Neurotoxicity Research

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MPTP-Induced apoptosis in the retina of goldfish
Neurotoxicity Research - Tập 3 - Trang 255-257 - 2001
Luigi Villani, Alina Beraudi, Anna Giuliani, Alessandro Poli
Neuronal degeneration, observed in the goldfish retina after MPTP administration, displays features of apoptosis, a physiological mechanism of cell death that occurs during development. The ultrastructural features of degenerating retinal neurons, that are seen in the inner nuclear layer two days after intravitreal MPTP administration, are consistent with classic changes observed in the programmed...... hiện toàn bộ
Quercetin Exhibits α7nAChR/Nrf2/HO-1-Mediated Neuroprotection Against STZ-Induced Mitochondrial Toxicity and Cognitive Impairments in Experimental Rodents
Neurotoxicity Research - Tập 39 - Trang 1859-1879 - 2021
Niraj Kumar Singh, Debapriya Garabadu
The objective of the present study was to investigate the α7nAChR-mediated Nrf2-dependant protective activity against streptozotocin (STZ)-induced brain mitochondrial toxicity in Alzheimer’s disease (AD)-like rats. STZ (3 mg/kg) was injected through an intracerebroventricular route to induce AD-like dementia. Repeated Quercetin (50 mg/kg, i.p.) administration attenuated cognitive impairments in th...... hiện toàn bộ
Activation of PI3k/Akt/mTOR Signaling Induces Deposition of p-tau to Promote Aluminum Neurotoxicity
Neurotoxicity Research - Tập 40 Số 5 - Trang 1516-1525 - 2022
Yirong Xu, Guangheng Zhang, Yingying Zhao, Bo Fan, Yeping Zhang
Alterations in Synaptic Plasticity and Oxidative Stress Following Long-Term Paracetamol Treatment in Rat Brain
Neurotoxicity Research - Tập 37 - Trang 455-468 - 2019
Laddawan Lalert, Wilawan Ji-au, Sirinapa Srikam, Tipthanan Chotipinit, Sompol Sanguanrungsirikul, Anan Srikiatkhachorn, Supang Maneesri-le Grand
Several studies have recently revealed that cognitive function can be affected by paracetamol (APAP) treatment. However, the exact impact of this drug treatment on learning and memory has not been clarified. This study aimed to investigate the effect of APAP treatment on the alteration of synapses and oxidative stress in the rat frontal cortex and hippocampus. APAP at a dose of 200 mg/kg bw was fe...... hiện toàn bộ
The Acute Toxicity of Acetylcholinesterase Reactivators in Mice in Relation to Their Structure
Neurotoxicity Research - - 2006
Lucie Bartosova, Kamil Kuca, Gabriela Kunesova, Daniel Jun
Oximes in combination with atropine, are an integral part of the treatment of acute intoxications with organophosphorus insecticides or with the nerve agents such as tabun, sarin, soman, cyclosarin or VX. Organophosphorus compounds are extremely potent inhibitors of the enzyme acetylcholinesterase (AChE, 3.1.1.7). The pharmacological action of oximes is multiple: they are able to reactivate the in...... hiện toàn bộ
Protective Effect of Hemin Against Experimental Chronic Fatigue Syndrome in Mice: Possible Role of Neurotransmitters
Neurotoxicity Research - Tập 38 - Trang 359-369 - 2020
Vandana Thakur, Sumit Jamwal, Mandeep Kumar, Vikrant Rahi, Puneet Kumar
Chronic fatigue syndrome (CFS) is a disorder characterized by persistent and relapsing fatigue along with long-lasting and debilitating fatigue, myalgia, cognitive impairment, and many other common symptoms. The present study was conducted to explore the protective effect of hemin on CFS in experimental mice. Male albino mice were subjected to stress-induced CFS in a forced swimming test apparatus...... hiện toàn bộ
Dopamine and glutamate dysfunctions in schizophrenia: Role of the dopamine D3 receptor
Neurotoxicity Research - Tập 6 - Trang 63-71 - 2004
Ludovic Leriche, Jorge Diaz, Pierre Sokoloff
Symptoms of schizophrenia are improved by dopamine antagonists and exacerbated by dopamine-releasing agents, suggesting hyperactivity of dopamine. However, chronic blockade of glutamate neurotransmission by antagonists at theN-methyl-D-aspartate (NMDA) receptor subtype produces a pathophysiological state resembling schizophrenia. A link between cortical glutamate/NMDA deficiency and subcortical do...... hiện toàn bộ
Effects of Hydroxyurea Exposure on the Rat Cerebellar Neuroepithelium: an Immunohistochemical and Electron Microscopic Study Along the Anteroposterior and Mediolateral Axes
Neurotoxicity Research - - 2017
Lucía Rodríguez‐Vázquez, Joaquı́n Martı́
Protective Effect of Moderate Exogenous Electric Field Stimulation on Activating Netrin-1/DCC Expression Against Mechanical Stretch-Induced Injury in Spinal Cord Neurons
Neurotoxicity Research - Tập 34 - Trang 285-294 - 2018
Meili Liu, Chuanwei Yin, Zhengtai Jia, Kun Li, Zhifa Zhang, Yuchen Zhao, Xianghui Gong, Xiaoyu Liu, Ping Li, Yubo Fan
Nerve cells detect and respond to electric field stimulation and extrinsic chemical guidance cues during development and regeneration; therefore, the development and optimization of an approach for functional neuronal regeneration are necessary for a nerve injury. In this study, we proposed using electric field stimulation to repair a nerve injury triggered by serious mechanical stretch loading. A...... hiện toàn bộ
Neonatal 6-hydroxydopamine-induced hypo/hyperactivity: Blockade by Dopamine reuptake Inhibitors and effect of acute D-amphetamine
Neurotoxicity Research - Tập 4 - Trang 247-266 - 2002
Trevor Archer, Tomas Palomo, Anders Fredriksson
Five experiments were performed to assess the changes in motor activity resulting from neonatal administration of 6-hydroxydopamine (6-OHDA) on Days 1 or 2 postnatal, at doses of either 75 or 100 μg in a volume of 10 μl vehicle, following pretreatment with either GBR 12909 (40 mg/kg, s.c.) or amphonelic acid (4.0 mg/kg, s.c.) or saline. Motor activity was measured either over 60-min test periods o...... hiện toàn bộ
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