Parasitology

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ABC transporters and β-tubulin in macrocyclic lactone resistance: prospects for marker development
Parasitology - Tập 134 Số 8 - Trang 1123-1132 - 2007
Roger K. Prichard, Alain Roulet
SUMMARYMacrocyclic lactones (MLs) are highly lipophilic anthelmintics which are known to bind to and open ligand-gated ion channels. However, these anthelmintics, and particularly the avermectin members of the ML class of endectocides, are potent substrates for ABC transporters and these transporters may regulate drug concentration in both the host and the parasite...... hiện toàn bộ
Anthelmintic metabolism in parasitic helminths: proteomic insights
Parasitology - Tập 139 Số 9 - Trang 1205-1217 - 2012
Peter M. Brophy, Neil Mackintosh, Russell M. Morphew
SUMMARYAnthelmintics are the cornerstone of parasitic helminth control. Surprisingly, understanding of the biochemical pathways used by parasitic helminths to detoxify anthelmintics is fragmented, despite the increasing global threat of anthelmintic resistance within the ruminant and equine industries. Reductionist biochemistry has likely over-estimated the enzymat...... hiện toàn bộ
Morphological effects and tegumental alterations induced by mefloquine on schistosomula and adult flukes ofSchistosoma mansoni
Parasitology - Tập 137 Số 1 - Trang 85-98 - 2010
Theresia Manneck, Yolanda Haggenmüller, Jennifer Keiser
SUMMARYThere is a pressing need to develop novel anti-schistosomal drugs, as current treatment relies largely on praziquantel (PZQ). To further strengthen current evidence of the anti-schistosomal properties of mefloquine (MQ), we studied the temporal effect of this compoundin vitroandin vivo, and examined alter...... hiện toàn bộ
Female mice mate preferentially with non-parasitized males
Parasitology - Tập 125 Số 5 - Trang 461-466 - 2002
Kimberly Ehman, Marilyn E. Scott
If parasitic infection is a driving force in female mate choice, then females should preferentially select parasite-free males. The role of infection on female mate choice in mammals was assessed using a 3-chambered apparatus. A female CD-1 mouse was allowed to choose between 2 tethered male mice, 1 uninfected and 1 infected with 200 larvae (L3) of the intestinal nemat...... hiện toàn bộ
Studies on the transmission and course of infection of a Kenyan strain of Theileria mutans
Parasitology - Tập 76 Số 1 - Trang 99-115 - 1978
A. S. Young, R.E. Purnell, Alan M. Wilson, C.G.D. Brown, G.K. Kanhai
SummaryTheileria mutans (Aitong) isolated from cattle exposed in the Narok District of Kenya and blood-passaged through cattle 8 times, appeared to have lost its original pathogenicity for cattle. It was demonstrated that the parasite was trans-stadially transmissible by the tick Amblyomma variegatum but not by ...... hiện toàn bộ
Enzyme electrophoresis and speciation of Schistosoma intermediate hosts
Parasitology - Tập 61 Số 1 - Trang 19-25 - 1970
Garill A. Coles
1. Enzyme electrophoretic patterns from populations of snails, intermediate hosts of Schistosoma, have been examined.2. Esterase patterns (α-naphthyl butyrate as substrate) have been used to differentiate snail populations of B. africanus and Biomph. pfeifferi.3. Malate, β-hyd...... hiện toàn bộ
Toxoplasmosis in prey species and consequences for prevalence in feral cats: not all prey species are equal
Parasitology - Tập 134 Số 14 - Trang 1963-1971 - 2007
Eve Afonso, P. Thulliez, Dominique Pontier, Emmanuelle Gilot‐Fromont
SUMMARYToxoplasma gondiiis largely transmitted to definitive felid hosts through predation. Not all prey species represent identical risks of infection for cats because of differences in prey susceptibility, exposure and/or lifespan. Previously published studies have shown that prevalence in rodent and lagomorph species is positively corr...... hiện toàn bộ
Nutritional requirements for protein synthesis during parasitic development of the entomophilic nematode Mermis nigrescens
Parasitology - Tập 64 Số 1 - Trang 161-172 - 1972
Roger Gordon, John Webster
Adult desert locusts were experimentally infected with a dose of 50 M. nigrescens ova and larval nematodes removed 14, 17, 21 and 24 days afterwards for in vitro radiotracer studies. These nematodes were incubated under controlled conditions either in a nutrient medium or in insect saline, which contained the appropriate 14... hiện toàn bộ
Neurosecretory granules in the infective stage of Haemonchus contortus
Parasitology - Tập 58 Số 3 - Trang 657-662 - 1968
W. P. Rogers
Large numbers of electron-dense bodies, 700–1900 Å in diameter, usually seen each with its own limiting membrane, were found in axons of the ventral nerve of infective juveniles of H. contortus. Axons containing these granules merged, without limiting membranes, with a ‘light’, diffusely granular region, about 1·5–2 μm3. The ‘light’ area also...... hiện toàn bộ
Amino acid catabolism in the nematodesHeligmosomoides polygyrusandPanagrellus redivivus. 1. Removal of the amino group
Parasitology - Tập 93 Số 3 - Trang 481-493 - 1986
B D Grantham, J. Barrett
SUMMARYThe major transaminase inHeligmosomoides polygyrus, Panagrellus redivivusand rat liver was the 2-oxoglutarate-glutamate system, with relatively few amino acids acting as donors for the pyruvate-alanine and oxaloacetate–aspartate systems. The relative effectiveness of the different amino acid donors in the three transaminase systems...... hiện toàn bộ
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