Endocannabinoid System and Synaptic Plasticity: Implications for Emotional Responses

Neural Plasticity - Tập 2007 - Trang 1-12 - 2007
María‐Paz Viveros1, Eva M. Marco1, Ricardo Llorente1, Meritxell López‐Gallardo1
1Departamento de Fisiología (Fisiología Animal II), Facultad de Biología, Universidad Complutense, Madrid 28040

Tóm tắt

The endocannabinoid system has been involved in the regulation of anxiety, and proposed as an inhibitory modulator of neuronal, behavioral and adrenocortical responses to stressful stimuli. Brain regions such as the amygdala, hippocampus and cortex, which are directly involved in the regulation of emotional behavior, contain high densities of cannabinoid CB1 receptors. Mutant mice lacking CB1 receptors show anxiogenic and depressive-like behaviors as well as an altered hypothalamus pituitary adrenal axis activity, whereas enhancement of endocannabinoid signaling produces anxiolytic and antidepressant-like effects. Genetic and pharmacological approaches also support an involvement of endocannabinoids in extinction of aversive memories. Thus, the endocannabinoid system appears to play a pivotal role in the regulation of emotional states. Endocannabinoids have emerged as mediators of short- and long- term synaptic plasticity in diverse brain structures. Despite the fact that most of the studies on this field have been performed using in vitro models, endocannabinoid-mediated plasticity might be considered as a plausible candidate underlying some of the diverse physiological functions of the endogenous cannabinoid system, including developmental, affective and cognitive processes. In this paper, we will focus on the functional relevance of endocannabinoid-mediated plasticity within the framework of emotional responses. Alterations of the endocannabinoid system may constitute an important factor in the aetiology of certain neuropsychiatric disorders, and, in turn, enhancers of endocannabinoid signaling could represent a potential therapeutical tool in the treatment of both anxiety and depressive symptoms.

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Tài liệu tham khảo

10.1016/S0301-0082(03)00087-X

10.1073/pnas.87.5.1932

1991, The Journal of Neuroscience, 11, 563, 10.1523/JNEUROSCI.11-02-00563.1991

10.1016/S0306-4522(96)00428-9

2001, The Journal of Neuroscience, 21, 9506, 10.1523/JNEUROSCI.21-23-09506.2001

2002, Chemistry and Physics of Lipids, 121, 73, 10.1016/S0009-3084(02)00149-4

2003, The Journal of Neuroscience, 23, 9374, 10.1523/JNEUROSCI.23-28-09374.2003

10.1016/j.neuropharm.2003.08.003

10.1016/S0006-8993(01)03127-4

10.1016/S0006-3223(03)00177-X

10.1016/S0278-5846(03)00162-3

10.1210/en.2004-0638

10.1111/j.1460-9568.2005.03916.x

10.1038/sj.npp.1300601

10.1016/S0301-0082(02)00080-1

10.1007/s00482-004-0342-2

2005, Cannabinoid function in learning, memory and plasticity, 168, 445

10.1038/nature00839

10.1523/JNEUROSCI.2134-04.2004

2003, The Journal of Neuroscience, 23, 4850, 10.1523/JNEUROSCI.23-12-04850.2003

2006, Cannabinoids, anxiety and depression, 18

10.1021/jm058183t

10.2174/1389557054368763

2006, CNS & Neurological Disorders - Drug Targets, 5, 272

10.1146/annurev.pharmtox.46.120604.141254

2006, Journal of Endocrinological Investigation, 29, 27

10.1124/pr.58.3.2

10.1210/er.2005-0009

10.1016/j.tips.2006.11.001

2006, Obesity, 14, 259S

10.1038/sj.bjp.0705666

10.1016/j.pbb.2005.01.027

10.2174/156800705774933104

10.2174/138955706776073466

2006, Journal of Endocrinological Investigation, 29, 15

10.1073/pnas.0601832103

10.1074/jbc.M604660200

10.1208/aapsj080247

10.1124/pr.54.2.161

10.1016/0306-4522(92)90409-U

10.1016/S0306-4522(97)00436-3

2005, Distribution of cannabinoid receptors in the central and peripheral nervous system, 168, 299

