ABC transporters and β-tubulin in macrocyclic lactone resistance: prospects for marker developmentParasitology - Tập 134 Số 8 - Trang 1123-1132 - 2007
Roger K. Prichard, Alain Roulet
SUMMARYMacrocyclic lactones (MLs) are highly lipophilic anthelmintics which are known to bind to and open ligand-gated ion channels. However, these anthelmintics, and particularly the avermectin members of the ML class of endectocides, are potent substrates for ABC transporters and these transporters may regulate drug concentration in both the host and the parasite...... hiện toàn bộ
Anthelmintic metabolism in parasitic helminths: proteomic insightsParasitology - Tập 139 Số 9 - Trang 1205-1217 - 2012
Peter M. Brophy, Neil Mackintosh, Russell M. Morphew
SUMMARYAnthelmintics are the cornerstone of parasitic helminth control. Surprisingly, understanding of the biochemical pathways used by parasitic helminths to detoxify anthelmintics is fragmented, despite the increasing global threat of anthelmintic resistance within the ruminant and equine industries. Reductionist biochemistry has likely over-estimated the enzymat...... hiện toàn bộ
Pharmacology of anthelmintic resistanceParasitology - Tập 113 Số S1 - Trang S201-S216 - 1996
N.C. Sangster
SUMMARYAnthelmintic resistance has compromised the control of nematode parasites in several animal-based industries. Studies of resistance have not only improved our understanding of this phenomenon but also shed light on physiological systems of parasitic helminths. In addition, research on molecular aspects of anthelmintic resistance may provide selectable marker...... hiện toàn bộ
Cloning and characterization of glutamate dehydrogenase (GDH) from the gut of Haemonchus contortusParasitology - Tập 118 Số 3 - Trang 297-304 - 1999
Philip Skuce, Elise M. Stewart, W.D. Smith, David P. Knox
Vaccination of lambs with the membrane-bound (S3) thiol-Sepharose
binding protein (TSBP) fraction derived from the
gut of Haemonchus contortus confers significant protection against
homologous challenge. The S3 TSBP peptide profile
is dominated by a major protein of ca. 60 kDa which is strongly
recognized by antisera from sheep dem...... hiện toàn bộ
The phylogeny of the Schistosomatidae based on three genes with emphasis on the interrelationships of Schistosoma Weinland, 1858Parasitology - Tập 126 Số 3 - Trang 203-224 - 2003
Anne E. Lockyer, Peter D. Olson, Pia Østergaard, David Rollinson, David A. Johnston, Stephen W. Attwood, V. R. Southgate, Petr Horák, Scott D. Snyder, Thanh Hoa Le, Takeshi Agatsuma, Donald P. McManus, A. Christopher Carmichael, Soraya Naem, D. Timothy J. Littlewood
Schistosomes are digenean flukes, parasitic of birds, mammals and crocodiles. The family Schistosomatidae contains species of considerable medical and veterinary importance, which cause the disease schistosomiasis. Previous studies, both morphological and molecular, which have provided a good deal of information on the phylogenetics of this group, have been limited in the number of species...... hiện toàn bộ
Experimental work on reproduction in the tsetse fly,Glossina palpalisParasitology - Tập 29 Số 1 - Trang 131-141 - 1937
Helen Mellanby
1. The reproductive cycle of the female fly was worked out at an average temperature of 24° C. The lowest egg of the right ovary develops first, and is ripe in 7 days. Ovulation never occurs earlier than the 8th day, and frequently later; it bears some relation to fertilization, for eggs in virgin females failed to ovulate for weeks. The first larva was produced in a variable time after fe...... hiện toàn bộ
Studies on ovarian development in tsetse flies (Glossina, Diptera)Parasitology - Tập 51 Số 3-4 - Trang 545-564 - 1961
D.S. Saunders
Five species of Glossina (G. morsitans, G. pallidipes, G. austeni, G. brevipalpis and G. palpalis) have ovaries containing two polytrophic ovarioles, each of which contains a single egg follicle. In all these species the right ovary is more highly developed than the left at emergence. This type of ovary is probably common to all species...... hiện toàn bộ