Neuropathology
SCOPUS (1993-2023)SCIE-ISI
0919-6544
1440-1789
Anh Quốc
Cơ quản chủ quản: Wiley-Blackwell Publishing Ltd , WILEY
Lĩnh vực:
Medicine (miscellaneous)Pathology and Forensic MedicineNeurology (clinical)
Các bài báo tiêu biểu
Tập 35 Số 4 - Trang 354-389 - 2015
Aging and Alzheimer's disease pathologyThe number of people with dementia worldwide is predicted to increase to 131.5 million by 2050. When studying dementia, understanding the basis of the neuropathological background is very important. Taking Alzheimer's disease (AD) neuropathology as an example, we know that the accumulation of abnormal structures such as senile plaques and neurofibrillary tangles is a hallmark. Macroscopic ... ...
Tập 40 Số 1 - Trang 22-29 - 2020
Human astrocytes express aquaporin‐1 and aquaporin‐4 in vitro and in vivoAquaporins (AQP) constitute an evolutionarily conserved family of integral membrane water transport channel proteins. Previous studies indicate that AQP1 is expressed exclusively in the choroid plexus epithelium, while AQP4 is localized on the vascular foot of astrocytes in the central nervous system (CNS) under physiological conditions. To investigate a role of AQP in the pathophysiology ... ...
Tập 27 Số 3 - Trang 245-256 - 2007
Prognostic significance of microvessel density determined by an anti‐CD105/endoglin monoclonal antibody in astrocytic tumors: Comparison with an anti‐CD31 monoclonal antibodyThere are conflicting reports as to whether the degree of angiogenesis as measured by microvessel density (MVD) has a prognostic value in astrocytic tumors. This may be due to the use of different antibodies against endothelial cells to highlight microvessels. It has been reported that unlike pan‐endothelial antibodies, such as CD31, anti‐CD105 antibodies preferentially react with endothel... ...
Tập 25 Số 3 - Trang 201-206 - 2005
The role of neuroimaging in mild cognitive impairmentThe main purposes of neuroimaging in Alzheimer's disease (AD) have been moved from diagnosis of advanced AD to diagnosis of very early AD at a prodromal stage of mild cognitive impairment, prediction of conversion from mild cognitive impairment (MCI) to AD, and differential diagnosis from other diseases causing dementia. Structural MRI studies and functional studies using F‐18 fluorodeoxyg... ...
Tập 27 Số 6 - Trang 570-577 - 2007
Chromosome 1p and 19q status and p53 and p16 expression patterns as prognostic indicators of oligodendroglial tumors: A clinicopathological study using fluorescence in situ hybridizationTo verify the prognostic implications of the statuses of chromosome 1p and 19q and the expressions of p53, p16 and GFAP in oligodendrogliomas, we investigated these parameters and correlated the results with patient outcome. Twenty‐seven cases of low‐grade oligodendroglioma (LO) and 29 cases of anaplastic oligodendroglioma (AO) were analyzed by FISH for 1p and 19q status and by immunohisto... ...
Tập 27 Số 1 - Trang 10-20 - 2007
Astrocytoma with pilomyxoid features presenting in an adultPilomyxoid histology is presently considered to occur in pediatric brain tumors. We report an astrocytoma with pilomyxoid features presenting in an adult and discuss its relationship to both the established childhood pilomyxoid astrocytoma (PMA) and recently reported tanycytoma. A 28‐year‐old man with medically intractable seizures presented for surgical evaluation. MRI revealed a discrete... ...
Tập 26 Số 1 - Trang 89-93 - 2006
Molecular mechanisms of the co‐deposition of multiple pathological proteins in neurodegenerative diseasesIntracellular inclusions composed of abnormal protein aggregates are one of the neuropathological features of neurodegenerative diseases, and the formation of intracellular aggregates is believed to be associated with neurodegeneration leading to the onset of these diseases. In typical or pure cases, characteristic pathologies with one particular protein, such as tau, alpha‐synuclein or tr... ...
Tập 38 Số 1 - Trang 64-71 - 2018
Spinocerebellar ataxia with ocular motor apraxia and DNA repairAt least four disorders, ataxia telangiectasia (AT), an ataxia‐telangiectasia‐like disorder, early‐onset ataxia with ocular motor apraxia and hypoalbuminemia (EAOH)/ataxia with oculomotor apraxia type 1 (AOA1), and ataxia with oculomotor apraxia type 2, are accompanied by ocular motor apraxia (OMA), which is an impairment of saccadic eye movement initiation. The characteristic pathological... ...
Tập 26 Số 4 - Trang 361-367 - 2006
Neuroimaging of epilepsyIt can sometimes be difficult, when examining surgical specimens, to detect underlying pathological abnormalities that may account for disordered electrical activity. For accurate diagnosis, neuropathologists and clinicians need to share common preoperative information about resected brain tissue. Our group has been able to use structural, functional, and electrophysiological neuroimaging ... ...
Tập 27 Số 6 - Trang 585-593 - 2007