Neuropathology
SCOPUS (1993-2025)SCIE-ISI
0919-6544
1440-1789
Anh Quốc
Cơ quản chủ quản: Wiley-Blackwell Publishing Ltd , WILEY
Lĩnh vực:
Medicine (miscellaneous)Pathology and Forensic MedicineNeurology (clinical)
Các bài báo tiêu biểu
Tập 35 Số 4 - Trang 354-389 - 2015
The Brain and Body Donation Program (BBDP) at Banner Sun Health Research
Institute (http://www.brainandbodydonationprogram.org) started in 1987 with
brain‐only donations and currently has banked more than 1600 brains. More than
430 whole‐body donations have been received since this service was commenced in
2005. The collective academic output of the BBDP is now described as the Arizona
Study of Ag...
Aging and Alzheimer's disease pathology
Tập 40 Số 1 - Trang 22-29 - 2020
The number of people with dementia worldwide is predicted to increase to 131.5
million by 2050. When studying dementia, understanding the basis of the
neuropathological background is very important. Taking Alzheimer's disease (AD)
neuropathology as an example, we know that the accumulation of abnormal
structures such as senile plaques and neurofibrillary tangles is a hallmark.
Macroscopic atrophy ...
Human astrocytes express aquaporin‐1 and aquaporin‐4 in vitro and in vivo
Tập 27 Số 3 - Trang 245-256 - 2007
Aquaporins (AQP) constitute an evolutionarily conserved family of integral
membrane water transport channel proteins. Previous studies indicate that AQP1
is expressed exclusively in the choroid plexus epithelium, while AQP4 is
localized on the vascular foot of astrocytes in the central nervous system (CNS)
under physiological conditions. To investigate a role of AQP in the
pathophysiology of neuro...
Prognostic significance of microvessel density determined by an anti‐CD105/endoglin monoclonal antibody in astrocytic tumors: Comparison with an anti‐CD31 monoclonal antibody
Tập 25 Số 3 - Trang 201-206 - 2005
There are conflicting reports as to whether the degree of angiogenesis as
measured by microvessel density (MVD) has a prognostic value in astrocytic
tumors. This may be due to the use of different antibodies against endothelial
cells to highlight microvessels. It has been reported that unlike
pan‐endothelial antibodies, such as CD31, anti‐CD105 antibodies preferentially
react with endothelial cell...
The role of neuroimaging in mild cognitive impairment
Tập 27 Số 6 - Trang 570-577 - 2007
The main purposes of neuroimaging in Alzheimer's disease (AD) have been moved
from diagnosis of advanced AD to diagnosis of very early AD at a prodromal stage
of mild cognitive impairment, prediction of conversion from mild cognitive
impairment (MCI) to AD, and differential diagnosis from other diseases causing
dementia. Structural MRI studies and functional studies using F‐18
fluorodeoxyglucose‐p...
Chromosome 1p and 19q status and p53 and p16 expression patterns as prognostic indicators of oligodendroglial tumors: A clinicopathological study using fluorescence in situ hybridization
Tập 27 Số 1 - Trang 10-20 - 2007
To verify the prognostic implications of the statuses of chromosome 1p and 19q
and the expressions of p53, p16 and GFAP in oligodendrogliomas, we investigated
these parameters and correlated the results with patient outcome. Twenty‐seven
cases of low‐grade oligodendroglioma (LO) and 29 cases of anaplastic
oligodendroglioma (AO) were analyzed by FISH for 1p and 19q status and by
immunohistochemistr...
Astrocytoma with pilomyxoid features presenting in an adult
Tập 26 Số 1 - Trang 89-93 - 2006
Pilomyxoid histology is presently considered to occur in pediatric brain tumors.
We report an astrocytoma with pilomyxoid features presenting in an adult and
discuss its relationship to both the established childhood pilomyxoid
astrocytoma (PMA) and recently reported tanycytoma. A 28‐year‐old man with
medically intractable seizures presented for surgical evaluation. MRI revealed a
discrete lesion ...
Molecular mechanisms of the co‐deposition of multiple pathological proteins in neurodegenerative diseases
Tập 38 Số 1 - Trang 64-71 - 2018
Intracellular inclusions composed of abnormal protein aggregates are one of the
neuropathological features of neurodegenerative diseases, and the formation of
intracellular aggregates is believed to be associated with neurodegeneration
leading to the onset of these diseases. In typical or pure cases, characteristic
pathologies with one particular protein, such as tau, alpha‐synuclein or
trans‐acti...
Spinocerebellar ataxia with ocular motor apraxia and DNA repair
Tập 26 Số 4 - Trang 361-367 - 2006
At least four disorders, ataxia telangiectasia (AT), an
ataxia‐telangiectasia‐like disorder, early‐onset ataxia with ocular motor
apraxia and hypoalbuminemia (EAOH)/ataxia with oculomotor apraxia type 1 (AOA1),
and ataxia with oculomotor apraxia type 2, are accompanied by ocular motor
apraxia (OMA), which is an impairment of saccadic eye movement initiation. The
characteristic pathological finding...
Adult‐onset angiocentric glioma of epithelioid cell‐predominant type of the mesial temporal lobe suggestive of a rare but distinct clinicopathological subset within a spectrum of angiocentric cortical ependymal tumors
Tập 32 Số 5 - Trang 479-491 - 2012
Angiocentric glioma (AG) is defined as an epilepsy‐associated stable or slowly
growing cerebral tumor primarily affecting children and young adults,
histologically consisting mainly of monomorphic, bipolar spindle‐shaped cells
and occasional round to monopolar columnar epithelioid cells, showing
angiocentric growth pattern and features of ependymal differentiation. We
describe two clinicopathologi...