Neurotoxicity Research

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Activation of PI3k/Akt/mTOR Signaling Induces Deposition of p-tau to Promote Aluminum Neurotoxicity
Neurotoxicity Research - Tập 40 Số 5 - Trang 1516-1525 - 2022
Yirong Xu, Guangheng Zhang, Yingying Zhao, Bo Fan, Yeping Zhang
Dopamine and glutamate dysfunctions in schizophrenia: Role of the dopamine D3 receptor
Neurotoxicity Research - Tập 6 - Trang 63-71 - 2004
Ludovic Leriche, Jorge Diaz, Pierre Sokoloff
Symptoms of schizophrenia are improved by dopamine antagonists and exacerbated by dopamine-releasing agents, suggesting hyperactivity of dopamine. However, chronic blockade of glutamate neurotransmission by antagonists at theN-methyl-D-aspartate (NMDA) receptor subtype produces a pathophysiological state resembling schizophrenia. A link between cortical glutamate/NMDA deficiency and subcortical do...... hiện toàn bộ
Co-expression and Interaction of Pax6 with Genes and Proteins of Immunological Surveillance in the Brain of Mice
Neurotoxicity Research - Tập 40 - Trang 2238-2252 - 2022
Shashank Kumar Maurya, Rajnikant Mishra
The Pax6 binds to promoter sequence elements of genes involved in immunological surveillance and interacts with Iba1, p53, Ras-GAP, and Sparc in the brain of mice. The Pax6 also affects the expression pattern of genes involved in neurogenesis and neurodegeneration. However, the expression and association of Pax6 in the brain under immunologically challenged conditions are still elusive. Therefore,...... hiện toàn bộ
Interference of α-Synuclein Uptake by Monomeric β-Amyloid1–40 and Potential Core Acting Site of the Interference
Neurotoxicity Research - Tập 30 - Trang 479-485 - 2016
Daniel K. Y. Chan, Nady Braidy, Ying Hua Xu, Tim Chataway, Feng Guo, Gilles J. Guillemin, Charlie Teo, Wei Ping Gai
Increasing evidence suggests an important role of alpha-synuclein (α-Syn) in the pathogenesis of Parkinson’s disease (PD). The inter-neuronal spread of α-Syn via exocytosis and endocytosis has been proposed as an explanation for the neuropathological findings of PD in sub-clinical and clinical phases. Therefore, interfering the uptake of α-Syn by neurons may be an important step in slowing or modi...... hiện toàn bộ
Polychlorinated Biphenyls PCB 153 and PCB 126 Impair the Glutamate–Nitric Oxide–cGMP Pathway in Cerebellar Neurons in Culture by Different Mechanisms
Neurotoxicity Research - Tập 16 Số 2 - Trang 97-105 - 2009
Marta Llansola, Blanca Piedrafita, Regina Rodrigo, Carmina Montoliú, Vicente Felipo
Parkin-Knockout Mice did not Display Increased Vulnerability to Intranasal Administration of 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)
Neurotoxicity Research - Tập 24 - Trang 280-287 - 2013
Aderbal S. Aguiar, Fabrine S. M. Tristão, Majid Amar, Caroline Chevarin, Laurence Lanfumey, Raymond Mongeau, Olga Corti, Rui D. Prediger, Rita Raisman-Vozari
The loss of nigral dopaminergic neurons in Parkinson’s disease (PD) is believed to result from interactions between genetic susceptibility and environmental factors. Although loss-of-function mutations in the parkin gene cause early-onset familial PD, the hybrid 129Sv-C57BL/6 parkin-deficient mice did not display spontaneous degeneration of the nigrostriatal pathway or enhanced vulnerability to ne...... hiện toàn bộ
Cell and receptor type-specific alterations in markers of GABA neurotransmission in the prefrontal cortex of subjects with schizophrenia
Neurotoxicity Research - Tập 14 Số 2-3 - Trang 237-248 - 2008
David A. Lewis, Takanori Hashimoto, Harvey M. Morris
Genetic Susceptibility in Solvent Induced Neurobehavioral Effects
Neurotoxicity Research - Tập 17 - Trang 268-278 - 2009
L. Godderis, N. Maertens, V. de Gelder, A. De Lamper, K. De Ruyck, M. Vernimmen, S. Bulterys, G. Moens, H. Thierens, M. K. Viaene
The aim of this investigation was to study the influence of genetic polymorphisms of biotransformation enzymes and dopamine receptors on neurobehavioral effects in referents (n = 53), solvent-workers (n = 144), and chronic toxic encephalopathy (CTE) patients (n = 33). All participants were interviewed for exposure data and confounding factors and underwent a clinical examination. Neurobehavioral c...... hiện toàn bộ
Cell culture protection andin vivo neuroprotective capacity of flavonoids
Neurotoxicity Research - Tập 5 - Trang 425-432 - 2003
Federico Dajas, Felicia Rivera, Fernanda Blasina, Florencia Arredondo, Carolina Echeverry, Laura Lafon, Andrea Morquio, Horacio Heizen
Flavonoids are an important group of recognized antioxidants ubiquitous in fruits, vegetables and herbs. There are epidemiological evidences for the stroke-protecting capacity of flavonoids and while the neuroprotective power of complex extracts rich in flavonoids like those of Ginkgo biloba, green tea or lyophilized red wine have been demonstrated in several studies, neuroprotection by individual...... hiện toàn bộ
Limited Potentiation of Blood Pressure in Response to Oral Tyramine by the Anti-Parkinson Brain Selective Multifunctional Monoamine Oxidase-AB Inhibitor, M30
Neurotoxicity Research - - 2009
Shunit Gal, Zaid A. Abassi, Moussa B. H. Youdim
One of the limitations of non-selective monoamine oxidase (MAO) inhibitors as anti-depressant or anti-Parkinson drugs is their ability to potentiate the cardiovascular effect of oral tyramine, resulting from inhibition of systemic MAO-A and release of noradrenaline. We have investigated the cardiovascular effect of oral tyramine in response to the novel multifunctional, brain selective MAO-AB inhi...... hiện toàn bộ
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