Organic and Medicinal Chemistry Letters
SCOPUS (2014)
2191-2858
Cơ quản chủ quản: N/A
Các bài báo tiêu biểu
Synthesis of new pyrazolyl-2, 4-thiazolidinediones as antibacterial and antifungal agents
Tập 1 Số 1 - Trang 15 - 2011
A rapid, convenient, solventless green approach for the synthesis of oximes using grindstone chemistry
Tập 1 Số 1 - 2011
Abstract Background Synthesis of oximes is an important reaction in organic
chemistry, because these versatile oximes are used for protection, purification,
and characterization of carbonyl compounds. Nitriles, amides via Beckmann
rearrangement, nitro compounds, nitrones, amines, and azaheterocycles can be
synthesised from oximes. They also find applications for selective α-activation.
In inorgani...
Silver triflate catalyzed synthesis of 3-aminoalkylated indoles and evaluation of their antibacterial activities
Tập 1 Số 1 - 2011
Abstract An efficient, one-pot synthesis was developed for 3-aminoalkylated
indoles by three-component coupling reaction of aldehydes, N-methylanilines, and
indoles using AgOTf as a catalyst. A series of twenty 3-aminoalkylated indoles
was evaluated for their antibacterial activities against both Gram negative and
Gram positive bacteria. Compounds 4b and 4r showed good antibacterial activity
again...
Synthesis and anti-HSV-1 evaluation of new 3H-benzo[b]pyrazolo[3,4-h]-1,6-naphthyridines and 3H-pyrido[2,3-b]pyrazolo[3,4-h]-1,6-naphthyridines
Tập 2 Số 1 - 2012
Abstract Background Herpes simplex virus type-1 (HSV-1) is the primary cause of
facial lesions (mouth, lips, and eyes) in humans. The widespread use of
acyclovir and nucleoside analogues has led to emergence of HSV strains that are
resistant to these drugs. Recently, non-nucleoside anti-HSV compounds have
received considerable attention. 1,6-Naphthyridines are a class of heterocyclic
compounds tha...
Plant polyphenols as electron donors for erythrocyte plasma membrane redox system: validation through in silico approach
Tập 2 Số 1 - 2012
Abstract Background The plasma membrane redox system (PMRS) has extensively been
studied in erythrocytes. The PMRS plays an important role in maintaining plasma
redox balance and provides a protective mechanism against oxidative stress.
Earlier it was proposed that only NADH or NADPH provided reducing equivalents to
PMRS; however, now it is acknowledged that some polyphenols also have the
ability ...
Bismuth nitrate pentahydrate-induced novel nitration of eugenol
- 2011
Abstract Background Eugenol, the main constituent of clove oil possesses a
number of medicinal activities. To enhance the medicinal property, structural
modification is required. On the other hand, bismuth nitrate pentahydrate has
been established as an excellent eco-friendly nitrating agent for several
classes of organic compounds. Results Bismuth nitrate pentahydrate-induced
nitration of eugenol...
Development of 4H-pyridopyrimidines: a class of selective bacterial protein synthesis inhibitors
Tập 2 Số 1 - 2012
Abstract Background We have identified a series of compounds that inhibit
protein synthesis in bacteria. Initial IC50's in aminoacylation/translation
(A/T) assays ranged from 3 to14 μM. This series of compounds are variations on a
5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4-ol scaffold (e.g.,
4H-pyridopyrimidine). Methods Greater than 80 analogs were prepared to
investigate the structure-activity r...