Neohesperidin enhances PGC-1α-mediated mitochondrial biogenesis and alleviates hepatic steatosis in high fat diet fed miceNutrition and Diabetes - Tập 10 Số 1
Siwei Wang, Hao Sheng, Yongfeng Bai, Yuanyuan Weng, Xueyu Fan, Li-jun Lou, Feng Zhang
AbstractBackgroundsMitochondria plays a critical role in the development and
pathogenesis of nonalcoholic fatty liver disease (NAFLD). Neohesperidin (NHP)
could lower blood glucose and prevent obesity in mice. However, the direct
effect of NHP on hepatic steatosis has not been reported.MethodsMice were fed
with either a chow diet or HFD with or without oral gavage of NHP for 12 weeks.
A variety of... hiện toàn bộ
Plasma phospholipids and fatty acid composition differ between liver biopsy-proven nonalcoholic fatty liver disease and healthy subjectsNutrition and Diabetes - Tập 6 Số 7 - Trang e220-e220
D W L, Bianca M. Arendt, Lyn M. Hillyer, Scott Fung, Ian D. McGilvray, Maha Guindi, Johane P. Allard
Abstract Background: There is growing evidence that nonalcoholic fatty liver
disease (NAFLD) is associated with perturbations in liver lipid metabolism.
Liver phospholipid and fatty acid composition have been shown to be altered in
NAFLD. However, detailed profiles of circulating lipids in the pathogenesis of
NAFLD are lacking. Objective: Therefore, the objective of the present study was
to examin... hiện toàn bộ
Correlation network analysis reveals relationships between diet-induced changes in human gut microbiota and metabolic healthNutrition and Diabetes - Tập 4 Số 6 - Trang e122-e122
Thomas Kelder, Johanna H. M. Stroeve, Sabina Bijlsma, Marijana Radonjić, Guus Roeselers
Abstract Background: Recent evidence suggests that the gut microbiota plays an
important role in human metabolism and energy homeostasis and is therefore a
relevant factor in the assessment of metabolic health and flexibility.
Understanding of these host–microbiome interactions aids the design of
nutritional strategies that act via modulation of the microbiota. Nevertheless,
relating gut microbiot... hiện toàn bộ