Pathology International

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Expression of E‐ and N‐cadherin and clinicopathology in hepatocellular carcinoma
Pathology International - Tập 58 Số 10 - Trang 635-642 - 2008
Sung Bum Cho, Kyung Hwa Lee, Jae Hyek Lee, Sun Young Park, Wan‐Sik Lee, Chang‐Hwan Park, Hyun Soo Kim, Sung Kyu Choi, Jong‐Sun Rew
Loss or reduced E‐cadherin expression and aberrant expression of N‐cadherin have been associated with invasiveness of human carcinoma cells and poor prognosis. The role of E‐ and N‐cadherin, however, in hepatocellular carcinoma (HCC) has not yet been elucidated. The aim of the present study was to investigate the expression pattern of E‐ and N‐cadherin in surgically resected HCC specimens ...... hiện toàn bộ
Altered expression of microRNA miR‐21, miR‐155, and let‐7a and their roles in pulmonary neuroendocrine tumors
Pathology International - Tập 62 Số 9 - Trang 583-591 - 2012
Hyoun Wook Lee, Eun Hee Lee, Seung Yeon Ha, Chang Hun Lee, Hee Kyung Chang, Sunhee Chang, Kun Young Kwon, Ilseon Hwang, Mee Sook Roh, Jeong‐Wook Seo
MicroRNA (miRNA) has a critical effect on tumorigenesis through post‐transcriptional modification and is considered to be potential biomarkers for cancer diagnosis and treatment monitoring. We evaluated the expression pattern of three selected miRNAs (miR‐21, miR‐155, and let‐7a) to evaluate their potential roles by quantitative reverse transcription‐polymerase chain reaction using formali...... hiện toàn bộ
Phenotypic alterations of mucins and cytokeratins during gallbladder carcinogenesis
Pathology International - Tập 54 Số 8 - Trang 576-584 - 2004
Hee Jin Chang, Sun‐Whe Kim, Byung Lan Lee, Eun Kyung Hong, Woo Ho Kim
In order to evaluate the significance of altered expression of mucin and cytokeratin during gallbladder carcinogenesis, we characteriazed the expressional profiles of MUC1, MUC2, MUC5AC, MUC6, CK7 and CK20 in 33 normal mucosa, 31 adenomas, 55 dysplasias and 131 carcinomas of the gallbladder. In normal gallbladder mucosa, the expressions of MUC5AC and MUC6 were diffuse and MUC1 expression w...... hiện toàn bộ
Usefulness of endoscopic biopsy using immunostaining of p53 and Ki‐67 in tumors of the ampulla of Vater
Pathology International - Tập 53 Số 6 - Trang 361-370 - 2003
Kensuke Kubota, Yukio Kakuta, Shunji Kawamura, Shuichi Saito, Hideyuki Seki, Takashi Kuniyoshi
We investigated the diagnostic and prognostic value of p53 expression and proliferative activity, as indicated by the Ki‐67, in endoscopic biopsy specimens. Specimens were immunologically stained with p53 and MIB‐1 (Ki‐67), and the MIB‐1/Ki‐67 labeling index (LI) was calculated. Classification of adenomas was based on findings of H&E‐stained preparations into those with low‐ or high‐gr...... hiện toàn bộ
The origin and future of oxidative stress pathology: From the recognition of carcinogenesis as an iron addiction with ferroptosis‐resistance to non‐thermal plasma therapy
Pathology International - Tập 66 Số 5 - Trang 245-259 - 2016
Shinya Toyokuni
Helmut Sies established the concept of oxidative stress in 1985. However, it took some time to introduce this concept into pathology, where investigators count on formalin‐fixed paraffin‐embedded tissue sections. I sought out antigens for this purpose based on an oxidative stress‐induced rat renal carcinogenesis model, which revealed that 8‐hydroxy‐2′‐deoxyguanosine and 4‐hydroxy‐2‐nonenal...... hiện toàn bộ
Hepatosplenic γδ T‐cell lymphoma following seven malaria infections
Pathology International - Tập 56 Số 11 - Trang 668-673 - 2006
Rocı́o Hassan, Sergio A L Franco, Cláudio Gustavo Stefanoff, Sérgio Romano, Hilda Rachel Diamond, Luiz G P Franco, Héctor N. Seuánez, Ilana Zalcberg
Hepatosplenic γδ T‐cell lymphoma (HSTL) is a clinicopathological entity associated with an immunocompromised status in approximately 25% of patients. Herein is described a case of HSTL in a 53‐year‐old Brazilian man with seven previous malaria infections, initially misdiagnosed as a hyperreactive splenomegaly due to chronic malaria. A characteristic lymphoid infiltrate was observed in sple...... hiện toàn bộ
Side‐to‐side linking of myocardial cells in hypertrophic cardiomyopathy: Whole heart microscopic observation with tangential sections
Pathology International - Tập 55 Số 11 - Trang 677-687 - 2005
Hirotake Masuda, Misa Yamauchi, Makoto Yoshida, Masato Takahashi, Hiroshi Nanjo, Yasushi Asari, Akihiro Sugita
By cross‐section or longitudinal section, it is difficult to investigate longitudinal features of myocardial cells in the whole heart. Here, introducing the use of tangential sections to obtain longitudinal aspect of myocardial cells in any part of myocardium, the authors evaluated myocardium in the left ventricle in 10 normal hearts and four hearts with hypertrophic cardiomyopathy (HCM). ...... hiện toàn bộ
Comparative study of histological features between core needle biopsy and surgical excision in phyllodes tumor
Pathology International - Tập 62 Số 2 - Trang 120-126 - 2012
Junjeong Choi, Ja Seung Koo
We analyzed histopathological features of core needle biopsy (CNB) and surgical excision specimen comparatively in 129 patients with surgically proven phyllodes tumor (PT). Stromal characteristics including cellularity, atypia, mitosis, overgrowth, tissue fragmentation, and the tumor margin were assessed. Benign/borderline/malignant phyllodes tumor (PT) were diagnosed in 90 (69.8%)/30 (23....... hiện toàn bộ
Bizarre parosteal osteochondromatous proliferation (Nora’s lesion) of the foot
Pathology International - Tập 51 Số 10 - Trang 816-823 - 2001
Hisashi Horiguchi, Masataka Sakane, Miwa Matsui, Yasuyoshi Wadano
A 22‐year‐old man presented with a growing lump on the fifth metatarsal of the right foot. Radiographically, the lesion was a calcified mass stuck on to the bone. The T2‐weighted magnetic resonance images showed heterogeneity in intensity. A tumor was suspected and an excisional biopsy was done. The lesion was composed of a cartilaginous cap and bone tissue. Histologic...... hiện toàn bộ
Etiology of IgA nephropathy syndrome
Pathology International - Tập 44 Số 1 - Trang 1-13 - 1994
Yuzo Endo, Hiroshi Kanbayashi
Since Berger's original paper on mesangial IgA‐IgG deposition with hematuria, there have been a number of clinical and pathological studies regarding IgA immune complexes, the mechanisms of glomerular IgA deposition leading to glomerular injury and animal models of IgA nephropathy. During the last quarter of this century, glomerular changes such as IgA nephropathy have also been observed i...... hiện toàn bộ
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