Pathology International
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Expression of E‐ and N‐cadherin and clinicopathology in hepatocellular carcinoma
Pathology International - Tập 58 Số 10 - Trang 635-642 - 2008
Loss or reduced E‐cadherin expression and aberrant expression of N‐cadherin have
been associated with invasiveness of human carcinoma cells and poor prognosis.
The role of E‐ and N‐cadherin, however, in hepatocellular carcinoma (HCC) has
not yet been elucidated. The aim of the present study was to investigate the
expression pattern of E‐ and N‐cadherin in surgically resected HCC specimens
accordin...
Altered expression of microRNA miR‐21, miR‐155, and let‐7a and their roles in pulmonary neuroendocrine tumors
Pathology International - Tập 62 Số 9 - Trang 583-591 - 2012
MicroRNA (miRNA) has a critical effect on tumorigenesis through
post‐transcriptional modification and is considered to be potential biomarkers
for cancer diagnosis and treatment monitoring. We evaluated the expression
pattern of three selected miRNAs (miR‐21, miR‐155, and let‐7a) to evaluate their
potential roles by quantitative reverse transcription‐polymerase chain reaction
using formalin‐fixed ...
Phenotypic alterations of mucins and cytokeratins during gallbladder carcinogenesis
Pathology International - Tập 54 Số 8 - Trang 576-584 - 2004
In order to evaluate the significance of altered expression of mucin and
cytokeratin during gallbladder carcinogenesis, we characteriazed the
expressional profiles of MUC1, MUC2, MUC5AC, MUC6, CK7 and CK20 in 33 normal
mucosa, 31 adenomas, 55 dysplasias and 131 carcinomas of the gallbladder. In
normal gallbladder mucosa, the expressions of MUC5AC and MUC6 were diffuse and
MUC1 expression was absen...
Usefulness of endoscopic biopsy using immunostaining of p53 and Ki‐67 in tumors of the ampulla of Vater
Pathology International - Tập 53 Số 6 - Trang 361-370 - 2003
We investigated the diagnostic and prognostic value of p53 expression and
proliferative activity, as indicated by the Ki‐67, in endoscopic biopsy
specimens. Specimens were immunologically stained with p53 and MIB‐1 (Ki‐67),
and the MIB‐1/Ki‐67 labeling index (LI) was calculated. Classification of
adenomas was based on findings of H&E‐stained preparations into those with low‐
or high‐grade atypia. ...
The origin and future of oxidative stress pathology: From the recognition of carcinogenesis as an iron addiction with ferroptosis‐resistance to non‐thermal plasma therapy
Pathology International - Tập 66 Số 5 - Trang 245-259 - 2016
Helmut Sies established the concept of oxidative stress in 1985. However, it
took some time to introduce this concept into pathology, where investigators
count on formalin‐fixed paraffin‐embedded tissue sections. I sought out antigens
for this purpose based on an oxidative stress‐induced rat renal carcinogenesis
model, which revealed that 8‐hydroxy‐2′‐deoxyguanosine and
4‐hydroxy‐2‐nonenal‐modifie...
Hepatosplenic γδ T‐cell lymphoma following seven malaria infections
Pathology International - Tập 56 Số 11 - Trang 668-673 - 2006
Hepatosplenic γδ T‐cell lymphoma (HSTL) is a clinicopathological entity
associated with an immunocompromised status in approximately 25% of patients.
Herein is described a case of HSTL in a 53‐year‐old Brazilian man with seven
previous malaria infections, initially misdiagnosed as a hyperreactive
splenomegaly due to chronic malaria. A characteristic lymphoid infiltrate was
observed in spleen, live...
Side‐to‐side linking of myocardial cells in hypertrophic cardiomyopathy: Whole heart microscopic observation with tangential sections
Pathology International - Tập 55 Số 11 - Trang 677-687 - 2005
By cross‐section or longitudinal section, it is difficult to investigate
longitudinal features of myocardial cells in the whole heart. Here, introducing
the use of tangential sections to obtain longitudinal aspect of myocardial cells
in any part of myocardium, the authors evaluated myocardium in the left
ventricle in 10 normal hearts and four hearts with hypertrophic cardiomyopathy
(HCM). Tangenti...
Comparative study of histological features between core needle biopsy and surgical excision in phyllodes tumor
Pathology International - Tập 62 Số 2 - Trang 120-126 - 2012
We analyzed histopathological features of core needle biopsy (CNB) and surgical
excision specimen comparatively in 129 patients with surgically proven phyllodes
tumor (PT). Stromal characteristics including cellularity, atypia, mitosis,
overgrowth, tissue fragmentation, and the tumor margin were assessed.
Benign/borderline/malignant phyllodes tumor (PT) were diagnosed in 90 (69.8%)/30
(23.3%)/9 (7...
Bizarre parosteal osteochondromatous proliferation (Nora’s lesion) of the foot
Pathology International - Tập 51 Số 10 - Trang 816-823 - 2001
A 22‐year‐old man presented with a growing lump on the fifth metatarsal of the
right foot. Radiographically, the lesion was a calcified mass stuck on to the
bone. The T2‐weighted magnetic resonance images showed heterogeneity in
intensity. A tumor was suspected and an excisional biopsy was done. The lesion
was composed of a cartilaginous cap and bone tissue. Histological examination
revealed chara...
Etiology of IgA nephropathy syndrome
Pathology International - Tập 44 Số 1 - Trang 1-13 - 1994
Since Berger's original paper on mesangial IgA‐IgG deposition with hematuria,
there have been a number of clinical and pathological studies regarding IgA
immune complexes, the mechanisms of glomerular IgA deposition leading to
glomerular injury and animal models of IgA nephropathy. During the last quarter
of this century, glomerular changes such as IgA nephropathy have also been
observed in cases ...
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