Neuropathology
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The role of neuroimaging in mild cognitive impairment
Neuropathology - Tập 27 Số 6 - Trang 570-577 - 2007
The main purposes of neuroimaging in Alzheimer's disease (AD) have been moved
from diagnosis of advanced AD to diagnosis of very early AD at a prodromal stage
of mild cognitive impairment, prediction of conversion from mild cognitive
impairment (MCI) to AD, and differential diagnosis from other diseases causing
dementia. Structural MRI studies and functional studies using F‐18
fluorodeoxyglucose‐p...
Aging and Alzheimer's disease pathology
Neuropathology - Tập 40 Số 1 - Trang 22-29 - 2020
The number of people with dementia worldwide is predicted to increase to 131.5
million by 2050. When studying dementia, understanding the basis of the
neuropathological background is very important. Taking Alzheimer's disease (AD)
neuropathology as an example, we know that the accumulation of abnormal
structures such as senile plaques and neurofibrillary tangles is a hallmark.
Macroscopic atrophy ...
Neuropathology - Tập 35 Số 4 - Trang 354-389 - 2015
The Brain and Body Donation Program (BBDP) at Banner Sun Health Research
Institute (http://www.brainandbodydonationprogram.org) started in 1987 with
brain‐only donations and currently has banked more than 1600 brains. More than
430 whole‐body donations have been received since this service was commenced in
2005. The collective academic output of the BBDP is now described as the Arizona
Study of Ag...
Human astrocytes express aquaporin‐1 and aquaporin‐4 in vitro and in vivo
Neuropathology - Tập 27 Số 3 - Trang 245-256 - 2007
Aquaporins (AQP) constitute an evolutionarily conserved family of integral
membrane water transport channel proteins. Previous studies indicate that AQP1
is expressed exclusively in the choroid plexus epithelium, while AQP4 is
localized on the vascular foot of astrocytes in the central nervous system (CNS)
under physiological conditions. To investigate a role of AQP in the
pathophysiology of neuro...
FKBP12 immunoreactivity in the human spinal cord of motor neuron disease patients
Neuropathology - Tập 22 Số 4 - Trang 269-274 - 2002
We investigated the FKBP12 immunoreactivity in the spinal cord of neurological
controls and motor neuron disease (MND) patients. In the neurological controls,
the spinal neurons were markedly stained with antihuman FKBP12 (N‐19 and C‐19)
antibodies. FKBP12 immunoreactivity was associated with lipofuscin in
formalin‐fixed paraffin‐embedded samples. In an electron microscopic view, the
10‐nm colloid...
Chameleons and mimics: Progressive supranuclear palsy and corticobasal degeneration
Neuropathology - Tập 40 Số 1 - Trang 57-67 - 2020
Progressive supranuclear palsy (PSP) and corticobasal degeneration (CBD) are
neurodegenerative disorders that show parkinsonism as their main symptom. Both
PSP and CBD are sporadic tauopathies associated with hyperphosphorylated
four‐repeat tau aggregation in neurons and glial cells. The characteristic
pathologies of PSP are midbrain atrophy and the appearance of tufted astrocytes
and globose‐type...
Neuropathology - Tập 34 Số 1 - Trang 77-82 - 2014
A nuclear protein, transactivation response (TAR) DNA binding protein 43 kDa
(TDP‐43), is the major component of neuronal cytoplasmic inclusions (NCIs) in
frontotemporal lobar degeneration with ubiquitin inclusions (FTLD‐U) and
sporadic amyotrophic lateral sclerosis (SALS). While initially thought to be
relatively specific to FTLD‐U and ALS, TDP‐43 pathology has now been detected in
a number of ot...
Molecular mechanisms of the co‐deposition of multiple pathological proteins in neurodegenerative diseases
Neuropathology - Tập 38 Số 1 - Trang 64-71 - 2018
Intracellular inclusions composed of abnormal protein aggregates are one of the
neuropathological features of neurodegenerative diseases, and the formation of
intracellular aggregates is believed to be associated with neurodegeneration
leading to the onset of these diseases. In typical or pure cases, characteristic
pathologies with one particular protein, such as tau, alpha‐synuclein or
trans‐acti...
Chromosome 1p and 19q status and p53 and p16 expression patterns as prognostic indicators of oligodendroglial tumors: A clinicopathological study using fluorescence in situ hybridization
Neuropathology - Tập 27 Số 1 - Trang 10-20 - 2007
To verify the prognostic implications of the statuses of chromosome 1p and 19q
and the expressions of p53, p16 and GFAP in oligodendrogliomas, we investigated
these parameters and correlated the results with patient outcome. Twenty‐seven
cases of low‐grade oligodendroglioma (LO) and 29 cases of anaplastic
oligodendroglioma (AO) were analyzed by FISH for 1p and 19q status and by
immunohistochemistr...
Pediatric glioblastoma with oligodendroglioma component: Aggressive clinical phenotype with distinct molecular characteristics
Neuropathology - Tập 33 Số 6 - Trang 652-657 - 2013
The 2007 World Health Organization classification defined a new variant of
glioblastoma (GBM) containing oligodendroglioma foci as GBM with an
oligodendroglioma component (GBMO), which shows a favorable clinical outcome
compared with “classic” GBM. However, all of the reported cases of GBMO have
been adult cases, with no previous reports of pediatric cases. In this report,
we demonstrated molecula...
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