Bismuth nitrate pentahydrate-induced novel nitration of eugenol

Organic and Medicinal Chemistry Letters - 2011
Luis Canales1, Debasish Bandyopadhyay1, Bimal K. Banik1
1Department of Chemistry, The University of Texas-Pan American, 1201, West University Drive, Edinburg, TX, 78539, USA

Tóm tắt

Abstract Background Eugenol, the main constituent of clove oil possesses a number of medicinal activities. To enhance the medicinal property, structural modification is required. On the other hand, bismuth nitrate pentahydrate has been established as an excellent eco-friendly nitrating agent for several classes of organic compounds. Results Bismuth nitrate pentahydrate-induced nitration of eugenol has been investigated very thoroughly. Twenty five different conditions have been studied. The microwave-induced solvent-free reaction has been identified as the best condition. Conclusions Spectral analyses confirm that 5-nitroeugenol is the sole product in all the cases. No oxidized or isomerized product could be detected.

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Organic and Medicinal Chemistry Letters

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