Parasitology
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Survey of Hepatocystis parasites of fruit bats in the Amurum forest reserve, Nigeria, identifies first host record for Rousettus aegyptiacus
Parasitology - Tập 146 Số 12 - Trang 1550-1554 - 2019
AbstractParasites of the genus Hepatocystis are close relatives of Plasmodium
that frequently infect epauletted fruit bats across West and East Africa. Our
understanding of susceptible hosts and prevalence of infection of Hepatocystis
remains fragmented. Non-invasive sampling of bat assemblages in representative
habitats critically contribute to haemosporidian parasite distribution maps.
Here, we ...
ABC transporters and β-tubulin in macrocyclic lactone resistance: prospects for marker development
Parasitology - Tập 134 Số 8 - Trang 1123-1132 - 2007
SUMMARYMacrocyclic lactones (MLs) are highly lipophilic anthelmintics which are
known to bind to and open ligand-gated ion channels. However, these
anthelmintics, and particularly the avermectin members of the ML class of
endectocides, are potent substrates for ABC transporters and these transporters
may regulate drug concentration in both the host and the parasite. There is
accumulating evidence ...
Anthelmintic metabolism in parasitic helminths: proteomic insights
Parasitology - Tập 139 Số 9 - Trang 1205-1217 - 2012
SUMMARYAnthelmintics are the cornerstone of parasitic helminth control.
Surprisingly, understanding of the biochemical pathways used by parasitic
helminths to detoxify anthelmintics is fragmented, despite the increasing global
threat of anthelmintic resistance within the ruminant and equine industries.
Reductionist biochemistry has likely over-estimated the enzymatic role of
glutathione transferas...
Pharmacology of anthelmintic resistance
Parasitology - Tập 113 Số S1 - Trang S201-S216 - 1996
SUMMARYAnthelmintic resistance has compromised the control of nematode parasites
in several animal-based industries. Studies of resistance have not only improved
our understanding of this phenomenon but also shed light on physiological
systems of parasitic helminths. In addition, research on molecular aspects of
anthelmintic resistance may provide selectable markers for use in future
transfection ...
Cloning and characterization of glutamate dehydrogenase (GDH) from the gut of Haemonchus contortus
Parasitology - Tập 118 Số 3 - Trang 297-304 - 1999
Vaccination of lambs with the membrane-bound (S3) thiol-Sepharose binding
protein (TSBP) fraction derived from the gut of Haemonchus contortus confers
significant protection against homologous challenge. The S3 TSBP peptide profile
is dominated by a major protein of ca. 60 kDa which is strongly recognized by
antisera from sheep demonstrably protected following immunization with S3 TSBP.
In an atte...
Nematode ligand-gated chloride channels: an appraisal of their involvement in macrocyclic lactone resistance and prospects for developing molecular markers
Parasitology - Tập 134 Số 8 - Trang 1111-1121 - 2007
SUMMARYLigand-gated chloride channels, including the glutamate-(GluCl) and
GABA-gated channels, are the targets of the macrocyclic lactone (ML) family of
anthelmintics. Changes in the sequence and expression of these channels can
cause resistance to the ML in laboratory models, such as Caenorhabditis elegans
and Drosophila melanogaster. Mutations in multiple GluCl subunit genes are
required for hi...
The phylogeny of the Schistosomatidae based on three genes with emphasis on the interrelationships of Schistosoma Weinland, 1858
Parasitology - Tập 126 Số 3 - Trang 203-224 - 2003
Schistosomes are digenean flukes, parasitic of birds, mammals and crocodiles.
The family Schistosomatidae contains species of considerable medical and
veterinary importance, which cause the disease schistosomiasis. Previous
studies, both morphological and molecular, which have provided a good deal of
information on the phylogenetics of this group, have been limited in the number
of species investi...
Experimental work on reproduction in the tsetse fly,Glossina palpalis
Parasitology - Tập 29 Số 1 - Trang 131-141 - 1937
1. The reproductive cycle of the female fly was worked out at an average
temperature of 24° C. The lowest egg of the right ovary develops first, and is
ripe in 7 days. Ovulation never occurs earlier than the 8th day, and frequently
later; it bears some relation to fertilization, for eggs in virgin females
failed to ovulate for weeks. The first larva was produced in a variable time
after fertilizat...
Studies on ovarian development in tsetse flies (Glossina, Diptera)
Parasitology - Tập 51 Số 3-4 - Trang 545-564 - 1961
Five species of Glossina (G. morsitans, G. pallidipes, G. austeni, G.
brevipalpis and G. palpalis) have ovaries containing two polytrophic ovarioles,
each of which contains a single egg follicle. In all these species the right
ovary is more highly developed than the left at emergence. This type of ovary is
probably common to all species of Glossina.The development of the egg follicles
in G. morsit...
Morphological effects and tegumental alterations induced by mefloquine on schistosomula and adult flukes ofSchistosoma mansoni
Parasitology - Tập 137 Số 1 - Trang 85-98 - 2010
SUMMARYThere is a pressing need to develop novel anti-schistosomal drugs, as
current treatment relies largely on praziquantel (PZQ). To further strengthen
current evidence of the anti-schistosomal properties of mefloquine (MQ), we
studied the temporal effect of this compoundin vitroandin vivo, and examined
alterations on the tegumental surface of schistosomula and adults ofS. mansoniby
means of sc...
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