FKBP12 immunoreactivity in the human spinal cord of motor neuron disease patients

Neuropathology - Tập 22 Số 4 - Trang 269-274 - 2002
Tameko Kihira1, Masaya Hironishi, Hidehiro Utunomiya, Tomoyoshi Kondo
1Department of Neurology, Wakayama Medical University, College of Medicine, Wakayama City, Kimiidera, Japan.

Tóm tắt

We investigated the FKBP12 immunoreactivity in the spinal cord of neurological controls and motor neuron disease (MND) patients. In the neurological controls, the spinal neurons were markedly stained with antihuman FKBP12 (N‐19 and C‐19) antibodies. FKBP12 immunoreactivity was associated with lipofuscin in formalin‐fixed paraffin‐embedded samples. In an electron microscopic view, the 10‐nm colloidal gold particles labeled by the anti‐FKBP12 (N‐19) antibody were present on the lipofuscin of the spinal anterior horn neurons. In the MND cases, atrophic neurons with an abundance of lipofuscin granules in the anterior horns of the spinal cord were mildly stained with the anti‐FKBP12 (N‐19 and C‐19) antibodies. Normal‐appearing neurons, inclusion‐laden neurons and chromatolytic neurons of MND cases were weak or negatively stained with anti‐FKBP12 (N‐19) antibodies. These findings suggest that FKBP12 (N‐19) may decrease in the early stages of degeneration in MND. Complexes of FKBP12 and ligands were reported to have neuroprotective and/or neuroregenerative properties. It is speculated that the decrease in FKBP12 (N‐19) plays some causative role in the development of neurodegeneration in MND. Further investigation of FKBP12 and ligands may help elucidate the pathogenesis of MND.

Từ khóa


Tài liệu tham khảo

10.1097/00001756-199802160-00031

10.1517/13543784.9.10.2331

10.1016/S0896-6273(00)80538-3

10.1016/S0169-328X(00)00210-2

10.1073/pnas.94.5.2019

10.1073/pnas.88.14.6368

10.1038/358584a0

10.1016/S0006-3495(96)79733-3

10.1006/exnr.1999.7119

10.1523/JNEUROSCI.15-04-02985.1995

Tanaka K, 2000, Immunophilin ligands prevent H2O2‐induced apoptotic cell death by increasing glutathione levels in neuron 2A neuroblastoma cells, Acta Med Okayama, 54, 275

10.1093/emboj/16.13.3866

10.1016/S0092-8674(00)80116-6

10.1126/science.275.5304.1318

Thông tin
Thông tin xuất bản

Neuropathology

Tập 22 Số 4

269-274

Thông tin tác giả