Neuropathology

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The role of neuroimaging in mild cognitive impairment
Neuropathology - Tập 27 Số 6 - Trang 570-577 - 2007
Hiroshi Matsuda
The main purposes of neuroimaging in Alzheimer's disease (AD) have been moved from diagnosis of advanced AD to diagnosis of very early AD at a prodromal stage of mild cognitive impairment, prediction of conversion from mild cognitive impairment (MCI) to AD, and differential diagnosis from other diseases causing dementia. Structural MRI studies and functional studies using F‐18 fluorodeoxyg...... hiện toàn bộ
Aging and Alzheimer's disease pathology
Neuropathology - Tập 40 Số 1 - Trang 22-29 - 2020
Renpei Sengoku
The number of people with dementia worldwide is predicted to increase to 131.5 million by 2050. When studying dementia, understanding the basis of the neuropathological background is very important. Taking Alzheimer's disease (AD) neuropathology as an example, we know that the accumulation of abnormal structures such as senile plaques and neurofibrillary tangles is a hallmark. Macroscopic ...... hiện toàn bộ
Arizona Study of Aging and Neurodegenerative Disorders and Brain and Body Donation Program
Neuropathology - Tập 35 Số 4 - Trang 354-389 - 2015
Thomas G. Beach, Charles H. Adler, Lucia I. Sue, Geidy E. Serrano, Holly A. Shill, Douglas G. Walker, Lih‐Fen Lue, Alex E. Roher, Brittany N. Dugger, Chera L. Maarouf, Alex C. Birdsill, Anthony J. Intorcia, Megan Saxon‐LaBelle, Joel Pullen, Alexander Scroggins, Jessica Filon, Sarah Scott, Brittany Hoffman, Angelica Garcia, John N. Caviness, Joseph G. Hentz, Erika Driver‐Dunckley, Sandra A. Jacobson, Kathryn Davis, Christine M. Belden, Kathy E. Long, Michael Malek‐Ahmadi, Jessica Powell, Lisa D. Gale, Lisa R. Nicholson, Richard J. Caselli, Bryan K. Woodruff, Steven Z. Rapscak, Geoffrey L. Ahern, Jiong Shi, Anna Burke, Eric M. Reiman, Marwan N. Sabbagh
The Brain and Body Donation Program (BBDP) at hiện toàn bộ
Human astrocytes express aquaporin‐1 and aquaporin‐4 in vitro and in vivo
Neuropathology - Tập 27 Số 3 - Trang 245-256 - 2007
Jun‐ichi Satoh, Hiroko Tabunoki, Takashi Yamamura, Kunimasa Arima, Hidehiko Konno
Aquaporins (AQP) constitute an evolutionarily conserved family of integral membrane water transport channel proteins. Previous studies indicate that AQP1 is expressed exclusively in the choroid plexus epithelium, while AQP4 is localized on the vascular foot of astrocytes in the central nervous system (CNS) under physiological conditions. To investigate a role of AQP in the pathophysiology ...... hiện toàn bộ
FKBP12 immunoreactivity in the human spinal cord of motor neuron disease patients
Neuropathology - Tập 22 Số 4 - Trang 269-274 - 2002
Tameko Kihira, Masaya Hironishi, Hidehiro Utunomiya, Tomoyoshi Kondo
We investigated the FKBP12 immunoreactivity in the spinal cord of neurological controls and motor neuron disease (MND) patients. In the neurological controls, the spinal neurons were markedly stained with antihuman FKBP12 (N‐19 and C‐19) antibodies. FKBP12 immunoreactivity was associated with lipofuscin in formalin‐fixed paraffin‐embedded samples. In an electron microscopic view, the 10‐nm...... hiện toàn bộ
Chameleons and mimics: Progressive supranuclear palsy and corticobasal degeneration
Neuropathology - Tập 40 Số 1 - Trang 57-67 - 2020
Maya Mimuro, Mari Yoshida
Progressive supranuclear palsy (PSP) and corticobasal degeneration (CBD) are neurodegenerative disorders that show parkinsonism as their main symptom. Both PSP and CBD are sporadic tauopathies associated with hyperphosphorylated four‐repeat tau aggregation in neurons and glial cells. The characteristic pathologies of PSP are midbrain atrophy and the appearance of tufted astrocytes and glob...... hiện toàn bộ
TDP‐43 pathology in polyglutamine diseases: With reference to amyotrphic lateral sclerosis
Neuropathology - Tập 34 Số 1 - Trang 77-82 - 2014
Yasuko Toyoshima, Hitoshi Takahashi
A nuclear protein, transactivation response (TAR) DNA binding protein 43 kDa (TDP‐43), is the major component of neuronal cytoplasmic inclusions...... hiện toàn bộ
Molecular mechanisms of the co‐deposition of multiple pathological proteins in neurodegenerative diseases
Neuropathology - Tập 38 Số 1 - Trang 64-71 - 2018
Takashi Nonaka, Masami Masuda‐Suzukake, Masato Hasegawa
Intracellular inclusions composed of abnormal protein aggregates are one of the neuropathological features of neurodegenerative diseases, and the formation of intracellular aggregates is believed to be associated with neurodegeneration leading to the onset of these diseases. In typical or pure cases, characteristic pathologies with one particular protein, such as tau, alpha‐synuclein or tr...... hiện toàn bộ
Chromosome 1p and 19q status and p53 and p16 expression patterns as prognostic indicators of oligodendroglial tumors: A clinicopathological study using fluorescence in situ hybridization
Neuropathology - Tập 27 Số 1 - Trang 10-20 - 2007
Yoon Kyung Jeon, Kyeongmee Park, Chul‐Kee Park, Sun Ha Paek, Hee‐Won Jung, Sung‐Hye Park
To verify the prognostic implications of the statuses of chromosome 1p and 19q and the expressions of p53, p16 and GFAP in oligodendrogliomas, we investigated these parameters and correlated the results with patient outcome. Twenty‐seven cases of low‐grade oligodendroglioma (LO) and 29 cases of anaplastic oligodendroglioma (AO) were analyzed by FISH for 1p and 19q status and by immunohisto...... hiện toàn bộ
Pediatric glioblastoma with oligodendroglioma component: Aggressive clinical phenotype with distinct molecular characteristics
Neuropathology - Tập 33 Số 6 - Trang 652-657 - 2013
Masahiro Mizoguchi, Nobuhiro Hata, Satoshi O. Suzuki, Yutaka Fujioka, Hideki Murata, Toshiyuki Amano, Akira Nakamizo, Koji Yoshimoto, Toru Iwaki, Tomio Sasaki
The 2007 World Health Organization classification defined a new variant of glioblastoma (GBM) containing oligodendroglioma foci as GBM with an oligodendroglioma component (GBMO), which shows a favorable cli...... hiện toàn bộ
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