Pediatric glioblastoma with oligodendroglioma component: Aggressive clinical phenotype with distinct molecular characteristics

Neuropathology - Tập 33 Số 6 - Trang 652-657 - 2013
Masahiro Mizoguchi1, Nobuhiro Hata1, Satoshi O. Suzuki2, Yutaka Fujioka1, Hideki Murata1, Toshiyuki Amano1, Akira Nakamizo1, Koji Yoshimoto1, Toru Iwaki2, Tomio Sasaki1
1Department of Neurosurgery, Kyushu University, Fukuoka, Japan
2Department of Neuropathology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan

Tóm tắt

The 2007 World Health Organization classification defined a new variant of glioblastoma (GBM) containing oligodendroglioma foci as GBM with an oligodendroglioma component (GBMO), which shows a favorable clinical outcome compared with “classic” GBM. However, all of the reported cases of GBMO have been adult cases, with no previous reports of pediatric cases. In this report, we demonstrated molecular characteristics of a pediatric GBMO case, showing aggressive clinical behavior with 8‐month overall survival. The case showed neither isocitrate dehydrogenase 1/2 genes (IDH1/2) mutation nor 1p/19q co‐deletion, a hallmark of oligodendroglioal tumors. In addition, microsatellite instability, leading to the putative mechanism of temozolomide (TMZ) resistance, was frequently detected. Molecular genetic analysis may provide critical prognostic and therapeutic insights, especially for the pediatric glioma containing oligodendroglioma components.

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Thông tin xuất bản

Neuropathology

Tập 33 Số 6

652-657

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