Diabetes and coronavirus (SARS-CoV-2): Molecular mechanism of Metformin intervention and the scientific basis of drug repurposingPLoS Pathogens - Tập 17 Số 6 - Trang e1009634
Elizabeth Varghese, Samson Mathews Samuel, Alena Líšková, Peter Kubatka, Dietrich Büsselberg
Coronavirus Disease 2019 (COVID-19), caused by a new strain of coronavirus called Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), was declared a pandemic by WHO on March 11, 2020. Soon after its emergence in late December 2019, it was noticed that diabetic individuals were at an increased risk of COVID-19–associated complications, ICU admissions, and mortality. Maintaining proper blood glucose levels using insulin and/or other oral antidiabetic drugs (such as Metformin) reduced the detrimental effects of COVID-19. Interestingly, in diabetic COVID-19 patients, while insulin administration was associated with adverse outcomes, Metformin treatment was correlated with a significant reduction in disease severity and mortality rates among affected individuals. Metformin was extensively studied for its antioxidant, anti-inflammatory, immunomodulatory, and antiviral capabilities that would explain its ability to confer cardiopulmonary and vascular protection in COVID-19. Here, we describe the various possible molecular mechanisms that contribute to Metformin therapy’s beneficial effects and lay out the scientific basis of repurposing Metformin for use in COVID-19 patients.
The Interactomes of Influenza Virus NS1 and NS2 Proteins Identify New Host Factors and Provide Insights for ADAR1 Playing a Supportive Role in Virus ReplicationPLoS Pathogens - Tập 9 Số 7 - Trang e1003440
Benoı̂t de Chassey, Anne Aublin‐Gex, Alessia Ruggieri, Laurène Meyniel‐Schicklin, Fabrine Pradezynski, Nathalie Davoust, Thibault Chantier, Lionel Tafforeau, Philippe Mangeot, Claire Ciancia, Laure Perrin‐Cocon, Ralf Bartenschlager, Patrice André, Vincent Lotteau
Identification of Amino Acids in HA and PB2 Critical for the Transmission of H5N1 Avian Influenza Viruses in a Mammalian HostPLoS Pathogens - Tập 5 Số 12 - Trang e1000709
Yuwei Gao, Ying Zhang, Kyoko Shinya, Guohua Deng, Yongping Jiang, Zejun Li, Yuntao Guan, Guobin Tian, Yanbing Li, Jianzhong Shi, Liling Liu, Xianying Zeng, Zhigao Bu, Xianzhu Xia, Yoshihiro Kawaoka, Hualan Chen
Lysis of Endogenously Infected CD4+ T Cell Blasts by rIL-2 Activated Autologous Natural Killer Cells from HIV-Infected Viremic IndividualsPLoS Pathogens - Tập 4 Số 7 - Trang e1000101
Manuela Fogli, Domenico Mavilio, Enrico Brunetta, Stefania Varchetta, Khaled Ata, Gregg Roby, Colin Kovacs, Dean Follmann, Daniela Pende, Jeffrey P. Ward, Edward Barker, Emanuela Marcenaro, Alessandro Moretta, Anthony S. Fauci
Increased CD8+ T Cell Response to Epstein-Barr Virus Lytic Antigens in the Active Phase of Multiple SclerosisPLoS Pathogens - Tập 9 Số 4 - Trang e1003220
Daniela F. Angelini, Barbara Serafini, Eleonora Piras, Martina Severa, Eliana M. Coccia, Barbara Rosicarelli, Serena Ruggieri, Claudio Gasperini, Fabio Buttari, Diego Centonze, Rosella Mechelli, Marco Salvetti, Giovanna Borsellino, Francesca Aloisi, Luca Battistini
