Neural Plasticity
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NeurologyNeurology (clinical)
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Các bài báo tiêu biểu
The Link between Depression and Chronic Pain: Neural Mechanisms in the Brain
Tập 2017 - Trang 1-10 - 2017
Chronic pain, as a stress state, is one of the critical factors for determining
depression, and their coexistence tends to further aggravate the severity of
both disorders. Unfortunately, their association remains unclear, which creates
a bottleneck problem for managing chronic pain-induced depression. In recent
years, studies have found considerable overlaps between pain- and
depression-induced n...
Alterations of GABAergic Signaling in Autism Spectrum Disorders
Tập 2011 - Trang 1-12 - 2011
Autism spectrum disorders (ASDs) comprise a heterogeneous group of pathological
conditions, mainly of genetic origin, characterized by stereotyped behavior,
marked impairment in verbal and nonverbal communication, social skills, and
cognition. Interestingly, in a small number of cases, ASDs are associated with
single mutations in genes encoding for neuroligin-neurexin families. These are
adhesion ...
Transcranial Alternating Current and Random Noise Stimulation: Possible Mechanisms
Tập 2016 - Trang 1-12 - 2016
Background. Transcranial alternating current stimulation (tACS) is a relatively
recent method suited to noninvasively modulate brain oscillations. Technically
the method is similar but not identical to transcranial direct current
stimulation (tDCS). While decades of research in animals and humans has revealed
the main physiological mechanisms of tDCS, less is known about the physiological
mechanis...
GABA Neuron Alterations, Cortical Circuit Dysfunction and Cognitive Deficits in Schizophrenia
Tập 2011 - Trang 1-24 - 2011
Schizophrenia is a brain disorder associated with cognitive deficits that
severely affect the patients' capacity for daily functioning. Whereas our
understanding of its pathophysiology is limited, postmortem studies suggest that
schizophrenia is associated with deficits of GABA-mediated synaptic
transmission. A major role of GABA-mediated transmission may be producing
synchronized network oscillat...
Neuroplasticity Underlying the Comorbidity of Pain and Depression
Tập 2015 - Trang 1-16 - 2015
Acute pain induces depressed mood, and chronic pain is known to cause
depression. Depression, meanwhile, can also adversely affect pain behaviors
ranging from symptomology to treatment response. Pain and depression
independently induce long-term plasticity in the central nervous system (CNS).
Comorbid conditions, however, have distinct patterns of neural activation. We
performed a review of the ch...
The Role and Mechanisms of Action of Glucocorticoid Involvement in Memory Storage
Tập 6 Số 3 - Trang 41-52 - 1998
Adrenal steroid hormones modulate learning and memory processes by interacting
with specific glucocorticoid receptors at different brain areas. In this
article, certain components of the physiological response to stress elicited by
learning situations are proposed to form an integral aspect of the
neurobiological mechanism underlying memory formation. By reviewing the work
carried out in different...
Brain Plasticity and Disease: A Matter of Inhibition
Tập 2011 - Trang 1-11 - 2011
One major goal in Neuroscience is the development of strategies promoting neural
plasticity in the adult central nervous system, when functional recovery from
brain disease and injury is limited. New evidence has underscored a pivotal role
for cortical inhibitory circuitries in regulating plasticity both during
development and in adulthood. This paper summarizes recent findings showing that
the in...
Cytokines in Bipolar Disorder: Paving the Way for Neuroprogression
Tập 2014 - Trang 1-9 - 2014
Bipolar disorder (BD) is a severe, chronic, and recurrent psychiatric illness.
It has been associated with high prevalence of medical comorbidities and
cognitive impairment. Its neurobiology is not completely understood, but recent
evidence has shown a wide range of immune changes. Cytokines are proteins
involved in the regulation and the orchestration of the immune response. We
performed a review...
Endocannabinoid System and Synaptic Plasticity: Implications for Emotional Responses
Tập 2007 - Trang 1-12 - 2007
The endocannabinoid system has been involved in the regulation of anxiety, and
proposed as an inhibitory modulator of neuronal, behavioral and adrenocortical
responses to stressful stimuli. Brain regions such as the amygdala, hippocampus
and cortex, which are directly involved in the regulation of emotional behavior,
contain high densities of cannabinoid CB1 receptors. Mutant mice lacking CB1
rece...
Amyloid-β-Induced Dysregulation of AMPA Receptor Trafficking
Tập 2016 - Trang 1-12 - 2016
Evidence from neuropathological, genetic, animal model, and biochemical studies
has indicated that the accumulation of amyloid-beta (Aβ) is associated with, and
probably induces, profound neuronal changes in brain regions critical for memory
and cognition in the development of Alzheimer’s disease (AD). There is
considerable evidence that synapses are particularly vulnerable to AD,
establishing syn...