The Link between Depression and Chronic Pain: Neural Mechanisms in the Brain Tập 2017 - Trang 1-10 - 2017
Jiyao Sheng, Liu Shui, Yicun Wang, Ranji Cui, Xuewen Zhang
Chronic pain, as a stress state, is one of the critical factors for determining depression, and their coexistence tends to further aggravate the severity of both disorders. Unfortunately, their association remains unclear, which creates a bottleneck problem for managing chronic pain-induced depression. In recent years, studies have found considerable overlaps between pain- and depression-i...... hiện toàn bộ Alterations of GABAergic Signaling in Autism Spectrum Disorders Tập 2011 - Trang 1-12 - 2011
Rocco Pizzarelli, Enrico Cherubini
Autism spectrum disorders (ASDs) comprise a heterogeneous group of pathological conditions, mainly of genetic origin, characterized by stereotyped behavior, marked impairment in verbal and nonverbal communication, social skills, and cognition. Interestingly, in a small number of cases, ASDs are associated with single mutations in genes encoding for neuroligin-neurexin families. These are a...... hiện toàn bộ Transcranial Alternating Current and Random Noise Stimulation: Possible Mechanisms Tập 2016 - Trang 1-12 - 2016
Andrea Antal, Christoph S. Herrmann
Background. Transcranial alternating current stimulation (tACS) is a relatively recent method suited to noninvasively modulate brain oscillations. Technically the method is similar but not identical to transcranial direct current stimulation (tDCS). While decades of research in animals and humans has revealed the main physiological mechanisms of tDCS, less is kno...... hiện toàn bộ GABA Neuron Alterations, Cortical Circuit Dysfunction and Cognitive Deficits in Schizophrenia Tập 2011 - Trang 1-24 - 2011
Guillermo González‐Burgos, Kenneth N. Fish, David A. Lewis
Schizophrenia is a brain disorder associated with cognitive deficits that severely affect the patients' capacity for daily functioning. Whereas our understanding of its pathophysiology is limited, postmortem studies suggest that schizophrenia is associated with deficits of GABA-mediated synaptic transmission. A major role of GABA-mediated transmission may be producing synchronized network ...... hiện toàn bộ Neuroplasticity Underlying the Comorbidity of Pain and Depression Tập 2015 - Trang 1-16 - 2015
Lisa Doan, Toby Manders, Jing Wang
Acute pain induces depressed mood, and chronic pain is known to cause depression. Depression, meanwhile, can also adversely affect pain behaviors ranging from symptomology to treatment response. Pain and depression independently induce long-term plasticity in the central nervous system (CNS). Comorbid conditions, however, have distinct patterns of neural activation. We performed a review o...... hiện toàn bộ The Role and Mechanisms of Action of Glucocorticoid Involvement in Memory Storage Tập 6 Số 3 - Trang 41-52 - 1998
Carmen Sandi
Adrenal steroid hormones modulate learning and memory processes by interacting with specific glucocorticoid receptors at different
brain areas. In this article, certain components of the physiological response to stress elicited by learning situations are proposed to form an
integral aspect of the neurobiological mechanism underlying memory formation. By reviewing the work carried out in d...... hiện toàn bộ Brain Plasticity and Disease: A Matter of Inhibition Tập 2011 - Trang 1-11 - 2011
Laura Baroncelli, Chiara Braschi, Maria Spolidoro, Tatjana Begenisic, Lamberto Maffei, Alessandro Sale
One major goal in Neuroscience is the development of strategies promoting neural plasticity in the adult central nervous system, when functional recovery from brain disease and injury is limited. New evidence has underscored a pivotal role for cortical inhibitory circuitries in regulating plasticity both during development and in adulthood. This paper summarizes recent findings showing tha...... hiện toàn bộ Cytokines in Bipolar Disorder: Paving the Way for Neuroprogression Tập 2014 - Trang 1-9 - 2014
Izabela Guimarães Barbosa, Moisés Evandro Bauer, Rodrigo Machado‐Vieira, Antônio Lúcio Teixeira
Bipolar disorder (BD) is a severe, chronic, and recurrent psychiatric illness. It has been associated with high prevalence of medical comorbidities and cognitive impairment. Its neurobiology is not completely understood, but recent evidence has shown a wide range of immune changes. Cytokines are proteins involved in the regulation and the orchestration of the immune response. We performed ...... hiện toàn bộ Endocannabinoid System and Synaptic Plasticity: Implications for Emotional Responses Tập 2007 - Trang 1-12 - 2007
María‐Paz Viveros, Eva M. Marco, Ricardo Llorente, Meritxell López‐Gallardo
The endocannabinoid system has been involved in the regulation of anxiety, and proposed as an inhibitory modulator of neuronal, behavioral and adrenocortical responses to stressful stimuli. Brain regions such as the amygdala, hippocampus and cortex, which are directly involved in the regulation of emotional behavior, contain high densities of cannabinoid CB1 receptors. Mutant mice lacking ...... hiện toàn bộ Amyloid-β-Induced Dysregulation of AMPA Receptor Trafficking Tập 2016 - Trang 1-12 - 2016
Sumasri Guntupalli, Jocelyn Widagdo, Victor Anggono
Evidence from neuropathological, genetic, animal model, and biochemical studies has indicated that the accumulation of amyloid-beta (Aβ) is associated with, and probably induces, profound neuronal changes in brain regions critical for memory and cognition in the development of Alzheimer’s disease (AD). There is considerable evidence that synapses are particularly...... hiện toàn bộ