because of its high positive charges and low cytotoxicity. In this study, low molecular weight chitosan (LMWC, molecular weight of 22 kDa) was characterized and evaluated as a gene carrier. Methods. Plasmid/LMWC complex was analyzed in 1% agarose gel electrophoresis. To confirm that the LMWC pro... hiện toàn bộ
Evidence for Overlapping Substrate Specificity Between Large Neutral Amino Acid (LNAA) and Dipeptide (hPEPTl) Transporters for PD 158473, an NMDA Antagonist
Pharmaceutical Research - Tập 16 Số 3 - Trang 391-395 - 1999
Surendran, Narayanan, Covitz, Kuang-Ming Y., Han, Hyo-kyung, Sadee, Wolfgang, Oh, Doo-Man, Amidon, Gordon L., Williamson, Rufus M., Bigge, Christopher F., Stewart, Barbra H.
Purpose. The objective of this research was to investigate the substrate specificity of large neutral amino acid carrier (LNAA) and di/tripeptide (hPEPTl) transporters with respect to PD 158473, an NMDA antagonist. Methods. Cellular uptake studies were carried out using two types of Chinese Hamster Ovary (CHO). CHO-K1 cells represent the wild type with inherent large neutral amino acid (LNAA) acti... hiện toàn bộ
5′-Amino Acid Esters of Antiviral Nucleosides, Acyclovir, and AZT Are Absorbed by the Intestinal PEPT1 Peptide Transporter
Pharmaceutical Research - Tập 15 Số 8 - Trang 1154-1159 - 1998
Han, Hyo-kyung, de Vrueh, Remco L. A., Rhie, Julie K., Covitz, Kuang-Ming Y., Smith, Philip L., Lee, Chao-Pin, Oh, Doo-Man, Sadee, Wolfgang, Amidon1, Gordon L.
Purpose. General use of nucleoside analogues in the treatment of viral infections and cancer is often limited by poor oral absorption. Valacyclovir, a water soluble amino acid ester prodrug of acyclovir has been reported to increase the oral bioavailability of acyclovir but its absorption mechanism is unknown. This study characterized the intestinal absorption mechanism of 5′-amino acid ester prod... hiện toàn bộ
Direct Evidence That Polysorbate-80-Coated Poly(Butylcyanoacrylate) Nanoparticles Deliver Drugs to the CNS via Specific Mechanisms Requiring Prior Binding of Drug to the Nanoparticles
Pharmaceutical Research - Tập 20 Số 3 - Trang 409-416 - 2003
Kreuter, Jörg, Ramge, Peter, Petrov, Valery, Hamm, Stefan, Gelperina, Svetlana E., Engelhardt, Britta, Alyautdin, Renad, von Briesen, Hagen, Begley, David J.
Purpose. It has recently been suggested that the poly(butylcyanoacrylate) (PBCA) nanoparticle drug delivery system has a generalized toxic effect on the blood-brain barrier (BBB) (8) and that this effect forms the basis of an apparent enhanced drug delivery to the brain. The purpose of this study is to explore more fully the mechanism by which PBCA nanoparticles can deliver drugs to the brain. Met... hiện toàn bộ
Development of a Remote Electrode System for Monitoring the Water Content of Materials Inside a Glass Vial
Pharmaceutical Research - Tập 19 Số 3 - Trang 337-344 - 2002
Suherman, Phe Man, Taylor, Peter M., Smith, Geoff
Purpose: This article explores the use of a remote electrode dielectric measurement system to monitor the water content of hydrated ovalbumin inside a glass vial. Methods: The intrinsic dielectric properties of hydrated ovalbumin were characterized first using conventional parallel plate electrodes. The second stage was to simulate a remote electrode measurement by placing nonconductive, nondisper... hiện toàn bộ
The Effect of Excipients on the Molecular Mobility of Lyophilized Formulations, as Measured by Glass Transition Temperature and NMR Relaxation-Based Critical Mobility Temperature
Pharmaceutical Research - Tập 16 Số 1 - Trang 135-140 - 1999
Yoshioka, Sumie, Aso, Yukio, Kojima, Shigeo
Purpose. The dependence of the molecular mobility of lyophilized formulations on pharmaceutical polymer excipients was studied. Molecular mobility as determined by NMR relaxation-based critical temperature of molecular mobility (Tmc) and glass transition temperature (Tg) is discussed in relation to the plasticizing effect of water in formulations. Methods. The Tmc and Tg of lyophilized γ-globulin ... hiện toàn bộ
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