Anthelmintic metabolism in parasitic helminths: proteomic insights

Parasitology - Tập 139 Số 9 - Trang 1205-1217 - 2012
Peter M. Brophy1, Neil Mackintosh1, Russell M. Morphew1
1Parasitology Group, Institute of Biological, Environmental and Rural Sciences (IBERS), Aberystwyth University, Aberystwyth, Ceredigion, Wales SY23 3FG, UK

Tóm tắt

SUMMARYAnthelmintics are the cornerstone of parasitic helminth control. Surprisingly, understanding of the biochemical pathways used by parasitic helminths to detoxify anthelmintics is fragmented, despite the increasing global threat of anthelmintic resistance within the ruminant and equine industries. Reductionist biochemistry has likely over-estimated the enzymatic role of glutathione transferases in anthelmintic metabolism and neglected the potential role of the cytochrome P-450 superfamily (CYPs). Proteomic technologies offers the opportunity to support genomics, reverse genetics and pharmacokinetics, and provide an integrated insight into both the cellular mechanisms underpinning response to anthelmintics and also the identification of biomarker panels for monitoring the development of anthelmintic resistance. To date, there have been limited attempts to include proteomics in anthelmintic metabolism studies. Optimisations of membrane, post-translational modification and interaction proteomic technologies in helminths are needed to especially study Phase I CYPs and Phase III ABC transporter pumps for anthelmintics and their metabolites.

Từ khóa


Tài liệu tham khảo

10.1074/jbc.M212453200

10.1016/j.exppara.2009.06.014

10.1002/1615-9861(200111)1:11<1463::AID-PROT1463>3.0.CO;2-H

10.1016/j.pt.2010.11.008

10.1074/mcp.M111.010157

10.1016/S0014-5793(02)02755-2

10.1007/s00436-003-1003-6

10.1016/j.chemosphere.2005.01.077

10.1016/j.jprot.2011.04.031

10.1371/journal.pone.0004098

10.1017/S0031182007000078

10.1016/0304-4165(89)90013-5

10.1002/pmic.200500420

10.1016/j.molbiopara.2007.03.013

10.1002/jez.528

10.1002/pmic.200700613

10.1074/mcp.M800206-MCP200

10.1016/j.ijpara.2009.10.002

10.1016/0014-4894(91)90081-7

10.1016/j.molbiopara.2004.06.016

10.1016/j.pt.2004.07.010

10.1016/j.tvjl.2009.05.021

10.1016/j.ijpara.2011.08.003

10.1002/pmic.200500368

10.1016/S0742-8413(98)10039-7

10.1002/pmic.200500571

10.1371/journal.pntd.0001666

10.1016/j.ijpara.2009.10.014

10.1371/journal.pbio.0000012

10.1371/journal.pntd.0000410

10.1371/journal.pntd.0000651

10.1038/ng.227

10.1016/j.vetpar.2012.06.009

10.1128/IAI.72.5.2780-2790.2004

10.1006/jmbi.1994.0102

10.1371/journal.pone.0033590

10.1002/pmic.200400953

10.1016/j.pt.2004.08.002

10.1016/j.yexmp.2007.01.009

10.1126/science.1074170

Keiser, 2010, The drugs we have and the drugs we need against major helminth infections, Advances in Parasitology, Vol 73: Important Helminth Infections in Southeast Asia: Diversity and Potential for Control and Elimination, Pt B, 197

10.2174/156720106776359195

10.1021/pr1000785

10.1017/S003118200999148X

10.1080/03602530802602880

10.1007/s00436-010-1923-x

10.1016/0020-7519(90)90109-Z

10.1002/1615-9861(200109)1:9<1128::AID-PROT1128>3.0.CO;2-0

10.1017/S0031182005009510

10.1016/S0020-7519(99)00022-3

10.1016/j.vetpar.2005.11.001

10.1007/s00436-010-1997-5

10.1007/s00436-010-2109-2

10.1002/pmic.200300719

10.1371/journal.pone.0021832

10.1016/0166-6851(90)90054-P

10.1007/s00216-008-1863-9

10.1371/journal.pgen.1000286

10.1007/BF00931534

10.1074/mcp.M600375-MCP200

10.1007/s00775-011-0826-3

10.1017/S0031182005007997

10.1017/S0022149X0001573X

10.1016/S0169-4758(00)01739-7

10.1111/j.1432-1033.1997.0269a.x

10.1146/annurev-phyto-080508-081839

10.1017/S0031182000061369

10.1021/pr8001035

10.1016/j.jprot.2011.06.011

10.1002/pmic.200600499

10.1002/pmic.200300487

10.1016/j.molbiopara.2010.04.003

10.1016/j.jprot.2011.06.002

10.1021/pr9009639

10.1038/nature06722

10.1074/mcp.M500097-MCP200

10.1016/0166-6851(81)90064-5

10.1016/j.abb.2008.02.002

10.1042/BJ20101346

10.1016/j.ab.2003.08.031

10.1002/pmic.200600068

10.1016/j.vetpar.2009.12.031

Mulvenna, 2010, The secreted and surface proteomes of the adult stage of the carcinogenic human liver fluke Opisthorchis viverrini, Proteomics, 10, 1063, 10.1002/pmic.200900393