Neurotoxicity Research

Công bố khoa học tiêu biểu

* Dữ liệu chỉ mang tính chất tham khảo

Sắp xếp:  
MPTP-Induced apoptosis in the retina of goldfish
Neurotoxicity Research - Tập 3 - Trang 255-257 - 2001
Luigi Villani, Alina Beraudi, Anna Giuliani, Alessandro Poli
Neuronal degeneration, observed in the goldfish retina after MPTP administration, displays features of apoptosis, a physiological mechanism of cell death that occurs during development. The ultrastructural features of degenerating retinal neurons, that are seen in the inner nuclear layer two days after intravitreal MPTP administration, are consistent with classic changes observed in the programmed...... hiện toàn bộ
Quercetin Exhibits α7nAChR/Nrf2/HO-1-Mediated Neuroprotection Against STZ-Induced Mitochondrial Toxicity and Cognitive Impairments in Experimental Rodents
Neurotoxicity Research - Tập 39 - Trang 1859-1879 - 2021
Niraj Kumar Singh, Debapriya Garabadu
The objective of the present study was to investigate the α7nAChR-mediated Nrf2-dependant protective activity against streptozotocin (STZ)-induced brain mitochondrial toxicity in Alzheimer’s disease (AD)-like rats. STZ (3 mg/kg) was injected through an intracerebroventricular route to induce AD-like dementia. Repeated Quercetin (50 mg/kg, i.p.) administration attenuated cognitive impairments in th...... hiện toàn bộ
Activation of PI3k/Akt/mTOR Signaling Induces Deposition of p-tau to Promote Aluminum Neurotoxicity
Neurotoxicity Research - Tập 40 Số 5 - Trang 1516-1525 - 2022
Yirong Xu, Guangheng Zhang, Yingying Zhao, Bo Fan, Yeping Zhang
The Acute Toxicity of Acetylcholinesterase Reactivators in Mice in Relation to Their Structure
Neurotoxicity Research - - 2006
Lucie Bartosova, Kamil Kuca, Gabriela Kunesova, Daniel Jun
Oximes in combination with atropine, are an integral part of the treatment of acute intoxications with organophosphorus insecticides or with the nerve agents such as tabun, sarin, soman, cyclosarin or VX. Organophosphorus compounds are extremely potent inhibitors of the enzyme acetylcholinesterase (AChE, 3.1.1.7). The pharmacological action of oximes is multiple: they are able to reactivate the in...... hiện toàn bộ
Protective Effect of Hemin Against Experimental Chronic Fatigue Syndrome in Mice: Possible Role of Neurotransmitters
Neurotoxicity Research - Tập 38 - Trang 359-369 - 2020
Vandana Thakur, Sumit Jamwal, Mandeep Kumar, Vikrant Rahi, Puneet Kumar
Chronic fatigue syndrome (CFS) is a disorder characterized by persistent and relapsing fatigue along with long-lasting and debilitating fatigue, myalgia, cognitive impairment, and many other common symptoms. The present study was conducted to explore the protective effect of hemin on CFS in experimental mice. Male albino mice were subjected to stress-induced CFS in a forced swimming test apparatus...... hiện toàn bộ
Dopamine and glutamate dysfunctions in schizophrenia: Role of the dopamine D3 receptor
Neurotoxicity Research - Tập 6 - Trang 63-71 - 2004
Ludovic Leriche, Jorge Diaz, Pierre Sokoloff
Symptoms of schizophrenia are improved by dopamine antagonists and exacerbated by dopamine-releasing agents, suggesting hyperactivity of dopamine. However, chronic blockade of glutamate neurotransmission by antagonists at theN-methyl-D-aspartate (NMDA) receptor subtype produces a pathophysiological state resembling schizophrenia. A link between cortical glutamate/NMDA deficiency and subcortical do...... hiện toàn bộ
Effects of Hydroxyurea Exposure on the Rat Cerebellar Neuroepithelium: an Immunohistochemical and Electron Microscopic Study Along the Anteroposterior and Mediolateral Axes
Neurotoxicity Research - - 2017
Lucía Rodríguez‐Vázquez, Joaquı́n Martı́
Survival motor Neuron protein regulates apoptosis in anin vitro model of Spinal muscular atrophy
Neurotoxicity Research - Tập 13 - Trang 39-48 - 2008
Graham C. Parker, Xingli Li, Roumen A. Anguelov, Gabor Toth, Adam Cristescu, Gyula Acsadi
Progressive spinal muscular atrophy (SMA), the most prevalent hereditary lower motor neuron disease, is caused by mutations in the telomeric copy of the survival of motor neuron(SMN1) gene. Unlike other cells, lower motor neurons cannot tolerate low levels of smn protein. However, it is unclear as to the nature of the cell death involved. There is evidence that lower motor neurons undergo apoptosi...... hiện toàn bộ
Co-expression and Interaction of Pax6 with Genes and Proteins of Immunological Surveillance in the Brain of Mice
Neurotoxicity Research - Tập 40 - Trang 2238-2252 - 2022
Shashank Kumar Maurya, Rajnikant Mishra
The Pax6 binds to promoter sequence elements of genes involved in immunological surveillance and interacts with Iba1, p53, Ras-GAP, and Sparc in the brain of mice. The Pax6 also affects the expression pattern of genes involved in neurogenesis and neurodegeneration. However, the expression and association of Pax6 in the brain under immunologically challenged conditions are still elusive. Therefore,...... hiện toàn bộ
Interference of α-Synuclein Uptake by Monomeric β-Amyloid1–40 and Potential Core Acting Site of the Interference
Neurotoxicity Research - Tập 30 - Trang 479-485 - 2016
Daniel K. Y. Chan, Nady Braidy, Ying Hua Xu, Tim Chataway, Feng Guo, Gilles J. Guillemin, Charlie Teo, Wei Ping Gai
Increasing evidence suggests an important role of alpha-synuclein (α-Syn) in the pathogenesis of Parkinson’s disease (PD). The inter-neuronal spread of α-Syn via exocytosis and endocytosis has been proposed as an explanation for the neuropathological findings of PD in sub-clinical and clinical phases. Therefore, interfering the uptake of α-Syn by neurons may be an important step in slowing or modi...... hiện toàn bộ
Tổng số: 1,423   
  • 1
  • 2
  • 3
  • 4
  • 5
  • 6
  • 10