10.1208/aapsj080231

1999, The Journal of Neuroscience, 19, 4544, 10.1523/JNEUROSCI.19-11-04544.1999

10.1016/S0306-4522(99)00086-X

10.1016/S0306-4522(01)00287-1

2003, Physiological Reviews, 83, 1017, 10.1152/physrev.00004.2003

10.1016/j.neuron.2006.07.006

10.1523/JNEUROSCI.0372-06.2006

10.1152/jn.00603.2006

10.1111/j.1432-1033.1995.tb20780.x

10.1006/taap.1996.8034

10.1016/j.pharmthera.2004.11.005

10.1126/science.1115740

10.1196/annals.1369.052

10.1016/j.neuroscience.2006.02.074

10.1523/JNEUROSCI.3303-06.2007

10.1016/j.tips.2005.11.003

10.1016/S0896-6273(01)00247-1

10.1038/35069076

10.1016/S0959-4388(02)00328-8

10.1038/nrn1247

2006, Cannabinoids, 1, 10

10.1146/annurev.neuro.29.051605.112834

10.1126/science.1088208

10.1038/sj.bjp.0705466

10.1038/sj.bjp.0705726

10.1016/S0140-6736(98)05021-1

10.1192/bjp.178.2.101

10.1136/bmj.325.7374.1195

10.1016/S0165-1781(03)00052-0

10.1002/hup.560

1990, Journal of Pharmacology and Experimental Therapeutics, 253, 1002

2003, Journal of Psychopharmacology, 17, A27

10.1097/00008877-200402000-00003

10.1007/s00213-002-1144-9

1996, Journal of Pharmacology and Experimental Therapeutics, 276, 56

10.1006/phrs.1999.0560

10.1016/S0091-3057(01)00578-0

10.1016/S0091-3057(02)01041-9

10.1016/j.pbb.2003.12.019

10.1016/j.ejphar.2004.06.069

10.1038/sj.npp.1300535

1999, Critical Reviews in Neurobiology, 13, 243, 10.1615/CritRevNeurobiol.v13.i3.20

10.1016/0091-3057(95)02066-7

10.1124/jpet.105.093286

10.1016/j.neuropharm.2006.10.013

10.1016/S0091-3057(97)00422-X

10.1046/j.1460-9568.2002.02192.x

10.1016/j.neuropharm.2004.01.003

10.1111/j.1460-9568.2004.03293.x

10.1097/00001756-199701200-00023

10.1016/0014-2999(96)00511-0

10.1046/j.1460-9568.2003.02548.x

10.1056/NEJMoa044537

10.1016/S0140-6736(05)66374-X

10.1001/jama.295.7.761

10.1038/nm803

10.1016/j.molmed.2003.09.005

10.1124/jpet.106.101287

10.1016/j.pbb.2006.03.011

10.1016/j.ijpsycho.2005.01.006

10.1016/j.biopsych.2005.10.012

10.1038/sj.mp.4001939

10.1016/j.nurx.2005.12.008

10.1038/sj.npp.1300655

10.1101/lm.217006

10.1016/j.ejphar.2005.01.008

10.1007/s00213-006-0650-6

10.1101/lm.86104

10.1523/JNEUROSCI.0153-06.2006

10.1016/j.jpsychires.2006.07.017

10.1016/j.pbb.2005.01.029

10.1007/s00213-001-0946-5

10.1097/00008877-200509000-00006

10.1016/j.pbb.2006.06.005

10.1016/j.euroneuro.2005.03.003

10.1073/pnas.0509591102

2006, Mount Sinai Journal of Medicine, 73, 931

10.1002/hipo.20156

10.1172/JCI25509

10.1111/j.1460-9568.2006.05061.x

10.1358/dnp.2006.19.10.1068007

10.1038/sj.npp.1301092

10.1016/j.ceca.2005.06.015

10.1002/glia.20084

10.1016/j.pbb.2005.01.030

10.1523/JNEUROSCI.3923-04.2005

10.2174/138161206777585139

10.1016/j.ejphar.2003.08.101

10.1097/00008877-200509000-00007

10.1192/bjp.184.2.110

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Neural Plasticity

Tập 2007

1-12

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