Potent Allosteric Dengue Virus NS5 Polymerase Inhibitors: Mechanism of Action and Resistance Profiling

PLoS Pathogens - Tập 12 Số 8 - Trang e1005737
Siew Pheng Lim1, Christian G. Noble1, Cheah C. Seh1, Tingjin Sherryl Soh1,2, Abbas El Sahili2, Grace Kar Yarn Chan2, Julien Lescar2,3, Rishi Arora4, Timothy E. Benson4, Shahul Nilar1, Ujjini H. Manjunatha1, Kah Fei Wan1, Hongping Dong1, Xuping Xie1, Pei‐Yong Shi1, Fumiaki Yokokawa1
1Novartis Institute for Tropical Diseases, Singapore
2School of Biological Sciences, Nanyang Technological University, Singapore
3UPMC UMRS CR7—CNRS ERL 8255-INSERM U1135 Centre d’Immunologie et des Maladies Infectieuses, Centre Hospitalier Universitaire Pitié-Salpêtrière, Faculté de Médecine Pierre et Marie Curie, Paris, France
4Novartis Institute for Biomedical Research, Cambridge, Massachusetts, United States of America

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